GOKHAN HOTAMISLIGIL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    G S Hotamisligil
    Department of Nutrition, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 46:451-5. 1997
  2. ncbi Endoplasmic reticulum stress and atherosclerosis
    Gokhan S Hotamisligil
    Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 16:396-9. 2010
  3. ncbi Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:900-17. 2010
  4. ncbi Inflammation and endoplasmic reticulum stress in obesity and diabetes
    G S Hotamisligil
    Department of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA, USA
    Int J Obes (Lond) 32:S52-4. 2008
  5. ncbi Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
  6. ncbi Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
  7. ncbi Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 54:S73-8. 2005
  8. ncbi Inflammatory pathways and insulin action
    G S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Obes Relat Metab Disord 27:S53-5. 2003
  9. ncbi GATA transcription factors and fat cell formation
    Qiang Tong
    Department of Pediatrics, ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
    Drug News Perspect 16:585-8. 2003
  10. ncbi The irresistible biology of resistin
    Gokhan S Hotamisligil
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 111:173-4. 2003

Research Grants

  1. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
  2. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  3. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  4. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  5. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
  6. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
  7. Inflammatory and stress signaling networks in metabolic disease
    Gokhan S Hotamisligil; Fiscal Year: 2010
  8. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
  9. LEPTIN, CYTOKINES AND INSULIN RESISTANCE
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
  10. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003

Detail Information

Publications16

  1. ncbi Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    G S Hotamisligil
    Department of Nutrition, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 46:451-5. 1997
    ..56, P < 0.001). These results suggest that TNFR2 might play a role in human obesity by modulating the actions of TNF-alpha...
  2. ncbi Endoplasmic reticulum stress and atherosclerosis
    Gokhan S Hotamisligil
    Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 16:396-9. 2010
    ..Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications...
  3. ncbi Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:900-17. 2010
    ..The ER and related signaling networks are emerging as a potential site for the intersection of inflammation and metabolic disease...
  4. ncbi Inflammation and endoplasmic reticulum stress in obesity and diabetes
    G S Hotamisligil
    Department of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA, USA
    Int J Obes (Lond) 32:S52-4. 2008
    ..Hence, ER stress and the related signaling networks present a critical mechanism underlying obesity-induced JNK activity, inflammatory response and insulin resistance...
  5. ncbi Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
    ....
  6. ncbi Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
    ..Collectively, these diseases constitute the greatest current threat to global human health and welfare...
  7. ncbi Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 54:S73-8. 2005
    ....
  8. ncbi Inflammatory pathways and insulin action
    G S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Obes Relat Metab Disord 27:S53-5. 2003
    ..Here, the role of the JNK pathway in insulin receptor signaling, the impact of blocking this pathway in obesity and the mechanisms underlying JNK-induced insulin resistance will be discussed...
  9. ncbi GATA transcription factors and fat cell formation
    Qiang Tong
    Department of Pediatrics, ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
    Drug News Perspect 16:585-8. 2003
    ..Whether GATA factors are also involved in the commitment of multipotent mesenchymal stem cells to progenitors of the adipogenic lineage is under investigation...
  10. ncbi The irresistible biology of resistin
    Gokhan S Hotamisligil
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 111:173-4. 2003
  11. ncbi Molecular mechanisms of insulin resistance and the role of the adipocyte
    G S Hotamisligil
    School of Public Health, Harvard University, Boston, Massachusetts 02115, USA
    Int J Obes Relat Metab Disord 24:S23-7. 2000
    ..Hence, abnormal TNFalpha action in adipocytes disturbs many aspects of metabolic homeostasis in obesity...
  12. ncbi Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  13. ncbi Association between dietary factors and plasma adiponectin concentrations in men
    Tobias Pischon
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 81:780-6. 2005
    ..However, little is known about dietary predictors of plasma adiponectin concentrations in humans...
  14. ncbi trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Dariush Mozaffarian
    Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 97:854-61. 2013
    ..Emerging evidence suggests that trans-palmitoleate (trans 16:1n-7), a fatty acid in dairy and also partially hydrogenated oils, may be associated with a more favorable metabolic profile and less incident diabetes...
  15. ncbi Inflammatory mechanisms in obesity
    Margaret F Gregor
    Departments of Genetics and Complex Diseases and Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 29:415-45. 2011
    ..Finally, we examine anti-inflammatory therapies for their potential in the treatment of obesity-related insulin resistance and glucose intolerance...
  16. ncbi Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...

Research Grants29

  1. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
    ..These experiments will allow us to study the role of TNF signaling through each TNF receptor in adipose tissue during the development of insulin resistance in vivo. ..
  2. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..We will examine the role of STAMP2 in adipose tissue inflammation and systemic insulin action and explore its mechanisms of regulation and action in adipose tissue. ..
  3. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..The proposed studies will provide important insights regarding the mechanisms by which FABPs integrate inflammatory and metabolic pathways regulate systemic energy homeostasis. ..
  4. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..abstract_text> ..
  5. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
    ..We will examine the role of STAMP2 in adipose tissue inflammation and systemic insulin action and explore its mechanisms of regulation and action in adipose tissue. ..
  6. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ....
  7. Inflammatory and stress signaling networks in metabolic disease
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ..Most importantly, the mechanism that we plan to study is a reversible mechanism and hence could be the basis of future therapeutic approaches. ..
  8. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
    ....
  9. LEPTIN, CYTOKINES AND INSULIN RESISTANCE
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ..The metabolic state of these animals will be characterized in detail and the role of TNF in regulating insulin action and leptin biology in vivo will be assessed in this model. ..
  10. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  11. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ....