Farren J Isaacs

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint RNA synthetic biology
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:545-54. 2006
  2. pmc A brave new synthetic world
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Genome Biol 10:302. 2009
  3. ncbi request reprint Engineered riboregulators enable post-transcriptional control of gene expression
    Farren J Isaacs
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Biotechnol 22:841-7. 2004
  4. ncbi request reprint Molecular biology. Signal processing in single cells
    Farren J Isaacs
    Lipper Center for Computational Genetics and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 307:1886-8. 2005
  5. doi request reprint Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 333:348-53. 2011
  6. pmc Prediction and measurement of an autoregulatory genetic module
    Farren J Isaacs
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:7714-9. 2003
  7. ncbi request reprint Synthetic biology evolves
    William J Blake
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Trends Biotechnol 22:321-4. 2004
  8. doi request reprint Programming cells by multiplex genome engineering and accelerated evolution
    Harris H Wang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:894-8. 2009

Detail Information

Publications8

  1. ncbi request reprint RNA synthetic biology
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:545-54. 2006
    ..Further challenges include designing RNA molecules to be sensors of intracellular and environmental stimuli, probes to explore the behavior of biological networks and components of engineered cellular control systems...
  2. pmc A brave new synthetic world
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Genome Biol 10:302. 2009
    ..A report of the first meeting on 'Frontiers in Synthetic Biology', Boston, USA, 1-2 December 2008...
  3. ncbi request reprint Engineered riboregulators enable post-transcriptional control of gene expression
    Farren J Isaacs
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Biotechnol 22:841-7. 2004
    ....
  4. ncbi request reprint Molecular biology. Signal processing in single cells
    Farren J Isaacs
    Lipper Center for Computational Genetics and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 307:1886-8. 2005
  5. doi request reprint Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 333:348-53. 2011
    ..Our methods treat the chromosome as both an editable and an evolvable template, permitting the exploration of vast genetic landscapes...
  6. pmc Prediction and measurement of an autoregulatory genetic module
    Farren J Isaacs
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:7714-9. 2003
    ..Such an approach could lead to the modular dissection of naturally occurring gene regulatory networks, the deduction of cellular processes such as differentiation, and the development of engineered cellular control...
  7. ncbi request reprint Synthetic biology evolves
    William J Blake
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Trends Biotechnol 22:321-4. 2004
    ..An integrated approach that includes a strategy of in silico design by evolution, together with efforts exploiting directed evolution in vivo, is likely to be the next step in the evolution of synthetic biology...
  8. doi request reprint Programming cells by multiplex genome engineering and accelerated evolution
    Harris H Wang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:894-8. 2009
    ..Our multiplex approach embraces engineering in the context of evolution by expediting the design and evolution of organisms with new and improved properties...