L B Holmes

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Teratogen-induced limb defects
    Lewis B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet 112:297-303. 2002
  2. pmc Protocol for a drugs exposure pregnancy registry for implementation in resource-limited settings
    Ushma Mehta
    Independent Pharmacovigilance Consultant, Cape Town, Kenilworth 7708, South Africa
    BMC Pregnancy Childbirth 12:89. 2012
  3. doi request reprint Newer anticonvulsants: lamotrigine, topiramate and gabapentin
    Lewis B Holmes
    Genetics Unit, MassGeneral Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Birth Defects Res A Clin Mol Teratol 94:599-606. 2012
  4. doi request reprint Using ICD-9 codes to establish prevalence of malformations in newborn infants
    Lewis B Holmes
    Active Malformations Surveillance Program, Department of Newborn Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Birth Defects Res A Clin Mol Teratol 94:208-14. 2012
  5. ncbi request reprint The teratogenicity of anticonvulsant drugs
    L B Holmes
    Pediatric Service, Massachusetts General Hospital, Boston 02114 2696, USA
    N Engl J Med 344:1132-8. 2001
  6. doi request reprint Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy
    L B Holmes
    Genetics Unit, MassGeneral Hospital for Children, CPZS 504, 175 Cambridge Street, Boston, MA 02114, USA
    Neurology 70:2152-8. 2008
  7. doi request reprint Chorionic villus sampling and hemangiomas
    Lewis B Holmes
    Genetics Unit, MassGeneral Hospital for Children, Boston, Massachusetts 02114, USA
    J Craniofac Surg 20:675-7. 2009
  8. pmc The teratogenicity of anticonvulsant drugs: a progress report
    L B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Warren 801, 55 Fruit Street, Boston, MA 02114 2696, USA
    J Med Genet 39:245-7. 2002
  9. doi request reprint Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations
    Lewis B Holmes
    North American AED Pregnancy Registry, Genetics Unit, MassGeneral Hospital for Children, Boston, MA 02114, USA
    Arch Neurol 68:1275-81. 2011
  10. doi request reprint Human teratogens: update 2010
    Lewis B Holmes
    Genetics Unit, Massachusetts General Hospital for Children, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Birth Defects Res A Clin Mol Teratol 91:1-7. 2011

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Teratogen-induced limb defects
    Lewis B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet 112:297-303. 2002
    ..The molecular basis for the limb defects produced by the recognized human teratogens remains unknown...
  2. pmc Protocol for a drugs exposure pregnancy registry for implementation in resource-limited settings
    Ushma Mehta
    Independent Pharmacovigilance Consultant, Cape Town, Kenilworth 7708, South Africa
    BMC Pregnancy Childbirth 12:89. 2012
    ..We describe a protocol for a Pregnancy Registry adapted to resource-limited settings aimed at providing evidence on the safety of medicines in pregnancy...
  3. doi request reprint Newer anticonvulsants: lamotrigine, topiramate and gabapentin
    Lewis B Holmes
    Genetics Unit, MassGeneral Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Birth Defects Res A Clin Mol Teratol 94:599-606. 2012
    ..Larger sample sizes are needed to clarify the questions that have been raised...
  4. doi request reprint Using ICD-9 codes to establish prevalence of malformations in newborn infants
    Lewis B Holmes
    Active Malformations Surveillance Program, Department of Newborn Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Birth Defects Res A Clin Mol Teratol 94:208-14. 2012
    ..These codes have been used to establish the prevalence of malformations and to assess potential teratogens. We have analyzed the accuracy of codes 740 to 759.9 to identify newborn infants with malformations...
  5. ncbi request reprint The teratogenicity of anticonvulsant drugs
    L B Holmes
    Pediatric Service, Massachusetts General Hospital, Boston 02114 2696, USA
    N Engl J Med 344:1132-8. 2001
    ..However, whether the abnormalities are caused by the maternal epilepsy itself or by exposure to anticonvulsant drugs is not known...
  6. doi request reprint Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy
    L B Holmes
    Genetics Unit, MassGeneral Hospital for Children, CPZS 504, 175 Cambridge Street, Boston, MA 02114, USA
    Neurology 70:2152-8. 2008
    ..A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a frequency of 1 in 1,000...
  7. doi request reprint Chorionic villus sampling and hemangiomas
    Lewis B Holmes
    Genetics Unit, MassGeneral Hospital for Children, Boston, Massachusetts 02114, USA
    J Craniofac Surg 20:675-7. 2009
    ..A question to be answered is whether the infantile hemangiomas in children exposed to CVS differ in immunohistologic characteristics from similar hemangiomas in children not exposed to CVS during pregnancy...
