E S Horton
Affiliation: Harvard University
- Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort databaseEdward S Horton
Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes Care 33:1759-65. 2010....
- Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trialsEdward S Horton
Joslin Diabetes Center, Section on Clinical Research, Boston, Massachusetts, USA
Obesity (Silver Spring) 17:S43-8. 2009..However, the effectiveness of lifestyle interventions for reductions in CVD events has yet to be determined...
- Defining the role of basal and prandial insulin for optimal glycemic controlEdward S Horton
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Coll Cardiol 53:S21-7. 2009..Alternatively, the use of pre-mixed insulin preparations, combining both long-acting and short-acting insulins, may be used...
- Multidisciplinary interventions: mapping new horizons in diabetes careEdward Horton
Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Diabetes Educ 34:78S-89S. 2008....
- Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetesE S Horton
Joslin Diabetes Center, Boston, Massachusetts 02215, USA
Diabetes Care 23:1660-5. 2000....
- Glucose ingestion causes GLUT4 translocation in human skeletal muscleL J Goodyear
Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
Diabetes 45:1051-6. 1996..These findings suggest that under physiological conditions the translocation of GLUT4 is an important mechanism for the stimulation of glucose uptake in human skeletal muscle...
- Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patientsA Veves
Department of Medicine, Deaconess Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Diabetes 46:1846-52. 1997..In addition, regular exercise training involving the lower extremities does not improve the endothelial function in the micro- and macrocirculation of the nonexercised upper extremity in type 1 diabetic patients...
- CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese ratsC J De Souza
Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes 46:1257-63. 1997..A particularly interesting observation was that the tissues responsible for this effect were white and brown adipose tissue, while skeletal muscle remained unaffected...
- Diet and exercise in type 2 diabetes mellitusO Hamdy
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
Endocrinol Metab Clin North Am 30:883-907. 2001..Exercise programs should be designed to start slowly, build up gradually, and emphasize moderately intense exercise performed at least three times a week and preferably five to seven times a week for best results...
- Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathyO Hamdy
Clinical Research Center, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Care 24:344-9. 2001..Acetylcholine and sodium nitroprusside cause vasodilation in the skin microcirculation through different pathways...
- Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscleR Napoli
Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 47:1549-54. 1998..Insulin and epinephrine have different effects on MAP kinase signaling pathways in skeletal muscle, which may be one of the underlying molecular mechanisms through which these hormones regulate opposing metabolic functions...
- The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patientsPanayiotis A Economides
Microcirculation Laboratory, Palmer 317, BIDMC/West, 1 Deaconess Rd, Boston, MA 02215, USA
Diabetes 54:204-11. 2005..Because vitamin E-treated patients had a worsening in some vascular reactivity measurements when compared with control subjects, the use of high dosages of vitamin E cannot be recommended...
- Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial functionMarie S O'Neill
Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
Circulation 111:2913-20. 2005..We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes...
- Troglitazone-induced changes in adiponectin do not affect endothelial function in diabetesJon Buras
Microcirculation Laboratory, Palmer 317, West Campus, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
Obes Res 13:1167-74. 2005..In addition, receptor for advanced glycation end-products expression in the skin microcirculation is not affected by troglitazone treatment...
- Physical activity in individuals at risk for diabetes: Diabetes Prevention ProgramAndrea M Kriska
Diabetes Prevention Program Research Group, George Washington University, Rockville, MD 20852, USA
Med Sci Sports Exerc 38:826-32. 2006..This provided the opportunity to examine the relationship between the three activity measures and to compare activity levels of the DPP sample with that of a national sample with IGT...
- Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trialXavier Pi-Sunyer
St Luke s Roosevelt Hospital Center, USA
Diabetes Care 30:1374-83. 2007..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
- Progress in the treatment of type 2 diabetes: new pharmacologic approaches to improve glycemic controlAllison Cohen
Joslin Diabetes Center, Boston, MA 02215, USA
Curr Med Res Opin 23:905-17. 2007....
- Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention ProgramWilliam H Herman
Department of Internal Medicine and Epidemiology, University of Michigan Health System, Ann Arbor, Michigan, USA
Diabetes Care 30:2453-7. 2007..We sought to examine racial and ethnic differences in A1C in individuals with impaired glucose tolerance (IGT)...
- Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistanceA Enrique Caballero
Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Care 31:576-82. 2008....
- The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in miceGabriela Orasanu
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 52:869-81. 2008..Our aim was to investigate if the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone modulates inflammation through PPARalpha mechanisms...
- Achieving weight and activity goals among diabetes prevention program lifestyle participantsRena R Wing
Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Obes Res 12:1426-34. 2004..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
- Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetesGreeshma K Shetty
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Diabetes Care 27:2450-7. 2004..Lipid profile and inflammatory marker changes produced by atorvastatin cannot be attributed to changes of either adiponectin or resistin...
- The effect of aspirin and various iontophoresis solution vehicles on skin microvascular reactivityKarim Abou-Elenin
Clinical Research Center, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Microvasc Res 63:91-5. 2002..In addition, a NaCl solution would be preferable to deionized water as the iontophoresis solution vehicle...
- Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivityCsaba Szabo
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
Circulation 106:2680-6. 2002....
- The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trialA Enrique Caballero
Joslin Diabetes Center, Microcirculation Laboratory, Division of Vascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Metabolism 52:173-80. 2003..This improvement was strongly associated with the improvement of fasting plasma insulin concentrations...
- Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndromeOsama Hamdy
Clinical Research Center, Joslin Diabetes Center, The Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Care 26:2119-25. 2003..We also measured plasma levels of soluble intercellular adhesion molecule (sICAM), vascular adhesion molecule, von Willebrand factor, plasminogen activator inhibitor-1 (PAI-1) antigen, and tissue plasminogen activator antigen...
- Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistanceLais U Monzillo
Clinical Research Center, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Obes Res 11:1048-54. 2003..Further studies are needed to elucidate the relationship between changes of adipokines and the health benefits of weight loss...
- Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003Richard W Nesto
Circulation 108:2941-8. 2003
- The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetesPanayiotis A Economides
Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
J Clin Endocrinol Metab 89:740-7. 2004..27 ng/ml (7-41 ng/ml) at baseline; P < 0.05] were observed. We conclude that atorvastatin improves endothelial function and decreases levels of markers of endothelial activation and inflammation...
- Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetesPanayiotis A Economides
Joslin Diabetes Center, Boston, MA, USA
Metabolism 53:222-7. 2004..Water diuresis failed to produce an improvement in renal medullary oxygenation in both patients with diabetes and subjects at risk for diabetes...
- Efficacy and tolerability of initial combination therapy with nateglinide and metformin in treatment-naÃ¯ve patients with type 2 diabetesEdward S Horton
Joslin Diabetes Center, Boston, Massachusetts, USA
Curr Med Res Opin 20:883-9. 2004....
- Exercise in the management of type 1 diabetes mellitusJeanne H Steppel
Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Rev Endocr Metab Disord 4:355-60. 2003
- Cardiovascular risk assessment in type 2 diabetes mellitusEbaa Al-Ozairi
Curr Diab Rep 6:333-6. 2006
- Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes AssociationRichard W Nesto
American Diabetes Association
Diabetes Care 27:256-63. 2004
- Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008....
- Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic ratsMargherita Matarazzo
Department of Internal Medicine and Cardiovascular Sciences, University of Federico II School of Medicine, Napoli, Italy
Cell Transplant 11:103-12. 2002..In conclusion, islet transplantation under the kidney capsule corrects the diabetes-induced abnormalities in glycogen and glucose-6-phosphate content and glycogen synthase activity in both liver and skeletal muscle...
- Beta-cell failure in the pathogenesis of type 2 diabetes mellitusJeanne H Steppel
Joslin Diabetes Center, One Joslin Place, Room 346, Boston, MA 02215, USA
Curr Diab Rep 4:169-75. 2004..In the past 15 years, clinical trials have given hope for potential therapies that may either delay or prevent the progression to diabetes. Lifestyle modification and pharmaceutical treatment remain the most promising interventions...
- Post-DPP Follow-Up StudyEdward Horton; Fiscal Year: 2007..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..