N K Hollenberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Renal function in the patient with hypertension
    Norman Kenneth Hollenberg
    Department of Radiology and Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Med Clin North Am 88:131-40. 2004
  2. ncbi request reprint The road ahead with beta-blockers: expanding treatment options in cardiovascular disease
    Norman K Hollenberg
    Department of Medicine, Physiologic Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 18:163S-164S. 2005
  3. ncbi request reprint What does the future hold? ACE inhibition, angiotensin II receptor blockade, and diabetic nephropathy
    N K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Blood Press Monit 5:S3-6. 2000
  4. ncbi request reprint Familial factors in the antihypertensive response to lisinopril
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 14:218-23. 2001
  5. ncbi request reprint Potential of the angiotensin II receptor 1 blocker eprosartan in the management of patients with hypertension or heart failure
    N K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Hypertens Rep 3:S25-8. 2001
  6. ncbi request reprint Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man
    N K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 2:14-8. 2001
  7. ncbi request reprint Literature alert
    Norman K Hollenberg
    Departments of Medicine and Radiology, Harvard Medical School, Brigham and Women s Hospital, Mailstop PBB1 Rad Building, 15 Francis Street, Boston, MA, 02115, USA
    Curr Hypertens Rep 12:4. 2010
  8. ncbi request reprint Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus
    Norman K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 63:172-8. 2003
  9. ncbi request reprint Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens 25:1921-6. 2007
  10. ncbi request reprint Renin angiotensin system blockade and nephropathy: why is it being called into question, and should it be?
    Norman K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 1:1046-8. 2006

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Renal function in the patient with hypertension
    Norman Kenneth Hollenberg
    Department of Radiology and Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Med Clin North Am 88:131-40. 2004
    ..The answer, of course, is that it can be either, neither, or both, at least before treatment is undertaken. Once treatment is undertaken, all patients have an element of kidney involvement...
  2. ncbi request reprint The road ahead with beta-blockers: expanding treatment options in cardiovascular disease
    Norman K Hollenberg
    Department of Medicine, Physiologic Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 18:163S-164S. 2005
  3. ncbi request reprint What does the future hold? ACE inhibition, angiotensin II receptor blockade, and diabetic nephropathy
    N K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Blood Press Monit 5:S3-6. 2000
    ....
  4. ncbi request reprint Familial factors in the antihypertensive response to lisinopril
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 14:218-23. 2001
    ..Although it is widely recognized that there are familial elements in the pathogenesis of hypertension, remarkably little is known about the influence of family history on response to specific antihypertensive agents...
  5. ncbi request reprint Potential of the angiotensin II receptor 1 blocker eprosartan in the management of patients with hypertension or heart failure
    N K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Hypertens Rep 3:S25-8. 2001
    ..If research already under way supports these early suggestions, then eprosartan will be an important addition to our therapeutic armamentarium...
  6. ncbi request reprint Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man
    N K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 2:14-8. 2001
    ....
  7. ncbi request reprint Literature alert
    Norman K Hollenberg
    Departments of Medicine and Radiology, Harvard Medical School, Brigham and Women s Hospital, Mailstop PBB1 Rad Building, 15 Francis Street, Boston, MA, 02115, USA
    Curr Hypertens Rep 12:4. 2010
    ..Future studies should focus on other commonly consumed subclasses (eg, anthocyanins and flavanones), examine dose-response effects, and be of long enough duration to allow assessment of clinically relevant endpoints...
  8. ncbi request reprint Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus
    Norman K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 63:172-8. 2003
    ..This constellation is generally attributed to predominant efferent arteriolar dilation...
  9. ncbi request reprint Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens 25:1921-6. 2007
    ..We aimed to investigate whether high doses of valsartan, an angiotensin receptor blocker, are superior to conventional doses to reduce urinary albumin excretion rates (UAER) in such patients...
  10. ncbi request reprint Renin angiotensin system blockade and nephropathy: why is it being called into question, and should it be?
    Norman K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 1:1046-8. 2006
  11. ncbi request reprint Obesity and the kidney: why is the kidney at risk?
    N K Hollenberg
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Kidney Int 71:187-8. 2007
    ..One study pointed to a role for renin-system activation. In the other study, the pattern of renal hemodynamics was compatible with a renin mechanism...
