Research Topics
Species | S L HouserSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Immunological unresponsiveness in chimeric miniature swine following MHC-mismatched spleen transplantationFrank J M F Dor
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Transplantation 80:1791-804. 2005..CONCLUSIONS: Successful SpTx can result in hematopoietic cell engraftment and in vitro donor-specific unresponsiveness, enabling prolonged survival of subsequent donor-matched kidney grafts without immunosuppression...
Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboonsStuart L Houser
Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Xenotransplantation 11:416-25. 2004..Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts...
Serum lipids and arterial plaque load are altered independently with high-dose progesterone in hypercholesterolemic male rabbitsS L Houser
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Cardiovasc Pathol 9:317-22. 2000..052) and H (p = 0.069) groups. These data suggest that the mechanism(s) involved with the antiatherogenic effect of HDP in this animal model is, or are, independent of an alteration in serum lipids...
Cardiac allograft vasculopathy: real or a normal morphologic variant?Stuart Houser
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Heart Lung Transplant 26:167-73. 2007..Naive coronary vessels may appear to have intimal thickening histologically characteristic of cardiac allograft vasculopathy (CAV). This study appraises the experimental and clinical impact of this observation...
Valvular heart disease in patients with hypocomplementemic urticarial vasculitis syndrome associated with Jaccoud's arthropathyS L Houser
Department of Pathology, Cardiovascular Pathology Section, Massachusetts General Hospital, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA 02114, USA
Cardiovasc Pathol 11:210-6. 2002..Since 1993, however, five patients with HUVS accompanied by Jaccoud's arthropathy (JA) were found to have serious valvular heart disease...
An MHC class II disparity raises the threshold for tolerance induction in pulmonary allografts in miniature swineT Shoji
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Transplant Proc 38:3268-70. 2006..These data suggest that the class II disparity inherent in a fully mismatched transplant increases the requirement for tolerance induction...
The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantationH Sahara
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Transplant Proc 38:3256-8. 2006..This appears particularly true for class I-derived allopeptides, suggesting that class II molecules may be less antigenic when presented indirectly...
Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboonsY Hisashi
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Am J Transplant 8:2516-26. 2008..In conclusion, despite the absence of the Gal epitope, acute and chronic antibody and cell-mediated rejection developed in grafts, maintained by chronic immunosupression, presumably due to de novo responses to non-Gal antigens...
The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allograftsM J Weiss
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 9:105-13. 2009..This suggests that the presence of T cells activated via indirect allorecognition represent a barrier to the induction but not the maintenance of tolerance...
Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature SwineH Sahara
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Transplant Proc 38:3253-5. 2006..CONCLUSIONS: These data suggest that thymus-independent peripheral regulatory mechanisms may be sufficient to induce and maintain long-term acceptance of the lung allografts...
Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allograftsR Hoerbelt
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Transplant Proc 38:3196-8. 2006....
Comparison of lung and kidney allografts in induction of tolerance by a mixed-chimerism approach in cynomolgus monkeysA Aoyama
Department of Surgery and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Transplant Proc 41:429-30. 2009..In the present study, we applied this same technique to lung allotransplantation in cynomolgus monkeys...
Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathyR S Lee
The Transplantation Biology Research Center and Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 98:3276-81. 2001..001), but they also developed obstructive fibroproliferative coronary artery lesions much earlier than unimmunized controls (<9 vs. >30 days). These results definitively link indirect allorecognition and cardiac allograft vasculopathy...
Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboonsF J M F Dor
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Transplant Proc 37:489-90. 2005..Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation...
Long-term acceptance of porcine pulmonary allografts without chronic rejectionT Shoji
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Transplant Proc 37:72-4. 2005..CONCLUSIONS: This study demonstrates the ability of a brief course of high-dose tacrolimus to induce long-term graft acceptance with donor-specific hyporesponsiveness in a class I-disparate preclinical lung transplant model...
Evaluation of intracoronary stenting by intravascular optical coherence tomographyB E Bouma
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Heart 89:317-20. 2003....
Porcine coronary imaging in vivo by optical coherence tomographyG J Tearney
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Acta Cardiol 55:233-7. 2000....
Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairsB Gollackner
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA
Transplantation 75:1799-806. 2003..CONCLUSION: Spleen Tx in major histocompatibility complex-matched pairs treated with CsA+/-thymic irradiation results in prolonged chimerism and is associated with the development of in vivo unresponsiveness to the transplanted spleen...
