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Genomes and Genes | Frances E JensenSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The role of glutamate receptor maturation in perinatal seizures and brain injuryFrances E Jensen
Program in Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 20:339-47. 2002..Further investigation of patterns of glutamate receptor subunit expression in human brain and in experimental animal models is necessary to determine potential age specific strategies as well as adverse effects...- Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortexDelia M Talos
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 497:42-60. 2006..Moreover, as demonstrated in part II, there are striking similarities between rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expression... - Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramatePamela L Follett
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 24:4412-20. 2004.... 
17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brainBettina Gerstner
Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
J Neurosci Res 87:2078-86. 2009..These results suggest a potential role for estrogens in attenuation of hypoxic-ischemic and oxidative injury to developing OLs and in the prevention of periventricular leukomalacia...- Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure modelPaven K Aujla
Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Epilepsia 50:694-701. 2009..We have previously shown that AMPARs play a critical role in the generation of acute seizures and later-life seizure susceptibility in this model of neonatal seizures... - Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial functionWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Neurochem 98:213-22. 2006..Therapeutic strategies targeting local glutamate concentration and mitochondrial injury during hypoxia-ischemia may be relevant to human disorders associated with pre-OL excitotoxicity... - Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampusAnatoli Y Kabakov
Department of Neurology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
J Neurophysiol 107:1881-9. 2012..These data suggest that tDCS may oppositely affect neurons in a stimulated cortical volume if these neurons are excited by oppositely orientated axons in a constant electrical field... - NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalaciaSimon M Manning
Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 28:6670-8. 2008..These protective doses of memantine do not affect normal myelination or cortical growth. Together, these data suggest that NMDAR blockade with memantine may provide an effective pharmacological prevention of PVL in the premature infant... - Altered inhibition in tuberous sclerosis and type IIb cortical dysplasiaDelia M Talos
Department of Neurology, Children s Hospital Boston, MA, USA
Ann Neurol 71:539-51. 2012.... - Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubersDelia M Talos
Department of Neurology, Children s Hospital, Boston, MA 02115, USA
Ann Neurol 63:454-65. 2008.... - NKCC1 transporter facilitates seizures in the developing brainVolodymyr I Dzhala
Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
Nat Med 11:1205-13. 2005..Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures... - Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizuresSanjay N Rakhade
Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 28:7979-90. 2008..Thus, the potentiation of AMPAR-containing synapses is a reversible, early step in epileptogenesis that offers a novel therapeutic target in the highly seizure-prone developing brain... - NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injurySookyong Koh
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Epilepsia 45:569-75. 2004.... - The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathwayDelia M Talos
Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e35885. 2012.... - The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brainSimon M Manning
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:767-73. 2011..Evaluating clinically approved drugs in preclinical neonatal animal models of early brain development is an important prerequisite to considering them for clinical trial in preterm infants and early childhood... - Altered development of glutamatergic synapses in layer V pyramidal neurons in NR3A knockout miceChengwen Zhou
Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
Mol Cell Neurosci 42:419-26. 2009..The data indicate that NR3A plays a significant role in the development of excitatory synapses in layer V of the developing neocortex... - Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicityWenbin Deng
Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:36004-11. 2006..Overall, these data suggest that targeting GluR2-lacking AMPARs or CREB may be a useful strategy for treating nervous system disorders associated with OL excitotoxicity... - Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortexDelia M Talos
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 497:61-77. 2006..Furthermore, these data help to validate specific rodent maturational stages as appropriate models for evaluation of H/I pathophysiology... - Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complexJune Goto
Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:E1070-9. 2011..This TSC brain model provides insights into the pathogenesis and organelle dysfunction of giant cells, as well as epilepsy control in patients with TSC... 
Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalaciaLauren L Jantzie
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Neuron Glia Biol 6:277-88. 2010..Group I mGluRs may represent important therapeutic targets for protection from HI-mediated white matter injury...- 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytesHong Wang
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Eur J Neurosci 20:2049-58. 2004..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death... - Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the ratAlexander Rotenberg
Department of Neurology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue Fegan 9, Boston, MA 02115, USA
Clin Neurophysiol 119:2697-702. 2008..To test the anticonvulsive potential of a range of repetitive transcranial magnetic stimulation (rTMS) frequencies by novel methods for simultaneous EEG and rTMS in a rat seizure model... - The developing oligodendrocyte: key cellular target in brain injury in the premature infantJoseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:423-40. 2011..The critical next step, i.e., clinical trials in the living infant, is now on the horizon... - A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized ratsTsung Hsun Hsieh
Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurophysiol 107:966-72. 2012..Thus ppTMS-MMG appears a well-tolerated biomarker for measuring GABA(A)-mediated cortical inhibition in rats... - Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neuronsChengwen Zhou
Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 31:18211-22. 2011..Thus, this study demonstrates a novel mechanism by which early life seizures could impair synaptic plasticity, suggesting a potential target for therapeutic strategies to prevent long-term cognitive deficits... - Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursorsWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:6801-6. 2003.... - Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizuresSanjay N Rakhade
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 32:17800-12. 2012..Finally, human hippocampal samples from neonatal seizure autopsy cases also showed an increase in GluR1 S831 and S845, supporting the validation of this potential therapeutic target in human tissue... - Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizuresSanjay N Rakhade
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
Epilepsia 52:753-65. 2011..To study the development of epilepsy following hypoxia-induced neonatal seizures in Long-Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures... - Developmental factors regulating susceptibility to perinatal brain injury and seizuresFrances E Jensen
Department of Neurology, Children s Hospital, Program in Neurobiology, Harvard Medical School, Boston, MA 02114, USA
Curr Opin Pediatr 18:628-33. 2006..To review the unique pattern of developmentally regulated factors that govern the susceptibility of the brain during the preterm and term windows of development... - Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathwaySeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:8514-9. 2003..In contrast, animals bearing a loss-of-function mutation in the tlr4 gene are resistant to neuronal injury in the same model. The present study demonstrates a mechanistic link among innate immunity, TLRs, and neurodegeneration... - Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stressWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:7751-6. 2004.... - A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survivalLynsey Meikle
Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 27:5546-58. 2007..This new TSC brain model replicates several features of human TSC brain lesions and implicates an important function of Tsc1/Tsc2 in neuronal development... - Epileptogenesis in the immature brain: emerging mechanismsSanjay N Rakhade
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Rev Neurol 5:380-91. 2009..An understanding of these factors could yield potential therapeutic targets for the prevention of epileptogenesis and also provide biomarkers for identifying patients at risk of developing epilepsy or for monitoring disease progression... - Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"Joseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:565-82. 2011..The critical next step, i.e., clinical trials in the living infant, is now on the horizon... - Role of glutamate receptors in periventricular leukomalaciaFrances E Jensen
Department of Neurology, Children s Hospital Boston, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
J Child Neurol 20:950-9. 2005..Pharmacologic agents acting on glutamate receptors might represent age-specific therapeutic strategies for the treatment of periventricular leukomalacia... - Neonatal seizures: an update on mechanisms and managementFrances E Jensen
Children s Hospital Boston, CLS 14073, 300 Longwood Avenue, Boston, MA 02115, USA
Clin Perinatol 36:881-900, vii. 2009.... - Measures of cortical inhibition by paired-pulse transcranial magnetic stimulation in anesthetized ratsAndrew M Vahabzadeh-Hagh
Department of Neurology, Children s Hospital, 300 Longwood Ave, Boston, MA 02215, USA
J Neurophysiol 105:615-24. 2011..These results suggest a potential for LI-ppTMS as a biomarker of impaired cortical inhibition in murine disease models... - Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissueYijun Li
Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Chromatogr B Analyt Technol Biomed Life Sci 879:998-1002. 2011..p.) injection of bumetanide, and were used to calculate bumetanide permeability through the blood-brain barrier... - Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscienceFrances E Jensen
Children s Hospital Boston, Harvard Medical School, MA, USA
Epilepsia 52:1-6. 2011..Current diagnostic methods are rapidly advancing to better delineate the nature and extent of ictal activity, and could soon be critical in identifying patterns unique to the cognitive and psychiatric comorbidities... - Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicityPaul A Rosenberg
Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci Res 71:237-45. 2003.... - The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNSSeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Neurosci 22:2478-86. 2002..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis... - Relationship between encephalopathy and abnormal neuronal activity in the developing brainFrances E Jensen
Department of Neurology, Children's Hospital, Program in Neuroscience Harvard Medical School, Boston, Massachusetts 02115, USA
Int Rev Neurobiol 49:23-35. 2002..In addition, this chapter evaluates the potential interplay between an associated developmental encephalopathy and enhanced neuronal hyperexcitability in infantile spasms... - AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brainRussell M Sanchez
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
J Neurosci 25:3442-51. 2005..These data suggest that Ca2+-permeable AMPARs and CaN regulate inhibitory synaptic transmission in a novel plasticity pathway that may play a role in epileptogenesis in the immature brain... - Pediatric epilepsy modelsFrances E Jensen
Epilepsy Res 68:28-31. 2006..No specific models exist for syndromes (e.g., Lennox-Gastaut, Landau-Kleffner). The interaction between brain development and epilepsy in humans can be assisted by use of high resolution MRI, diffusion tensor imaging, and functional MRI... - Improving the treatment of neonatal seizures: National Institute of Neurological Disorders and Stroke workshop reportFaye S Silverstein
Department of Pediatrics and Neurology University of Michigan, Ann Arbor, MI, USA
J Pediatr 153:12-5. 2008 - Neonatal seizuresFaye S Silverstein
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0646, USA
Ann Neurol 62:112-20. 2007....