  12. ncbi request reprint Organ systems dependent on nitric oxide and the potential for nitric oxide-targeted therapies in related diseases
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Hypertens (Greenwich) 8:63-73. 2006
    ..Further investigation of NO-targeted therapies in these diverse diseases is clearly mandated...
  13. ncbi request reprint Plasma aldosterone concentration in the patient with diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 65:1435-9. 2004
    ..Evidence for renin-system activation in many patients with type 1 diabetes mellitus has raised the possibility that aldosterone-widely recognized as a contributor to vascular injury-could play a role...
  14. ncbi request reprint Vascular action of cocoa flavanols in humans: the roots of the story
    Norman K Hollenberg
    Department of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cardiovasc Pharmacol 47:S99-102; discussion S119-21. 2006
    ..The next decade will be interesting...
  15. ncbi request reprint The influence of dietary sodium on blood pressure
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical Center, Boston, MA 02115, USA
    J Am Coll Nutr 25:240S-246S. 2006
    ..On the bright side, prognosis is improved substantially by the array of antihypertensive drugs available today...
  16. ncbi request reprint Nonmodulation and essential hypertension
    Norman K Hollenberg
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Hypertens Rep 8:127-31. 2006
    ..Genes governing renin substrate (angiotensinogen) production showed gene polymorphisms in nonmodulators. As nonmodulation occurs in approximately 40% of patients with essential hypertension, clearly other genes must contribute...
  17. ncbi request reprint Diabetes, nephropathy, and the renin system
    Norman K Hollenberg
    Department of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens Suppl 24:S81-7. 2006
    ..The renin system is important in patients with diabetes mellitus because so many relevant factors converge on the intrarenal renin system...
  18. ncbi request reprint Stress and blood pressure in Kuna Amerinds
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Hypertens (Greenwich) 7:714-20. 2005
    ..Life satisfaction is less influenced, possibly providing a measure of the degree of stress...
  19. ncbi request reprint Impact of angiotensin II on the kidney: does an angiotensin II receptor blocker make sense?
    N K Hollenberg
    Radiology Department, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 36:S18-23. 2000
    ..ARBs are currently undergoing clinical trials to assess their efficacy in hypertensive patients with nephropathy...
  20. ncbi request reprint The role of beta-blockers as a cornerstone of cardiovascular therapy
    Norman K Hollenberg
    Department of Medicine, Phsyiologic Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 18:165S-168S. 2005
    ..Endothelial dysfunction with loss of nitric oxide production is a common feature in many cardiovascular diseases. This fascinating class of drugs continues to provide us with new and important therapeutic opportunities...
  21. ncbi request reprint Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humans
    S Y Osei
    Department of Medicine and Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 33:559-64. 1999
    ..PRA did not change with hyperglycemia. Enhancement of renal vasodilation during hyperglycemia by captopril without alteration of PRA suggests activation of the intrarenal renin angiotensin system...
  22. ncbi request reprint Effect of angiotensin II antagonist eprosartan on hyperglycemia-induced activation of intrarenal renin-angiotensin system in healthy humans
    S Y Osei
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 36:122-6. 2000
    ..The enhancement of the renal vasodilator effect of eprosartan during hyperglycemia is consistent with activation of the intrarenal renin-angiotensin system...
  23. ncbi request reprint Type 2 diabetes, obesity, and the renal response to blocking the renin system with irbesartan
    D A Price
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Diabet Med 19:858-61. 2002
    ..As obesity is a common finding in diabetic individuals, and obesity has been linked to an increase in plasma angiotensinogen levels, we enrolled diabetic subjects with a wide range of body mass index (BMI) for this study...
  24. ncbi request reprint Renal perfusion and function in healthy African Americans
    D A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 59:1037-43. 2001
    ..Despite their increased risk of nephropathy, remarkably little is known about renal perfusion and function in healthy African Americans...
  25. ncbi request reprint Adrenal response to angiotensin II in black hypertension: lack of sexual dimorphism
    N D Fisher
    Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 38:373-8. 2001
    ..Mechanisms protecting against a blunted adrenal response to Ang II in young white women are absent in blacks. These differences may contribute to the markedly increased prevalence of hypertension in young black women...
