J Eric Jensen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Region-specific changes in phospholipid metabolism in chronic, medicated schizophrenia: (31)P-MRS study at 4.0 Tesla
    J Eric Jensen
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada N6A 5A5
    Br J Psychiatry 180:39-44. 2002
  2. ncbi request reprint Grey and white matter GABA level differences in the human brain using two-dimensional, J-resolved spectroscopic imaging
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    NMR Biomed 18:570-6. 2005
  3. ncbi request reprint Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    Exp Clin Psychopharmacol 16:199-206. 2008
  4. ncbi request reprint Grey and white matter differences in brain energy metabolism in first episode schizophrenia: 31P-MRS chemical shift imaging at 4 Tesla
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    Psychiatry Res 146:127-35. 2006
  5. ncbi request reprint Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Magn Reson Med 54:783-8. 2005
  6. doi request reprint Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
    J Eric Jensen
    McLean Hospital, Belmont, MA 02478, USA
    NMR Biomed 22:762-9. 2009
  7. ncbi request reprint Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    Br J Psychiatry 184:409-15. 2004
  8. pmc Effects of sleep deprivation on brain bioenergetics, sleep, and cognitive performance in cocaine-dependent individuals
    George H Trksak
    Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Sleep Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    ScientificWorldJournal 2013:947879. 2013
  9. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
  10. doi request reprint Age-related changes in brain energetics and phospholipid metabolism
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    NMR Biomed 23:242-50. 2010

