Ru Rong Ji

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Targeting astrocyte signaling for chronic pain
    Yong Jing Gao
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 7:482-93. 2010
  2. pmc Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia
    Yong Jing Gao
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 115:505-14. 2010
  3. pmc Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    Yong Jing Gao
    Sensory Plasticity Laboratory, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Pain Research Center, Boston, Massachusetts 02115, USA
    Glia 58:1871-80. 2010
  4. pmc Chemokines, neuronal-glial interactions, and central processing of neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Pharmacol Ther 126:56-68. 2010
  5. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
  6. ncbi request reprint Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord
    Tatsuro Kohno
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA
    Pain 117:77-87. 2005
  7. ncbi request reprint p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
  8. pmc Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, Massachusetts 02115, USA
    Nat Med 14:331-6. 2008
  9. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
  10. pmc Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1
    Chul Kyu Park
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Neurosci 31:15072-85. 2011

Collaborators

Detail Information

Publications60

  1. pmc Targeting astrocyte signaling for chronic pain
    Yong Jing Gao
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 7:482-93. 2010
    ..Therefore, interventions in specific signaling pathways in astrocytes may offer new approaches for the management of chronic pain...
  2. pmc Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia
    Yong Jing Gao
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 115:505-14. 2010
    ....
  3. pmc Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    Yong Jing Gao
    Sensory Plasticity Laboratory, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Pain Research Center, Boston, Massachusetts 02115, USA
    Glia 58:1871-80. 2010
    ..Taken together, our results suggest that activated astrocytes are sufficient to produce persistent pain symptom in naïve mice by releasing MCP-1...
  4. pmc Chemokines, neuronal-glial interactions, and central processing of neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Pharmacol Ther 126:56-68. 2010
    ..Insights into the role of chemokines in neuronal-glial interactions after nerve injury will identify new targets for therapeutic intervention of neuropathic pain...
  5. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  6. ncbi request reprint Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord
    Tatsuro Kohno
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA
    Pain 117:77-87. 2005
    ..Axotomy-induced changes in MOR may contribute to opioid- insensitive components of neuropathic pain while the absence of these changes in intact afferents may contribute to the opioid sensitive components...
  7. ncbi request reprint p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..Coactivation of p38 in DRG neurons and spinal microglia may contribute to later phases of neuropathic pain...
  8. pmc Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, Massachusetts 02115, USA
    Nat Med 14:331-6. 2008
    ..Inhibition of MMP may provide a novel therapeutic approach for the treatment of neuropathic pain at different phases...
  9. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
    ..Our findings demonstrate a critical role of TLR3 in regulating sensory neuronal excitability, spinal cord synaptic transmission, and central sensitization. TLR3 may serve as a new target for developing anti-itch treatment...
  10. pmc Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1
    Chul Kyu Park
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Neurosci 31:15072-85. 2011
    ..Our findings demonstrate a novel role of NPD1 in regulating TRPV1/TNF-α-mediated spinal synaptic plasticity and identify NPD1 as a novel analgesic for treating inflammatory pain...
  11. pmc The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition
    Yong Jing Gao
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 148:309-19. 2010
    ..Our findings also reveal a unique role of JNK1 and astrocyte network in regulating tactile allodynia and contralateral pain...
  12. ncbi request reprint Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism
    Jianren Mao
    Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:7650-61. 2002
    ..These results indicate an opioid-induced neurotoxic consequence regulated by the NMDAR-caspase pathway, a mechanism that may have clinical implications in opioid therapy and substance abuse...
  13. ncbi request reprint p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  14. pmc Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Medical Research Building, Boston, MA 02115, USA
    Brain Behav Immun 21:642-51. 2007
    ....
  15. pmc Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 5:53. 2009
    ....
  16. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  17. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..Our studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch. Elimination of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch...
  18. ncbi request reprint Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss
    Suzhen Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 6:1186-93. 2003
    ....
  19. ncbi request reprint ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
    ..Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1...
