Affiliation: Harvard University
- Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated regionJack T Rogers
Genetics and Aging Unit, Massachusetts General Hospital Harvard Medical School, Charlestown 02129 4404, USA
J Mol Neurosci 19:77-82. 2002..These APP 5'UTR directed drugs exemplify a new strategy to identify RNA-directed agents to lower APP translation and A beta peptide output for Alzheimer's disease therapeutics...
- Redox-active metals, oxidative stress, and Alzheimer's disease pathologyXudong Huang
Laboratory for Oxidation Biology, Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Ann N Y Acad Sci 1012:153-63. 2004....
- High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticlesFuhai Li
The Center for Biomedical Informatics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
BMC Biotechnol 7:66. 2007..This system has been proved to be an essential tool in our study...
- Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptidesXudong Huang
Department of Psychiatry, and Laboratory for Oxidation Biology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Biol Inorg Chem 9:954-60. 2004..These data suggest that protein self-assembly and oligomerization are not spontaneous in this system as previously thought, and that there may be an obligatory role for metal ions in initiating Abeta amyloidosis and oligomerization...
- Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's diseaseSanghamitra Bandyopadhyay
Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
PLoS ONE 8:e65978. 2013..Our data evidenced a novel therapeutic strategy of potential impact for people with trisomy of the APP gene on chromosome 21, which is a phenotype long associated with Down syndrome (DS) that can also cause familial Alzheimer's disease. ..
- Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's diseaseJack T Rogers
Department of Psychiatry, Neurochemistry Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
Biochem Soc Trans 36:1282-7. 2008..The same constellation of RNA-binding proteins [IRP1/IRP2/poly(C) binding protein] control ferritin and APP translation with implications for the biology of metals in AD...
- The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and PosiphenJack T Rogers
Neurochemistry Laboratory, Psychiatry Neuroscience, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Neural Transm 118:493-507. 2011..These are candidate drugs with the potential to limit toxic SNCA expression in the brains of PD patients and animal models in vivo...
- Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1Hyun Hee Cho
Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 285:31217-32. 2010..Functionally, shRNA knockdown of IRP1 caused increased expression of neural APP consistent with IRP1-APP IRE-driven translation...
- Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseasesCatherine M Cahill
Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital East, Harvard Medical School, CNY2, Building 149, Charlestown, MA 02129, USA
Biochim Biophys Acta 1790:615-28. 2009..In the case of AD, metal based therapeutics may ultimately prove more cost effective than the use of an amyloid vaccine as the preferred anti-amyloid therapeutic strategy to ameliorate the cognitive decline of AD patients...
- Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's diseaseSeiichi Nagano
Laboratory for Oxidation Biology, Genetics and Aging Research Unit, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 279:14673-8. 2004..COX-2-mediated cross-linking may inhibit Abeta catabolism and possibly generate toxic intracellular forms of oligomeric Abeta...
- Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive elementDavid Olivares
Department of Psychiatry Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
Int J Mol Sci 10:1226-60. 2009....
- Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated regionStephanie Tucker
Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02125, USA
Curr Alzheimer Res 2:249-54. 2005..These data also demonstrated a statistically significant anti-amyloid trend for paroxetine, NAC and erythromycin. The potential for conducting further studies with these compounds using larger cohorts of TgCRND8 mice is discussed...
- A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesionsJack Y Yang
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BMC Genomics 9:S23. 2008....
- Investigation of transmembrane proteins using a computational approachJack Y Yang
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
BMC Genomics 9:S7. 2008....
- A special local clustering algorithm for identifying the genes associated with Alzheimer's diseaseChao Yang Pang
Biomedical Informatics and Cheminformatics Group, Conjugate and Medicinal Chemistry Laboratory, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
IEEE Trans Nanobioscience 9:44-50. 2010..Application of a clustering algorithm in disease-associated gene identification such as in AD is rarely reported...
- Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's diseaseLee E Goldstein
Laboratory for Oxidation Biology, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
Lancet 361:1258-65. 2003..We aimed to investigate the hypothesis that molecular pathological findings associated with Alzheimer's disease overlap in the lens and brain...
- An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcriptJack T Rogers
Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
J Biol Chem 277:45518-28. 2002....
- Copper mediates dityrosine cross-linking of Alzheimer's amyloid-betaCraig S Atwood
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Biochemistry 43:560-8. 2004..Given the elevated concentration of Cu in senile plaques, our results suggest that Cu interactions with Abeta could be responsible for causing the covalent cross-linking of Abeta in these structures...
- Iron inhibits neurotoxicity induced by trace copper and biological reductantsAnthony R White
Department of Pathology and Centre for Neuroscience, The University of Melbourne, 3010, Carlton South, Victoria, Australia
J Biol Inorg Chem 9:269-80. 2004..These findings have important implications for trace biometal interactions and free radical-mediated damage during neurodegenerative illnesses such as Alzheimer's disease and old-age dementia...
- Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesisAlpaslan Dedeoglu
Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, MA 01730, USA
Exp Gerontol 39:1641-9. 2004..Collectively, these preliminary findings carry implication for XH1 being a BBB-permeable lead compound for AD therapeutics targeting Alzheimer's amyloidogenesis, although further studies are needed...
- Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubesCarol Huang
Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 280:19426-35. 2005....
- Metal exposure and Alzheimer's pathogenesisGuijian Liu
Environmental Science Division, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, China
J Struct Biol 155:45-51. 2006..Nevertheless, the study of APP and Abeta metallobiology may identify potential targets for therapeutic intervention and/or provide diagnostic methods for AD...
- RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteineStephanie Tucker
Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Alzheimer Res 3:221-7. 2006..It will be possible to employ the chemical structures of paroxetine and erythromycin as starting points for drug design and development for AD therapeutics...
- Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)Carlos Opazo
Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 114 D, Chile
J Biol Chem 277:40302-8. 2002..Cu. Therefore, microregional catalytic H(2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value...
- A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillationsJinhui Wang
Environmental Science Division, School of Earth and Space Science, University of Science and Technology of China, Hefei, Anhui Province 230026, China
J Theor Biol 245:510-9. 2007..lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells...
- Supervised learning-based tagSNP selection for genome-wide disease classificationsQingzhong Liu
Department of Computer Science, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA
BMC Genomics 9:S6. 2008..To find that subset while reducing study burden in terms of time and costs, one can potentially reconcile information redundancy from associations between SNP markers...