Farouc A Jaffer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
    Hongki Yoo
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 17:1680-4. 2011
  2. pmc Optical and multimodality molecular imaging: insights into atherosclerosis
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Brigham and Women s Hospital, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 29:1017-24. 2009
  3. ncbi request reprint Molecular imaging of cardiovascular disease
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Circulation 116:1052-61. 2007
  4. pmc Intravital fluorescence microscopic molecular imaging of atherosclerosis
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 680:131-40. 2011
  5. pmc Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 57:2516-26. 2011
  6. pmc Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
    Farouc A Jaffer
    MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
    Circulation 118:1802-9. 2008
  7. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
  8. pmc Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging
    Crystal M Ripplinger
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center, 185 Cambridge St, Suite 3206, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 32:2616-24. 2012
  9. ncbi request reprint Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
    Circulation 115:2292-8. 2007
  10. pmc Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy
    Jason R McCarthy
    Center for Systems Biology, Harvard Medical School and Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Nanomedicine (Lond) 7:1017-28. 2012

Detail Information

Publications53

  1. pmc Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
    Hongki Yoo
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 17:1680-4. 2011
    ....
  2. pmc Optical and multimodality molecular imaging: insights into atherosclerosis
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Brigham and Women s Hospital, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 29:1017-24. 2009
    ..This review highlights particular molecular imaging strategies that possess strong potential for clinical translation...
  3. ncbi request reprint Molecular imaging of cardiovascular disease
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Circulation 116:1052-61. 2007
  4. pmc Intravital fluorescence microscopic molecular imaging of atherosclerosis
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 680:131-40. 2011
    ..Here we describe applications of near-infrared fluorescence reporter technology and intravital fluorescence microscopy to elucidate important biological processes in atherosclerosis in vivo...
  5. pmc Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 57:2516-26. 2011
    ..This study sought to develop a 2-dimensional (2D) intravascular near-infrared fluorescence (NIRF) imaging strategy for investigation of arterial inflammation in coronary-sized vessels...
  6. pmc Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
    Farouc A Jaffer
    MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
    Circulation 118:1802-9. 2008
    ..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization...
  7. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
    ..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
  8. pmc Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging
    Crystal M Ripplinger
    Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center, 185 Cambridge St, Suite 3206, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 32:2616-24. 2012
    ..Here, we develop and evaluate 2 integrated fluorescence molecular-structural imaging strategies to quantify DVT-related inflammation and architecture and to assess the effect of thrombus inflammation on subsequent DVT resolution in vivo...
  9. ncbi request reprint Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
    Circulation 115:2292-8. 2007
    ..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis...
  10. pmc Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy
    Jason R McCarthy
    Center for Systems Biology, Harvard Medical School and Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Nanomedicine (Lond) 7:1017-28. 2012
    ..These PAs may also impair normal hemostasis, leading to life-threatening bleeding, including intracerebral hemorrhage...
  11. pmc Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 3:84ra45. 2011
    ..The atheroma-targeting capability of ICG has the potential to accelerate the clinical development of NIRF molecular imaging of high-risk plaques in humans...
  12. pmc Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging
    Kiyuk Chang
    Cardiovascular Research Center and the Cardiology Division, Massachusetts General Hospital, Boston, Mass 02114, USA
    Arterioscler Thromb Vasc Biol 30:1933-9. 2010
    ..To investigate the effects of pioglitazone (PIO), a peroxisome proliferator-activated receptor γ agonist, on plaque matrix metalloproteinase (MMP) and macrophage (Mac) responses in vivo in a molecular imaging study...
  13. ncbi request reprint Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007
    ..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure...
  14. ncbi request reprint Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  15. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008
    ..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...
  16. ncbi request reprint Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Circulation 110:170-6. 2004
    ..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi...
  17. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  18. pmc Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
    Marcella A Calfon
    Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
    J Biomed Opt 15:011107. 2010
    ....
  19. ncbi request reprint In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Arterioscler Thromb Vasc Biol 22:1929-35. 2002
    ..In this study, we investigated the ability of a novel thrombin-activatable molecular probe to provide in vivo images of thrombin activity in experimental thrombi...
