F Ichinose

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, 55 Fruit St, Boston, Mass 02114, USA
    Circulation 109:3106-11. 2004
  2. ncbi request reprint Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
    Fumito Ichinose
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 286:H1070-5. 2004
  3. ncbi request reprint Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice
    F Ichinose
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 88:832-8. 2001
  4. ncbi request reprint Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension
    F Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Crit Care Med 29:1000-5. 2001
  5. ncbi request reprint A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice
    Fumito Ichinose
    Department of Anesthesia and Critical Care and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2620, USA
    Am J Physiol Heart Circ Physiol 285:H2524-30. 2003
  6. pmc Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 109:1493-500. 2002
  7. pmc Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice
    R Ullrich
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 104:1421-9. 1999
  8. ncbi request reprint Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs
    F Ichinose
    Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Appl Physiol 78:1288-95. 1995
  9. ncbi request reprint Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
  10. ncbi request reprint Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms
    M Takata
    Cardiovascular Research Center and Arthritis Unit, Massachusetts General Hospital, and Departments of Medicine and Anesthesia, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Physiol Lung Cell Mol Physiol 280:L272-8. 2001

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, 55 Fruit St, Boston, Mass 02114, USA
    Circulation 109:3106-11. 2004
  2. ncbi request reprint Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
    Fumito Ichinose
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 286:H1070-5. 2004
    ..These results suggest that the absence of NOS3 augments LV dysfunction and remodeling in a murine model of chronic pressure overload...
  3. ncbi request reprint Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice
    F Ichinose
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 88:832-8. 2001
    ..Taken together, these findings demonstrate that a 5-LO product, most likely a cysteinyl LT, contributes to the attenuation of HPV and to pulmonary injury after challenge with endotoxin...
  4. ncbi request reprint Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension
    F Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Crit Care Med 29:1000-5. 2001
    ..To determine whether inhalation of aerosolized sildenafil with and without inhaled nitric oxide (NO) causes selective pulmonary vasodilation in a sheep model of pulmonary hypertension...
  5. ncbi request reprint A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice
    Fumito Ichinose
    Department of Anesthesia and Critical Care and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2620, USA
    Am J Physiol Heart Circ Physiol 285:H2524-30. 2003
    ..Selective inhibition of NOS2 dimerization with BBS-2, while sparing the activities of other NOS isoforms, may prove to be a useful treatment strategy in sepsis...
  6. pmc Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 109:1493-500. 2002
    ..These results indicate that cPLA(2) contributes to the murine pulmonary vasoconstrictor response to hypoxia. Augmenting pulmonary vascular tone restores HPV in the absence of cPLA(2) activity...
  7. pmc Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice
    R Ullrich
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 104:1421-9. 1999
    ....
  8. ncbi request reprint Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs
    F Ichinose
    Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Appl Physiol 78:1288-95. 1995
    ..A stable level of pulmonary vasodilation was demonstrated in four additional lambs by combining intermittent NO breathing with an intravenous infusion of Zaprinast...
  9. ncbi request reprint Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
  10. ncbi request reprint Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms
    M Takata
    Cardiovascular Research Center and Arthritis Unit, Massachusetts General Hospital, and Departments of Medicine and Anesthesia, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Physiol Lung Cell Mol Physiol 280:L272-8. 2001
    ..These results demonstrate that levels of NO and cGMP produced in cytokine-exposed PASMC are sufficient to decrease sGC subunit mRNA levels. In addition, cytokines can decrease sGC subunit mRNA levels via NO-independent mechanisms...
  11. pmc Inhaled nitric oxide enables artificial blood transfusion without hypertension
    Binglan Yu
    Anesthesia Center for Critical Care Research of the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1982-90. 2008
    ..One of the major obstacles hindering the clinical development of a cell-free, hemoglobin-based oxygen carrier (HBOC) is systemic vasoconstriction...
