D J Hunter

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Breast Cancer Res 7:R171-5. 2005
  2. pmc A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
    David G Cox
    Program in Genetic and Molecular Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R3. 2007
  3. pmc Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
    Heather J Baer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 7:R314-25. 2005
  4. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  5. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
  6. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
  7. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
  8. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
  9. ncbi request reprint Scanning the horizon: what is the future of genome-wide association studies in accelerating discoveries in cancer etiology and prevention?
    D J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 18:479-84. 2007
  10. ncbi request reprint The influence of genetic polymorphism
    David J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 136:2711S-3S. 2006

Research Grants

Collaborators

Detail Information

Publications171 found, 100 shown here

  1. pmc Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Breast Cancer Res 7:R171-5. 2005
    ..Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadic breast cancer...
  2. pmc A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
    David G Cox
    Program in Genetic and Molecular Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R3. 2007
    ..Polymorphisms in the PTGS2 gene have been associated with various diseases, including inflammatory bowel disease and cancer of the lung, colorectum, and breast...
  3. pmc Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
    Heather J Baer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 7:R314-25. 2005
    ..We examined prospectively the relation between body fatness during childhood and adolescence and the incidence of breast cancer in premenopausal women...
  4. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  5. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  6. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
    ..Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results...
  7. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
    ..We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together...
  8. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
    ..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers...
  9. ncbi request reprint Scanning the horizon: what is the future of genome-wide association studies in accelerating discoveries in cancer etiology and prevention?
    D J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 18:479-84. 2007
    ....
  10. ncbi request reprint The influence of genetic polymorphism
    David J Hunter
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 136:2711S-3S. 2006
  11. ncbi request reprint A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Cancer 87:204-10. 2000
    ..4. The lack of an established effect on CYP19 function associated with the 10 allele means that these findings should be interpreted with caution...
  12. ncbi request reprint Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..However, our findings of differences in associations for UGT1A1 and AIB1 genotypes with breast density by menopausal status needs additional corroboration...
  13. ncbi request reprint Dietary fat and protein in relation to risk of non-Hodgkin's lymphoma among women
    S Zhang
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:1751-8. 1999
    ..In this study, we examined the intake of specific types of dietary fat and protein in relation to the risk of non-Hodgkin's lymphoma...
  14. ncbi request reprint Dietary carotenoids and vitamins A, C, and E and risk of breast cancer
    S Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:547-56. 1999
    ..Furthermore, studies of vitamins A, C, and E in relation to breast cancer risk are inconclusive. We have conducted a large, prospective study to evaluate long-term intakes of these nutrients and breast cancer risk...
  15. ncbi request reprint A prospective study of folate intake and the risk of breast cancer
    S Zhang
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 281:1632-7. 1999
    ..Folate is involved in DNA synthesis and methylation and may reduce breast cancer risk, particularly among women with greater alcohol consumption...
  16. ncbi request reprint Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Cancer Causes Control 13:221-30. 2002
    ..We examined prospectively intakes of vitamins A. C, and E, folate, and specific carotenoids in relation to the risk of basal cell carcinoma of the skin (BCC) in women...
  17. doi request reprint The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period
    M D Crema
    Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:336-43. 2010
    ..To investigate the association of different types of magnetic resonance imaging (MRI)-detected medial meniscal pathology with subregional cartilage loss in the medial tibiofemoral compartment...
  18. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  19. pmc Oral contraceptive use and risk of melanoma in premenopausal women
    D Feskanich
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 81:918-23. 1999
    ..Further research is needed to determine whether low-dose oestrogen pills in particular are associated with an increase in risk and to describe possible interactions between OC use and sun exposure or other risk factors for melanoma...
  20. ncbi request reprint Change in joint space width: hyaline articular cartilage loss or alteration in meniscus?
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Arthritis Center, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:2488-95. 2006
    ..To explore the relative contribution of hyaline cartilage morphologic features and the meniscus to the radiographic joint space...
