Jacob M Hooker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
  2. ncbi Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
  3. ncbi Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
  4. ncbi Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
  5. ncbi One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
  6. ncbi Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
  7. ncbi [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
  8. ncbi Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
  9. ncbi Modular strategies for PET imaging agents
    Jacob M Hooker
    Brookhaven National Laboratory, Medical Department, Building 555, Upton, NY 11973 5000, USA
    Curr Opin Chem Biol 14:105-11. 2010
  10. ncbi A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008

Research Grants

  1. Design of Class-specific HDAC Imaging Probes for Positron Emission Tomography
    Jacob M Hooker; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
    ..However, the characterization of [(11)C]metergoline pharmacokinetics and binding in the brain and peripheral organs using PET improves our understanding of metergoline drug pharmacology...
  2. ncbi Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  3. ncbi Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  4. ncbi Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
    ..Our results suggest that protecting salvinorin A derivatives from metabolism will prolong duration of action, but only when administered by routes giving slow absorption...
  5. ncbi One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
    ..This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications...
  6. ncbi Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
    ....
  7. ncbi [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
    ..A preliminary muPET-experiment demonstrates the reversible, highly specific binding of [(11)C]PR04.MZ in the brain of a male Sprague-Dawley rat...
  8. ncbi Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
    ....
  9. ncbi Modular strategies for PET imaging agents
    Jacob M Hooker
    Brookhaven National Laboratory, Medical Department, Building 555, Upton, NY 11973 5000, USA
    Curr Opin Chem Biol 14:105-11. 2010
    ....
  10. ncbi A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008
  11. ncbi Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
    ..divinorum when smoked. The effects of salvinorin A may occur at <10 mug in the human brain, emphasizing its remarkable potency...
  12. ncbi Metabolic changes in the rodent brain after acute administration of salvinorin A
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 11:137-43. 2009
    ..Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been determined...

Research Grants1

  1. Design of Class-specific HDAC Imaging Probes for Positron Emission Tomography
    Jacob M Hooker; Fiscal Year: 2010
    ..These tools will be use to accelerate epigenetic research and will ultimately be translated to human PET imaging and clinicians for diagnosing disease and monitoring treatment. ..