I Chueh Huang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 7:e1001258. 2011
  2. pmc Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    EMBO J 24:1634-43. 2005
  3. pmc Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School and New England Primate Research Center, Southborough, Massachusetts, USA
    J Virol 80:4211-9. 2006
  4. pmc Ifitm3 limits the severity of acute influenza in mice
    Charles C Bailey
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 8:e1002909. 2012
  5. pmc Influenza A virus neuraminidase limits viral superinfection
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 82:4834-43. 2008
  6. pmc Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors
    Matthew Brudner
    Programs of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60838. 2013
  7. pmc IFITM proteins restrict antibody-dependent enhancement of dengue virus infection
    Ying Kai Chan
    New England Primate Research Center, Department of Microbiology and Immunobiology, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS ONE 7:e34508. 2012
  8. pmc The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Virology 367:367-74. 2007

Collaborators

Detail Information

Publications8

  1. pmc Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 7:e1001258. 2011
    ..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression...
  2. pmc Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    EMBO J 24:1634-43. 2005
    ..Collectively, these data describe molecular interactions important to the adaptation of SARS-CoV to human cells, and provide insight into the severity of the 2002-2003 SARS epidemic...
  3. pmc Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School and New England Primate Research Center, Southborough, Massachusetts, USA
    J Virol 80:4211-9. 2006
  4. pmc Ifitm3 limits the severity of acute influenza in mice
    Charles C Bailey
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 8:e1002909. 2012
    ..Collectively, these findings establish a central role for Ifitm3 in limiting acute influenza in vivo, and provide further insight into Ifitm3 expression and regulation...
  5. pmc Influenza A virus neuraminidase limits viral superinfection
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 82:4834-43. 2008
    ..Our data indicate that NA alone among viral proteins limits influenza A virus superinfection...
  6. pmc Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors
    Matthew Brudner
    Programs of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60838. 2013
    ..Our findings confirm our hypothesis that the pressure of infectious diseases may have contributed in part to evolutionary selection of MBL mutant haplotypes...
  7. pmc IFITM proteins restrict antibody-dependent enhancement of dengue virus infection
    Ying Kai Chan
    New England Primate Research Center, Department of Microbiology and Immunobiology, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS ONE 7:e34508. 2012
    ..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections...
  8. pmc The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
    Wenhui Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Virology 367:367-74. 2007
    ..These studies indicate that HCoV-NL63, like SARS-CoV, associates region of human ACE2 that includes a key loop formed by beta-strands 4 and 5...