  8. pmc The teratogenicity of anticonvulsant drugs: a progress report
    L B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Warren 801, 55 Fruit Street, Boston, MA 02114 2696, USA
    J Med Genet 39:245-7. 2002
  9. doi request reprint Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations
    Lewis B Holmes
    North American AED Pregnancy Registry, Genetics Unit, MassGeneral Hospital for Children, Boston, MA 02114, USA
    Arch Neurol 68:1275-81. 2011
    ..To determine the frequency of malformations among infants born to women who had taken lamotrigine or carbamazepine as part of polytherapy during the first trimester of pregnancy...
  10. doi request reprint Human teratogens: update 2010
    Lewis B Holmes
    Genetics Unit, Massachusetts General Hospital for Children, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Birth Defects Res A Clin Mol Teratol 91:1-7. 2011
    ....
  11. doi request reprint Inclusion and exclusion criteria for malformations in newborn infants exposed to potential teratogens
    Lewis B Holmes
    Active Malformations Surveillance Program, Department of Newborn Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    Birth Defects Res A Clin Mol Teratol 91:807-12. 2011
    ..The purpose of this study was to develop criteria and definitions for identifying malformations and for identifying the more common and less severe physical features that would be excluded as not being malformations...
  12. ncbi request reprint The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs
    Lewis B Holmes
    Genetics and Teratology Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    J Pediatr 146:118-22. 2005
    ..Some children also have cognitive dysfunction. The hypothesis tested is that the anticonvulsant drug-exposed child with midface and digit hypoplasia is more likely to have cognitive dysfunction...
  13. ncbi request reprint Increased rate of major malformations in offspring exposed to valproate during pregnancy
    D F Wyszynski
    Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    Neurology 64:961-5. 2005
    ....
  14. ncbi request reprint Adams-Oliver syndrome associated with cardiovascular malformations
    A E Lin
    Department of Newborn Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Dysmorphol 7:235-41. 1998
    ..Cardiology consultation should be offered to most patients with AOS...
  15. ncbi request reprint Prenatal diagnosis and molecular cytogenetics in a case of partial trisomy 14 and monosomy 21
    C Lee
    Department of Obstetrics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Med Genet 100:246-50. 2001
    ..More precise definitions of chromosomal breakpoints in such clinical cases should provide more accurate prognosis for individuals with unbalanced karyotypes and assist in the identification of putative developmentally important genes...
  16. doi request reprint Comparative safety of antiepileptic drugs during pregnancy
    S Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Neurology 78:1692-9. 2012
    ..To assess the safety of the newer antiepileptic drugs (AEDs) during pregnancy...
  17. ncbi request reprint Anticonvulsant teratogenesis 5: observer bias in a cohort study
    Elizabeth A Harvey
    Genetics and Teratology Unit, Mass General Hospital for Children, Boston, Massachusetts 02114 2696, USA
    Birth Defects Res A Clin Mol Teratol 67:452-6. 2003
    ..The purpose of this analysis was to determine whether or not there was evidence of observer bias in the detection of presumed anticonvulsant drug-related physical features...
  18. ncbi request reprint Limb deficiencies in newborn infants
    C K McGuirk
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pediatrics 108:E64. 2001
    ..The objective of this study was to determine this prevalence rate...
  19. ncbi request reprint Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers
    Aqiba Bokhari
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114 2606, USA
    Teratology 66:19-23. 2002
    ..Asymmetry of the distribution of dermal ridge patterns has been attributed to environmental exposures and genetic factors...
  20. ncbi request reprint Effects on toes from prenatal exposure to anticonvulsants
    Aqiba Bokhari
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Teratology 66:122-6. 2002
    ..We hypothesized that the frequency of these changes would also be increased in the toes of children exposed to these drugs in comparison to unexposed children...
  21. ncbi request reprint Cardiovascular malformations: changes in prevalence and birth status, 1972-1990
    A E Lin
    Department of Newborn Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Med Genet 84:102-10. 1999
    ....
  22. ncbi request reprint Craniofacial skeletal deviations following in utero exposure to the anticonvulsant phenytoin: monotherapy and polytherapy
    H I Orup
    The Department of Growth and Development, Harvard School of Dental Medicine, Boston, MA, USA
    Orthod Craniofac Res 6:2-19. 2003
    ..To identify and quantify the craniofacial effects from prenatal exposure to phenytoin monotherapy and polytherapy using cephalometric, hand-wrist, and panoramic radiographs and to determine if such deviations persist with age...
