S Huang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology
    Amy Brock
    Vascular Biology Program, Department of Pathology, Harvard Medical School and Children s Hospital, Enders 1007, 300 Longwood Ave, Boston, MA 02115, USA
    BMC Cell Biol 4:6. 2003
  2. ncbi request reprint Bifurcation dynamics in lineage-commitment in bipotent progenitor cells
    Sui Huang
    Department of Surgery and Vascular Biology Program, Children s Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Children s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA
    Dev Biol 305:695-713. 2007
  3. ncbi request reprint Genomics, complexity and drug discovery: insights from Boolean network models of cellular regulation
    S Huang
    Surgical Research, Enders 1007, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Pharmacogenomics 2:203-22. 2001
  4. ncbi request reprint Dimensions of systems biology
    S Huang
    Harvard Medical School, Department of Surgery and Vascular Biology Program, Karp 11 212, Children s Hospital, 300 Longwood Avenue, Boston, 02115 MA, USA
    Rev Physiol Biochem Pharmacol 157:81-104. 2006
  5. ncbi request reprint Back to the biology in systems biology: what can we learn from biomolecular networks?
    Sui Huang
    Department of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Brief Funct Genomic Proteomic 2:279-97. 2004
  6. ncbi request reprint Rational drug discovery: what can we learn from regulatory networks?
    Sui Huang
    Dept of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Drug Discov Today 7:S163-9. 2002
  7. pmc In vivo quantification of transvascular water exchange during the acute phase of permanent stroke
    Y R Kim
    Athinoula A Martinos Center for Biomedical Imaging Radiology, Massachusetts General Hospital, Charleston, Massachusetts 02129, USA
    Magn Reson Med 60:813-21. 2008
  8. ncbi request reprint Gene expression profiling, genetic networks, and cellular states: an integrating concept for tumorigenesis and drug discovery
    S Huang
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 77:469-80. 1999
  9. ncbi request reprint In vivo retinal gene expression in early diabetes
    A M Joussen
    Children's Hospital, Surgical Research Laboratories, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 42:3047-57. 2001
  10. pmc Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells
    H Zhu
    Hematology Division, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:14742-7. 1999

Collaborators

Detail Information

Publications40

  1. pmc Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology
    Amy Brock
    Vascular Biology Program, Department of Pathology, Harvard Medical School and Children s Hospital, Enders 1007, 300 Longwood Ave, Boston, MA 02115, USA
    BMC Cell Biol 4:6. 2003
    ....
  2. ncbi request reprint Bifurcation dynamics in lineage-commitment in bipotent progenitor cells
    Sui Huang
    Department of Surgery and Vascular Biology Program, Children s Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Children s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA
    Dev Biol 305:695-713. 2007
    ....
  3. ncbi request reprint Genomics, complexity and drug discovery: insights from Boolean network models of cellular regulation
    S Huang
    Surgical Research, Enders 1007, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Pharmacogenomics 2:203-22. 2001
    ....
  4. ncbi request reprint Dimensions of systems biology
    S Huang
    Harvard Medical School, Department of Surgery and Vascular Biology Program, Karp 11 212, Children s Hospital, 300 Longwood Avenue, Boston, 02115 MA, USA
    Rev Physiol Biochem Pharmacol 157:81-104. 2006
    ....
  5. ncbi request reprint Back to the biology in systems biology: what can we learn from biomolecular networks?
    Sui Huang
    Department of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Brief Funct Genomic Proteomic 2:279-97. 2004
    ....
  6. ncbi request reprint Rational drug discovery: what can we learn from regulatory networks?
    Sui Huang
    Dept of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Drug Discov Today 7:S163-9. 2002
    ..Understanding the nature of these constraints in gene-activation state space will pave the way to a holistic yet formal and genomics-based approach to rational drug development...
  7. pmc In vivo quantification of transvascular water exchange during the acute phase of permanent stroke
    Y R Kim
    Athinoula A Martinos Center for Biomedical Imaging Radiology, Massachusetts General Hospital, Charleston, Massachusetts 02129, USA
    Magn Reson Med 60:813-21. 2008
    ..Although the measured ADC in the ipsilesional cortex continuously decreased, the abnormally high intra-/extravascular WEI remained constant at a significantly elevated level, indicating apparent BBB injury at this early stage of stroke...
