T J Huppert

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation
    Theodore J Huppert
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1262-79. 2007
  2. pmc A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans
    T J Huppert
    Harvard Medical School Graduate Program in Biophysics, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 29:368-82. 2006
  3. pmc Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
    Theodore J Huppert
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064018. 2006
  4. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
  5. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
  6. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
  7. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
  8. ncbi request reprint Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
  9. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
  10. pmc Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex
    R C Mesquita
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Phys Med Biol 54:175-85. 2009

Detail Information

Publications11

  1. pmc A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation
    Theodore J Huppert
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1262-79. 2007
    ..Finally, we compare this model to earlier work and find that the multicompartment model more accurately describes the observed oxygenation changes when compared with a single compartment version...
  2. pmc A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans
    T J Huppert
    Harvard Medical School Graduate Program in Biophysics, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 29:368-82. 2006
    ..The observed co-variance in these parameters between subjects is in agreement with hemodynamic models and provides further support that fMRI and NIRS have similar vascular sensitivity...
  3. pmc Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
    Theodore J Huppert
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064018. 2006
    ..73, p=5x10(-6) and R=0.71, p=9x10(-6), respectively) than the flow to deoxyhemoglobin spatial correlation (R=0.26, p=0.10)...
  4. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
    ....
  5. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
    ..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs...
  6. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    ..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis...
  7. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
    ....
  8. ncbi request reprint Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
    ..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging...
  9. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
    ..Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT may be adapted for BOLD fMRI analysis and multimodal studies...
  10. pmc Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex
    R C Mesquita
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Phys Med Biol 54:175-85. 2009
    ..At the same time, we characterize the metabolic and vascular neural response functions and interpret their physiological significance...
  11. pmc Direct estimation of evoked hemoglobin changes by multimodality fusion imaging
    Theodore J Huppert
    The Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:054031. 2008
    ..Using this multimodal method, we estimate the calibration of the 3 tesla BOLD signal to be -0.55%+/-0.40% signal change per micromolar change of deoxyhemoglobin...