Histopathology of coronary in-stent restenosis following gamma brachytherapyH C Lowe
Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02144-2696, USA
Heart 89:11-3. 2003..Surprisingly, there was a relatively small cellular (myofibroblastic) component, with an absence of endothelial cells and little evidence of active proliferation. ISR after gamma brachytherapy may be a pathologically distinct entity...
Significant atheromatous debris following uncomplicated vein graft direct stenting: evidence supporting routine use of distal protection devicesHarry C Lowe
Division of Cardiology, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Bullfinch 105, Boston, MA 02144-2696, USA
J Invasive Cardiol 14:636-9. 2002..This case illustrates the severity of distal embolization that can go clinically unnoticed after direct stenting and also supports the routine use of distal protection devices for vein graft intervention...
Quantification of macrophage content in atherosclerotic plaques by optical coherence tomographyGuillermo J Tearney
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Circulation 107:113-9. 2003..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps...
Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaquesMasanori Kawasaki
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 48:81-8. 2006....
Characterization of human atherosclerosis by optical coherence tomographyHiroshi Yabushita
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Circulation 106:1640-5. 2002..These results represent an important step in validating this new intravascular imaging modality and will provide a basis for the interpretation of intracoronary OCT images obtained from patients...
Modeling chronic lung allograft rejection in miniature swineJames S Allan
Division of Thoracic Surgery, and the Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Transplantation 73:447-53. 2002..We have developed a new preclinical model of chronic lung rejection using MHC-inbred miniature swine...
Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomographySeemantini K Nadkarni
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 49:1474-81. 2007..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)...
Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swinePatricia S Cho
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Blood 110:3996-4004. 2007..These results suggest the possibility of developing a transplantable tumor model in this large-animal system...
3.0 T plaque imagingDenise P Hinton-Yates
Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Top Magn Reson Imaging 18:389-400. 2007..The overall endeavor is to improve prospective assessment of atherosclerosis stage and stability for reduction of atherothrombotic event risk...
Operational tolerance to class I disparate lungs can be induced despite pretransplant immunization with class I allopeptidesTsuyoshi Shoji
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Transplantation 84:1467-73. 2007..Using a class I-disparate swine lung transplant model, we examined whether an intensive course of tacrolimus could induce operational tolerance and whether preoperative allopeptide immunization would prevent the development of tolerance...
Transmyocardial coil implants: a novel approach to transmyocardial revascularizationDavid Meerkin
Department of Medicine, Montreal Heart Institute, Quebec, Canada
Ann Thorac Surg 74:488-92. 2002..The presence of angiogenesis at the implant site and the maintenance of this reaction for 3 months implies that TMI may offer an alternative to TMLR while providing a platform for delivery of angiogenic factors...
The effects of tolerance on allograft damage caused by the innate immune systemRuediger Hoerbelt
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
Transplantation 85:314-22. 2008..To address these questions, we studied the effects of rIFN-gamma infusion on porcine cardiac allograft survival...
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Am J Pathol 172:1471-81. 2008....
Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasoundIk Kyung Jang
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 39:604-9. 2002..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients...
Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature SwineRuediger Hoerbelt
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Transplantation 80:1275-82. 2005..CONCLUSIONS: These results are the first to demonstrate the ability of DST to induce operational tolerance to cardiac allografts in large animals, and they suggest that peripheral mechanisms of tolerance mediate this effect...
Effects of mycophenolate mofetil on cardiac allograft survival and cardiac allograft vasculopathy in miniature swineMargaret L Schwarze
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Thorac Surg 80:1787-93. 2005..The salutary effect of mycophenolate mofetil may be related to its ability to decrease interferon-gamma expression in the myocardium and prevent the generation of alloantibodies...
Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery diseaseBriain D Macneill
Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 44:972-9. 2004..By providing a means of detecting increases in plaque macrophage content before an acute event, this technique may aid in determining prognosis and guiding preventive therapy...
Histocompatible miniature swine: an inbred large-animal modelJoshua D Mezrich
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Transplantation 75:904-7. 2003..We conclude that G7 animals are sufficiently inbred to accept first set skin and heart grafts indefinitely...
Histomorphometric comparison of cardiac allograft vasculopathy in miniature swineStuart L Houser
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02214, USA
J Heart Lung Transplant 23:50-60. 2004..These results suggest that the origin of CAV cannot be determined by histology alone...
