E S Horton

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database
    Edward S Horton
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:1759-65. 2010
  2. doi request reprint Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trials
    Edward S Horton
    Joslin Diabetes Center, Section on Clinical Research, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:S43-8. 2009
  3. doi request reprint Defining the role of basal and prandial insulin for optimal glycemic control
    Edward S Horton
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 53:S21-7. 2009
  4. doi request reprint Multidisciplinary interventions: mapping new horizons in diabetes care
    Edward Horton
    Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Educ 34:78S-89S. 2008
  5. ncbi request reprint Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes
    E S Horton
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes Care 23:1660-5. 2000
  6. ncbi request reprint Glucose ingestion causes GLUT4 translocation in human skeletal muscle
    L J Goodyear
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 45:1051-6. 1996
  7. ncbi request reprint Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients
    A Veves
    Department of Medicine, Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes 46:1846-52. 1997
  8. ncbi request reprint CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats
    C J De Souza
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 46:1257-63. 1997
  9. ncbi request reprint Diet and exercise in type 2 diabetes mellitus
    O Hamdy
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 30:883-907. 2001
  10. ncbi request reprint Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy
    O Hamdy
    Clinical Research Center, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:344-9. 2001

Research Grants

  1. Post-DPP Follow-Up Study
    Edward Horton; Fiscal Year: 2007

Detail Information

Publications37

  1. pmc Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database
    Edward S Horton
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:1759-65. 2010
    ....
  2. doi request reprint Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trials
    Edward S Horton
    Joslin Diabetes Center, Section on Clinical Research, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:S43-8. 2009
    ..However, the effectiveness of lifestyle interventions for reductions in CVD events has yet to be determined...
  3. doi request reprint Defining the role of basal and prandial insulin for optimal glycemic control
    Edward S Horton
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 53:S21-7. 2009
    ..Alternatively, the use of pre-mixed insulin preparations, combining both long-acting and short-acting insulins, may be used...
  4. doi request reprint Multidisciplinary interventions: mapping new horizons in diabetes care
    Edward Horton
    Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Educ 34:78S-89S. 2008
    ....
  5. ncbi request reprint Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes
    E S Horton
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes Care 23:1660-5. 2000
    ....
  6. ncbi request reprint Glucose ingestion causes GLUT4 translocation in human skeletal muscle
    L J Goodyear
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 45:1051-6. 1996
    ..These findings suggest that under physiological conditions the translocation of GLUT4 is an important mechanism for the stimulation of glucose uptake in human skeletal muscle...
  7. ncbi request reprint Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients
    A Veves
    Department of Medicine, Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes 46:1846-52. 1997
    ..In addition, regular exercise training involving the lower extremities does not improve the endothelial function in the micro- and macrocirculation of the nonexercised upper extremity in type 1 diabetic patients...
  8. ncbi request reprint CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats
    C J De Souza
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 46:1257-63. 1997
    ..A particularly interesting observation was that the tissues responsible for this effect were white and brown adipose tissue, while skeletal muscle remained unaffected...
  9. ncbi request reprint Diet and exercise in type 2 diabetes mellitus
    O Hamdy
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 30:883-907. 2001
    ..Exercise programs should be designed to start slowly, build up gradually, and emphasize moderately intense exercise performed at least three times a week and preferably five to seven times a week for best results...
  10. ncbi request reprint Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy
    O Hamdy
    Clinical Research Center, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:344-9. 2001
    ..Acetylcholine and sodium nitroprusside cause vasodilation in the skin microcirculation through different pathways...
  11. ncbi request reprint Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscle
    R Napoli
    Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 47:1549-54. 1998
    ..Insulin and epinephrine have different effects on MAP kinase signaling pathways in skeletal muscle, which may be one of the underlying molecular mechanisms through which these hormones regulate opposing metabolic functions...
  12. ncbi request reprint The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients
    Panayiotis A Economides
    Microcirculation Laboratory, Palmer 317, BIDMC West, 1 Deaconess Rd, Boston, MA 02215, USA
    Diabetes 54:204-11. 2005
    ..Because vitamin E-treated patients had a worsening in some vascular reactivity measurements when compared with control subjects, the use of high dosages of vitamin E cannot be recommended...
  13. ncbi request reprint Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function
    Marie S O'Neill
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 111:2913-20. 2005
    ..We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes...
  14. ncbi request reprint Troglitazone-induced changes in adiponectin do not affect endothelial function in diabetes
    Jon Buras
    Microcirculation Laboratory, Palmer 317, West Campus, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Obes Res 13:1167-74. 2005
    ..We have examined the relationship between the increase in adiponectin levels that is associated with troglitazone treatment and endothelium-dependent vasodilation in type 2 diabetic patients...
  15. pmc Physical activity in individuals at risk for diabetes: Diabetes Prevention Program
    Andrea M Kriska