  26. ncbi request reprint Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus
    M C Lansang
    Department of Medicine, Brigham and Women's Hospital, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 59:1432-8. 2001
    ..The high correlation between the renal hemodynamic response to captopril and to candesartan indicates that reduced angiotensin II formation is the main mechanism of action of the ACE inhibitor...
  27. ncbi request reprint Altered adrenal sensitivity to angiotensin II in low-renin essential hypertension
    N D Fisher
    Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 34:388-94. 1999
    ..The factors that mediate enhanced adrenal response to Ang II with sodium restriction may be defective, suggesting the existence of alternative physiological mechanisms for sodium homeostasis in the low-renin state...
  28. ncbi request reprint Renal response to captopril reflects state of local renin system in healthy humans
    N D Fisher
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 56:635-41. 1999
    ..In this study we tested the hypothesis that variation in the renal vasodilator response to ACE inhibition in healthy humans reflected the variation in angiotensin-mediated renal vasoconstriction provoked by a low-salt diet...
  29. ncbi request reprint Nonmodulating trait may precede the development of hypertension
    M S Gordon
    Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, Massachusetts 02115-5817
    Am J Hypertens 7:789-93. 1994
    ..We conclude that the nonmodulating trait may be a heritable defect that leads to the development of hypertension and is not an epiphenomenon...
  30. ncbi request reprint Age, gender, and non-modulation. A sexual dimorphism in essential hypertension
    N D Fisher
    Department of Medicine, Harvard Medical School, Boston, Mass, USA
    Hypertension 29:980-5. 1997
    ..This "override" of genotype, manifest by a very low frequency of non-modulation in young women, may participate in their known protection against cardiovascular disease...
  31. ncbi request reprint Effect of ACE inhibition on pressor, renal vascular, and adrenal responses to infusion of angiotensin I in normal subjects eating a low-salt diet
    N K Hollenberg
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 13:498-503. 2000
    ..Under the conditions of this study, ACE inhibition led to nonuniform changes in the response to exogenous Ang I, suggesting intrarenal conversion of Ang I to Ang II...
  32. ncbi request reprint The paradox of the low-renin state in diabetic nephropathy
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 10:2382-91. 1999
    ..This increase could account for suppressed circulating renin, the exaggerated renal vasodilator response to irbesartan, and the therapeutic effectiveness of interrupting the renin system in diabetic nephropathy...
  33. ncbi request reprint The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
    Am J Hypertens 12:348-55. 1999
    ..The infrequency of a low renin state, and the inappropriately high renin levels on a high salt intake, provide a rational basis for pharmacologic interruption of the renin system to treat patients with type II diabetes...
  34. ncbi request reprint Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake
    A Raji
    Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens 19:99-105. 2001
    ..This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake...
  35. ncbi request reprint Sodium pump inhibition and regional expression of sodium pump alpha-isoforms in lens
    Q F Tao
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 34:1168-74. 1999
    ..In conclusion, the present study suggests that digitalis-like factor may provide a link between hypertension and cataract formation...
  36. ncbi request reprint Sodium pump isoform specificity for the digitalis-like factor isolated from human peritoneal dialysate
    Q F Tao
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 29:815-21. 1997
    ....
  37. ncbi request reprint Renal hemodynamic response to an angiotensin II antagonist, eprosartan, in healthy men
    D A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 30:240-6. 1997
    ..Thus, eprosartan probably exerted its effect via the angiotensin receptor. More complete blockade of the renin system can be achieved by pharmacological interruption at this level, a finding that could have therapeutic implications...
  38. ncbi request reprint Volume sensitive hypertension and the digoxin-like factor. Reversal by a Fab directed against digoxin in DOCA-salt hypertensive rats
    H Krep
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 8:921-7. 1995
    ..The results are consistent with a role for a circulating digitalis-like factor in this volume-dependent model, but events at the VSM level are complex...
  39. ncbi request reprint Specificity of the vascular smooth muscle contractile response to a labile digitalis-like factor in peritoneal dialysate: the influence of potassium
    P Soszynski
    Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 10:1342-8. 1997
    ..The findings indicate that the VSM contractile response induced by the agent isolated from PD reflects VSM sodium pump inhibition, supporting its candidacy as a circulating regulator of the sodium pump...
