Chao Wei Hwang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Thrombosis modulates arterial drug distribution for drug-eluting stents
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Circulation 111:1619-26. 2005
  2. ncbi request reprint Arterial ultrastructure influences transport of locally delivered drugs
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 90:826-32. 2002
  3. ncbi request reprint Local and systemic drug competition in drug-eluting stent tissue deposition properties
    Andrew D Levin
    Harvard MIT Division of Health Sciences and Technology, Massachusetts, Institute of Technology, Cambridge, 02139, USA
    J Control Release 109:236-43. 2005
  4. pmc Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel
    Andrew D Levin
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Proc Natl Acad Sci U S A 101:9463-7. 2004
  5. pmc Vascular regeneration by local growth factor release is self-limited by microvascular clearance
    Kha N Le
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room E25 442, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Circulation 119:2928-35. 2009
  6. ncbi request reprint Vacuum-assisted closure: microdeformations of wounds and cell proliferation
    Vishal Saxena
    Department of Mechanical Engineering and the Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass, USA
    Plast Reconstr Surg 114:1086-96; discussion 1097-8. 2004
  7. ncbi request reprint Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries
    Christian Janicki
    McGill University Health Center, Department of Medical Physics, Montreal, Quebec H36 1A4, Canada
    Med Phys 30:2622-8. 2003
  8. ncbi request reprint Impact of transport and drug properties on the local pharmacology of drug-eluting stents
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and, Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Int J Cardiovasc Intervent 5:7-12. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Thrombosis modulates arterial drug distribution for drug-eluting stents
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Circulation 111:1619-26. 2005
    ..Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as to whether thrombi affect drug elution and arterial uptake...
  2. ncbi request reprint Arterial ultrastructure influences transport of locally delivered drugs
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 90:826-32. 2002
    ..The role of the local composition and geometric organization of arterial tissue in influencing vascular pharmacokinetics is likely to become a critical consideration for local vascular drug delivery...
  3. ncbi request reprint Local and systemic drug competition in drug-eluting stent tissue deposition properties
    Andrew D Levin
    Harvard MIT Division of Health Sciences and Technology, Massachusetts, Institute of Technology, Cambridge, 02139, USA
    J Control Release 109:236-43. 2005
    ..Local competitive binding therefore should not limit the placement of rapamycin and paclitaxel eluting stents in close proximity...
  4. pmc Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel
    Andrew D Levin
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Proc Natl Acad Sci U S A 101:9463-7. 2004
    ..These results offer further insight into the mechanism of local drug delivery and the specific use of existing drug-eluting stent formulations...
  5. pmc Vascular regeneration by local growth factor release is self-limited by microvascular clearance
    Kha N Le
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room E25 442, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Circulation 119:2928-35. 2009
    ..Induced neocapillaries increase drug clearance and limit tissue retention and subsequent angiogenesis even in the face of sustained delivery...
  6. ncbi request reprint Vacuum-assisted closure: microdeformations of wounds and cell proliferation
    Vishal Saxena
    Department of Mechanical Engineering and the Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass, USA
    Plast Reconstr Surg 114:1086-96; discussion 1097-8. 2004
    ..Finite element modeling of the VAC device is consistent with this mechanism of action...
  7. ncbi request reprint Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries
    Christian Janicki
    McGill University Health Center, Department of Medical Physics, Montreal, Quebec H36 1A4, Canada
    Med Phys 30:2622-8. 2003
    ..Also, variability in the delivery efficacy of drug delivery devices makes accurate dosimetry difficult and the drug washout in the systemic circulatory system may yield an unnecessary activity build-up and dose to healthy organs...
  8. ncbi request reprint Impact of transport and drug properties on the local pharmacology of drug-eluting stents
    Chao Wei Hwang
    Harvard MIT Division of Health Sciences and, Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Int J Cardiovasc Intervent 5:7-12. 2003
    ..This type of analysis may well become increasingly relevant given the trend toward stent-based drug therapy in cardiovascular care...