  23. ncbi request reprint Methodologic issues in epidemiologic studies of congenital microcephaly
    Alan Leviton
    Department of Neurology, Harvard Medical School and Children s Hospital, Neuroepidemiology Unit, Boston, MA 02115 5724, USA
    Early Hum Dev 69:91-105. 2002
    ..We pay particular attention to three concerns: Who is a case? How should cases be classified? To whom should cases be compared?..
  24. ncbi request reprint Maternally inherited duplication of chromosome 7, dup(7)(p11.2p12), associated with mild cognitive deficit without features of Silver-Russell syndrome
    Natalia T Leach
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Am J Med Genet A 143:1489-93. 2007
    ..2, showed that it is not duplicated in our patients. Our study helps refine the SRS critical region on 7p and extends our understanding of the clinical manifestations associated with 7p duplications...
  25. ncbi request reprint Clonazepam use in pregnancy and the risk of malformations
    Angela E Lin
    Genetics and Teratology Unit, MassGeneral Hospital for Children, Boston, Massachusetts 02114, USA
    Birth Defects Res A Clin Mol Teratol 70:534-6. 2004
    ..However, the current findings about its use in pregnancy are derived from limited studies of small sample size. Because it is commonly prescribed during pregnancy, more information about its safety is needed...
  26. pmc Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program
    Barbara R Pober
    Genetics and Teratology, MassGeneral Hospital for Children, Boston, Massachusetts, USA
    Am J Med Genet A 138:81-8. 2005
    ..The twin data also raise the possibility that epigenetic abnormalities contribute to the development of CDH...
  27. ncbi request reprint Congenital microcephaly: phenotypic features in a consecutive sample of newborn infants
    J E Vargas
    Division of Genetics and the Neuroepidemiology Unit, Children's Hospital, Boston, USA
    J Pediatr 139:210-4. 2001
    ..CONCLUSIONS: Congenital microcephaly is infrequently accompanied by major malformations and occurs rarely as part of a recognizable syndrome...
  28. doi request reprint Valproate teratogenicity and epilepsy syndrome
    Edward B Bromfield
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Epilepsia 49:2122-4. 2008
    ..There was a trend toward increased malformation risk with higher VPA doses (p = 0.07). VPA, and not the underlying genetic syndrome, seems to be associated with the elevated risk for malformations in the drug-exposed fetus...
  29. ncbi request reprint Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
    Helen M Lyon
    Children s Hospital, Boston, Massachusetts, USA
    Birth Defects Res A Clin Mol Teratol 67:993-6. 2003
    ..The characteristics of the phenotype of the malformed phenytoin-exposed infant can help to clarify the mechanism of the drug's teratogenesis. One postulated mechanism is vascular disruption...
  30. ncbi request reprint Bob was right
    L B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston 02114 2696, USA
    Reprod Toxicol 11:613-6. 1997
    ..Bob has recorded in several publications how he carried out these systematic analyses. This literature will be a very valuable legacy...
  31. ncbi request reprint The AED (antiepileptic drug) pregnancy registry: a 6-year experience
    Lewis B Holmes
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, USA
    Arch Neurol 61:673-8. 2004
    ..Pregnancy registries are a new method for assessing the fetal risks from exposures in pregnancy. We present the findings of the North American AED (antiepileptic drug) Pregnancy Registry for phenobarbital sodium-exposed pregnancies...
  32. ncbi request reprint Chorionic villus sampling: a distinctive teratogenic effect on fingers?
    Caroline M Golden
    Genetics and Teratology Unit, MassGeneral Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Birth Defects Res A Clin Mol Teratol 67:557-62. 2003
    ....
  33. pmc Findings from aCGH in patients with congenital diaphragmatic hernia (CDH): a possible locus for Fryns syndrome
    S Kantarci
    Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Am J Med Genet A 140:17-23. 2006
    ..12 that was confirmed by FISH. Given prior reports of CDH in association with cytogenetic abnormalities in this region, we propose that this represents a locus for Fryns syndrome, a Fryns syndrome phenocopy, or CDH...
  34. ncbi request reprint Pattern of skeletal malformations produced by Dominant hemimelia (Dh)
    B J Morin
    Harvard School of Dental Medicine, Boston, Massachusetts 02115 5898, USA
    Teratology 60:348-55. 1999
    ..The interrelationship of the hindlimb malformations and the reduction in the vertebral number suggests a relationship between the development of the axial skeleton and the abnormal limb...