  40. ncbi request reprint Sodium-sensitive hypertension. Implications of pathogenesis for therapy
    N K Hollenberg
    Department of Medicine, Harvard Medical School, Boston, MA
    Am J Hypertens 2:809-15. 1989
    ..Accumulating evidence suggests that the abnormality is inherited and may be the most common form of hypertension...
  41. ncbi request reprint Renal implications of angiotensin receptor blockers
    N K Hollenberg
    Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 14:237S-241S. 2001
    ..From a renoprotective perspective, the ARB appear to have tremendous potential in the management of hypertension...
  42. ncbi request reprint Is there a future for renin inhibitors?
    N D Fisher
    Departments of Radiology and Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA
    Expert Opin Investig Drugs 10:417-26. 2001
    ..We believe that the potential of renin inhibition in human therapy has been under estimated and still shows substantial promise...
  43. ncbi request reprint Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate in chronic renal failure
    Q F Tao
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Kidney Int 49:420-9. 1996
    ..Together, these experiments demonstrate that the PD candidate specifically, and reversibly, inhibits the sodium pump via the cardioglycoside binding site, and hence, meets this crucial criterion for candidacy...
  44. ncbi request reprint Angiotensin receptor blockers in diabetic nephropathy
    D A Price
    Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Diab Rep 1:267-74. 2001
    ..Because angiotensin receptor blockers do provide this specific blockade, they offer far more promise than ACE inhibitors...
  45. ncbi request reprint Reversal of sodium pump inhibitor induced vascular smooth muscle contraction with digibind. Stoichiometry and its implications
    H H Krep
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
    Am J Hypertens 9:39-46. 1996
    ..These findings are compatible with a role for one or more endogenous sodium pump inhibitors as the determinant of vascular smooth muscle tone in the volume-sensitive hypertension of renal disease...
  46. ncbi request reprint Renal sodium pump regulation in deoxycorticosterone salt hypertension in the rat
    P A Soszynski
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 10:525-34. 1997
    ..Increased renal sodium pump activity in DOCA high salt animals would, if unmitigated, favor sodium reabsorption and may contribute to hypertension...
  47. ncbi request reprint Effects of gender and genotype on the phenotypic expression of nonmodulating essential hypertension
    G H Williams
    Endocrine Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Kidney Int 57:1404-7. 2000
    ..This suggests that the expression of the nonmodulating phenotype, presumably secondary to changes in the expression of the angiotensinogen gene, is modulated by female sex hormones...
  48. ncbi request reprint Metabolic derangements in nonmodulating hypertension
    C L Gaboury
    Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 8:870-5. 1995
    ..NM had elevated fasting insulin levels compared to M, compatible with an insulin resistant state, but this insulin resistance are dissociable in the hypertensive population...
  49. ncbi request reprint Postmarketing surveillance in 70,898 patients treated with a triamterene/hydrochlorothiazide combination (Maxzide)
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Am J Cardiol 63:37B-41B. 1989
    ....
  50. ncbi request reprint Dopamine and nonmodulating hypertension
    G H Williams
    Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115
    Am J Hypertens 3:112S-115S. 1990
    ..Thus, the sodium retaining tendency of nonmodulators may reflect, at least in part, a reduction in intrarenal dopamine production in response to a sodium load...
  51. ncbi request reprint AT(1)-receptor blockade and the kidney: importance of non-ACE pathways in health and disease
    N K Hollenberg
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Hum Hypertens 16:S59-63. 2002
    ..Effective and early blockade of this system is therefore an important aspect of management...
  52. ncbi request reprint Salt sensitivity of hypertension and responses to angiotensin converting enzyme inhibition with benazepril
    T J Moore
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 9:54-60. 1996
    ..We conclude that the factors that influence sensitivity of BP to salt intake do not influence the systemic or renal hemodynamic response to ACE inhibition...
  53. ncbi request reprint Tissue-specific regulation of the sodium pump in DOCA-salt hypertension
    P A Soszynski
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 10:1132-9. 1997
    ..Reductions in aldosterone or hypertension might reduce alpha2 in the heart. Only the renal response would favor sodium reabsorption, which could contribute to the hypertensive process...
