Katherine A Janeway
Affiliation: Harvard University
- Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumorsKatherine A Janeway
Department of Medicine, Children s Hospital Boston, MA, USA
Cancer Res 67:9084-8. 2007..KIT activation levels in pediatric KIT-wild-type GISTs are comparable with those in KIT-mutant GISTs. Therapies that inhibit KIT activation, or crucial KIT signaling intermediates, should be explored in pediatric KIT-wild-type GIST...
- Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinibKatherine A Janeway
Pediatric Oncology, Dana Farber Cancer Institute and Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Pediatr Blood Cancer 52:767-71. 2009..Sunitinib prolongs survival in adult patients with imatinib-resistant gastrointestinal stromal tumor (GIST). We report the experience with sunitinib in pediatric patients with advanced GIST following failure of imatinib...
- Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplificationKatherine A Janeway
Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
Int J Cancer 127:2718-22. 2010..Despite the absence of apparent genomic activation mechanisms accounting for overexpression, clinical study of IGF1R-directed therapies in pediatric WT GIST is warranted...
- Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effectsKatherine A Janeway
Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Boston, MA, USA
Lancet Oncol 11:670-8. 2010....
- Modeling human osteosarcoma in the mouse: From bedside to benchKatherine A Janeway
Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
Bone 47:859-65. 2010....