Research Topics
Genomes and Genes | S IuchiSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Three classes of C2H2 zinc finger proteinsS Iuchi
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Mol Life Sci 58:625-35. 2001..In contrast to proteins with triple-C2H2 fingers, proteins with multiple-adjacent-C2H2 fingers can bind multiple, different ligands. Proteins with a number of separated-paired fingers bind to the target by means of only a single pair...
Alternative subcellular locations of keratinocyte basonuclinS Iuchi
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Exp Dermatol 9:178-84. 2000..We conclude that different states of the keratinocyte require greater or less activity of basonuclin, and the subcellular location of the protein is probably related to the magnitude of its action on the cells...
Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoterS Iuchi
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston MA 02115, USA
Proc Natl Acad Sci U S A 96:9628-32. 1999..The upstream part, but not the downstream part, is known to bind UBF1, a transcription factor for rDNA. Basonuclin is likely to be a cell-type-specific regulatory protein for rDNA transcription...
Cellular and molecular physiology of Escherichia coli in the adaptation to aerobic environmentsS Iuchi
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biochem 120:1055-63. 1996..E. coli thus employs at least four global regulatory systems which monitor the cellular oxidative/metabolic conditions, and adjust the expression of more than 70 operons to give the organism a better aerobic life...
Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamineS Iuchi
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:2409-14. 2003..The resistance of oligomer and polymer to formic acid suggests the participation of covalent bonds in their stabilization...
Conservation of human and mouse basonuclins as a guide to important features of the proteinK Matsuzaki
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Gene 195:87-92. 1997..The highly conserved regions are likely to be essential for the common function of the proteins, and the more divergent regions may be either unconstrained or adapted to different requirements in the two species...
Three overlapping lct genes involved in L-lactate utilization by Escherichia coliJ M Dong
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
J Bacteriol 175:6671-8. 1993..A phi (lctD-lac) mutant was inducible by L-lactate but not D-lactate. Although the mutant lost the ability to grow on L-lactate, growth on D-lactate, known to depend on a different enzyme, remained normal...
Adaptation of Escherichia coli to redox environments by gene expressionS Iuchi
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
Mol Microbiol 9:9-15. 1993..In addition, the regulator FhlA is involved in a cascade-controlled pathway for the formate branch of the pyruvate fermentation pathway...
Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylationS Iuchi
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston MA 02115, USA
Proc Natl Acad Sci U S A 94:7948-53. 1997..Different subcellular locations of basonuclin in different keratinocyte subtypes are therefore most likely to be controlled by the state of phosphorylation of Ser-541...