  8. ncbi request reprint Gene expression profiling, genetic networks, and cellular states: an integrating concept for tumorigenesis and drug discovery
    S Huang
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 77:469-80. 1999
    ..Implications for a rational approach to the identification of new drug targets for cancer treatment are discussed...
  9. ncbi request reprint In vivo retinal gene expression in early diabetes
    A M Joussen
    Children's Hospital, Surgical Research Laboratories, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 42:3047-57. 2001
    ..Beyond providing insight into the general nature of the response to a pathogenic challenge, gene expression profiling may also allow the efficient identification of potential drug targets and markers for monitoring the course of disease...
  10. pmc Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells
    H Zhu
    Hematology Division, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:14742-7. 1999
    ..The properties of this protein make it a plausible candidate oxygen sensor...
  11. ncbi request reprint Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistence
    S Huang
    Vascular Biology Program, Departments of Surgery and Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Motil Cytoskeleton 61:201-13. 2005
    ....
  12. ncbi request reprint Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells
    Shamit Soneji
    Weatherall Institute of Molecular Medicine, Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Ann N Y Acad Sci 1106:30-40. 2007
    ..An understanding of the architecture and behavior of transcriptional networks should lend insight into how the huge number of potential gene expression programs is constrained and facilitates efforts to direct or redirect cell fate...
  13. ncbi request reprint A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks
    Sui Huang
    Vascular Biology Program, Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Dis 26:27-54. 2006
    ....
  14. pmc Empirical multiscale networks of cellular regulation
    Benjamin de Bivort
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Comput Biol 3:1968-78. 2007
    ....
  15. ncbi request reprint Cell fates as high-dimensional attractor states of a complex gene regulatory network
    Sui Huang
    Vascular Biology Program, Departments of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Phys Rev Lett 94:128701. 2005
    ....
  16. ncbi request reprint Perinucleolar compartment prevalence has an independent prognostic value for breast cancer
    Rajesh V Kamath
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Res 65:246-53. 2005
    ..These findings also show the potential of PNC prevalence as a prognostic marker for breast cancer...
  17. pmc Multistable and multistep dynamics in neutrophil differentiation
    Hannah H Chang
    Vascular Biology Program, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cell Biol 7:11. 2006
    ..However, the dynamics of mammalian cell differentiation has not been analyzed with respect to bistability...
  18. doi request reprint Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancy
    John T Norton
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer 113:861-9. 2008
    ..Previous studies using breast cancer as a model system demonstrated that PNC prevalence (the percentage of cells with 1 or more PNC) increased with disease progression and was associated with poor patient outcomes...
  19. pmc Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner
    Chen Wang
    Department of Cell and Molecular Biology, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 283:20277-87. 2008
    ..These data demonstrate that PTB is not oncogenic and can either promote or antagonize a malignant trait dependent upon the specific intra-cellular environment...
  20. ncbi request reprint The next step in systems biology: simulating the temporospatial dynamics of molecular network
    Hao Zhu
    Bioinformatics Institute of Singapore, Singapore
    Bioessays 26:68-72. 2004
    ..The aim of this paper is to present a brief and informative, but not all-inclusive, viewpoint on the computational aspects of modeling and simulation of a non-static molecular network...
  21. doi request reprint Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    Hannah H Chang
    Vascular Biology Programme, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 453:544-7. 2008
    ....
  22. pmc PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:985-90. 2008
    ..Our results provide a mechanistic rationale for evaluating the clinical benefits of PPARalpha agonists in cancer treatment, alone and in combination with other therapies...
  23. pmc Dynamics of cellular level function and regulation derived from murine expression array data
    Benjamin de Bivort
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 101:17687-92. 2004
    ....
