DAVID JOHN HUNTER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
  2. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  3. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
  4. pmc Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer
    Jingmei Li
    Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
    Breast Cancer Res 12:R19. 2010
  5. ncbi request reprint Gene-environment interactions in human diseases
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Genet 6:287-98. 2005
  6. pmc Oral contraceptive use and breast cancer: a prospective study of young women
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:2496-502. 2010
  7. ncbi request reprint Genomics and proteomics in epidemiology: treasure trove or "high-tech stamp collecting"?
    David J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 17:487-9. 2006
  8. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
  9. ncbi request reprint Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
  10. ncbi request reprint Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Cancer Causes Control 13:221-30. 2002

Collaborators

Detail Information

Publications87

  1. ncbi request reprint The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
    ..This study suggests that the Arg72Pro polymorphism may play a role in skin carcinogenesis...
  2. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  3. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
    ..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features...
  4. pmc Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer
    Jingmei Li
    Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
    Breast Cancer Res 12:R19. 2010
    ..In this study, we evaluate the association between mammographic density and genetic variants of the estrogen metabolic pathway...
  5. ncbi request reprint Gene-environment interactions in human diseases
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Genet 6:287-98. 2005
    ..Current systems for reporting epidemiological studies make it difficult to assess whether the observed interactions are reproducible, so suggestions are made for improvements in this area...
  6. pmc Oral contraceptive use and breast cancer: a prospective study of young women
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:2496-502. 2010
    ..The relation of contemporary oral contraceptive formulations to breast cancer risk is less clear...
  7. ncbi request reprint Genomics and proteomics in epidemiology: treasure trove or "high-tech stamp collecting"?
    David J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 17:487-9. 2006
  8. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  9. ncbi request reprint Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..However, our findings of differences in associations for UGT1A1 and AIB1 genotypes with breast density by menopausal status needs additional corroboration...
  10. ncbi request reprint Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Cancer Causes Control 13:221-30. 2002
    ..We examined prospectively intakes of vitamins A. C, and E, folate, and specific carotenoids in relation to the risk of basal cell carcinoma of the skin (BCC) in women...
  11. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  12. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  13. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  14. pmc Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium
    Mia M Gaudet
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Epidemiol Biomarkers Prev 18:1610-6. 2009
    ....
  15. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  16. ncbi request reprint Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
    J Natl Cancer Inst 97:457-60. 2005
    ....
  17. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  18. ncbi request reprint HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
    ..05) was suggested. These findings suggest that the HSD17B1 may be associated with circulating estradiol levels and interact with body mass index in postmenopausal breast cancer...
  19. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  20. pmc Facet orientation and tropism: associations with spondylolysis
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    J Spinal Disord Tech 23:101-5. 2010
    ..Cross-sectional study...
  21. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  22. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  23. ncbi request reprint Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies
    Satu Mannisto
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:40-8. 2004
    ..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk...
  24. ncbi request reprint Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
    Joline W J Beulens
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 56:2388-94. 2007
    ..We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes...
  25. ncbi request reprint Genetic association and functional studies of major polymorphic variants of MGMT
    James M Bugni
    Biological Engineering Division, Biology Department, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    DNA Repair (Amst) 6:1116-26. 2007
    ..Overall, the effects of polymorphic variation on protein function are subtle, and further investigation is required to provide a comprehensive mechanism that explains the observed associations of these variants with risk for cancer...
  26. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
    ..Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC)...
  27. ncbi request reprint Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 99:1471-83. 2007
    ..Statistical power to examine associations by colon site has been limited in previous studies...
  28. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  29. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    ..68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk...
  30. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  31. doi request reprint The role of analgesics and intra-articular injections in disease management
    William F Harvey
    Division of Rheumatology, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Rheum Dis Clin North Am 34:777-88. 2008
    ..Specific attention is paid to current trends and controversies related to pharmacologic management, including the use of oral, topical, and injectable agents...
  32. pmc Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 136:2127-2136.e1. 2009
    ..We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib...
  33. ncbi request reprint The effect of body weight on progression of knee osteoarthritis is dependent on alignment
    David T Felson
    Boston University Clinical Epidemiology Research and Training, Boston, Massachusetts, USA
    Arthritis Rheum 50:3904-9. 2004
    ..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...