  21. ncbi request reprint Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis
    K M Fairfield
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer 92:2318-26. 2001
    ..Antioxidant vitamins may decrease risk of cancer by limiting oxidative DNA damage leading to cancer initiation. Few prospective studies have assessed relations between antioxidant vitamins and ovarian carcinoma...
  22. pmc Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study
    G H Lo
    Tufts New England Medical Center, Boston, MA 02111, USA
    Osteoarthritis Cartilage 16:261-7. 2008
    ..We hypothesized that knees with higher M:L BMD, consistent with increased medial subchondral BMD, would be associated with medial meniscal damage, and lower ratios with lateral meniscal damage...
  23. ncbi request reprint A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 58:3307-11. 1998
    ..02). These prospective data, which need to be confirmed in other studies, suggest that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk...
  24. pmc Patella malalignment, pain and patellofemoral progression: the Health ABC Study
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
    Osteoarthritis Cartilage 15:1120-7. 2007
    ..Risk factors for pain and structural progression in PF OA are poorly understood. Our objective was to determine the association between patella malalignment and its relation to pain severity, and PF OA disease progression...
  25. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  26. ncbi request reprint The association of bone attrition with knee pain and other MRI features of osteoarthritis
    G Hernández-Molina
    Clinical Epidemiology Reseach and Training Unit and the Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:43-7. 2008
    ....
  27. pmc Does cartilage volume or thickness distinguish knees with and without mild radiographic osteoarthritis? The Framingham Study
    S Reichenbach
    Clinical Epidemiology Unit, Boston University Medical Center, Boston, Massachusetts, USA
    Ann Rheum Dis 69:143-9. 2010
    ..To examine whether the quantity of cartilage or semiquantitative scores actually differ in knees with mild radiographic osteoarthritis compared with knees without osteoarthritis...
  28. ncbi request reprint N-acetyl transferase 2 genotypes, meat intake and breast cancer risk
    D M Gertig
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cancer 80:13-7. 1999
    ..We observed no evidence of differential susceptibility to these exposures by NAT2 genotype...
  29. ncbi request reprint Physical activity and breast cancer risk in a cohort of young women
    B Rockhill
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 90:1155-60. 1998
    ..Increased physical activity has been hypothesized to be a means of breast cancer prevention. We examined the associations between physical activity at two different times in life and breast cancer risk...
  30. pmc Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Ann Rheum Dis 68:349-56. 2009
    ..Our objective was to assess the rate of natural disease progression of cartilage morphometry measures from baseline to 1 year in knees with osteoarthritis (OA) from a subset of participants from the Osteoarthritis Initiative (OAI)...
  31. pmc Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis
    W F Harvey
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Ann Rheum Dis 67:1524-8. 2008
    ..We measured various knee alignment indices among Chinese and Caucasians and assessed whether these indices were different between the two racial groups...
  32. ncbi request reprint Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study
    F Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Int J Cancer 91:568-74. 2001
    ..83 for PCB 153 (95% CI: 0.47-1.48), and 0.98 for PCB 180 (95% CI: 0.55-1.75). Sub-group analyses were also performed. Overall, our results do not support the hypothesis that exposure to DDT and PCBs increases the risk of breast cancer...
  33. pmc Premorbid knee osteoarthritis is not characterised by diffuse thinness: the Framingham Osteoarthritis Study
    D J Hunter
    Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:1545-9. 2008
    ....
  34. ncbi request reprint Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies
    S A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 285:769-76. 2001
    ..CONCLUSION: These results suggest that fruit and vegetable consumption during adulthood is not significantly associated with reduced breast cancer risk...
  35. pmc Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania
    S Mehta
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 64:808-17. 2010
    ..There is limited published research examining lipid-soluble vitamins in human immunodeficiency virus (HIV)-infected pregnant women, particularly in resource-limited settings...
  36. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  37. ncbi request reprint MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 58:1381-7. 2002
    ..Also, the association between never smoking and PD risk may be present only in people with the MAOB G allele...
  38. pmc Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?
    D J Hunter
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:175-83. 2010
    ..We examined if by selecting regions of interest with denuded cartilage, the remaining cartilage within this region of interest was susceptible to greater rates of cartilage loss...
