Frances E Jensen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The role of glutamate receptor maturation in perinatal seizures and brain injury
    Frances E Jensen
    Program in Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 20:339-47. 2002
  2. ncbi request reprint Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 497:42-60. 2006
  3. ncbi request reprint Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate
    Pamela L Follett
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:4412-20. 2004
  4. pmc Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
    Ryan T Cleary
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57148. 2013
  5. pmc Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures
    Sanjay N Rakhade
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:17800-12. 2012
  6. pmc 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain
    Bettina Gerstner
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    J Neurosci Res 87:2078-86. 2009
  7. pmc Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model
    Paven K Aujla
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Epilepsia 50:694-701. 2009
  8. ncbi request reprint Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 98:213-22. 2006
  9. pmc Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus
    Anatoli Y Kabakov
    Department of Neurology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Neurophysiol 107:1881-9. 2012
  10. pmc NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia
    Simon M Manning
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:6670-8. 2008

Collaborators

Detail Information

Publications52

  1. ncbi request reprint The role of glutamate receptor maturation in perinatal seizures and brain injury
    Frances E Jensen
    Program in Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 20:339-47. 2002
    ..Further investigation of patterns of glutamate receptor subunit expression in human brain and in experimental animal models is necessary to determine potential age specific strategies as well as adverse effects...
  2. ncbi request reprint Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 497:42-60. 2006
    ..Moreover, as demonstrated in part II, there are striking similarities between rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expression...
  3. ncbi request reprint Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate
    Pamela L Follett
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:4412-20. 2004
    ....
  4. pmc Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
    Ryan T Cleary
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57148. 2013
    ..Taken together, these data provide preclinical support for clinical trials of bumetanide in human neonates at risk for hypoxic encephalopathy and seizures...
  5. pmc Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures
    Sanjay N Rakhade
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:17800-12. 2012
    ..Finally, human hippocampal samples from neonatal seizure autopsy cases also showed an increase in GluR1 S831 and S845, supporting the validation of this potential therapeutic target in human tissue...
  6. pmc 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain
    Bettina Gerstner
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    J Neurosci Res 87:2078-86. 2009
    ..These results suggest a potential role for estrogens in attenuation of hypoxic-ischemic and oxidative injury to developing OLs and in the prevention of periventricular leukomalacia...
  7. pmc Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model
    Paven K Aujla
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Epilepsia 50:694-701. 2009
    ..We have previously shown that AMPARs play a critical role in the generation of acute seizures and later-life seizure susceptibility in this model of neonatal seizures...
  8. ncbi request reprint Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 98:213-22. 2006
    ..Therapeutic strategies targeting local glutamate concentration and mitochondrial injury during hypoxia-ischemia may be relevant to human disorders associated with pre-OL excitotoxicity...
  9. pmc Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus
    Anatoli Y Kabakov
    Department of Neurology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Neurophysiol 107:1881-9. 2012
    ..These data suggest that tDCS may oppositely affect neurons in a stimulated cortical volume if these neurons are excited by oppositely orientated axons in a constant electrical field...
  10. pmc NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia
    Simon M Manning
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:6670-8. 2008
    ..These protective doses of memantine do not affect normal myelination or cortical growth. Together, these data suggest that NMDAR blockade with memantine may provide an effective pharmacological prevention of PVL in the premature infant...
  11. pmc Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia
    Delia M Talos
    Department of Neurology, Children s Hospital Boston, MA, USA
    Ann Neurol 71:539-51. 2012
    ....
  12. ncbi request reprint NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures...
  13. ncbi request reprint NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury
    Sookyong Koh
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Epilepsia 45:569-75. 2004
    ....
  14. pmc Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures
    Sanjay N Rakhade
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:7979-90. 2008
    ..Thus, the potentiation of AMPAR-containing synapses is a reversible, early step in epileptogenesis that offers a novel therapeutic target in the highly seizure-prone developing brain...
  15. pmc Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, MA 02115, USA
    Ann Neurol 63:454-65. 2008
    ....
  16. doi request reprint AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures
    Jocelyn J Lippman-Bell
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, U S A Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U S A
    Epilepsia 54:1922-32. 2013
    ....