  34. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  35. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  36. ncbi request reprint Dietary patterns and the risk of postmenopausal breast cancer
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Int J Cancer 116:116-21. 2005
    ..However, a Western-type diet may elevate risk of breast cancer among smokers, and a prudent diet may protect against estrogen receptive-negative tumors...
  37. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  38. ncbi request reprint Estrogen receptor beta (ESR2 ) polymorphisms and endometrial cancer (United States)
    Veronica Wendy Setiawan
    Channing Laboratory, Department of Epidemiology, Harvard School of Public Health 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 15:627-33. 2004
    ..We validated and screened for variants in the ESR2 gene and examined whether they are associated with endometrial cancer risk...
  39. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  40. ncbi request reprint The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study
    Christopher A Haiman
    Department of Epidemiology, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:1045-9. 2002
    ..However, these data suggest that longer AR [CAG](n) repeat alleles may increase breast cancer risk among women with a first-degree family history of breast cancer...
  41. ncbi request reprint Fruits, vegetables and lung cancer: a pooled analysis of cohort studies
    Stephanie A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 107:1001-11. 2003
    ..However, we cannot rule out the possibility that our results are due to residual confounding by smoking. The primary focus for reducing lung cancer incidence should continue to be smoking prevention and cessation...
  42. doi request reprint Association between age, sex, BMI and CT-evaluated spinal degeneration features
    Leonid Kalichman
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    J Back Musculoskelet Rehabil 22:189-95. 2009
    ..The aim of our study was to evaluate the association between age, sex and body mass index (BMI) and lumbar spine degeneration features evaluated on computed tomography (CT) in a community-based sample...
  43. ncbi request reprint Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
    Teresa T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:110-5. 2003
    ..No evidence was found that vitamins A, C and E; folate; or carotenoids play an important protective role against incident SCC...
  44. doi request reprint From Darwin's finches to canaries in the coal mine--mining the genome for new biology
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    N Engl J Med 358:2760-3. 2008
  45. pmc Evaluation of 8q24 and 17q risk loci and prostate cancer mortality
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Harvard University, Cambridge, Massachusetts, USA
    Clin Cancer Res 15:3223-30. 2009
    ..We investigated whether the 8q24 and 17q risk variants are associated with clinical variables as well as prostate cancer mortality...
  46. pmc Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 34:199-205. 2009
    ..Cross-sectional study...
  47. ncbi request reprint Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2160-7. 2005
    ..Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer...
  48. ncbi request reprint Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Prostate 67:911-23. 2007
    ..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes...
  49. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  50. ncbi request reprint Associations between polymorphisms in the vitamin D receptor and breast cancer risk
    Wendy Y Chen
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2335-9. 2005
    ..Our results suggest that the VDR may be a mediator of breast cancer risk and could represent a target for cancer prevention efforts...
  51. ncbi request reprint XPA, haplotypes, and risk of basal and squamous cell carcinoma
    Katie L Miller
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 27:1670-5. 2006
    ..The common G allele of the A23G polymorphism was associated with an increased risk of BCC and SCC and this polymorphism appeared to be the determining polymorphism in XPA that alters cancer susceptibility...
  52. ncbi request reprint Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:1211-8. 2004
    ....
  53. ncbi request reprint Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:129-36. 2007
    ..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...
  54. ncbi request reprint Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  55. ncbi request reprint Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006
    ..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk...
  56. ncbi request reprint Molecular epidemiology of cancer
    Yen Ching Chen
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    CA Cancer J Clin 55:45-54; quiz 57. 2005
    ..Examples will be given of how use of molecular techniques is informative in epidemiological studies of cancer and is predicted to lead to improvements in cancer incidence, early detection, and mortality...
  57. ncbi request reprint Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease
    Folkert W Asselbergs
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U S A
    Clin Sci (Lond) 112:291-8. 2007
    ..05). However, no overall effect was demonstrated between LTA gene polymorphisms and risk of CHD...
  58. ncbi request reprint Drinking from the fire hose--statistical issues in genomewide association studies
    David J Hunter
    Harvard School of Public Health, Boston, USA
    N Engl J Med 357:436-9. 2007
  59. pmc The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand
    Barton L Wise
    Framingham Heart Study, National Heart, Lung and Blood Institute, National Institutes of Health, Boston, Massachusetts, USA
    J Rheumatol 36:2772-9. 2009
    ..We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2)...
  60. ncbi request reprint Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1119-22. 2002
    ..Alcohol intake was associated with BCC, but the association appeared to be different for each type of alcoholic beverage. Other studies are needed to confirm these results...
  61. ncbi request reprint Dietary fat and risk of lung cancer in a pooled analysis of prospective studies
    Stephanie A Smith-Warner
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:987-92. 2002
    ..These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking...
  62. ncbi request reprint Knee buckling: prevalence, risk factors, and associated limitations in function
    David T Felson
    Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women s Hospital, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Intern Med 147:534-40. 2007
    ..Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence in the community is unknown...
