Research Topics
| Denise L JacobsonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Evolution and predictors of change in total bone mineral density over time in HIV-infected men and women in the nutrition for healthy living studyDenise L Jacobson
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 49:298-308. 2008..We evaluated the association of host factors, disease severity, and ART to changes in total body bone mineral density (total BMD) over time in HIV-infected men (n = 283) and women (n = 96)...
Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort StudyDenise L Jacobson
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 94:1485-95. 2011..Associations between abnormal body fat distribution and clinical variables are poorly understood in pediatric HIV disease...
Clinical management and follow-up of hypercholesterolemia among perinatally HIV-infected children enrolled in the PACTG 219C studyDenise L Jacobson
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 57:413-20. 2011..Hypercholesterolemia is common in perinatally HIV-infected (HIV+) children, but little is known about the clinical course and management in this population...
Total body and spinal bone mineral density across Tanner stage in perinatally HIV-infected and uninfected children and youth in PACTG 1045Denise L Jacobson
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, USA
AIDS 24:687-96. 2010..To characterize total body bone mineral content (BMC) and total body and spinal bone mineral density (BMD) in perinatally HIV-infected and uninfected children/youth across puberty...
Insulin resistance in HIV-infected men and women in the nutrition for healthy living cohortClara Y Jones
Division of Nutrition and Infectious Disease, Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
J Acquir Immune Defic Syndr 40:202-11. 2005..We evaluated insulin resistance (IR) in an HIV-infected cohort and compared our results with those of the National Health and Nutrition Examination Survey III (NHANES III)...
Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey)Denise L Jacobson
Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue Posner 4, Boston, MA 02111, USA
J Acquir Immune Defic Syndr 43:458-66. 2006..Metabolic syndrome increases the risk of cardiovascular outcomes and type II diabetes. Most of the metabolic abnormalities defining metabolic syndrome are observed in HIV...
Predictors of bone mineral density in human immunodeficiency virus-1 infected childrenDenise L Jacobson
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
J Pediatr Gastroenterol Nutr 41:339-46. 2005..Dietary intake of calcium and vitamin D were not associated with bone loss, but most children had suboptimal intake. However, multivitamin use was strongly associated with better bone mineral density...
Incident depression symptoms are associated with poorer HAART adherence: a longitudinal analysis from the Nutrition for Healthy Living studyDeborah Kacanek
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA
J Acquir Immune Defic Syndr 53:266-72. 2010..To determine the relationship between incident depression symptoms and suboptimal adherence to HIV highly active antiretroviral therapy (HAART)...
Metabolic syndrome before and after initiation of antiretroviral therapy in treatment-naive HIV-infected individualsSupriya Krishnan
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 61:381-9. 2012..We examined prevalence and incidence of MetS and risk factors for MetS in ART-naive HIV-infected individuals starting ART...
Understanding the role of HIV load in determining weight change in the era of highly active antiretroviral therapyD Mkaya Mwamburi
Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
Clin Infect Dis 40:167-73. 2005..In this prospective cohort study, we determined the relationship between human immunodeficiency virus (HIV) RNA load and body weight in patients with HIV infection...
Increasing risk of 5% or greater unintentional weight loss in a cohort of HIV-infected patients, 1995 to 2003Alice M Tang
Division of Nutrition and Infection, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
J Acquir Immune Defic Syndr 40:70-6. 2005..This is particularly important because recent studies have shown that even a 5% weight loss in 6 months markedly increases the risk of death...
Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adultsJane C Lindsey
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
J Acquir Immune Defic Syndr 59:325-8. 2012..Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes...
Metabolic syndrome and subclinical atherosclerosis in patients infected with HIVAlexandra Mangili
Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Clin Infect Dis 44:1368-74. 2007..The present study examines the association between carotid and coronary atherosclerosis and metabolic syndrome in human immunodeficiency virus (HIV)-infected adults...
Prevalence of, evolution of, and risk factors for fat atrophy and fat deposition in a cohort of HIV-infected men and womenDenise L Jacobson
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02066, USA
Clin Infect Dis 40:1837-45. 2005..The risk factors for fat atrophy (FA) and central fat deposition (FD) are multifactorial. We assessed the evolution and predictors of FA and FD in HIV-infected men and women...
A trigger-based design for evaluating the safety of in utero antiretroviral exposure in uninfected children of human immunodeficiency virus-infected mothersPaige L Williams
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Epidemiol 175:950-61. 2012..Minor losses in efficiency when comparing AE rates between persons exposed and unexposed in utero to particular antiretroviral drugs or drug classes were observed under most scenarios...
Incidence of non-AIDS-defining cancer in antiretroviral treatment-naïve subjects after antiretroviral treatment initiation: an ACTG longitudinal linked randomized trials analysisSupriya Krishnan
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass, USA
Oncology 80:42-9. 2011..Prospective data on factors associated with the non-AIDS-defining cancer (NADC) incidence in HIV-infected individuals are limited...
Difficulty swallowing and lack of receipt of highly active antiretroviral therapy predict acute weight loss in human immunodeficiency virus diseaseDenise L Jacobson
Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Clin Infect Dis 37:1349-56. 2003..Even when HAART is being administered, clinicians should remain vigilant regarding weight loss, oral symptoms, and trouble swallowing...
Immune response to influenza vaccine in children with inflammatory bowel diseaseYing Lu
Division of Gastroenterology, Hepatology, and Nutrition, Inflammatory Bowel Disease Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Am J Gastroenterol 104:444-53. 2009..The immune response in these patients to vaccines has not been well studied. We conducted a prospective, open label study to evaluate the serologic response to influenza vaccine in children with IBD...