Detail Information

Publications35

  1. ncbi request reprint Region-specific changes in phospholipid metabolism in chronic, medicated schizophrenia: (31)P-MRS study at 4.0 Tesla
    J Eric Jensen
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada N6A 5A5
    Br J Psychiatry 180:39-44. 2002
    ..Membrane phospholipid abnormalities in people with schizophrenia, measured with (31)P magnetic resonance spectroscopy ((31)P-MRS), have been previously reported in brain regions involved in this disorder...
  2. ncbi request reprint Grey and white matter GABA level differences in the human brain using two-dimensional, J-resolved spectroscopic imaging
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    NMR Biomed 18:570-6. 2005
    ..Our findings are consistent with ex vivo studies in the literature of both animal and human brain and demonstrate the significant potential of this technique for detecting and quantifying tissue-specific neurochemical pathology in vivo...
  3. ncbi request reprint Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    Exp Clin Psychopharmacol 16:199-206. 2008
    ..These results suggest that TAU treatment may decrease symptoms of depression and improve mitochondrial functioning...
  4. ncbi request reprint Grey and white matter differences in brain energy metabolism in first episode schizophrenia: 31P-MRS chemical shift imaging at 4 Tesla
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    Psychiatry Res 146:127-35. 2006
    ..Our data suggest that differences in grey and white matter tissue content between past studies may account for some of the variance in the literature...
  5. ncbi request reprint Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Magn Reson Med 54:783-8. 2005
    ..Six healthy human subjects underwent scanning at 4T with this sequence, yielding a global brain GABA concentration of 0.76 +/- 0.20 mM after correction for 12% macromolecule contribution...
  6. doi request reprint Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
    J Eric Jensen
    McLean Hospital, Belmont, MA 02478, USA
    NMR Biomed 22:762-9. 2009
    ..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction...
  7. ncbi request reprint Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478 9106, USA
    Br J Psychiatry 184:409-15. 2004
    ..Membrane phospholipid and high-energy abnormalities measured with phosphorus magnetic resonance spectroscopy ((31)P-MRS) have been reported in patients with schizophrenia in several brain regions...
  8. pmc Effects of sleep deprivation on brain bioenergetics, sleep, and cognitive performance in cocaine-dependent individuals
    George H Trksak
    Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Sleep Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    ScientificWorldJournal 2013:947879. 2013
    ....
  9. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
    ..We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study...
  10. doi request reprint Age-related changes in brain energetics and phospholipid metabolism
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    NMR Biomed 23:242-50. 2010
    ..Unlike some previous studies of aging and brain chemistry, this study examined healthy, non-demented and psychiatrically stable older adults and specifically analyzed gray-white matter differences in brain metabolism...
  11. doi request reprint T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010
    ....
  12. pmc Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 70:169-74. 2011
    ..Accumulating evidence suggests that the Gln/Glu ratio is a putative index of glutamatergic neurotransmission but interpretation of changes in the Gln/Glu ratio depends on the conditions of the system, including ammonia levels...
  13. pmc Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole
    Brian P Brennan
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:834-46. 2010
    ..Further investigation of the Gln/Glu ratio as a possible early biomarker of response to glutamate-modulating therapies is warranted...
  14. pmc Brain metabolite concentrations across cortical regions in healthy adults
    Bethany K Bracken
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Brain Res 1369:89-94. 2011
    ..MRS may be a useful tool for studying physical properties of the living human brain...
  15. pmc A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 203:819-29. 2009
    ..A great deal is known about the behavioral effects of this drug in humans and laboratory animals, but little is known about zolpidem's specific effects on neurochemistry in vivo...
  16. pmc Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome
    Yasmin Mashhoon
    McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1709-13. 2011
    ..Growing evidence suggests that glutamate neurotransmission is involved in mediating nicotine dependence. We hypothesized that prior to a cessation attempt, dACC glutamate levels would be lower in relapse vulnerable smokers...
  17. pmc Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study
    George H Trksak
    Behavioral Pharmacology Research Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02472, USA
    Drug Alcohol Depend 106:79-91. 2010
    ..Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function...
  18. pmc Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys
    Xiaoxu Liu
    Brain Imaging Center, McLean Hospital, Harvard Medical School, 115 Mill, St Belmont, MA 02478, USA
    Psychopharmacology (Berl) 217:367-75. 2011
    ..Chronic cocaine exposure has been associated with progressive brain structural and functional changes. Clarifying mechanisms underlying cocaine's progressive brain effects may help in the development of effective cocaine abuse treatments...
  19. ncbi request reprint In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T
    Andrew P Prescot
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 55:681-6. 2006
    ..LC-model analysis provided a means for quantifying TE-averaged (1)H-MRS spectra and a mean test-retest variability measure of 15% was established for brain Gly* levels in studies of six healthy subjects...
  20. doi request reprint 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    Int J Geriatr Psychiatry 24:788-97. 2009
    ....
  21. ncbi request reprint Tissue-specific differences in brain phosphodiesters in late-life major depression
    David G Harper
    Geriatric Psychiatry Program, McLean Hospital, Belmont, MA Department of Psychiatry, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:499-509. 2014
    ....
  22. ncbi request reprint Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder
    Roscoe O Brady
    Department of Psychiatry, Beth Israel Deaconess Hospital, Salt Lake City, UT, USA Department of Psychiatry, Harvard Medical School, Salt Lake City, UT, USA Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 15:434-9. 2013
    ..Using proton magnetic resonance spectroscopy, we investigated tissue levels of GABA in the anterior cingulate cortex and parieto-occipital cortex of participants with bipolar disorder and healthy controls...
  23. doi request reprint Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy
    Isabelle M Rosso
    Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Depress Anxiety 31:115-23. 2014
    ..We report results from what we believe is the first study applying proton magnetic resonance spectroscopy ((1) H-MRS) to measure brain GABA in PTSD...
  24. ncbi request reprint Altered anterior cingulate neurochemistry in emerging adult binge drinkers with a history of alcohol-induced blackouts
    Marisa M Silveri
    Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts McLean Imaging Center, McLean Hospital, Belmont, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Alcohol Clin Exp Res 38:969-79. 2014
    ..Magnetic resonance spectroscopy (MRS) studies have demonstrated neurochemical alterations in the frontal lobe of alcohol users, although most studies focused on older, alcohol-dependent subjects...
  25. pmc A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder
    Brian P Brennan
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 73:24-31. 2013
    ..We conclude with suggestions for possible future proton magnetic resonance spectroscopy studies in OCD...
  26. ncbi request reprint Brain phosphorus magnetic resonance spectroscopy imaging of sleep homeostasis and restoration in drug dependence
    George H Trksak
    Behavioral Pharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA
    ScientificWorldJournal 7:217-22. 2007
    ..Additional sleep studies in drug abusing populations are needed, particularly those that examine potential differential effects of sleep deprivation...
  27. pmc Frontal lobe γ-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition
    Marisa M Silveri
    Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 74:296-304. 2013
    ..Thus, the objective of this study was to characterize in vivo developmental differences in brain GABA levels...
  28. ncbi request reprint In vivo brain (31)P-MRS: measuring the phospholipid resonances at 4 Tesla from small voxels
    J Eric Jensen
    Department of Nuclear Medicine and Magnetic Resonance, St Joseph s Health Center, London, Ontario, Canada
    NMR Biomed 15:338-47. 2002
    ..This is the first study to our knowledge that has been able to quantify each of these individual phospholipid metabolites from such small voxels in the brain within a clinically reasonable scan time and without (1)H-decoupling or NOE...
  29. ncbi request reprint Comparative study of proton and phosphorus magnetic resonance spectroscopy in schizophrenia at 4 Tesla
    Jean Théberge
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Psychiatry Res 132:33-9. 2004
    ..The negative correlation between N-acetylaspartate and glycerophosphocholine may reflect the presence of neurodegeneration...
  30. doi request reprint Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Psychiatry 63:1127-34. 2008
    ..We assessed whether changes in brain bioenergetics measured with phosphorus magnetic resonance spectroscopy ((31)P MRS) correlate with treatment outcome during augmentation treatment with triiodothyronine (T3) in MDD...
  31. ncbi request reprint Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T
    Seth D Friedman
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98105, USA
    J Cereb Blood Flow Metab 27:646-53. 2007
    ..Other mitigating factors, such as anesthesia-induced deregulation of the cerebrovasculature, might have contributed to the exaggerated metabolic changes observed in previous animal investigations...
  32. ncbi request reprint Regarding "Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study"
    Jean Théberge
    Biol Psychiatry 61:1218-9; author reply 1219-20. 2007
  33. ncbi request reprint Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment
    Chris C Streeter
    Division of Psychiatry, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA
    Psychopharmacology (Berl) 182:516-26. 2005
    ..There is evidence that prefrontal lobe GABA levels are low in cocaine-dependent (CD) individuals, and treatment with GABA agonists decreases cocaine self-administration...
  34. ncbi request reprint Yoga Asana sessions increase brain GABA levels: a pilot study
    Chris C Streeter
    Division of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
    J Altern Complement Med 13:419-26. 2007
    ..It was hypothesized that an individual yoga session would be associated with an increase in brain GABA levels...
  35. doi request reprint High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam
    Mark H Pollack
    Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:739-43. 2008
    ..Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD)...