  17. pmc The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35885. 2012
    ....
  18. pmc The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain
    Simon M Manning
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:767-73. 2011
    ..Evaluating clinically approved drugs in preclinical neonatal animal models of early brain development is an important prerequisite to considering them for clinical trial in preterm infants and early childhood...
  19. pmc Altered development of glutamatergic synapses in layer V pyramidal neurons in NR3A knockout mice
    Chengwen Zhou
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    Mol Cell Neurosci 42:419-26. 2009
    ..The data indicate that NR3A plays a significant role in the development of excitatory synapses in layer V of the developing neocortex...
  20. ncbi request reprint Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:36004-11. 2006
    ..Overall, these data suggest that targeting GluR2-lacking AMPARs or CREB may be a useful strategy for treating nervous system disorders associated with OL excitotoxicity...
  21. pmc Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 497:61-77. 2006
    ..Furthermore, these data help to validate specific rodent maturational stages as appropriate models for evaluation of H/I pathophysiology...
  22. doi request reprint Antiepileptic effects of levetiracetam in a rodent neonatal seizure model
    Delia M Talos
    Department of Neurology, Children s Hospital Boston, Boston, MA, USA
    Pediatr Res 73:24-30. 2013
    ..Preclinical data regarding the acute or long-term efficacy of LEV are lacking...
  23. pmc Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
    June Goto
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E1070-9. 2011
    ..This TSC brain model provides insights into the pathogenesis and organelle dysfunction of giant cells, as well as epilepsy control in patients with TSC...
  24. doi request reprint Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia
    Lauren L Jantzie
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Neuron Glia Biol 6:277-88. 2010
    ..Group I mGluRs may represent important therapeutic targets for protection from HI-mediated white matter injury...
  25. ncbi request reprint 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes
    Hong Wang
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:2049-58. 2004
    ..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death...
  26. pmc Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat
    Alexander Rotenberg
    Department of Neurology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue Fegan 9, Boston, MA 02115, USA
    Clin Neurophysiol 119:2697-702. 2008
    ..To test the anticonvulsive potential of a range of repetitive transcranial magnetic stimulation (rTMS) frequencies by novel methods for simultaneous EEG and rTMS in a rat seizure model...
  27. pmc Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures
    Hongyu Sun
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:5199-204. 2013
    ..Application of the mTOR inhibitor rapamycin prevented post-hypoxic seizure impairment of homeostasis, suggesting that homeostatic plasticity mechanisms may be potentially modifiable therapeutic targets in epileptogenesis...
  28. pmc The developing oligodendrocyte: key cellular target in brain injury in the premature infant
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:423-40. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  29. pmc A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats
    Tsung Hsun Hsieh
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 107:966-72. 2012
    ..Thus ppTMS-MMG appears a well-tolerated biomarker for measuring GABA(A)-mediated cortical inhibition in rats...
  30. pmc Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons
    Chengwen Zhou
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 31:18211-22. 2011
    ..Thus, this study demonstrates a novel mechanism by which early life seizures could impair synaptic plasticity, suggesting a potential target for therapeutic strategies to prevent long-term cognitive deficits...
  31. pmc Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6801-6. 2003
    ....
  32. doi request reprint Epilepsy biomarkers
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
    Epilepsia 54:61-9. 2013
    ..Research to identify reliable biomarkers may also reveal underlying mechanisms that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compounds...
  33. ncbi request reprint A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival
    Lynsey Meikle
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 27:5546-58. 2007
    ..This new TSC brain model replicates several features of human TSC brain lesions and implicates an important function of Tsc1/Tsc2 in neuronal development...
  34. pmc Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:7751-6. 2004
    ....
  35. pmc Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures
    Sanjay N Rakhade
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Epilepsia 52:753-65. 2011
    ..To study the development of epilepsy following hypoxia-induced neonatal seizures in Long-Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures...
  36. pmc Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8514-9. 2003
    ..In contrast, animals bearing a loss-of-function mutation in the tlr4 gene are resistant to neuronal injury in the same model. The present study demonstrates a mechanistic link among innate immunity, TLRs, and neurodegeneration...
