Peng Huang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
  2. pmc Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Genet 8:e1002762. 2012
  3. pmc Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs
    James A Gagnon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e98186. 2014
  4. pmc Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb
    Junhao Mao
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Cell 16:600-6. 2009

Collaborators

Detail Information

Publications4

  1. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
    ..These results reveal a conserved requirement for cilia in transducing the activity of upstream regulators of Hh signaling but distinct phenotypic effects due to differential regulation and differing roles of transcriptional mediators...
  2. pmc Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Genet 8:e1002762. 2012
    ....
  3. pmc Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs
    James A Gagnon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e98186. 2014
    ..This limitation was overcome by knock-in of a stop codon cassette that ensured coding frame truncation. Our improved methods and detailed protocols make Cas9-mediated mutagenesis an attractive approach for labs of all sizes. ..
  4. pmc Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb
    Junhao Mao
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Cell 16:600-6. 2009
    ..This study identifies another level of genetic interaction between the orthogonal axes during limb development...