Research Topics
Species | Bruce JenkinsSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Mapping dopamine function in primates using pharmacologic magnetic resonance imagingBruce G Jenkins
Massachusetts General Hospital (MGH) Nuclear Magnetic Resonance Center, Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts 02129, USA
J Neurosci 24:9553-60. 2004..These data indicate that phMRI is a powerful tool for assessment of dynamic changes associated with normal and dysfunctional DA brain circuitry in primates...
Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brainBruce G Jenkins
AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuroimage 62:1072-85. 2012..Data and arguments will be presented to show that phMRI can provide information on neuro-receptor signaling and function that complements the static picture generated by PET studies of receptor numbers and occupancies...
An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniquesB G Jenkins
Department of Radiology, Massachusetts General Hospital NMR Center, Charlestown, USA
Ann N Y Acad Sci 893:214-42. 1999..The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam...- Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's diseaseBruce G Jenkins
MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurochem 95:553-62. 2005..Our results indicate profound metabolic defects that are strongly affected by CAG repeat length, as well as gene expression levels and protein context... - Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease miceB G Jenkins
Department of Radiology, MGH NMR Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
J Neurochem 74:2108-19. 2000..We present arguments that the elevated glutamine results from a decrease in neuronal-glial glutamate-glutamine cycling and a decrease in glutaminase activity... - Magnetic resonance spectroscopy in toxic encephalopathy and neurodegenerationB G Jenkins
MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Curr Opin Neurol 12:753-60. 1999.... - Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease modelAnna Liisa Brownell
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroimage 20:1064-75. 2003..These experimental results obtained in primate studies of striato-thalamo-cortico circuitry show a similar trend as hypothetized in Parkinson's disease-type degeneration... - Dopaminergic response to graded dopamine concentration elicited by four amphetamine dosesJiaqian Ren
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Synapse 63:764-72. 2009..In conclusion, degree of postsynaptic signal transduction is linearly correlated to the extracellular DA concentration. However, the presynaptic binding may dominate the overall DA innervation at the lower range of DA concentration... - Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imagingYin-Ching I Chen
Athinoula A. Martinos Center for Biomedical Imaging and MGH-NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
Psychopharmacology (Berl) 180:705-15. 2005..CONCLUSIONS: These results suggest that phMRI may potentially prove useful to map DAR function non-invasively in multiple brain regions simultaneously... - The role of the basal ganglia in bimanual coordinationEduard Kraft
Nuclear Magnetic Resonance Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Brain Res 1151:62-73. 2007..Our results suggest a critical role of the basal ganglia in the neural control of bimanual coordination... - Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepawY Iris Chen
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Room 2301, Charlestown, MA 02129, USA
Neurosci Lett 431:231-5. 2008..These data provide evidence for physiologic modulation caused by electroacupuncture at points near the median nerve... - Transcription MRI: a new view of the living brainPhilip K Liu
Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Neuroscientist 14:503-20. 2008..Transcription MRI will lend itself to myriad applications in living organs... - In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesiasRosario Sanchez-Pernaute
McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Neurobiol Dis 27:220-7. 2007.... - Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse modelsJi Kyung Choi
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA 02114, USA
Neuropharmacology 59:353-7. 2010..Given the ease with which scyllo-inositol can be measured in human MRS data with high signal to noise ratios, these data suggest that MRS will prove useful for evaluation of inositol treatment trials in AD subjects... - Pharmacologic neuroimaging of the ontogeny of dopamine receptor functionY Iris Chen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Dev Neurosci 32:125-38. 2010..These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age... - Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRIY Iris Chen
MGH-NMR Center and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Synapse 55:80-8. 2005..These experiments demonstrate the utility of phMRI for probing, in a noninvasive manner, the temporal and spatial dynamics of neurotransmitter interactions... - Basal ganglia activity remains elevated after movement in focal hand dystoniaAnne J Blood
Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Ann Neurol 55:744-8. 2004..We posit that inhibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we observe in "resting" activity may mask basal ganglia abnormalities in standard imaging contrast analyses... - Insights into Parkinson's disease models and neurotoxicity using non-invasive imagingRosario Sanchez-Pernaute
