Research Topics
Genomes and Genes | KARIN MARIA HOFFMEISTERSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
The role of lectins and glycans in platelet clearanceK M Hoffmeister
Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Thromb Haemost 9:35-43. 2011....
Glycosylation restores survival of chilled blood plateletsKarin M Hoffmeister
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 301:1531-4. 2003..Platelet-associated galactosyltransferase produces efficient galactosylation when uridine diphosphate-galactose is added, affording a potentially simple method for storing platelets in the cold...- Dual roles for hepatic lectin receptors in the clearance of chilled plateletsViktoria Rumjantseva
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 15:1273-80. 2009..Inhibition of chilled platelet clearance by both beta(2) integrin and Ashwell-Morell receptors may afford a potentially simple method for storing platelets in the cold... - Novel and unexpected clearance mechanisms for cold plateletsViktoria Rumjantseva
Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Transfus Apher Sci 42:63-70. 2010..Here we review current knowledge of the mechanisms of platelet removal, the existing knowledge of refrigerated platelet function, and methods to preserve platelet concentrates long-term for transfusion... - Mechanisms and implications of platelet discoid shapeJoseph E Italiano
Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Blood 101:4789-96. 2003..Together, these findings highlight the essential requirements of the MK/platelet-restricted beta1-tubulin isoform in platelet structure and suggest that spherocytosis does not impair many aspects of platelet function... - In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigerationAleksandar M Babic
Department of Pathology, Division of Translational Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Transfusion 47:442-51. 2007..PLT-associated galactosyltransferase efficiently galactosylates chilled PLTs in the presence of its substrate UDP-galactose is added to PLT-rich plasma... - The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled plateletsEmma C Josefsson
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:18025-32. 2005.... 
Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIPHervé Falet
Division of Translational Medicine, Brigham and Women s Hospital, One Blackfan Cir, Karp 6, Boston, MA02115, USA
Blood 114:4729-37. 2009..Together, the data indicate that platelet-associated IgAs negatively modulate GPVI signaling and function in WIP KO mice...- Normal Arp2/3 complex activation in platelets lacking WASpHervé Falet
Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
Blood 100:2113-22. 2002..Taken together, our findings show that platelets activate Arp2/3 complex, assemble actin, and change shape in the absence of WASp, indicating a more specialized role for WASp in these cells... - Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse plateletsWolfgang Bergmeier
The CBR Institute for Biomedical Research, Inc, 800 Huntington Ave, Boston, MA 02115, USA
Blood 102:4229-35. 2003..Surface expression of GPIbalpha might be a powerful marker to determine the quality of platelet concentrates, because it reflects metalloproteinase activity in vitro... - The clearance mechanism of chilled blood plateletsKarin M Hoffmeister
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Cell 112:87-97. 2003..Chilled platelets bind vWf and function normally in vitro and ex vivo after transfusion into CR3-deficient mice. Therefore, GPIb modification might permit cold platelet storage... - Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblastsHervé Falet
Division of Hematology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:16782-7. 2002..We conclude that Arp23 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping... - Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatmentNisreen El-Hashemite
Brigham and Women's Hospital, Hematology Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 64:3436-43. 2004..Rapamycin-IFN-gamma has unique potential therapeutic benefit for management of TSC tumors...
Research Grants
- Carbohydrate-mediated platelet clearanceKARIN MARIA HOFFMEISTER; Fiscal Year: 2010..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
- Carbohydrate-mediated platelet clearanceKarin Hoffmeister; Fiscal Year: 2007..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
- Carbohydrate-mediated platelet clearanceKarin Hoffmeister; Fiscal Year: 2009..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
- Carbohydrate-mediated platelet clearanceKarin Hoffmeister; Fiscal Year: 2009..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..