  54. pmc Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy
    A R Saxena
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertens Pregnancy 31:22-30. 2012
    ..To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum...
  55. ncbi request reprint Sustained volume expansion and [Na,K]ATPase inhibition in chronic renal failure
    K A Glatter
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115
    Am J Hypertens 7:1016-25. 1994
    ..Moreover, the application of stringent criteria to the confusing array of factors in plasma that may affect assays for DLF appears to reduce the field dramatically, to a single candidate in this setting...
  56. ncbi request reprint Variation in apparent serum digitalis-like factor levels with different digoxin antibodies. The "immunochemical fingerprint"
    S Naomi
    Department of Medicine, Harvard Medical School, Boston, Massachusetts
    Am J Hypertens 4:795-801. 1991
    ..DLF in at least three different patient populations probably represents identical chemical species.(ABSTRACT TRUNCATED AT 250 WORDS)..
  57. ncbi request reprint Assessment of quality of life by patient and spouse during antihypertensive therapy with atenolol and nifedipine gastrointestinal therapeutic system
    M A Testa
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115
    Am J Hypertens 4:363-73. 1991
    ..Comparison of adverse reactions provides an incomplete measure of how well a drug is tolerated. In contrast, findings indicate that even subtle CNS-mediated effects on mood and well-being can be detected by quality-of-life evaluation...
  58. ncbi request reprint Hyperkalemia in diabetes mellitus. Effect of a triamterene-hydrochlorothiazide combination
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Arch Intern Med 149:1327-30. 1989
    ....
  59. ncbi request reprint The effect of naftidrofuryl, a 5-HT2 antagonist, on collateral vascular responses to serotonin and to platelet activation
    N K Hollenberg
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, U S A
    J Cardiovasc Pharmacol 16:S36-9. 1990
    ..The observations strengthen the hypothesis that supersensitivity of collateral arterial vessels to serotonin reflects a 5-HT2 receptor mechanism...
  60. doi request reprint Improving genetic testing for Gitelman's syndrome
    Norman K Hollenberg
    Departments of Medicine and Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Hypertens Rep 13:328-9. 2011
    ....
  61. ncbi request reprint Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines
    W S Lee
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Mass 02115, USA
    Circ Res 82:845-51. 1998
    ..Thus, Thy-1 appears to be a marker of adult but not embryonic angiogenesis. The upregulation of Thy-1 by cytokines but not growth factors indicates the importance of inflammation in the pathogenesis of adult angiogenesis...
  62. ncbi request reprint Mortality in type 2 diabetes mellitus
    Norman K Hollenberg
    J Hypertens 25:2381-2. 2007
  63. ncbi request reprint Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes
    Ana R Stankovic
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 17:3293-9. 2006
    ....
  64. doi request reprint Aliskiren combined with losartan in type 2 diabetes and nephropathy
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 358:2433-46. 2008
    ....
  65. doi request reprint Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
    Naomi D L Fisher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3199-205. 2008
    ..We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
  66. ncbi request reprint Renin report: spotlight on Renin: therapeutic opportunities for Renin inhibitors
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Renin Angiotensin Aldosterone Syst 6:107-9. 2005
  67. ncbi request reprint Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitus
    Radomir D Stevanovic
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Renin Angiotensin Aldosterone Syst 6:78-83. 2005
    ..1+/-17.6 ml/minute/1.73 m2). When it was above the median, the RPF response was also larger (62.2+/-13.9 ml/minute/1.73 m2; p=0.006). Renin response to ACE-I and ARB confirms activation of the RAS in diabetic patients...
  68. ncbi request reprint Renin inhibition with aliskiren: where are we now, and where are we going?
    Michel Azizi
    Clinical Investigation Center 9201, Hospital European Georges Pompidou, Paris, France
    J Hypertens 24:243-56. 2006
    ..The relevant and necessary studies are ongoing...
  69. ncbi request reprint Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects
    Todd S Perlstein
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 18:944-51. 2007
    ..Further studies are warranted to address this balance in states of insulin resistance and the possible implications for the association of insulin resistance with risk for chronic kidney disease...
  70. ncbi request reprint Cocoa flavanols and brain perfusion
    Naomi D L Fisher
    Department of Internal Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Pharmacol 47:S210-4. 2006
    ..With the modalities of transcranial Doppler and MRI, we have the capabilities of analyzing the potential benefits of flavanols on brain perfusion and, subsequently, on cognition...
