David Horst

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Eur J Cancer 45:2034-40. 2009
  2. pmc Southeast Asian diversity: first insights into the complex mtDNA structure of Laos
    Martin Bodner
    Institute of Legal Medicine, Innsbruck Medical University, Austria
    BMC Evol Biol 11:49. 2011
  3. doi request reprint Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Munich, Germany
    Cancer 115:4946-58. 2009
  4. doi request reprint A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
  5. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
  6. doi request reprint Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
  7. pmc Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer
    Lydia Kriegl
    Institute of Pathology, University of Munich, Munich, Germany
    PLoS ONE 7:e51654. 2012
  8. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
  9. doi request reprint The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors
    Tobias Vogler
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Straße 36, D 80337 München, Germany
    Exp Mol Pathol 92:111-7. 2012
  10. doi request reprint Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer
    Abdelhamid Beji
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Munich, Germany
    Clin Cancer Res 18:956-68. 2012

Collaborators

  • Lydia Kriegl
  • Jutta Engel
  • Jens Neumann
  • Heiko Hermeking
  • Markus F Neurath
  • Rupert Langer
  • Alexander Meining
  • Jan Budczies
  • Enrico N De Toni
  • Thomas Brabletz
  • Frank Thomas Kolligs
  • Falk Hlubek
  • Florian R Greten
  • Thomas Kirchner
  • Steffen Ormanns
  • Sarah Schwitalla
  • Helge Siemens
  • Andreas Jung
  • Abdelhamid Beji
  • Tobias Vogler
  • Martin Bodner
  • Marlon R Schneider
  • Jutta M Nagel
  • Jutta Maria Nagel
  • Burkhard Goke
  • Christos S Mantzoros
  • Valentin Becker
  • Olivia Prazeres da Costa
  • Irina Kerle
  • Rene Jackstadt
  • Ulrich Mansmann
  • Julia Slotta-Huspenina
  • Andre Lechel
  • Yvonne Begus-Nahrmann
  • K Lenhard Rudolph
  • Paul K Ziegler
  • Franz G Bader
  • Sabine Sagebiel
  • Achim J Schäffauer
  • Axel Ullrich
  • Tanja Krämer
  • Anita Kloss-Brandstätter
  • Torpong Sanguansermsri
  • Jurgen Horst
  • Bettina Zimmermann
  • Basil Horst
  • Alexander Röck
  • Walther Parson
  • Sourideth Sengchanh
  • Peter M Schneider
  • Konrad Trulzsch
  • Maik Dahlhoff
  • Ingrid Renner-Müller
  • Andreas Hoeflich
  • Michael Vogeser
  • Jürgen Staffa
  • Eckhard Wolf
  • Michael Allgäuer
  • Markus Gerhard
  • Benjamin Hirschi
  • Josef Müller-Höcker
  • Roger Vogelmann
  • Markus Langkamp
  • Shiva Gautam
  • Sylvia Steininger

Detail Information

Publications17

  1. ncbi request reprint CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Eur J Cancer 45:2034-40. 2009
    ....
  2. pmc Southeast Asian diversity: first insights into the complex mtDNA structure of Laos
    Martin Bodner
    Institute of Legal Medicine, Innsbruck Medical University, Austria
    BMC Evol Biol 11:49. 2011
    ..In order to describe the mtDNA setup of Laos more thoroughly, the data were subjected to population genetic comparisons with 16 East Asian groups...
  3. doi request reprint Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Munich, Germany
    Cancer 115:4946-58. 2009
    ....
  4. doi request reprint A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
    ..The aim of this study was to develop a simple and robust test for risk assessment of distant metastases in CC...
  5. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
    ..Thus, we conclude that CD133 expression is a marker with high prognostic impact for colon cancer, while it seems to have no obvious functional role as a driving force of this malignancy...
  6. doi request reprint Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
    ..Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer...
  7. pmc Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer
    Lydia Kriegl
    Institute of Pathology, University of Munich, Munich, Germany
    PLoS ONE 7:e51654. 2012
    ....
  8. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
    ....
  9. doi request reprint The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors
    Tobias Vogler
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Straße 36, D 80337 München, Germany
    Exp Mol Pathol 92:111-7. 2012
    ..As CSCs were shown to be the driving force of tumor progression and metastases we suspected that the expression of ALDH1 correlated with the prognostic 5 year survival of colorectal cancer...
  10. doi request reprint Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer
    Abdelhamid Beji
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Munich, Germany
    Clin Cancer Res 18:956-68. 2012
    ..We have previously shown that in melanoma HER3 is frequently overexpressed and is associated with poor prognosis. However, the importance of HER3 in colon cancer and its putative prognostic significance is still unknown...
  11. pmc LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Thalkirchnerstr, 36, 80337, Munich, Germany
    J Transl Med 8:123. 2010
    ..In this study we investigated the expression of β-Catenin, LEF1 and TCF4 in colorectal carcinomas and their prognostic significance...
  12. doi request reprint The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität, Munich, Germany
    Cancer 115:2063-70. 2009
    ..Herein, the authors investigated whether the intratumoral distribution of nuclear beta-catenin can serve as a prognostic marker for survival and tumor progression of stage IIA colon cancer patients...
  13. doi request reprint γ-Catenin is an independent prognostic marker in early stage colorectal cancer
    Jutta Maria Nagel
    Department of Medicine II, University of Munich, Marchioninistrasse 15, Munich, Germany
    Int J Colorectal Dis 25:1301-9. 2010
    ..Expression and role of γ-catenin in colorectal carcinogenesis is not well understood. We aimed at characterizing γ-catenin's expression pattern during colorectal carcinogenesis...
  14. doi request reprint Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice
    Jutta M Nagel
    Department of Medicine II, Klinikum Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
    Horm Cancer 1:320-30. 2010
    ..001). Chronic insulin treatment results in higher colonic epithelial proliferation and ACF formation, but the use of insulin glargine vs. NPH insulin is not associated with increased risk...
  15. ncbi request reprint WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling
    Steffen Ormanns
    Institute of Pathology, Ludwig Maximilians Universitat, Munich, Germany
    Oncotarget 5:2999-3011. 2014
    ..Thus, the detection of high nuclear β-Catenin expression and simultaneous PI3K pathway activation identifies colon cancer patients with a high risk for distant metastasis. ..
  16. doi request reprint Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 23:93-106. 2013
    ..Thus, we propose a p53-controlled tumor-suppressive function that is independent of its well-established role in cell-cycle regulation, apoptosis, and senescence...
  17. pmc A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation
    Marlon R Schneider
    Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, University of Munich, Munich, Germany
    PLoS ONE 5:e14325. 2010
    ..Down-regulation of E-cadherin is associated with the pathogenesis of infections with enteropathogenic bacteria and Crohn's disease...