  39. ncbi request reprint Vitamin supplement use and the risk of non-Hodgkin's lymphoma among women and men
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:1056-63. 2001
    ..Because an elevated risk among multivitamin users was not observed consistently in the two cohorts and the pooled data were not significant, the elevated risk among women may be the result of chance...
  40. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  41. ncbi request reprint Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:477-85. 2000
    ..Higher intake of vegetables, particularly cruciferous vegetables, may reduce the risk of non-Hodgkin's lymphoma among women...
  42. ncbi request reprint Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies
    K B Michels
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 153:275-83. 2001
    ..11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer...
  43. ncbi request reprint Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness
    M Englund
    Clinical Epidemiology Branch and Training Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 56:4048-54. 2007
    ..To evaluate the effect of meniscal damage on the development of frequent knee pain, aching, or stiffness in middle-aged and older adults...
  44. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  45. pmc Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Ave, Building 2, 3rd Floor, Boston, MA 02115, USA
    J Neurol 258:1676-82. 2011
    ..91, 95% CI: 0.80, 1.04). This preliminary finding suggests the possibility that the putative beneficial effect of vitamin D on MS risk maybe attenuated in individuals carrying the HLA-DR15 MS risk allele...
  46. pmc The relation of plasma homocysteine to radiographic knee osteoarthritis
    M Fayfman
    Boston University School of Medicine, Boston, USA
    Osteoarthritis Cartilage 17:766-71. 2009
    ..In the present study we considered the possible relationship between plasma homocysteine levels and the development and progression of knee osteoarthritis (OA)...
  47. ncbi request reprint Prospective study of recreational physical activity and ovarian cancer
    E R Bertone
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 93:942-8. 2001
    ..The only prospective study to date reported a positive association between frequent vigorous exercise and ovarian cancer risk. We further evaluated this relationship in the Nurses' Health Study cohort...
  48. ncbi request reprint A prospective study of oral contraceptives and NIDDM among U.S. women
    L Chasan-Taber
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 20:330-5. 1997
    ..To examine prospectively the association between modern oral contraceptives with low doses of estrogen and progestin and subsequent incidence of NIDDM...
  49. ncbi request reprint Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention
    B Rockhill
    B Rockhill, C Byrne, Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 93:358-66. 2001
    ..to aid decision making regarding potential prevention options for breast cancer, including chemoprevention with tamoxifen...
  50. ncbi request reprint A prospective study of recreational physical activity and breast cancer risk
    B Rockhill
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 159:2290-6. 1999
    ..We thus examined this issue in a large cohort of women, using several different measures of adult physical activity...
  51. ncbi request reprint Rotating night shifts and risk of breast cancer in women participating in the nurses' health study
    E S Schernhammer
    E S Schernhammer, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1563-8. 2001
    ..There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer...
  52. ncbi request reprint Determinants of low birth weight among HIV-infected pregnant women in Tanzania
    M L Dreyfuss
    Departments of Nutrition, Biostatistics, and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 74:814-26. 2001
    ..Low birth weight (LBW) increases the risk of infant death, but little is known about its causes among HIV-infected populations in sub-Saharan Africa...
  53. pmc The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 17:748-53. 2009
    ..To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA)...
  54. ncbi request reprint Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
    J Natl Cancer Inst 97:457-60. 2005
    ....
  55. ncbi request reprint HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
    ..05) was suggested. These findings suggest that the HSD17B1 may be associated with circulating estradiol levels and interact with body mass index in postmenopausal breast cancer...
  56. ncbi request reprint The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
    ..This study suggests that the Arg72Pro polymorphism may play a role in skin carcinogenesis...
  57. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  58. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    ..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies...
  59. ncbi request reprint Prospective study of oral contraceptives and hypertension among women in the United States
    L Chasan-Taber
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:483-9. 1996
    ..However, neither the responsible hormone in the oral contraceptive nor particular subgroups of women who might be susceptible to the hypertensive effect of oral contraceptives have been identified...
  60. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  61. ncbi request reprint Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    ..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...
