Antonis Ioannou

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury
    Antonis Ioannou
    Rheumatology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 304:G283-92. 2013
  2. doi Immunopathogenesis of ischemia/reperfusion-associated tissue damage
    Antonis Ioannou
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Clin Immunol 141:3-14. 2011
  3. pmc The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39934. 2012
  4. doi Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 302:G888-97. 2012
  5. doi Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1416-22. 2012
  6. doi Platelets, complement and tissue inflammation
    Antonis Ioannou
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Autoimmunity 46:1-5. 2013
  7. pmc Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32260. 2012

Collaborators

Detail Information

Publications7

  1. doi Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury
    Antonis Ioannou
    Rheumatology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 304:G283-92. 2013
    ..These data also suggest that complement inhibition at earlier, rather than late, stages can have clinical benefit in conditions that are complicated with IR injury...
  2. doi Immunopathogenesis of ischemia/reperfusion-associated tissue damage
    Antonis Ioannou
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Clin Immunol 141:3-14. 2011
    ..Clinical trials that will determine the therapeutic value of each approach is needed...
  3. pmc The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39934. 2012
    ..In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage...
  4. doi Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 302:G888-97. 2012
    ....
  5. doi Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1416-22. 2012
    ..The use of small-molecule inhibitors may be valuable to prevent tissue damage in remote organs following I/R injury...
  6. doi Platelets, complement and tissue inflammation
    Antonis Ioannou
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Autoimmunity 46:1-5. 2013
    ..Interventions such as limiting complement decoration and suppression of signaling processes leading to platelet activation should be met with clinical benefit...
  7. pmc Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury
    Peter H Lapchak
    Rheumatology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32260. 2012
    ..Together, these findings suggest that multiple mechanisms are involved in local and remote tissue injury and also identify platelet-expressed CD40 and/or CD154 as mediators of remote tissue damage...