  12. ncbi request reprint Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Cardiology Division of the Department of Medicine, Harvard Medical School, USA
    Eur Heart J 27:1868-75. 2006
    ..Tissue Doppler imaging (TDI) can detect subtle LV dysfunction. The aim of this study was to investigate whether TDI indices can predict LV systolic dysfunction and mortality following exposure to doxorubicin (DOX) in mice...
  13. ncbi request reprint Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circ Res 100:130-9. 2007
    ....
  14. ncbi request reprint Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload
    Emmanuel S Buys
    Cardiac Ultrasound Laboratory, 55 Fruit Street, Boston, MA 02115 2696, USA
    Am J Physiol Heart Circ Physiol 293:H620-7. 2007
    ..Restoration of NOS3 to the heart of NOS3-deficient mice attenuates LV hypertrophy and dysfunction after TAC, suggesting that NOS3 protects against the adverse LV remodeling induced by prolonged pressure overload...
  15. pmc Inhaled NO as a therapeutic agent
    Kenneth D Bloch
    Cardiovascular Research Center and the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Res 75:339-48. 2007
    ..This review also highlights the application of inhaled NO to treat adults with cardiopulmonary disease, strategies to augment the efficacy of inhaled NO, and potential applications of the systemic effects of the gas...
  16. ncbi request reprint Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin
    Tomas G Neilan
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Charlestown, MA, USA
    Circulation 116:506-14. 2007
    ....
  17. ncbi request reprint Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia
    Pieter Vermeersch
    Center for Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
    Circulation 116:936-43. 2007
    ..We therefore studied pulmonary vascular responses to acute and chronic hypoxia in wild-type (WT) mice and mice with a nonfunctional alpha1-subunit (sGCalpha1-/-)...
  18. ncbi request reprint Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury
    Rong Liu
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1300-5. 2007
    ..171 +/- 17 mmHg; P < 0.05). We conclude that either congenital NOS2 deficiency or selective inhibition of NOS2 protects mice from the impairment of HPV occurring after 6 h of HV(T) ventilation...
  19. ncbi request reprint Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice
    Bodil Petersen
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 294:L300-8. 2008
    ..These data indicate that TLR2 activation impairs HPV and induces deleterious systemic effects in mice and suggest that TLR2 pathways may be important in sepsis-induced respiratory failure...
  20. doi request reprint Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice
    Emmanuel S Buys
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, Technologiepark 927, B 9052 Ghent, Belgium
    Cardiovasc Res 79:179-86. 2008
    ....
  21. ncbi request reprint [Impact of nitric oxide synthase 3 on myocardial dysfunction in sepsis]
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Harvard Medical School and Massachusetts General Hospital, USA
    Masui 57:294-301. 2008
    ....
  22. doi request reprint Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine
    Guohua Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Neurosci 28:4551-60. 2008
    ....
  23. ncbi request reprint Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice
    Ryuji Hataishi
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Exp Physiol 91:633-9. 2006
    ..A load-independent index of contractility, Emax, was similar in both strains 42 days after TAC. In conclusion, NOS2 does not appear to have a critical role in the development of LV hypertrophy after chronic pressure overload...
  24. ncbi request reprint Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury
    Ryuji Hataishi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Havard Medical School, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 291:H379-84. 2006
    ..Breathing 40 or 80 ppm NO markedly and significantly decreased MI size and improved LV function after ischemia and reperfusion in mice. NO inhalation may represent a novel method to salvage myocardium at risk of I/R injury...
  25. ncbi request reprint Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide
    Yehuda Raveh
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 96:926-33. 2002
    ..The authors investigated whether scavengers of reactive oxygen species could preserve inhaled NO responsiveness in endotoxin-challenged mice...
  26. ncbi request reprint Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice
    Hemanth A Baboolal
    Department of Anesthesia and Critical Care, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesthesiology 97:1227-33. 2002
    ..Reactive oxygen species (ROS) are implicated in the pathogenesis of sepsis-induced lung injury. The authors investigated whether treatment with scavengers of ROS prevents impairment of HPV in mice challenged with endotoxin...