  63. ncbi request reprint Multiple displacement amplification prior to single nucleotide polymorphism genotyping in epidemiologic studies
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Biotechnol Lett 25:1031-6. 2003
    ..These results suggest that MDA will provide a sufficiently robust amplification of limiting samples of genomic DNA that can be used for SNP genotyping in large case-control studies of complex diseases...
  64. ncbi request reprint Dietary fat intake and ovarian cancer in a cohort of US women
    Elizabeth R Bertone
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 156:22-31. 2002
    ..Overall, results suggest no association between intake of any type of fat and ovarian cancer...
  65. doi request reprint Facet orientation and tropism: associations with facet joint osteoarthritis and degeneratives
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Spine (Phila Pa 1976) 34:E579-85. 2009
    ..Cross-sectional study...
  66. ncbi request reprint Cardiac sodium channel gene variants and sudden cardiac death in women
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:16-23. 2008
    ..Mutations or rare variants in these genes have been proposed as potential contributors to more common forms of SCD, but this hypothesis has not been assessed systematically...
  67. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  68. pmc Common variants of FUT2 are associated with plasma vitamin B12 levels
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
    Nat Genet 40:1160-2. 2008
    ..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels...
  69. ncbi request reprint Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pharmacogenetics 12:339-42. 2002
    ..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism...
  70. ncbi request reprint Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  71. ncbi request reprint A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 2:704-12. 2004
    ..Genetic variation in this enzyme may modulate the influence of aspirin and smoking on adenoma risk...
  72. pmc The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial
    Kim L Bennell
    Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, University of Melbourne, Australia
    BMC Musculoskelet Disord 8:121. 2007
    ..The aim of this randomised, single-blind controlled trial is to determine whether hip abductor and adductor muscle strengthening can reduce knee load and improve pain and physical function in people with medial compartment knee OA...
  73. ncbi request reprint Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    Meredith Yeager
    SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Nat Genet 39:645-9. 2007
    ..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...
  74. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  75. ncbi request reprint Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:2148-54. 2006
    ..These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer...
  76. ncbi request reprint Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies
    Jo L Freudenheim
    Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Am J Clin Nutr 82:657-67. 2005
    ..Although smoking is the primary cause of lung cancer, much is unknown about lung cancer etiology, including risk determinants for nonsmokers and modifying factors for smokers...
  77. ncbi request reprint CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...
  78. ncbi request reprint Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:825-34. 2008
    ..The methods utilized in this study, applied to multiple populations, provide a framework for testing in association studies in diverse populations...
  79. doi request reprint Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  80. doi request reprint CYP1B1 polymorphisms and k-ras mutations in patients with pancreatic ductal adenocarcinoma
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica IMIM, CIBER de EpidemiologĂ­a y Salud PĂșblica CIBERESP, Barcelona, Spain
    Dig Dis Sci 53:1417-21. 2008
    ..The Val/Val genotype was over five times more frequent in PDA cases with a K-ras mutation than in wild-type cases (OR = 5.25; P = 0.121). In PDA, polymorphisms in CYP1B1 might be related with K-ras activation pathways...
  81. pmc Height, body mass index, and ovarian cancer: a pooled analysis of 12 cohort studies
    Leo J Schouten
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:902-12. 2008
    ..Although many studies have investigated the association between anthropometry and ovarian cancer risk, results have been inconsistent...
  82. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  83. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  84. ncbi request reprint Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
    Lisa M Hines
    Department of Pharmacology, University of Colorado Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80010, USA
    Atherosclerosis 182:293-300. 2005
    ....
  85. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  86. pmc Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers
    Meredith Yeager
    Core Genotyping Facility, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Hum Genet 124:161-70. 2008
    ....
  87. ncbi request reprint Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies
    Satu Mannisto
    National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 165:246-55. 2007
    ..00). The associations observed were generally similar across studies, for both sexes, and for colon cancer and rectal cancer. These pooled data did not suggest that carotenoids play an important role in the etiology of colorectal cancer...

Research Grants23

  1. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..They conclude that confirmation of risk genotypes would also be useful in identifying persons at high risk of colon cancer and assist in focusing screening efforts. ..
  2. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2006
    ..5 or greater for the main effects of most of the genotypes of interest. We will also have substantial power to detect interactions between these genotypes and established breast cancer risk factors. ..
  3. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2007
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..
  4. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2009
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..
  5. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 1999
    ..They conclude that confirmation of risk genotypes would also be useful in identifying persons at high risk of colon cancer and assist in focusing screening efforts. ..
  6. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2000
    ..The availability of this information is critical to our ability to appropriately counsel women with these genotypes. ..
  7. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    DAVID JOHN HUNTER; Fiscal Year: 2010
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..