  20. ncbi request reprint A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  21. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    ..PICs may further induce long-term synaptic plasticity through CREB-mediated gene transcription. Blockade of PIC signaling could be an effective way to suppress central sensitization and alleviate chronic pain...
  22. ncbi request reprint Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity
    Jianren Mao
    Massachusetts General Hospital Pain Center and Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:8312-23. 2002
    ..These results indicate that spinal GTs may contribute to the neural mechanisms of morphine tolerance and associated abnormal pain sensitivity by means of regulating regional glutamate homeostasis...
  23. ncbi request reprint Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    Grewo Lim
    Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 105:275-83. 2003
    ..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain...
  24. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..TNF-α is shown to play a critical role in regulating spinal cord synaptic plasticity and central sensitization, and TNFR1 and TNFR2 play a distinct role in regulating different phases of inflammatory pain...
  25. pmc Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1
    Chul Kyu Park
    Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:18433-8. 2011
    ..Our findings suggest distinct roles of resolvins in regulating TRP channels and identify RvD2 as a potent endogenous inhibitor for TRPV1/TRPA1 and inflammatory pain...
  26. ncbi request reprint Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
    Gary J Brenner
    Neural Plasticity Research Group, Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02110, USA
    Eur J Neurosci 20:375-84. 2004
    ..These data provide evidence for an activity-dependent NMDAR phosphorylation at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons initiated by peripheral noxious stimuli...
  27. ncbi request reprint Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    Yeong Ray Wen
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 107:312-21. 2007
    ..Nerve injury-induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia...
  28. pmc Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance
    Yeong Ray Wen
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Formos Med Assoc 110:487-94. 2011
    ....
  29. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain...
  30. ncbi request reprint Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pharmacol Exp Ther 316:601-7. 2006
    ....
  31. ncbi request reprint Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8300-9. 2004
    ..Therefore, PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner. The PI3K pathway also appears to play a role that is distinct from ERK by regulating the early onset of inflammatory pain...
  32. pmc p38 MAPK, microglial signaling, and neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Pain 3:33. 2007
    ..Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management...
  33. ncbi request reprint Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord
    Helene Beloeil
    Department of Anesthesiology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 105:139-45. 2006
    ....
  34. pmc Emerging roles of resolvins in the resolution of inflammation and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Trends Neurosci 34:599-609. 2011
    ..Resolvins may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation...
  35. ncbi request reprint Mitogen-activated protein kinases as potential targets for pain killers
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Medical Research Building, Room 604, 75 Francis Street, Boston, MA 02115, USA
    Curr Opin Investig Drugs 5:71-5. 2004
    ..Inhibition of ERK or p38 alleviates inflammatory pain and neuropathic pain in animal models. Development of specific inhibitors for these two MAPKs may lead to new therapies for pathological pain...
  36. pmc Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, HIM 829, Boston, MA 02115, USA
    FASEB J 26:1755-65. 2012
    ..Moreover, immunoresolvents of the innate immune response, such as MaR1, offer new opportunities for assessing MΦs and their local DHA metabolome in the return to tissue homeostasis...
  37. pmc Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury
    Zhen Zhong Xu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 8:37-41. 2013
    ..Our data suggest that RvE1 may attenuate neuropathic pain via inhibiting microglial signaling. Targeting the anti-inflammatory and pro-resolution lipid mediators may offer new options for preventing and treating neuropathic pain...
  38. pmc Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, MA 02115, USA
    Exp Neurol 219:146-55. 2009
    ..Our data reveal a marked peripheral neuropathy in this skin cancer model and important roles of the JNK pathway in cancer pain development and tumor growth. JNK inhibitors such as D-JNKI-1 may be used to treat cancer pain...
  39. pmc Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation
    Go Kato
    Department of Anaesthesia and Critical Care, DA 719, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Physiol 580:815-33. 2007
    ..This differential organization of excitatory and inhibitory inputs suggests a principle for the wiring of local circuitry within the substantia gelatinosa...
  40. pmc Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
    Temugin Berta
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 8:18. 2012