  24. ncbi request reprint Phase II study of epirubicin plus oxaliplatin and infusional 5-fluorouracil as first-line combination therapy in patients with metastatic or advanced gastric cancer
    Chen X Zhang
    Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PRC
    Anticancer Drugs 18:581-6. 2007
    ..1%). The epirubicin, oxaliplatin and infusional 5-fluorouracil regimen was effective and well tolerated as a front-line chemotherapy for patients with metastatic or advanced gastric cancer, and should be evaluated further...
  25. doi request reprint The mechanism of action of the vacuum-assisted closure device
    Sandra Saja Scherer
    Division of Plastic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Plast Reconstr Surg 122:786-97. 2008
    ..In this study, the authors designed a partially splinted full-thickness murine vacuum-assisted closure model to better understand the mechanism of action of the vacuum-assisted closure device...
  26. ncbi request reprint Synthesis and anticancer activities of 6-amino amonafide derivatives
    John T Norton
    Department of Cell and Molecular Biology, The Mary Beth Donnelley Clinical Pharmacology Core Facility, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Anticancer Drugs 19:23-36. 2008
    ....
  27. ncbi request reprint Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts
    Akiko Mammoto
    Vascular Biology Program, Department of Pathology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Cell Sci 120:456-67. 2007
    ....
  28. ncbi request reprint Ribosomal chromatin organization
    Sui Huang
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Biochem Cell Biol 84:444-9. 2006
    ..This review will attempt to summarize our current understanding of the structure and organization of ribosomal chromatin...
  29. ncbi request reprint Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility
    Yasushi Numaguchi
    Vascular Biology Program, Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Angiogenesis 6:55-64. 2003
    ....
  30. ncbi request reprint Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
    Gabriel S Eichler
    Vascular Biology Program, Department of Pathology, Children s Hospital Harvard Medical School, Boston, MA 02115, USA
    Bioinformatics 19:2321-2. 2003
    ..Important changes in genome-wide activities may be quickly identified based on 'Gestalt' recognition and hence, GEDI may be especially useful for non-specialist end users, such as physicians...
  31. pmc Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA
    Megan P Hall
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Biol Cell 15:774-86. 2004
    ..These results indicate that PTB and KSRP do indeed interact with the c-src transcript in vivo, and that these associations change with the differentiated state of the cell...
  32. ncbi request reprint Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition
    Akiko Mammoto
    Vascular Biology Program, Department of Pathology, Children s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:26323-30. 2004
    ....
  33. ncbi request reprint A novel trap for dynamic protein interactions in cytokine signaling
    Amy Brock
    Trends Biotechnol 20:145. 2002
  34. ncbi request reprint Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension
    Kimberly A Moore
    Vascular Biology Program, Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Dyn 232:268-81. 2005
    ....
  35. pmc TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes
    Danyang Chen
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Biol Cell 13:276-84. 2002
    ..We propose a novel model in which the association of TBP-TAF complexes with chromatin during mitosis marks genes for rapid transcriptional activation as cells emerge from mitosis...
  36. ncbi request reprint Cell tension, matrix mechanics, and cancer development
    Sui Huang
    Harvard Medical School and Children s Hospital, Boston, Massachusetts 02115, USA
    Cancer Cell 8:175-6. 2005
    ..This mechanical "autocrine loop" brings solid-state mechanotransduction on a par with oncogenic signaling pathways in malignant transformation...
  37. ncbi request reprint Physical and functional modularity of the protein network in yeast
    Thomas Wilhelm
    Institute of Molecular Biotechnology, Jena, Germany
    Mol Cell Proteomics 2:292-8. 2003
    ..This promiscuity accounts for the high clustering in the protein net-work graph. Our results underscore the need to include the information contained in observed protein complexes into protein network analyses...
  38. pmc Evidence by molecular profiling for a placental origin of infantile hemangioma
    Carmen M Barnes
    Vascular Biology Program and Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:19097-102. 2005
    ..Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium...
  39. ncbi request reprint A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent
    Sui Huang
    Department of Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Exp Cell Res 275:255-64. 2002
    ....
  40. ncbi request reprint PPARgamma as a therapeutic target for tumor angiogenesis and metastasis
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 4:687-93. 2005
    ..This will be paramount if the potent biological activity of PPARgamma agonists are to be harnessed for cancer therapy...