Research Topics
| Michael D HowellSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Performance of severity of illness scoring systems in emergency department patients with infectionMichael D Howell
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Acad Emerg Med 14:709-14. 2007....
Managing ICU throughput and understanding ICU censusMichael D Howell
Silverman Institute for Healthcare Quality and Safety, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Crit Care 17:626-33. 2011..Therefore, ICUs need additional tools to manage census, inflow, and throughput...
Sustained effectiveness of a primary-team-based rapid response systemMichael D Howell
Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 40:2562-8. 2012..We sought to determine whether a rapid-response system that relied on a patient's usual care providers, not a critical-care-trained rapid-response team, would improve patient outcomes...- Intensivist time allocation: economic and ethical issues surrounding how intensivists use their timeMichael D Howell
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Semin Respir Crit Care Med 33:401-12. 2012..balance these issues with the very real workforce concern of accelerated professional burnout? (2) What are the hidden financial impacts of intensivist participation in quality improvement programs, given current reimbursement systems?.. - Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infectionMichael D Howell
Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Arch Intern Med 170:784-90. 2010..The incidence and severity of Clostridium difficile infections are increasing. Acid-suppressive therapy has been suggested as a risk factor for C difficile, but this remains controversial... - A 37-year-old man trying to choose a high-quality hospital: review of hospital quality indicatorsMichael D Howell
Silverman Institute for Health Care Quality and Safety, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
JAMA 302:2353-60. 2009..Nevertheless, hospital quality information and metrics are an important component of the strategy Mr A should take to solve this challenging problem... - Occult hypoperfusion and mortality in patients with suspected infectionMichael D Howell
Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Medicine, KB 23, 330 Brookline Avenue, Boston, MA 02215, USA
Intensive Care Med 33:1892-9. 2007..To determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospital mortality... - Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transferMaura Kennedy
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Acad Emerg Med 17:1080-5. 2010..Understanding risk factors leading to undertriage would be useful, but these factors are not well characterized... - Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortalityNathan I Shapiro
Department of Emergency Medicine, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Boston, MA
Crit Care Med 35:192-8. 2007..To assess the predictive performance for 1-yr mortality of the previously derived and validated Mortality in Emergency Department Sepsis (MEDS) score... - Diabetes is not associated with increased mortality in emergency department patients with sepsisPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Ann Emerg Med 58:438-44. 2011..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED... - The costs and cost-effectiveness of an integrated sepsis treatment protocolDaniel Talmor
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
Crit Care Med 36:1168-74. 2008..Sepsis is associated with high mortality and treatment costs. International guidelines recommend the implementation of integrated sepsis protocols; however, the true cost and cost-effectiveness of these are unknown... - Initial management of septic patients with hyperglycemia in the noncritical care inpatient settingPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Med 125:670-8. 2012..The impact of hyperglycemia and glycemic control in patients with infection before developing severe sepsis or shock remains undefined... - Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocolNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 34:1025-32. 2006..No statistically significant decrease in mortality was demonstrated, as this trial was not sufficiently powered to assess mortality benefits... - Proof of principle: the predisposition, infection, response, organ failure sepsis staging systemMichael D Howell
Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Crit Care Med 39:322-7. 2011..The objective of this investigation was to derive and validate a sepsis staging system based on the PIRO concept that risk stratifies patients with suspected infection... - Simple triage scoring system predicting death and the need for critical care resources for use during epidemicsDaniel Talmor
Trauma Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Crit Care Med 35:1251-6. 2007..To date, no standardized method for allocating scarce resources when the number of patients in need far exceeds capacity exists. We sought to derive and validate such a triage scheme... - Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically illTal Mandelbaum
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 1 Deaconess Rd CC 470, Boston, MA 02215, USA
Intensive Care Med 39:414-9. 2013.... - Acid-suppressive medication use and the risk for hospital-acquired pneumoniaShoshana J Herzig
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
