GOKHAN HOTAMISLIGIL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Aberrant islet unfolded protein response in type 2 diabetes
    Feyza Engin
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115
    Sci Rep 4:4054. 2014
  2. pmc Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    Ebru Erbay
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 15:1383-91. 2009
  3. pmc A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    SARA N VALLERIE
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3151. 2008
  4. pmc Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 473:528-31. 2011
  5. pmc Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 8:e1002902. 2012
  6. pmc Endoplasmic reticulum stress and atherosclerosis
    Gokhan S Hotamisligil
    Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 16:396-9. 2010
  7. pmc Inflammation and endoplasmic reticulum stress in obesity and diabetes
    G S Hotamisligil
    Department of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA, USA
    Int J Obes (Lond) 32:S52-4. 2008
  8. pmc Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
  9. pmc Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:900-17. 2010
  10. ncbi request reprint Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    G S Hotamisligil
    Department of Nutrition, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 46:451-5. 1997

Research Grants

  1. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
  2. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2006
  3. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  4. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  5. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
  6. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
  7. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
  8. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
  9. Inflammatory and stress signaling networks in metabolic disease
    Gokhan S Hotamisligil; Fiscal Year: 2010
  10. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2006

Collaborators

Detail Information

Publications22

  1. pmc Aberrant islet unfolded protein response in type 2 diabetes
    Feyza Engin
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115
    Sci Rep 4:4054. 2014
    ..These data suggest alterations in the expression of UPR mediators may contribute to the decline in islet function in type 2 diabetes in mice and humans. ..
  2. pmc Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    Ebru Erbay
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 15:1383-91. 2009
    ....
  3. pmc A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    SARA N VALLERIE
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3151. 2008
    ..These data indicate that while the JNK1 activity in BMDE is involved in metabolic regulation and adipose milieu, it is epistatic to JNK1 activity in the parenchymal tissue for regulation of metabolic homeostasis...
  4. pmc Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 473:528-31. 2011
    ..Hence, we established that abnormal lipid and calcium metabolism are important contributors to hepatic ER stress in obesity...
  5. pmc Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 8:e1002902. 2012
    ..Together, our work defines dynamic regulation of the liver translatome by obesity and nutrient availability, and it identifies a novel role for bile acid metabolism in the pathogenesis of metabolic abnormalities associated with obesity...
  6. pmc Endoplasmic reticulum stress and atherosclerosis
    Gokhan S Hotamisligil
    Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 16:396-9. 2010
    ..Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications...
  7. pmc Inflammation and endoplasmic reticulum stress in obesity and diabetes
    G S Hotamisligil
    Department of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA, USA
    Int J Obes (Lond) 32:S52-4. 2008
    ..Hence, ER stress and the related signaling networks present a critical mechanism underlying obesity-induced JNK activity, inflammatory response and insulin resistance...
  8. pmc Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
    ....
  9. pmc Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:900-17. 2010
    ..The ER and related signaling networks are emerging as a potential site for the intersection of inflammation and metabolic disease...
  10. ncbi request reprint Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    G S Hotamisligil
    Department of Nutrition, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 46:451-5. 1997
    ..56, P < 0.001). These results suggest that TNFR2 might play a role in human obesity by modulating the actions of TNF-alpha...
  11. pmc The irresistible biology of resistin
    Gokhan S Hotamisligil
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 111:173-4. 2003
  12. ncbi request reprint GATA transcription factors and fat cell formation
    Qiang Tong
    Department of Pediatrics, ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
    Drug News Perspect 16:585-8. 2003
    ..Whether GATA factors are also involved in the commitment of multipotent mesenchymal stem cells to progenitors of the adipogenic lineage is under investigation...
  13. ncbi request reprint Molecular mechanisms of insulin resistance and the role of the adipocyte
    G S Hotamisligil
    School of Public Health, Harvard University, Boston, Massachusetts 02115, USA
    Int J Obes Relat Metab Disord 24:S23-7. 2000
    ..Hence, abnormal TNFalpha action in adipocytes disturbs many aspects of metabolic homeostasis in obesity...
  14. ncbi request reprint Inflammatory pathways and insulin action
    G S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Obes Relat Metab Disord 27:S53-5. 2003
    ..Here, the role of the JNK pathway in insulin receptor signaling, the impact of blocking this pathway in obesity and the mechanisms underlying JNK-induced insulin resistance will be discussed...
  15. ncbi request reprint Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 54:S73-8. 2005
    ....
  16. ncbi request reprint Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
    ..Collectively, these diseases constitute the greatest current threat to global human health and welfare...
  17. ncbi request reprint Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  18. ncbi request reprint Association between dietary factors and plasma adiponectin concentrations in men
    Tobias Pischon
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 81:780-6. 2005
    ..However, little is known about dietary predictors of plasma adiponectin concentrations in humans...
  19. pmc trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Dariush Mozaffarian
    Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 97:854-61. 2013
    ..Emerging evidence suggests that trans-palmitoleate (trans 16:1n-7), a fatty acid in dairy and also partially hydrogenated oils, may be associated with a more favorable metabolic profile and less incident diabetes...
  20. doi request reprint Inflammatory mechanisms in obesity
    Margaret F Gregor
    Departments of Genetics and Complex Diseases and Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 29:415-45. 2011
    ..Finally, we examine anti-inflammatory therapies for their potential in the treatment of obesity-related insulin resistance and glucose intolerance...
  21. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...