  20. pmc A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis
    Jason R McCarthy
    Harvard Medical School, Boston, MA 02114, USA
    Small 6:2041-9. 2010
    ..Importantly, these agents display limited skin photosensitivity, are highly efficacious, and provide an integrated imaging and therapeutic nanoplatform for atherosclerosis...
  21. pmc Multimodal nanoagents for the detection of intravascular thrombi
    Jason R McCarthy
    Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, Massachusetts 02129, USA
    Bioconjug Chem 20:1251-5. 2009
    ..As demonstrated by in vitro and in vivo studies, both nanoagents possess high affinities for thrombi, and enable mutimodal fluorescence and magnetic resonance imaging...
  22. pmc High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury
    Amit Saxena
    Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Room 3206, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Mol Imaging Biol 15:282-9. 2013
    ..Here we utilize intravital microscopy (IVM) and a dextran-coated nanosensor to spatially map inflammatory macrophages in vivo following endovascular injury of murine carotid arteries...
  23. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
    ....
  24. pmc Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence
    Tetsuya Hara
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 5:607-15. 2012
    ..The goal of this study was to develop and validate a new fibrin-targeted imaging agent that enables high-resolution near-infrared fluorescence (NIRF) imaging of deep vein thrombosis (DVT)...
  25. doi request reprint Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles
    S Sibel Erdem
    Center for Systems Biology, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Methods Enzymol 508:191-209. 2012
    ..Lastly, the in vivo binding of the targeted thrombolytic to intravascular thrombi is examined...
  26. doi request reprint Progress on multimodal molecular / anatomical intravascular imaging of coronary vessels combining near infrared fluorescence and ultrasound
    Georgios Mallas
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:1117-20. 2011
    ..We include some results and models that showcase the potential power of this kind of hybrid imaging...
  27. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
    ..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model...
  28. pmc Intravascular optical imaging technology for investigating the coronary artery
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:1022-39. 2011
    ..Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future...
  29. pmc Improving quantification of intravascular fluorescence imaging using structural information
    Georgios Mallas
    Department of Electrical and Computer Engineering, Communications and Digital Signal Processing Research Center, 409 Dana Building, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Phys Med Biol 57:6395-406. 2012
    ..The findings herein point to quantification improvements when employing hybrid iNIRF, with possible implications to the clinical detection of high-risk plaques or blood vessel theranostics...
  30. doi request reprint Projected cost-effectiveness of smoking cessation interventions in patients hospitalized with myocardial infarction
    Joseph A Ladapo
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 171:39-45. 2011
    ..Supportive contact after discharge improves quit rates but is rarely used...
  31. ncbi request reprint Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
    Dong Eog Kim
    Department of Radiology, Center for Molecular Imaging Research corrected Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cereb Blood Flow Metab 25:226-33. 2005
    ..This demonstrates the feasibility of simultaneous in vivo monitoring of thrombus and BBB permeability in an animal model of cerebral venous thrombosis...
  32. ncbi request reprint A branched fluorescent peptide probe for imaging of activated platelets
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Pharm 2:92-5. 2005
    ..2PF fluorescence was also found 5.5-fold higher than that of the control probe, 2CF. Overall, our results suggest that 2PF binds tightly to GP-IIb/IIIa and potentially can be used for in vivo imaging of thrombosis...
  33. ncbi request reprint A macrophage-targeted theranostic nanoparticle for biomedical applications
    Jason R McCarthy
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Small 2:983-7. 2006
  34. ncbi request reprint Novel factor XIII probes for blood coagulation imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chembiochem 4:897-9. 2003
  35. ncbi request reprint Seeing within: molecular imaging of the cardiovascular system
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circ Res 94:433-45. 2004
    ....
  36. ncbi request reprint Molecular and cellular imaging of atherosclerosis: emerging applications
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 47:1328-38. 2006
    ..We envision that several molecular imaging approaches will become important adjuncts to the clinical management of high-risk atherosclerosis...