JAMA 301:2120-8. 2009..The use of acid-suppressive medication has been steadily increasing, particularly in the inpatient setting, despite lack of an accepted indication in the majority of these patients... - Predictors and correlates of dissatisfaction with intensive careSabina Hunziker
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and the Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, Children s Hospital Boston, and Harvard Medical School, Boston, MA, USA
Crit Care Med 40:1554-61. 2012..Dissatisfaction is an important threat to high-quality care. The aim of this study was to identify factors independently associated with dissatisfaction with critical care... - Red cell distribution width and mortality in newly hospitalized patientsSabina Hunziker
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Med 125:283-91. 2012..Less research has focused on the prognostic utility of red cell distribution width in an acutely hospitalized population... - The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infectionNathan Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
Ann Emerg Med 48:583-90, 590.e1. 2006.... - Acid-suppressive medication use and the risk for nosocomial gastrointestinal tract bleedingShoshana J Herzig
Division of General Medicine, Beth Israel Deaconess Medical Center, Brookline, MA 02446, USA
Arch Intern Med 171:991-7. 2011..We aimed to define the incidence of nosocomial GI bleeding outside of the intensive care unit and examine the association between acid-suppressive medication use and this complication... - Serum lactate as a predictor of mortality in emergency department patients with infectionNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 45:524-8. 2005..We determine whether a serum venous lactate is associated with an increased risk of death in ED patients with infection... - Lactate clearance as a predictor of mortality in trauma patientsStephen R Odom
Division of Acute Care Surgery, Trauma and Surgical Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Trauma Acute Care Surg 74:999-1004. 2013..Initial serum lactate has been associated with mortality in trauma patients. It is not known if lactate clearance is predictive of death in a broad cohort of trauma patients... - International validation of the out-of-hospital cardiac arrest score in the United StatesSabina Hunziker
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 39:1670-4. 2011..The aim of this study is to externally validate this score in an independent patient population in the United States... - Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteriaTal Mandelbaum
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Crit Care Med 39:2659-64. 2011..Accurate urine output measurements as well as serum creatinine values from our database were used to detect patients with acute kidney injury and calculate their corresponding mortality risk and length of stay... - Teamwork and leadership in cardiopulmonary resuscitationSabina Hunziker
Medical Intensive Care Unit, University Hospital Basel, Basel, Switzerland
J Am Coll Cardiol 57:2381-8. 2011..g., equipment, algorithms, institutional characteristics) on team performance in resuscitation situations are critical to improve CPR performance and medical outcomes of patients... - Risk factors for nosocomial gastrointestinal bleeding and use of Acid-suppressive medication in non-critically ill patientsShoshana J Herzig
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
J Gen Intern Med 28:683-90. 2013..It is unknown whether there exist certain subsets of patients outside of the intensive care unit in whom the risk of nosocomial gastrointestinal bleeding is high enough that prophylactic use of acid-suppressive medication may be warranted... - Proton-pump inhibitor use is associated with low serum magnesium concentrationsJohn Danziger
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Kidney Int 83:692-9. 2013..Thus, we verify case reports of the association between PPI use and hypomagnesemia in those concurrently taking diuretics. Hence, serum magnesium concentrations should be followed in susceptible individuals on chronic PPI therapy... - Residents' and nurses' perceptions of team function in the medical intensive care unitJulia Adler-Milstein
Harvard University PhD Program in Health Policy, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Crit Care 26:104.e7-15. 2011..Therefore, we compared residents' perceptions to those of nurses', the other predominant direct caregiver group, in the medical ICU... - Commentary: Is the glass half empty? Code blue training in the modern eraJulius Yang
Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
Acad Med 86:680-3. 2011..Finally, the authors consider the question of whether code blue training remains an appropriate goal for general medicine trainees in the face of evolving trends in health care systems... - Inadequate blood volume collected for culture: a survey of health care professionalsMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Hospital, One Deaconess Road, Boston, MA 02215, USA
Mayo Clin Proc 82:1069-72. 2007..Because volume remains the most important determinant for the optimal yield of organisms, these findings raise an important quality assurance issue... - Sick? Or, not sick?Nathan Shapiro
Crit Care Med 33:1151-3. 2005 - Surviving sepsis outside the intensive care unitMichael D Howell
Crit Care Med 35:1422-3. 2007 - Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiationMichael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 128:2248-58. 2008..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...