  71. pmc Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama
    Vicente Bayard
    Instituto Commemorative Gorgas de Estudios de la Salud and The Department of Preventive Medicine, School of Medicine, University of Panama, Panama City, Panama
    Int J Med Sci 4:53-8. 2007
    ..However, there are many risk factors and an observational study cannot provide definitive evidence...
  72. ncbi request reprint The renin system: is direct renin inhibition different from blockade at the AT1 receptor or the ACE step?
    Norman K Hollenberg
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Rev Cardiovasc Med 8:S7-13. 2007
    ..For many patients, this is likely to lead to improved treatment...
  73. ncbi request reprint Renin inhibition: what are the clinical perspectives?
    Norman K Hollenberg
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Nephrol 27:511-8. 2007
    ..In many patients, this is likely to lead to improved treatment...
  74. ncbi request reprint Effects of the PPAR-gamma agonist rosiglitazone on renal haemodynamics and the renin-angiotensin system in diabetes
    M Cecilia Lansang
    Department of Medicine, University of Florida, Gainesville, Florida, FL 32610 0226, USA
    J Renin Angiotensin Aldosterone Syst 7:175-80. 2006
    ..We aimed to determine if the TZD rosiglitazone could reduce RAS activation...
  75. ncbi request reprint Gender and the renal nitric oxide synthase system in healthy humans
    Sofia B Ahmed
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 2:926-31. 2007
    ..Animal models suggest that the renal vasculature of men may be significantly more dependent on nitric oxide than that of women...
  76. ncbi request reprint A brief response to Sealey and Laragh
    Norman K Hollenberg
    Harvard Medical School Brigham and Women s Hospital, Boston, MA, USA
    J Renin Angiotensin Aldosterone Syst 8:53. 2007
  77. ncbi request reprint Aging and vascular responses to flavanol-rich cocoa
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and the Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Hypertens 24:1575-80. 2006
    ..We have previously shown that flavanol-rich cocoa induced peripheral vasodilation, improving endothelial function via a nitric oxide (NO)-dependent mechanism...
  78. ncbi request reprint Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus
    Radomir D Stevanovic
    Department of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
    J Renin Angiotensin Aldosterone Syst 8:85-92. 2007
    ..72; p=0.008). Conversely, HbA1C correlated with none of the measures of renin system activation (r=0.05;p=0.7). In type 1 diabetic subjects, short-term hyperglycaemia, but not long-term glycaemic control, enhanced the RR to captopril...
  79. ncbi request reprint Hypertension, the Kuna, and the epidemiology of flavanols
    Marjorie L McCullough
    Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30309 4251, USA
    J Cardiovasc Pharmacol 47:S103-9; discussion 119-21. 2006
    ..Among dietary factors that varied among migrating Kuna, the notably higher intake of flavanol-rich cocoa is a potential candidate for further study...
  80. pmc (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
    Hagen Schroeter
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:1024-9. 2006
    ..Collectively, our data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa...
  81. ncbi request reprint Is there a pharmacologic basis for combination renin axis blockade?
    Norman K Hollenberg
    Kidney Int 68:2901-3. 2005
  82. ncbi request reprint Genetic determinants of nonmodulating hypertension
    Natapong Kosachunhanun
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 42:901-8. 2003
    ..For this subclass of essential hypertension, it is likely that genotyping can be substituted for complex phenotyping for therapeutic and preventive decision making...
  83. ncbi request reprint Reduced reactivity of renal microvessels to pressure and AngII in fawn-hooded rats
    Norman K Hollenberg
    Harvard Medical School and Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 5:286-7. 2003
  84. ncbi request reprint Nephron number in patients with primary hypertension
    Norman K Hollenberg
    Harvard Medical School and Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 5:285-6. 2003
  85. ncbi request reprint Reduction of proteinuria; combined effects of receptor blockade and low dose angiotensin-converting enzyme inhibition
    Norman K Hollenberg
    Harvard Medical School and Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 5:284-5. 2003
  86. ncbi request reprint Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type
    Shelley Hurwitz
    Departments of Medicine and Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Hypertens 21:951-9. 2003
    ..The validity of this approach relative to the homogeneity of sodium-sensitive hypertension was investigated while simultaneously controlling multiple putative factors...