  62. ncbi request reprint Prospective study of talc use and ovarian cancer
    D M Gertig
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 92:249-52. 2000
    ..In this study, we conducted a prospective analysis of perineal talc use and the risk of ovarian cancer...
  63. doi request reprint Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 17:1170-6. 2009
    ..To ascertain the contribution of articular cartilage morphometry and meniscal position on MRI to joint space width (JSW) measured in the Lyon schuss radiograph of the knee...
  64. pmc Facet orientation and tropism: associations with spondylolysis
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    J Spinal Disord Tech 23:101-5. 2010
    ..Cross-sectional study...
  65. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  66. pmc Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
    S Wu
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA
    Br J Cancer 110:1855-61. 2014
    ....
  67. ncbi request reprint Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
    C G Solomon
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 286:2421-6. 2001
    ..Although oligomenorrhea has been associated cross-sectionally with insulin resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for increased future risk of type 2 diabetes mellitus (DM)...
  68. ncbi request reprint Multivitamin supplementation in HIV-positive pregnant women: impact on depression and quality of life in a resource-poor setting
    M C Smith Fawzi
    Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    HIV Med 8:203-12. 2007
    ....
  69. ncbi request reprint Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected pregnant women in Dar es Salaam, Tanzania
    G Antelman
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    AIDS 15:1865-74. 2001
    ..Lack of disclosure may have limited their ability to engage in preventive behaviors or to obtain the necessary emotional support for coping with their serostatus or illness...
  70. pmc Polymorphic repeat in AIB1 does not alter breast cancer risk
    C A Haiman
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 191 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 2:378-85. 2000
    ..These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population...
  71. doi request reprint The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis
    V Stein
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:192-9. 2010
    ..The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume...
  72. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
    ..Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC)...
  73. ncbi request reprint Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
    Joline W J Beulens
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 56:2388-94. 2007
    ..We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes...
  74. ncbi request reprint Genetic association and functional studies of major polymorphic variants of MGMT
    James M Bugni
    Biological Engineering Division, Biology Department, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    DNA Repair (Amst) 6:1116-26. 2007
    ..Overall, the effects of polymorphic variation on protein function are subtle, and further investigation is required to provide a comprehensive mechanism that explains the observed associations of these variants with risk for cancer...
  75. pmc Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 136:2127-2136.e1. 2009
    ..We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib...
  76. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  77. ncbi request reprint Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 99:1471-83. 2007
    ..Statistical power to examine associations by colon site has been limited in previous studies...
  78. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  79. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  80. doi request reprint The role of analgesics and intra-articular injections in disease management
    William F Harvey
    Division of Rheumatology, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Rheum Dis Clin North Am 34:777-88. 2008
    ..Specific attention is paid to current trends and controversies related to pharmacologic management, including the use of oral, topical, and injectable agents...
  81. ncbi request reprint Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies
    Satu Mannisto
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:40-8. 2004
    ..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk...
  82. ncbi request reprint Estrogen receptor beta (ESR2 ) polymorphisms and endometrial cancer (United States)
    Veronica Wendy Setiawan
    Channing Laboratory, Department of Epidemiology, Harvard School of Public Health 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 15:627-33. 2004
    ..We validated and screened for variants in the ESR2 gene and examined whether they are associated with endometrial cancer risk...
  83. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  84. ncbi request reprint The effect of body weight on progression of knee osteoarthritis is dependent on alignment
    David T Felson
    Boston University Clinical Epidemiology Research and Training, Boston, Massachusetts, USA
    Arthritis Rheum 50:3904-9. 2004
    ..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...
  85. ncbi request reprint Dietary patterns and the risk of postmenopausal breast cancer
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Int J Cancer 116:116-21. 2005
    ..However, a Western-type diet may elevate risk of breast cancer among smokers, and a prudent diet may protect against estrogen receptive-negative tumors...
  86. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    ..68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk...
  87. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  88. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  89. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  90. pmc Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA, USA Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Electronic address
    Osteoarthritis Cartilage 22:415-30. 2014
    ..We sought to determine the target populations and drug efficacy, toxicity, cost, and initiation age thresholds under which a pharmacologic regimen for knee osteoarthritis (OA) prevention could be cost-effective...