  35. ncbi request reprint Autosomal dominant sensorineural hearing loss. Pedigrees, audiologic findings, and temporal bone findings in two kindreds
    U Khetarpal
    Department of Otology and Laryngology, Harvard Medical School, Boston, Mass
    Arch Otolaryngol Head Neck Surg 117:1032-42. 1991
    ..The end result is strangulation and degeneration of dendrites followed by retrograde neuronal degeneration in association with varying degrees of atrophic change in the sense organs...
  36. ncbi request reprint Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
    M Bamshad
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Nat Genet 16:311-5. 1997
    ..We suggest that during the evolution of TBX3 and TBX5 from a common ancestral gene, each has acquired specific yet complementary roles in patterning the mammalian upper limb...
  37. ncbi request reprint Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?
    Sophie Choulika
    Genetics and Teratology Unit, MassGeneral Hospital for Children, Boston, USA
    Am J Obstet Gynecol 190:882-3. 2004
    ..No hemorrhagic disease was observed, and the incidence of bleeding tendencies was not higher in infants exposed to these drugs compared with control infants, despite no prenatal vitamin K supplementation in all but 1 epileptic woman...
  38. ncbi request reprint Case records of the Massachusetts General Hospital. Case 11-2005. A 32-year-old pregnant woman with an abnormal fetal karyotype
    Lewis B Holmes
    Genetics and Teratology Unit, Mass General Hospital for Children, USA
    N Engl J Med 352:1579-87. 2005
  39. ncbi request reprint Four cases with hypoplastic thumbs and encephaloceles
    Taosheng Huang
    Division of Genetics and Metabolism, Children s Hospital, Boston, Massachusetts, USA
    Am J Med Genet 111:178-81. 2002
    ..The literature and database were searched intensively. No similar cases were reported previously, suggesting that the constellations might represent a new genetic syndrome...
  40. ncbi request reprint Trends in congenital malformations, 1974-1999: effect of prenatal diagnosis and elective termination
    Allyson J Peller
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    Obstet Gynecol 104:957-64. 2004
    ..To examine trends in congenital malformations, elective terminations for malformations and correlates for the decision to terminate a pregnancy with a malformation...
  41. ncbi request reprint Unilateral transverse arm defect with subterminal digital nubbins
    Ronny I Drapkin
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Pediatr Dev Pathol 6:348-54. 2003
    ..This fetus has the rare phenotype of terminal transverse limb defects with residual nubbins, but differs in that the nubbins are not at the tip of the terminal transverse limb defect...
  42. ncbi request reprint Putative new teratogens
    Lewis B Holmes
    Genetics and Teratology Unit, Mass General Hospital for Children, Boston, Massachusetts, USA
    Teratology 65:204-5. 2002
  43. doi request reprint Effects of retinoic acid on Dominant hemimelia expression in mice
    Mary H Owen
    Biology Department, Simmons College, Boston, Massachusetts 02115 5898, USA
    Birth Defects Res A Clin Mol Teratol 85:36-41. 2009
    ..This study was undertaken to determine whether retinoic acid (RA), which is involved in A-P patterning and coordination of bilaterally synchronized somitogenesis, affects phenotypic expression of the Dh gene...
  44. pmc Ensuring the safe and effective use of medications during pregnancy: planning and prevention through preconception care
    Janet D Cragan
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, MS E 86, 1600 Clifton Road, N E, Atlanta, Georgia 30333, USA
    Matern Child Health J 10:S129-35. 2006
  45. ncbi request reprint Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide
    Jurgen Kohlhase
    Institute for Human Genetics and Anthropology, University of Freiburg, Freiburg, Germany
    Birth Defects Res A Clin Mol Teratol 70:550-1. 2004
  46. ncbi request reprint North American antiepileptic drug pregnancy registry
    Lewis B Holmes
    Epilepsia 45:1465. 2004
  47. ncbi request reprint Guidelines for case classification for the National Birth Defects Prevention Study
    Sonja A Rasmussen
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Birth Defects Res A Clin Mol Teratol 67:193-201. 2003
    ..Case classification uses knowledge of embryologic and pathogenetic mechanisms to make case groups more homogeneous and is important to the success of birth defects studies...
  48. pmc Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations
    Jennifer J Johnston
    National Institutes of Health, National Human Genome Research Institute, Bethesda, MD 20892 4472, USA
    Am J Hum Genet 76:609-22. 2005
    ..These results demonstrate a robust correlation of genotype and phenotype for GLI3 mutations and strongly support the hypothesis that these two allelic disorders have distinct modes of pathogenesis...