Jacob M Hooker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation
    Adam S Kamlet
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
    PLoS ONE 8:e59187. 2013
  2. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
  3. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
  4. pmc Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
  5. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
  6. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
  7. pmc One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
  8. doi request reprint Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
  9. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
  10. doi request reprint Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain
    Young Jun Seo
    Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA Department of Chemistry, Chonbuk National University, Jeonju 561 756, South Korea
    Bioorg Med Chem Lett 23:6700-5. 2013

Collaborators

Detail Information

Publications14

  1. pmc Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation
    Adam S Kamlet
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
    PLoS ONE 8:e59187. 2013
    ..The method, which transforms [(18)F]fluoride into an electrophilic fluorination reagent, provides access to aryl-(18)F bonds that would be challenging to synthesize via conventional radiochemistry methods...
  2. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
    ..However, the characterization of [(11)C]metergoline pharmacokinetics and binding in the brain and peripheral organs using PET improves our understanding of metergoline drug pharmacology...
  3. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  4. pmc Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
    ..Our results suggest that protecting salvinorin A derivatives from metabolism will prolong duration of action, but only when administered by routes giving slow absorption...
  5. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  6. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
    ....
  7. pmc One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
    ..This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications...
  8. doi request reprint Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
    ....
  9. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
    ..A preliminary muPET-experiment demonstrates the reversible, highly specific binding of [(11)C]PR04.MZ in the brain of a male Sprague-Dawley rat...
  10. doi request reprint Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain
    Young Jun Seo
    Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA Department of Chemistry, Chonbuk National University, Jeonju 561 756, South Korea
    Bioorg Med Chem Lett 23:6700-5. 2013
    ..Further structural refinement is needed for the development of brain-penetrant, metabolically stable HDAC radiotracers and to understand the role of fluorine substitution on brain penetration. ..
  11. pmc Modular strategies for PET imaging agents
    Jacob M Hooker
    Brookhaven National Laboratory, Medical Department, Building 555, Upton, NY 11973 5000, USA
    Curr Opin Chem Biol 14:105-11. 2010
    ....
  12. pmc A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008
  13. pmc Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
    ..divinorum when smoked. The effects of salvinorin A may occur at <10 mug in the human brain, emphasizing its remarkable potency...
  14. pmc Metabolic changes in the rodent brain after acute administration of salvinorin A
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 11:137-43. 2009
    ..Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been determined...

Research Grants1

  1. Design of Class-specific HDAC Imaging Probes for Positron Emission Tomography
    Jacob M Hooker; Fiscal Year: 2010
    ..These tools will be use to accelerate epigenetic research and will ultimately be translated to human PET imaging and clinicians for diagnosing disease and monitoring treatment. ..