McLean Hospital Harvard University, Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Toxicol Appl Pharmacol 207:251-6. 2005..Functional imaging techniques are instrumental to our understanding and modeling of disease mechanisms, which should in turn lead to development of new therapies for Parkinson's disease and other neurodegenerative disorders... - Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 TJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston 02129, USA
Magn Reson Med 52:1272-81. 2004..The derived field dependencies for relative sensitivity and MRI estimates of the percentage change in CBV suggest that the benefits provided by exogenous agents will persist even at much higher magnetic fields than 9.4 T... - Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRIJi Kyung Choi
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 21:157-62. 2010..It may be plausible to use a passive amphetamine challenge as a biomarker to assess progression of the disease and efficacy of potential treatments... - Anti-inflammatory treatment in AD mice protects against neuronal pathologyJi Kyung Choi
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Exp Neurol 223:377-84. 2010..NAA levels significantly correlated with plaque burden. These results suggest that selective NSAIDs (ibuprofen and possibly celecoxib) treatment can protect against the neuronal pathology... - 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopyAnna Liisa Brownell
Department of Radiology, Bartlett Hall 504R, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurochem 89:1206-14. 2004..Animals that did not develop lesions showed reversible enhancement in cortical glucose utilization and no change in striatal glucose utilization or neurochemicals or locomotor activity... - High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imagingJi-Kyung Choi
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Synapse 60:152-7. 2006..The high spatial and temporal resolution of the phMRI technique lends itself well to further, more detailed, studies of nicotine dynamics... - Application of MRS to mouse models of neurodegenerative illnessJi Kyung Choi
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
NMR Biomed 20:216-37. 2007..The argument is made that use of MRS, combined with correlative histology and other MRI techniques, will enable objective markers with which potential therapies can be followed in a quantitative fashion... - Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonistsJi Kyung Choi
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
Psychopharmacology (Berl) 212:59-72. 2010..Dopamine D3 receptors (D3R) may be important therapeutic targets for both drug abuse and dyskinesias in Parkinson's disease; however, little is known about their functional circuitry... - Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular couplingJi-Kyung Choi
MGH-NMR Center and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street Charlestown, MA 02129, USA
Neuroimage 30:700-12. 2006..These data provide additional support for the role of local post-synaptic events in neurovascular coupling and emphasize that the interpretation of fMRI signals exclusively in terms of neuronal activity may be incomplete... - Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 miceEdward C Stack
Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA
J Neurosci 27:12908-15. 2007..Thus, modulation of synaptic influences continues to have therapeutic potential in HD... - Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's diseaseRobert J Ferrante
Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA
J Neurosci 22:1592-9. 2002.... - Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelLars M Bjorklund
Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 99:2344-9. 2002..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease... - Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer miceAnn C McKee
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Brain Res 1207:225-36. 2008..These findings provide further support for intraneuronal Abeta as a cause of cognitive impairment, and suggest that pathological alterations of tau are associated with intraneuronal oligomeric Abeta accumulation... - Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profileAlpaslan Dedeoglu
Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, MA 01730, USA
Brain Res 1012:60-5. 2004..Correlation between the severity of Abeta deposition and altered neurochemical profile remains to be studied. Nevertheless, the altered neurochemical profile may be a valuable marker to test therapeutics in this mouse model...
Research Grants
- Imaging Dopamine Mediated Neurovascular CouplingBruce Jenkins; Fiscal Year: 2010..Finally, we will improve both our quantitative ability to acquire the data using higher contrast to noise techniques as well as model the signal changes using dopaminergic release and reuptake curves. ..
- Imaging Dopamine-Mediated Neuro-Vascular CouplingBruce Jenkins; Fiscal Year: 2005..Ultimately, application of these tools will aid in developing a biological and physiological basis for understanding of human drug abuse. ..
- Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataBruce Jenkins; Fiscal Year: 2007....
- Imaging Dopamine Mediated Neurovascular CouplingBruce Jenkins; Fiscal Year: 2007..Finally, we will improve both our quantitative ability to acquire the data using higher contrast to noise techniques as well as model the signal changes using dopaminergic release and reuptake curves. ..