Research Topics
Genomes and Genes | David HorstSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancerDavid Horst
Pathologisches Institut der Ludwig Maximilians Universität München, Germany
Eur J Cancer 45:2034-40. 2009....
Southeast Asian diversity: first insights into the complex mtDNA structure of LaosMartin Bodner
Institute of Legal Medicine, Innsbruck Medical University, Austria
BMC Evol Biol 11:49. 2011..In order to describe the mtDNA setup of Laos more thoroughly, the data were subjected to population genetic comparisons with 16 East Asian groups...- Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancerDavid Horst
Pathologisches Institut der Ludwig Maximilians Universität München, Munich, Germany
Cancer 115:4946-58. 2009.... - A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancerJens Neumann
Pathologisches Institut der Ludwig Maximilians Universität München, Germany
Histopathology 60:416-26. 2012..The aim of this study was to develop a simple and robust test for risk assessment of distant metastases in CC... - The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancerDavid Horst
Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
J Pathol 219:427-34. 2009..Thus, we conclude that CD133 expression is a marker with high prognostic impact for colon cancer, while it seems to have no obvious functional role as a driving force of this malignancy... - SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancerJens Neumann
Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
BMC Cancer 11:518. 2011.... - The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumorsTobias Vogler
Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Straße 36, D 80337 München, Germany
Exp Mol Pathol 92:111-7. 2012..As CSCs were shown to be the driving force of tumor progression and metastases we suspected that the expression of ALDH1 correlated with the prognostic 5 year survival of colorectal cancer... - Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancerAbdelhamid Beji
Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Munich, Germany
Clin Cancer Res 18:956-68. 2012..We have previously shown that in melanoma HER3 is frequently overexpressed and is associated with poor prognosis. However, the importance of HER3 in colon cancer and its putative prognostic significance is still unknown... - The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancerDavid Horst
Pathologisches Institut der Ludwig Maximilians Universität, Munich, Germany
Cancer 115:2063-70. 2009..Herein, the authors investigated whether the intratumoral distribution of nuclear beta-catenin can serve as a prognostic marker for survival and tumor progression of stage IIA colon cancer patients... - LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancerLydia Kriegl
Department of Pathology, Ludwig Maximilians Universität LMU, Thalkirchnerstr, 36, 80337, Munich, Germany
J Transl Med 8:123. 2010..In this study we investigated the expression of β-Catenin, LEF1 and TCF4 in colorectal carcinomas and their prognostic significance... - γ-Catenin is an independent prognostic marker in early stage colorectal cancerJutta Maria Nagel
Department of Medicine II, University of Munich, Marchioninistrasse 15, Munich, Germany
Int J Colorectal Dis 25:1301-9. 2010..Expression and role of γ-catenin in colorectal carcinogenesis is not well understood. We aimed at characterizing γ-catenin's expression pattern during colorectal carcinogenesis... - Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancerHelge Siemens
Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
Clin Cancer Res 19:710-20. 2013..Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer... - Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancerLydia Kriegl
Institute of Pathology, University of Munich, Munich, Germany
PLoS ONE 7:e51654. 2012.... - Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic miceJutta M Nagel
Department of Medicine II, Klinikum Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
Horm Cancer 1:320-30. 2010..001). Chronic insulin treatment results in higher colonic epithelial proliferation and ACF formation, but the use of insulin glargine vs. NPH insulin is not associated with increased risk... - Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumorsSarah Schwitalla
Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
Cancer Cell 23:93-106. 2013..Thus, we propose a p53-controlled tumor-suppressive function that is independent of its well-established role in cell-cycle regulation, apoptosis, and senescence... - A key role for E-cadherin in intestinal homeostasis and Paneth cell maturationMarlon R Schneider
Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, University of Munich, Munich, Germany
PLoS ONE 5:e14325. 2010..Down-regulation of E-cadherin is associated with the pathogenesis of infections with enteropathogenic bacteria and Crohn's disease...