Eric H Holbrook
Affiliation: Harvard University
- Immunohistochemical characterization of human olfactory tissueEric H Holbrook
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Laryngoscope 121:1687-701. 2011..Furthermore, a comparison of the molecular phenotype of olfactory epithelial cells between rodents and humans will improve our ability to correlate human histopathology with olfactory dysfunction...
- Abnormalities of axon growth in human olfactory mucosaEric H Holbrook
Department of Otolaryngology, MA Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 115:2144-54. 2005..However, detailed analysis of the subepithelial tissue with specific attention to the fascicles of the olfactory nerve and abnormalities of axonal growth may improve the correlation of histopathology with sensory function...
- An updated review of clinical olfactionEric H Holbrook
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
Curr Opin Otolaryngol Head Neck Surg 14:23-8. 2006..Disorders of the sense of smell can result through hundreds of different processes, but most commonly occur from upper-respiratory-tract infections, trauma, and chronic rhinosinusitis...
- Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastomaStacey T Gray
Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otolaryngol Head Neck Surg 147:147-51. 2012..The purpose of this study was to review our experience with olfactory neuroblastoma and to identify all patients who had a history of SIADH prior to the diagnosis of ONB...
- Outcomes analysis in epistaxis management: development of a therapeutic algorithmJosef Shargorodsky
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
Otolaryngol Head Neck Surg 149:390-8. 2013..This study explored the outcomes of epistaxis treatment modalities to optimize management and enable the development of a therapeutic algorithm...
- Diagnostic characteristics of sinonasal organizing hematomas: avoiding misdiagnosisArthur W Wu
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
Int Forum Allergy Rhinol 3:598-602. 2013..Diagnostic criteria for correctly identifying these lesions are not well known...
- Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophreniaHarry Pantazopoulos
Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Schizophr Res 150:366-72. 2013..Given the role CSPGs play in OE cell differentiation and axon guidance, we suggest that altered CSPG expression may contribute to ORN lineage dysregulation, and olfactory identification abnormalities, observed in SZ. ..
- A new model for collection of clinical outcomes data in patients with chronic rhinosinusitisJosh C Meier
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA Department of Otology and Laryngology, Harvard Medical School, Boston, MA
Int Forum Allergy Rhinol 4:411-5. 2014..The purpose of this study is to describe the implementation of an online model for collection of clinical outcomes data in patients with chronic rhinosinusitis (CRS)...
- Management of severe epistaxis after Young's procedure: a case reportJonathan Y Ting
Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Int Forum Allergy Rhinol 3:334-7. 2013..While this procedure results in loss of smell and permanent nasal obstruction, proponents note significant improvement in patient symptomatology...
- Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitisMoshe Yamin
Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA
J Allergy Clin Immunol 122:1145-1153.e3. 2008..Chronic rhinosinusitis (CRS) is characterized by persistent mucosal inflammation and frequent exacerbations...
- Olfactory loss as a result of toxic exposureUrmen D Upadhyay
Tufts University School of Medicine, New England Medical Center, 750 Washington Street, NEMC 850, Boston, MA 02111, USA
Otolaryngol Clin North Am 37:1185-207. 2004..Furthermore, with increasing regulations of occupational environments and stricter policies on industrial air pollution, olfactory dysfunction secondary to toxicity should become less prevalent...
- Lack of significant correlation between rhinosinusitis symptoms and specific regions of sinus computer tomography scansEric H Holbrook
Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Rhinol 19:382-7. 2005..The sinonasal computer tomography (CT) scan is frequently used to help confirm the diagnosis of rhinosinusitis. However, little data exist correlating patient symptoms with CT findings...
- Anosmia: diagnosis and managementEric H Holbrook
Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 1225, USA
Curr Opin Otolaryngol Head Neck Surg 11:54-60. 2003..A detailed history and physical examination are the most powerful tools in the evaluation of smell disorders, whereas imaging studies are reserved for preoperative planning or detailed assessment of positive physical findings...
- Matrix metalloproteinase expression in the olfactory epitheliumToshiaki Tsukatani
Department of Physiology, School of Medicine, Kanazawa University, 13 1 Takaramachi Kanazawa 920 0934, Japan
Neuroreport 14:1135-40. 2003..The results show a correlation between MMP and TIMP levels and the stages of neural degeneration, regeneration and recovery of the olfactory epithelium following injury...
- Enhancement of olfactory neuron survival and targeting via odorant exposureEric Holbrook; Fiscal Year: 2007....