  37. ncbi request reprint Developmental factors regulating susceptibility to perinatal brain injury and seizures
    Frances E Jensen
    Department of Neurology, Children s Hospital, Program in Neurobiology, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Pediatr 18:628-33. 2006
    ..To review the unique pattern of developmentally regulated factors that govern the susceptibility of the brain during the preterm and term windows of development...
  38. pmc Neonatal seizures: an update on mechanisms and management
    Frances E Jensen
    Children s Hospital Boston, CLS 14073, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Perinatol 36:881-900, vii. 2009
    ....
  39. pmc Epileptogenesis in the immature brain: emerging mechanisms
    Sanjay N Rakhade
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Neurol 5:380-91. 2009
    ..An understanding of these factors could yield potential therapeutic targets for the prevention of epileptogenesis and also provide biomarkers for identifying patients at risk of developing epilepsy or for monitoring disease progression...
  40. ncbi request reprint Role of glutamate receptors in periventricular leukomalacia
    Frances E Jensen
    Department of Neurology, Children s Hospital Boston, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Child Neurol 20:950-9. 2005
    ..Pharmacologic agents acting on glutamate receptors might represent age-specific therapeutic strategies for the treatment of periventricular leukomalacia...
  41. ncbi request reprint Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:565-82. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  42. pmc Measures of cortical inhibition by paired-pulse transcranial magnetic stimulation in anesthetized rats
    Andrew M Vahabzadeh-Hagh
    Department of Neurology, Children s Hospital, 300 Longwood Ave, Boston, MA 02215, USA
    J Neurophysiol 105:615-24. 2011
    ..These results suggest a potential for LI-ppTMS as a biomarker of impaired cortical inhibition in murine disease models...
  43. ncbi request reprint α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
    Soma Sengupta
    Department of Neurology, Boston Children s Hospital, Boston, MA, USA
    Acta Neuropathol . 2013
    ....
  44. pmc Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue
    Yijun Li
    Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 879:998-1002. 2011
    ..p.) injection of bumetanide, and were used to calculate bumetanide permeability through the blood-brain barrier...
  45. doi request reprint Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience
    Frances E Jensen
    Children s Hospital Boston, Harvard Medical School, MA, USA
    Epilepsia 52:1-6. 2011
    ..Current diagnostic methods are rapidly advancing to better delineate the nature and extent of ictal activity, and could soon be critical in identifying patterns unique to the cognitive and psychiatric comorbidities...
  46. ncbi request reprint Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity
    Paul A Rosenberg
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 71:237-45. 2003
    ....
  47. ncbi request reprint The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  48. ncbi request reprint Relationship between encephalopathy and abnormal neuronal activity in the developing brain
    Frances E Jensen
    Department of Neurology, Children s Hospital, Program in Neuroscience Harvard Medical School, Boston, Massachusetts 02115, USA
    Int Rev Neurobiol 49:23-35. 2002
    ..In addition, this chapter evaluates the potential interplay between an associated developmental encephalopathy and enhanced neuronal hyperexcitability in infantile spasms...
  49. ncbi request reprint AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain
    Russell M Sanchez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Neurosci 25:3442-51. 2005
    ..These data suggest that Ca2+-permeable AMPARs and CaN regulate inhibitory synaptic transmission in a novel plasticity pathway that may play a role in epileptogenesis in the immature brain...
  50. ncbi request reprint Neonatal seizures
    Faye S Silverstein
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0646, USA
    Ann Neurol 62:112-20. 2007
    ....
  51. doi request reprint Improving the treatment of neonatal seizures: National Institute of Neurological Disorders and Stroke workshop report
    Faye S Silverstein
    Department of Pediatrics and Neurology University of Michigan, Ann Arbor, MI, USA
    J Pediatr 153:12-5. 2008
  52. ncbi request reprint Pediatric epilepsy models
    Frances E Jensen
    Epilepsy Res 68:28-31. 2006
    ..No specific models exist for syndromes (e.g., Lennox-Gastaut, Landau-Kleffner). The interaction between brain development and epilepsy in humans can be assisted by use of high resolution MRI, diffusion tensor imaging, and functional MRI...