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceKenji Kuwaki
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH-East, 13th Street, Boston, Massachusetts 02129, USA
Nat Med 11:29-31. 2005..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
Histopathology of spleen allograft rejection in miniature swineFrank J M F Dor
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA
Int J Exp Pathol 86:57-66. 2005..This study establishes histologic guidelines for diagnosing and, perhaps, in future studies, predicting acute rejection of splenic allografts transplanted across known histocompatibility barriers in a large-animal model...
Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swineTsuyoshi Shoji
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Transplant 5:1626-34. 2005..These studies suggest that indirect allorecognition is operative during lung allograft rejection, and that pre-transplant sensitization to donor-derived MHC allopeptides can accelerate graft rejection...
Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swineJoshua D Mezrich
Transplantation Biology Research Center, Massachusetts General Hospital-Harvard Medical School, 13th Street, Boston, MA, USA
Transplantation 79:1663-73. 2005..Group 5 animals developed CAV but no significant increase in interstitial infiltrates. CONCLUSIONS: Both the kidney and thymus were necessary for maintenance of tolerance to heart allografts...
Composite "thymoheart" transplantation improves cardiac allograft survivalMatthew T Menard
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 4:79-86. 2004..The transfer of vascularized, functional donor thymic tissue to the host at the time of cardiac transplantation may provide a novel approach to the induction of tolerance in human heart transplant recipients...
Characterization of atherosclerotic plaques by laser speckle imagingSeemantini K Nadkarni
Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
Circulation 112:885-92. 2005..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque...
Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell populationJoshua D Mezrich
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
Transplantation 76:625-31. 2003..CONCLUSIONS: Radiosensitive elements in kidney allograft may be responsible for tolerance induction and prevention of chronic vascular lesions in recipients of simultaneous heart and kidney allografts...
Heart and en-bloc thymus transplantation in miniature swineDouglas R Johnston
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Thorac Cardiovasc Surg 130:554-9. 2005..CONCLUSION: We have validated a new technique of donor thymus transplantation that could have utility in human heart transplantation...
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2004. A 75-year-old woman with acute onset of chest pain followed by feverAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center. Boston, USA
N Engl J Med 351:1240-8. 2004
Calcified plaque: measurement of area at thin-section flat-panel CT and 64-section multidetector CT and comparison with histopathologic findingsAmmar Sarwar
Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge St, 4th Floor, Suite 400, Boston, MA 02114, USA
Radiology 249:301-6. 2008..18/1.02]), and the predicted difference was smaller (1.16 mm(2), P = .08). The extent of the blooming artifact in visualizing calcified coronary plaque is reduced by using flat-panel-volume CT...
Coronary in-stent restenosis following beta brachytherapy: a histopathological examinationChristian F Witzke
Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
Cardiovasc Pathol 13:85-90. 2004..Previously unreported histopathology of directed atherectomy specimens of such restenotic lesions and a discussion of their proposed significance form the basis of this report...
Constitutive expression of major histocompatibility complex class II antigens in pulmonary epithelium and endothelium varies among different speciesStuart L Houser
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Transplantation 77:605-7. 2004..These interspecies differences may explain experimental differences observed between murine and large-animal constructs...
Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swineFrank J M F Dor
Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149, 13th Street, Boston, MA 02129, USA
Transplantation 78:286-91. 2004..PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD...
Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque ruptureRodolfo Carrillo-Jimenez
Cardiology Division, Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circulation 112:e267. 2005
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-2004. A 38-year-old woman with acute onset of pain in the chestAlan J Greenfield
Cardiovascular Division, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, USA
N Engl J Med 350:1666-74. 2004
Arterial wall imaging: evaluation with 16-section multidetector CT in blood vessel phantoms and ex vivo coronary arteriesMaros Ferencik
Department of Radiology, Wellman Laboratories of Photomedicine, Boston, MA 02114, USA
Radiology 240:708-16. 2006..001). CONCLUSION: Determination of composition of individual plaques from attenuation values can be more challenging because of overlapping values for different tissue types...
Vulnerable plaque detection by 3.0 tesla magnetic resonance imagingRicardo C Cury
Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Invest Radiol 41:112-5. 2006..5 T. Further studies validating contrast mechanisms of plaque at 3.0 T are required, but atherosclerotic plaque imaging has clear benefit from application at the higher magnetic field strength...
Safe induction of diabetes by high-dose streptozotocin in pigsHidetaka Hara
Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Pancreas 36:31-8. 2008..As a result, pancreatectomy has been advocated in this species. We have investigated the effects of 2 dosages of STZ to safely induce diabetes in pigs...