Research Grants29

  1. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
    ..These experiments will allow us to study the role of TNF signaling through each TNF receptor in adipose tissue during the development of insulin resistance in vivo. ..
  2. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2006
    ..We will examine the role of STAMP2 in adipose tissue inflammation and systemic insulin action and explore its mechanisms of regulation and action in adipose tissue. ..
  3. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..We will examine the role of STAMP2 in adipose tissue inflammation and systemic insulin action and explore its mechanisms of regulation and action in adipose tissue. ..
  4. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..The proposed studies will provide important insights regarding the mechanisms by which FABPs integrate inflammatory and metabolic pathways regulate systemic energy homeostasis. ..
  5. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2007
    ..abstract_text> ..
  6. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
    ....
  7. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2009
    ..We will examine the role of STAMP2 in adipose tissue inflammation and systemic insulin action and explore its mechanisms of regulation and action in adipose tissue. ..
  8. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ....
  9. Inflammatory and stress signaling networks in metabolic disease
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ..Most importantly, the mechanism that we plan to study is a reversible mechanism and hence could be the basis of future therapeutic approaches. ..
  10. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2006
    ..The proposed studies will provide important insights regarding the mechanisms by which FABPs integrate inflammatory and metabolic pathways regulate systemic energy homeostasis. ..
  11. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
    ..The proposed studies will provide important insights regarding the mechanisms by which FABPs integrate inflammatory and metabolic pathways regulate systemic energy homeostasis. ..
  12. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
    ....
  13. LEPTIN, CYTOKINES AND INSULIN RESISTANCE
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
    ..The metabolic state of these animals will be characterized in detail and the role of TNF in regulating insulin action and leptin biology in vivo will be assessed in this model. ..
  14. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2000
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  15. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ....
  16. LEPTIN, CYTOKINES AND INSULIN RESISTANCE
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ..The metabolic state of these animals will be characterized in detail and the role of TNF in regulating insulin action and leptin biology in vivo will be assessed in this model. ..
  17. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  18. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2002
    ....
  19. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2002
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  20. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  21. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ....
  22. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2004
    ....
  23. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ....
  24. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2004
    ..The proposed studies will provide important insights regarding the mechanisms by which FABPs integrate inflammatory and metabolic pathways regulate systemic energy homeostasis. ..
  25. Lipids, Inflammation and Insulin Action
    Gokhan S Hotamisligil; Fiscal Year: 2010
    ....