Research Topics
Species | S HuangSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technologyAmy Brock
Vascular Biology Program, Department of Pathology, Harvard Medical School and Children s Hospital, Enders 1007, 300 Longwood Ave, Boston, MA 02115, USA
BMC Cell Biol 4:6. 2003....
Bifurcation dynamics in lineage-commitment in bipotent progenitor cellsSui Huang
Department of Surgery and Vascular Biology Program, Children s Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Children s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA
Dev Biol 305:695-713. 2007....- Genomics, complexity and drug discovery: insights from Boolean network models of cellular regulationS Huang
Surgical Research, Enders 1007, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Pharmacogenomics 2:203-22. 2001.... - Dimensions of systems biologyS Huang
Harvard Medical School, Department of Surgery and Vascular Biology Program, Karp 11 212, Children s Hospital, 300 Longwood Avenue, Boston, 02115 MA, USA
Rev Physiol Biochem Pharmacol 157:81-104. 2006.... - Back to the biology in systems biology: what can we learn from biomolecular networks?Sui Huang
Department of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Brief Funct Genomic Proteomic 2:279-97. 2004.... - Rational drug discovery: what can we learn from regulatory networks?Sui Huang
Dept of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Drug Discov Today 7:S163-9. 2002..Understanding the nature of these constraints in gene-activation state space will pave the way to a holistic yet formal and genomics-based approach to rational drug development... - In vivo quantification of transvascular water exchange during the acute phase of permanent strokeY R Kim
Athinoula A Martinos Center for Biomedical Imaging Radiology, Massachusetts General Hospital, Charleston, Massachusetts 02129, USA
Magn Reson Med 60:813-21. 2008..Although the measured ADC in the ipsilesional cortex continuously decreased, the abnormally high intra-/extravascular WEI remained constant at a significantly elevated level, indicating apparent BBB injury at this early stage of stroke... - Gene expression profiling, genetic networks, and cellular states: an integrating concept for tumorigenesis and drug discoveryS Huang
Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Mol Med (Berl) 77:469-80. 1999..Implications for a rational approach to the identification of new drug targets for cancer treatment are discussed... - In vivo retinal gene expression in early diabetesA M Joussen
Children's Hospital, Surgical Research Laboratories, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 42:3047-57. 2001..Beyond providing insight into the general nature of the response to a pathogenic challenge, gene expression profiling may also allow the efficient identification of potential drug targets and markers for monitoring the course of disease... - Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cellsH Zhu
Hematology Division, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 96:14742-7. 1999..The properties of this protein make it a plausible candidate oxygen sensor... - Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistenceS Huang
Vascular Biology Program, Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Motil Cytoskeleton 61:201-13. 2005.... - Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cellsShamit Soneji
Weatherall Institute of Molecular Medicine, Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Ann N Y Acad Sci 1106:30-40. 2007..An understanding of the architecture and behavior of transcriptional networks should lend insight into how the huge number of potential gene expression programs is constrained and facilitates efforts to direct or redirect cell fate... - A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networksSui Huang
Vascular Biology Program, Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Breast Dis 26:27-54. 2006.... - Empirical multiscale networks of cellular regulationBenjamin de Bivort
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
PLoS Comput Biol 3:1968-78. 2007.... - Cell fates as high-dimensional attractor states of a complex gene regulatory networkSui Huang
Vascular Biology Program, Departments of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Phys Rev Lett 94:128701. 2005.... - Perinucleolar compartment prevalence has an independent prognostic value for breast cancerRajesh V Kamath
Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
Cancer Res 65:246-53. 2005..These findings also show the potential of PNC prevalence as a prognostic marker for breast cancer... - Multistable and multistep dynamics in neutrophil differentiationHannah H Chang
Vascular Biology Program, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
BMC Cell Biol 7:11. 2006..However, the dynamics of mammalian cell differentiation has not been analyzed with respect to bistability... 
Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancyJohn T Norton
Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Cancer 113:861-9. 2008..Previous studies using breast cancer as a model system demonstrated that PNC prevalence (the percentage of cells with 1 or more PNC) increased with disease progression and was associated with poor patient outcomes...- Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent mannerChen Wang
Department of Cell and Molecular Biology, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
J Biol Chem 283:20277-87. 2008..These data demonstrate that PTB is not oncogenic and can either promote or antagonize a malignant trait dependent upon the specific intra-cellular environment... - The next step in systems biology: simulating the temporospatial dynamics of molecular networkHao Zhu
Bioinformatics Institute of Singapore, Singapore
Bioessays 26:68-72. 2004..The aim of this paper is to present a brief and informative, but not all-inclusive, viewpoint on the computational aspects of modeling and simulation of a non-static molecular network... - Transcriptome-wide noise controls lineage choice in mammalian progenitor cellsHannah H Chang
Vascular Biology Programme, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 453:544-7. 2008.... - PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibitionDipak Panigrahy
Vascular Biology Program, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:985-90. 2008..Our results provide a mechanistic rationale for evaluating the clinical benefits of PPARalpha agonists in cancer treatment, alone and in combination with other therapies... - Dynamics of cellular level function and regulation derived from murine expression array dataBenjamin de Bivort
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 101:17687-92. 2004.... - Phase II study of epirubicin plus oxaliplatin and infusional 5-fluorouracil as first-line combination therapy in patients with metastatic or advanced gastric cancerChen X Zhang
Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PRC
Anticancer Drugs 18:581-6. 2007..1%). The epirubicin, oxaliplatin and infusional 5-fluorouracil regimen was effective and well tolerated as a front-line chemotherapy for patients with metastatic or advanced gastric cancer, and should be evaluated further... - The mechanism of action of the vacuum-assisted closure deviceSandra Saja Scherer
Division of Plastic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
Plast Reconstr Surg 122:786-97. 2008..In this study, the authors designed a partially splinted full-thickness murine vacuum-assisted closure model to better understand the mechanism of action of the vacuum-assisted closure device... - Synthesis and anticancer activities of 6-amino amonafide derivativesJohn T Norton
Department of Cell and Molecular Biology, The Mary Beth Donnelley Clinical Pharmacology Core Facility, Northwestern University Medical School, Chicago, Illinois 60611, USA
Anticancer Drugs 19:23-36. 2008.... - Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid raftsAkiko Mammoto
Vascular Biology Program, Department of Pathology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Cell Sci 120:456-67. 2007.... - Ribosomal chromatin organizationSui Huang
Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Biochem Cell Biol 84:444-9. 2006..This review will attempt to summarize our current understanding of the structure and organization of ribosomal chromatin... - Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractilityYasushi Numaguchi
Vascular Biology Program, Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Angiogenesis 6:55-64. 2003.... - Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profilesGabriel S Eichler
Vascular Biology Program, Department of Pathology, Children's Hospital/Harvard Medical School, Boston, MA 02115, USA
Bioinformatics 19:2321-2. 2003..0 is written in Matlab, and binary Matlab.dll files which require Matlab to run can be downloaded for free by academic institutions at http://www.chip.org/~ge/gedihome.html Supplementary information: http://www.chip.org/~ge/gedihome.html.. - Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNAMegan P Hall
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
Mol Biol Cell 15:774-86. 2004..These results indicate that PTB and KSRP do indeed interact with the c-src transcript in vivo, and that these associations change with the differentiated state of the cell... - Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transitionAkiko Mammoto
Vascular Biology Program, Department of Pathology, Children s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 279:26323-30. 2004.... - A novel trap for dynamic protein interactions in cytokine signalingAmy Brock
Trends Biotechnol 20:145. 2002 - Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tensionKimberly A Moore
Vascular Biology Program, Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Dev Dyn 232:268-81. 2005.... - TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomesDanyang Chen
Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
Mol Biol Cell 13:276-84. 2002..We propose a novel model in which the association of TBP-TAF complexes with chromatin during mitosis marks genes for rapid transcriptional activation as cells emerge from mitosis... - Cell tension, matrix mechanics, and cancer developmentSui Huang
Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115, USA
Cancer Cell 8:175-6. 2005..This mechanical "autocrine loop" brings solid-state mechanotransduction on a par with oncogenic signaling pathways in malignant transformation... - Physical and functional modularity of the protein network in yeastThomas Wilhelm
Institute of Molecular Biotechnology, Jena, Germany
Mol Cell Proteomics 2:292-8. 2003..This promiscuity accounts for the high clustering in the protein net-work graph. Our results underscore the need to include the information contained in observed protein complexes into protein network analyses... - Evidence by molecular profiling for a placental origin of infantile hemangiomaCarmen M Barnes
Vascular Biology Program and Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:19097-102. 2005..Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium... - A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independentSui Huang
Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Exp Cell Res 275:255-64. 2002.... - PPARgamma as a therapeutic target for tumor angiogenesis and metastasisDipak Panigrahy
Vascular Biology Program, Children's Hospital, Department of Surgery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Biol Ther 4:687-93. 2005..This will be paramount if the potent biological activity of PPARgamma agonists are to be harnessed for cancer therapy...