  37. ncbi request reprint Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy
    Ashvin N Pande
    Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:021009. 2006
    ..86). The validated experimental methodology thus establishes a platform for investigating macrophage activity in atherosclerosis in vivo, and has implications for the detection of clinical vulnerable plaques...
  38. ncbi request reprint A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
    Chembiochem 3:207-11. 2002
    ..In addition to potentially furthering our understanding of thrombin regulation in vivo, the thrombin-activated near-infrared probe may have broad clinical application to the diagnosis of arterial and venous thrombosis...
  39. pmc Advances in molecular imaging of atherosclerotic vascular disease
    Eric A Osborn
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02114, USA
    Curr Opin Cardiol 23:620-8. 2008
    ..Here we present recent exciting advances in molecular imaging of atherosclerotic vascular disease...
  40. doi request reprint Optical molecular imaging in atherosclerosis
    Sharath Subramanian
    Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    J Nucl Cardiol 17:135-44. 2010
    ..This review highlights the various optical imaging techniques and their application in assessing biological processes in atherosclerosis...
  41. pmc The year in molecular imaging
    Eric A Osborn
    Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 3:1181-95. 2010
    ..The added information garnered by molecular imaging can improve risk assessment and prognosticative studies, this is of particular benefit in the management of cardiovascular disease (CVD)...
  42. pmc Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
    Filip K Swirski
    Center for Molecular Imaging Research and Donald W Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:10340-5. 2006
    ..These results provide insights into mechanisms of atherogenesis and have implications for the duration of therapies directed at leukocyte recruitment...
  43. pmc Biological imaging of atherosclerosis: moving beyond anatomy
    Johan W Verjans
    Massachusetts General Hospital, Cardiovascular Research Center, Harvard Medical School, 185 Cambridge Street, Simches Building, Room 3206, Boston, MA, 02114, USA
    J Cardiovasc Transl Res 6:681-94. 2013
    ..The illuminated examples and discussions will highlight how biological imaging is providing new clinical approaches to identify high-risk plaques, and to streamline the development process of new atherosclerosis therapies. ..
  44. pmc Imaging atherosclerosis and risk of plaque rupture
    Eric A Osborn
    Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Curr Atheroscler Rep 15:359. 2013
    ..Here we focus on recent imaging insights into high-risk arterial plaques, the etiologic agent of acute myocardial infarction, stroke, and sudden cardiac death. ..
  45. pmc High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo
    Viviany R Taqueti
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Integr Biol (Camb) 5:278-90. 2013
    ..Here we review recent advances in IVM that have provided new in vivo biological insights into atherosclerosis and thrombosis...
  46. doi request reprint Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain
    Joseph A Ladapo
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 54:2409-22. 2009
    ....
  47. ncbi request reprint Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque rupture
    Rodolfo Carrillo-Jimenez
    Cardiology Division, Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:e267. 2005
  48. ncbi request reprint Molecular imaging in the clinical arena
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    JAMA 293:855-62. 2005
    ..To specifically demonstrate the potential of molecular imaging, we highlight recent advances in clinical and preclinical molecular imaging of cancer and atherosclerosis...
  49. ncbi request reprint Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata
    Sekar Kathiresan
    Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:310-4. 2007
    ..In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >or=2 imaging tests...
  50. pmc The advancing clinical impact of molecular imaging in CVD
    Eric A Osborn
    Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    JACC Cardiovasc Imaging 6:1327-41. 2013
    ..Here, we present state-of-the-art clinical cardiovascular molecular imaging strategies, and explore promising translational approaches positioned for clinical testing in the near term. ..
  51. pmc Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall
    Zeinab Hajjarian
    Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biomed Opt 16:026005. 2011
    ..Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI...
  52. ncbi request reprint Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failure
    Paula A Johnson
    Division of Women s Health, Brigham and Women s Hospital, Massachusetts General Hospital, Boston, USA
    N Engl J Med 355:2022-31. 2006
  53. pmc Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
    Circulation 113:1196-202. 2006
    ..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...