    Diabetes Prevention Program Research Group, George Washington University, Rockville, MD 20852, USA
    Med Sci Sports Exerc 38:826-32. 2006
    ..This provided the opportunity to examine the relationship between the three activity measures and to compare activity levels of the DPP sample with that of a national sample with IGT...
  16. pmc Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    Xavier Pi-Sunyer
    St Luke s Roosevelt Hospital Center, USA
    Diabetes Care 30:1374-83. 2007
    ..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
  17. ncbi request reprint Progress in the treatment of type 2 diabetes: new pharmacologic approaches to improve glycemic control
    Allison Cohen
    Joslin Diabetes Center, Boston, MA 02215, USA
    Curr Med Res Opin 23:905-17. 2007
    ....
  18. pmc Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program
    William H Herman
    Department of Internal Medicine and Epidemiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Diabetes Care 30:2453-7. 2007
    ..We sought to examine racial and ethnic differences in A1C in individuals with impaired glucose tolerance (IGT)...
  19. ncbi request reprint Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance
    A Enrique Caballero
    Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 31:576-82. 2008
    ....
  20. pmc The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice
    Gabriela Orasanu
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 52:869-81. 2008
    ..Our aim was to investigate if the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone modulates inflammation through PPARalpha mechanisms...
  21. pmc Achieving weight and activity goals among diabetes prevention program lifestyle participants
    Rena R Wing
    Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Obes Res 12:1426-34. 2004
    ..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
  22. ncbi request reprint Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes
    Greeshma K Shetty
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Care 27:2450-7. 2004
    ....
  23. ncbi request reprint The effect of aspirin and various iontophoresis solution vehicles on skin microvascular reactivity
    Karim Abou-Elenin
    Clinical Research Center, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Microvasc Res 63:91-5. 2002
    ..In addition, a NaCl solution would be preferable to deionized water as the iontophoresis solution vehicle...
  24. ncbi request reprint Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity
    Csaba Szabo
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Circulation 106:2680-6. 2002
    ....
  25. ncbi request reprint The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial
    A Enrique Caballero
    Joslin Diabetes Center, Microcirculation Laboratory, Division of Vascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 52:173-80. 2003
    ..This improvement was strongly associated with the improvement of fasting plasma insulin concentrations...
  26. ncbi request reprint Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome
    Osama Hamdy
    Clinical Research Center, Joslin Diabetes Center, The Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 26:2119-25. 2003
    ..We also measured plasma levels of soluble intercellular adhesion molecule (sICAM), vascular adhesion molecule, von Willebrand factor, plasminogen activator inhibitor-1 (PAI-1) antigen, and tissue plasminogen activator antigen...
  27. ncbi request reprint Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance
    Lais U Monzillo
    Clinical Research Center, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Obes Res 11:1048-54. 2003
    ..To study the effect of weight loss in response to a lifestyle modification program on the circulating levels of adipose tissue derived cytokines (adipokines) in obese individuals with insulin resistance...
  28. ncbi request reprint Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003
    Richard W Nesto
    Circulation 108:2941-8. 2003
  29. ncbi request reprint The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetes
    Panayiotis A Economides
    Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:740-7. 2004
    ..27 ng/ml (7-41 ng/ml) at baseline; P < 0.05] were observed. We conclude that atorvastatin improves endothelial function and decreases levels of markers of endothelial activation and inflammation...
  30. ncbi request reprint Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetes
    Panayiotis A Economides
    Joslin Diabetes Center, Boston, MA, USA
    Metabolism 53:222-7. 2004
    ..Water diuresis failed to produce an improvement in renal medullary oxygenation in both patients with diabetes and subjects at risk for diabetes...
  31. ncbi request reprint Efficacy and tolerability of initial combination therapy with nateglinide and metformin in treatment-naïve patients with type 2 diabetes
    Edward S Horton
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Curr Med Res Opin 20:883-9. 2004
    ..2%, and 10.2 mmol/L, respectively...
  32. ncbi request reprint Exercise in the management of type 1 diabetes mellitus
    Jeanne H Steppel
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Rev Endocr Metab Disord 4:355-60. 2003
  33. ncbi request reprint Cardiovascular risk assessment in type 2 diabetes mellitus
    Ebaa Al-Ozairi
    Curr Diab Rep 6:333-6. 2006
  34. ncbi request reprint Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association
    Richard W Nesto
    American Diabetes Association
    Diabetes Care 27:256-63. 2004
  35. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  36. ncbi request reprint Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats
    Margherita Matarazzo
    Department of Internal Medicine and Cardiovascular Sciences, University of Federico II School of Medicine, Napoli, Italy
    Cell Transplant 11:103-12. 2002
    ..In conclusion, islet transplantation under the kidney capsule corrects the diabetes-induced abnormalities in glycogen and glucose-6-phosphate content and glycogen synthase activity in both liver and skeletal muscle...
  37. ncbi request reprint Beta-cell failure in the pathogenesis of type 2 diabetes mellitus
    Jeanne H Steppel
    Joslin Diabetes Center, One Joslin Place, Room 346, Boston, MA 02215, USA
    Curr Diab Rep 4:169-75. 2004
    ..In the past 15 years, clinical trials have given hope for potential therapies that may either delay or prevent the progression to diabetes. Lifestyle modification and pharmaceutical treatment remain the most promising interventions...

Research Grants2

  1. Post-DPP Follow-Up Study
    Edward Horton; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..