  91. pmc Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:655-67. 2013
    ..Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment...
  92. ncbi request reprint The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Ann Rheum Dis 67:206-11. 2008
    ..The aim of this work was to assess the reliability of a novel MRI scoring system for evaluating OA of the knee and explore the validity of the bone marrow lesion (BML) scoring component of this new tool...
  93. pmc Psychological factors and their relation to osteoarthritis pain
    B L Wise
    University School of Medicine, Boston, MA, USA
    Osteoarthritis Cartilage 18:883-7. 2010
    ..We assessed associations between mental health and osteoarthritis (OA) pain...
  94. doi request reprint Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3-6 months' observation using advanced image analysis of 3T MRI?
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:677-83. 2010
    ..The primary outcome was the cartilage thickness in the central medial femur...
  95. ncbi request reprint The ratio of medial to lateral tibial plateau bone mineral density and compartment-specific tibiofemoral osteoarthritis
    G H Lo
    Tufts New England Medical Center, Boston, MA 0211, USA
    Osteoarthritis Cartilage 14:984-90. 2006
    ..Bone is thought to play an important role in osteoarthritis (OA) pathophysiology. Our aim was to look at specific features of OA and their relation to the ratio of medial:lateral tibial plateau bone mineral density (M:L BMD Ratio)...
  96. ncbi request reprint Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA)
    F E Speizer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 10:475-82. 1999
    ..We therefore examine prospectively the relation between cigarette smoking and lung cancer incidence among women, and quantify the associations between dietary antioxidants, other nutrients, and lung cancer risk...
  97. ncbi request reprint A polymorphism in CYP17 and endometrial cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 61:3955-60. 2001
    ..9%; P = 0.05) and estradiol (+8.5%; P = 0.17). These data suggest that the A2 allele of CYP17 decreases endometrial cancer risk, but has only weak effects on endogenous estrogen levels among postmenopausal women...
  98. pmc Physical activity and mortality: a prospective study among women
    B Rockhill
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Am J Public Health 91:578-83. 2001
    ..This study examined the association between recreational physical activity and mortality in middle-aged and older women and the possibility that physical activity serves as an important marker of health...
  99. pmc Genetic variation in XRCC1, sun exposure, and risk of skin cancer
    J Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Br J Cancer 91:1604-9. 2004
    ..These two polymorphisms were not associated with BCC or melanoma risk. Our data suggest that the Arg194Trp and Arg399Gln polymorphisms may be differently associated with skin cancer risk according to exposure dose and skin cancer type...
  100. ncbi request reprint Association of age and reproductive factors with benign breast tissue composition
    D M Gertig
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:873-9. 1999
    ..The quantitative measurement of epithelial and stromal proportion may be useful for measuring changes in breast composition...
  101. ncbi request reprint Electric blanket use and breast cancer in the Nurses' Health Study
    F Laden
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 152:41-9. 2000
    ..While 95% confidence intervals for these estimates did not exclude small risks, overall, results did not support an association between breast cancer risk and exposure to EMFs from electric blankets...

Research Grants6

  1. Risk Factors for Endometriosis
    David Hunter; Fiscal Year: 2002
    ..These analyses will be the first prospective data with adequate power to evaluate this important and understudied cause of morbidity among premenopausal women. ..
  2. DNA repair, genetic variation and skin cancer
    David Hunter; Fiscal Year: 2003
    ..This study will be among the first studies of the association of polymorphisms in candidate DNA repair genes with skin cancer, which assess potential interactions between genotype and sunlight exposure. ..
  3. Folate, 1-Carbon Nutrients, Gene Variants & Colon Cancer
    David Hunter; Fiscal Year: 2007
    ..These highly interrelated studies will help integrate epidemiologic and mechanistic observations and help provide a basis for public health recommendations on optimal levels of folate and B vitamin intake. ..
  4. Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3
    David Hunter; Fiscal Year: 2007
    ..The alliance of the BPC3 with the BCAC will facilitate communications and pooled analyses between the two largest sets of studies examining inherited susceptibility to breast cancer. ..