  87. ncbi request reprint Parallel renal and extremity blood supply abnormalities in nonmodulation: responses to ACE inhibition
    Ramiro A Sanchez
    Sección Hipertensión Arterial, Instituto de Cardiologia y Cirugia Cardiovascular, Fundacion Favaloro, Belgrano 1746, 1093 Buenos Aires, Argentina
    Hypertension 41:919-24. 2003
    ..The effectiveness of ramipril in reducing minimum FVR and urinary albumin excretion in NMHT also suggests a common mechanism...
  88. ncbi request reprint Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin
    Norman K Hollenberg
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 4:413; discussion 413-4. 2002
  89. ncbi request reprint A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    Norman K Hollenberg
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 4:411; discussion 412. 2002
  90. ncbi request reprint Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril
    Norman K Hollenberg
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, MA 02115, USA
    Curr Hypertens Rep 4:269-70. 2002
  91. ncbi request reprint Renal perfusion in blacks: alterations caused by insuppressibility of intrarenal renin with salt
    Deborah A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Hypertension 40:186-9. 2002
    ..The mechanism involved may contribute to the increased susceptibility to renal injury in blacks...
  92. ncbi request reprint Renal perfusion and the renal hemodynamic response to blocking the renin system in diabetes: are the forces leading to vasodilation and vasoconstriction linked?
    M Cecilia Lansang
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Diabetes 51:2025-8. 2002
    ..The complex interrelationships between hyperglycemia, insulin, NO, and the RAS may result in phenotypes that indicate varying risk of diabetic nephropathy and underlying genetic polymorphisms...
  93. ncbi request reprint Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension
    Paul N Hopkins
    Cardiovascular Genetics, Cardiology Division, University of Utah, Salt Lake City, UT, USA
    Circulation 105:1921-7. 2002
    ..We examine herein angiotensinogen (AGT) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies...
  94. ncbi request reprint Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Hypertens 21:2281-6. 2003
    ..Cocoa can contain extraordinary concentrations of flavanols, a flavonoid subclass shown to activate nitric oxide synthase in vitro...
  95. ncbi request reprint Considerations for management of fluid dynamic issues associated with thiazolidinediones
    Norman K Hollenberg
    Section for Physiologic Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Med 115:111S-115S. 2003
    ..Diagnoses of NYHA class III and IV CHF were not studied in clinical trials of TZDs, and thus TZDs are not recommended for patients with CHF of this severity...
  96. ncbi request reprint Sodium glomerulopathy: tubuloglomerular feedback and renal injury in African Americans
    Abraham Aviv
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Kidney Int 65:361-8. 2004
    ..Increased susceptibility to glomerular hyperfiltration of African Americans on a high salt intake may explain their proclivity to progressive renal injury associated with essential hypertension...
  97. ncbi request reprint Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
    ..Weight loss should be considered in the overweight or obese patient for renal protection...
  98. ncbi request reprint Oral contraceptives, angiotensin-dependent renal vasoconstriction, and risk of diabetic nephropathy
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, PBB 3, 75 Francis St, Boston, MA 02115, USA
    Diabetes Care 28:1988-94. 2005
    ..RAS activation occurs in healthy women using oral contraceptives (OCs), but the effects of OC use on the diabetic kidney are unclear...
  99. ncbi request reprint Flavanols for cardiovascular health: the science behind the sweetness
    Naomi D L Fisher
    Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hypertens 23:1453-9. 2005
    ..However, many new studies have brought more confusion than clarity to the enterprise. This review provides guidelines for legitimate research in this promising field...
  100. ncbi request reprint ACE and non-ACE pathways in the renal vascular response to RAS interruption in type 1 diabetes mellitus
    M Cecilia Lansang
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0226, USA
    Kidney Int 67:1033-7. 2005
    ..Our aim was to determine the degree to which the non-ACE pathways contribute to RAS activation in type 1 diabetes mellitus (DM)...
  101. ncbi request reprint Advanced glycation end-product cross-link breakers. A novel therapeutic pathway for cardiovascular disease
    Norman K Hollenberg
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 17:21S-22S. 2004