    ..We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1β in dorsal root ganglia (DRGs), and further investigated the involvement of MMP-9 in these opioid-induced peripheral changes...
  41. pmc Microglia and spinal cord synaptic plasticity in persistent pain
    Sarah Taves
    Pain Signaling and Plasticity Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Neural Plast 2013:753656. 2013
    ..Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management...
  42. pmc Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice
    Yen Chin Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 8:19. 2012
    ..We examined MMP-9 expression and localization in dorsal root ganglia (DRGs) after acute morphine treatment and, furthermore, the role of MMP-9 in modulating acute morphine-induced analgesia and hyperalgesia in mice...
  43. pmc Toll-like receptor 7 mediates pruritus
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1460-2. 2010
    ..Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions...
  44. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
    ..Although it is well documented that MAPK pathways can increase pain sensitivity via peripheral mechanisms, this review will focus on central mechanisms of MAPKs, especially ERK...
  45. ncbi request reprint DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties
    Tarek A Samad
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 24:2027-36. 2004
    ..The dynamic expression, ordered spatial localization, and adhesive properties of the RGM-related family of membrane-associated proteins are compatible with specific roles in development...
  46. ncbi request reprint Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Drug Targets Inflamm Allergy 3:299-303. 2004
    ..Development of specific MAPK inhibitors will open a new avenue to the pharmacological intervention of inflammatory pain...
  47. ncbi request reprint Cell signaling and the genesis of neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2004:reE14. 2004
    ....
  48. pmc Emerging role of Toll-like receptors in the control of pain and itch
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:131-44. 2012
    ..Given the prevalence of chronic pain and itch and the suffering of affected people, insights into TLR signaling in the nervous system will open a new avenue for the management of clinical pain and itch...
  49. pmc Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    Neuron Glia Biol 2:259-69. 2006
    ..Investigation of signaling mechanisms in spinal astrocytes will identify new molecular targets for the management of chronic pain...
  50. pmc Resolvins are potent analgesics for arthritic pain
    Zhen Zhong Xu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Pharmacol 164:274-7. 2011
    ..LINKED ARTICLE This article is a commentary on Lima-Garcia et al., pp. 278-293 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2011.01345.x...
  51. pmc Intracellular signaling in primary sensory neurons and persistent pain
    Jen Kun Cheng
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 611, Boston, MA 02115, USA
    Neurochem Res 33:1970-8. 2008
    ..Targeting the critical signaling pathways in the periphery will tackle pain at the source...
  52. ncbi request reprint ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..The sequential activation of ERK in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain...
  53. pmc Activation of JNK pathway in persistent pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurosci Lett 437:180-3. 2008
    ..Thus, targeting JNK pathway might be a useful strategy to treat both neurodegeneration and chronic pain...
  54. ncbi request reprint Central sensitization and LTP: do pain and memory share similar mechanisms?
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Trends Neurosci 26:696-705. 2003
    ....
  55. pmc Do glial cells control pain?
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron Glia Biol 3:255-68. 2007
    ..Investigating signaling mechanisms in microglia might lead to more effective management of devastating chronic pain...
  56. pmc Matrix metalloprotease regulation of neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Trends Pharmacol Sci 30:336-40. 2009
    ..Inhibition of MMP-9 or MMP-2 might provide a new strategy for the prevention and treatment of neuropathic pain...
  57. pmc Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn
    Go Kato
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 29:5088-99. 2009
    ..These results reveal a specific three-dimensional organization in the local patterns of excitatory and inhibitory connectivity that has implications for the processing of information related to both somatotopy and sensory modality...
  58. pmc Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1397-405. 2008
    ..BLA has several potential targets, including voltage-gated Na+ channels. We tested whether BLA elicited long-lasting cutaneous analgesia, when co-injected with lidocaine and epinephrine, as a model for prolonged infiltration anesthesia...
  59. pmc Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:145-54. 2012
    ..To investigate the role of oxidative stress in itch-indicative scratching behavior in mice, and furthermore, to define the cellular and molecular mechanisms underlying oxidative stress-mediated itch...
  60. doi request reprint Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study
    Qing Zeng
    Department of Radiology, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Cancer 46:1132-43. 2010
    ..Overall our results show that rapamycin plus cyclophosphamide can achieve an improved efficacy in suppressing tumour growth and metastasis, suggesting that the combination therapy can be a promising treatment option for TN cancer...