  27. ncbi request reprint BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    Hideyuki Beppu
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1241-7. 2004
    ..Our results suggest that, in mice, mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing...
  28. ncbi request reprint Relationship of systolic dysfunction to area at risk and infarction size after ischemia-reperfusion in mice
    Ana Clara Tude Rodrigues
    Cardiac Ultrasounds Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Am Soc Echocardiogr 17:948-53. 2004
    ..Echocardiography can reliably assess AAR after ischemia-reperfusion in mice; however, it does not allow for precise quantification of the small areas of necrosis that often occur in this setting...
  29. ncbi request reprint NOS3 deficiency augments hypoxic pulmonary vasoconstriction and enhances systemic oxygenation during one-lung ventilation in mice
    Rong Liu
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    J Appl Physiol 98:748-52. 2005
    ..These findings indicate that NO derived from NOS3 modulates HPV in vivo and that inhibition of NOS3 improves systemic oxygenation during acute unilateral lung hypoxia...
  30. ncbi request reprint Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs
    Oleg V Evgenov
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, CLN 309, Boston, Mass 02114, USA
    Circulation 110:2253-9. 2004
    ..We examined whether direct stimulation of sGC by BAY 41-2272 would produce pulmonary vasodilation and augment the pulmonary responses to inhaled NO or CO...
  31. ncbi request reprint Inhaled nitric oxide in pediatric cardiac surgery
    Hiromasa Kawakami
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston 02114, USA
    Int Anesthesiol Clin 42:93-100. 2004
  32. ncbi request reprint Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis
    Xinsheng Zhu
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:598-604. 2005
    ..In this study we tested the hypothesis that alterations in cardiac calcium homeostasis due to sepsis underlie the observed myocyte dysfunction...
  33. pmc 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury
    Pietro Caironi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Am J Respir Crit Care Med 172:334-43. 2005
    ..Recent experimental studies have revealed an important role for leukotriene (LT) biosynthesis by 5-lipoxygenase (5LO) in the impairment of HPV by endotoxin...
  34. pmc Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury
    Yasuko Nagasaka
    Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 109:675-82. 2008
    ..Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood...
  35. ncbi request reprint Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension
    Oleg V Evgenov
    Dept of Anesthesia and Critical Care, Mass General Hospital, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 290:L723-L729. 2006
    ..Our findings demonstrate that selective inhibition of PDE1 augments the therapeutic efficacy of inhaled NO in an ovine model of acute chemically induced pulmonary hypertension...
  36. ncbi request reprint Inhaled nitric oxide does not reduce systemic vascular resistance in mice
    Ryuji Hataishi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 290:H1826-9. 2006
    ..Our findings suggest that absorption of NO or adducts during NO breathing is insufficient to cause systemic vasodilation in mice, even when endogenous endothelial NO production is congenitally absent...
  37. ncbi request reprint In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice
    Michael J Raher
    Cardiac Ultrasound Laboratory, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 116:1250-7. 2007
    ..Wild-type (WT) and nitric oxide synthase 3 (NOS3)-deficient (NOS3-/-) mice were studied...
  38. pmc Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse
    Gian Paolo Volpato
    Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, USA
    Anesthesiology 108:659-68. 2008
    ..However, the impact of H2S breathing on cardiovascular function remains incompletely understood. In this study, the authors investigated the cardiovascular and metabolic effects of inhaled H2S in a murine model...
  39. ncbi request reprint Quantitative assessment of regional myocardial function in mice by tissue Doppler imaging: comparison with hemodynamics and sonomicrometry
    Igal A Sebag
    Cardiac Ultrasound Laboratory in the Cardiology Division of the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mas 02114, USA
    Circulation 111:2611-6. 2005
    ..The objective of this study was to assess whether myocardial velocities and strain rate (SR) could be obtained by TDI in mice and whether these indices accurately quantified alterations in left ventricular (LV) systolic function...