KARIN MARIA HOFFMEISTER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The role of lectins and glycans in platelet clearance
    K M Hoffmeister
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 9:35-43. 2011
  2. ncbi request reprint Glycosylation restores survival of chilled blood platelets
    Karin M Hoffmeister
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 301:1531-4. 2003
  3. doi request reprint Dual roles for hepatic lectin receptors in the clearance of chilled platelets
    Viktoria Rumjantseva
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 15:1273-80. 2009
  4. doi request reprint Novel and unexpected clearance mechanisms for cold platelets
    Viktoria Rumjantseva
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Transfus Apher Sci 42:63-70. 2010
  5. ncbi request reprint Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
  6. ncbi request reprint In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration
    Aleksandar M Babic
    Department of Pathology, Division of Translational Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Transfusion 47:442-51. 2007
  7. ncbi request reprint The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets
    Emma C Josefsson
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:18025-32. 2005
  8. pmc Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP
    Hervé Falet
    Division of Translational Medicine, Brigham and Women s Hospital, One Blackfan Cir, Karp 6, Boston, MA02115, USA
    Blood 114:4729-37. 2009
  9. ncbi request reprint Normal Arp2/3 complex activation in platelets lacking WASp
    Hervé Falet
    Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
    Blood 100:2113-22. 2002
  10. ncbi request reprint Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets
    Wolfgang Bergmeier
    The CBR Institute for Biomedical Research, Inc, 800 Huntington Ave, Boston, MA 02115, USA
    Blood 102:4229-35. 2003

Research Grants

  1. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2010
  2. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2007
  3. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
  4. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009

Collaborators

Detail Information

Publications13

  1. doi request reprint The role of lectins and glycans in platelet clearance
    K M Hoffmeister
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 9:35-43. 2011
    ....
  2. ncbi request reprint Glycosylation restores survival of chilled blood platelets
    Karin M Hoffmeister
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 301:1531-4. 2003
    ..Platelet-associated galactosyltransferase produces efficient galactosylation when uridine diphosphate-galactose is added, affording a potentially simple method for storing platelets in the cold...
  3. doi request reprint Dual roles for hepatic lectin receptors in the clearance of chilled platelets
    Viktoria Rumjantseva
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 15:1273-80. 2009
    ..Inhibition of chilled platelet clearance by both beta(2) integrin and Ashwell-Morell receptors may afford a potentially simple method for storing platelets in the cold...
  4. doi request reprint Novel and unexpected clearance mechanisms for cold platelets
    Viktoria Rumjantseva
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Transfus Apher Sci 42:63-70. 2010
    ..Here we review current knowledge of the mechanisms of platelet removal, the existing knowledge of refrigerated platelet function, and methods to preserve platelet concentrates long-term for transfusion...
  5. ncbi request reprint Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
    ..Together, these findings highlight the essential requirements of the MK/platelet-restricted beta1-tubulin isoform in platelet structure and suggest that spherocytosis does not impair many aspects of platelet function...
  6. ncbi request reprint In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration
    Aleksandar M Babic
    Department of Pathology, Division of Translational Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Transfusion 47:442-51. 2007
    ..PLT-associated galactosyltransferase efficiently galactosylates chilled PLTs in the presence of its substrate UDP-galactose is added to PLT-rich plasma...
  7. ncbi request reprint The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets
    Emma C Josefsson
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:18025-32. 2005
    ....
  8. pmc Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP
    Hervé Falet
    Division of Translational Medicine, Brigham and Women s Hospital, One Blackfan Cir, Karp 6, Boston, MA02115, USA
    Blood 114:4729-37. 2009
    ..Together, the data indicate that platelet-associated IgAs negatively modulate GPVI signaling and function in WIP KO mice...
  9. ncbi request reprint Normal Arp2/3 complex activation in platelets lacking WASp
    Hervé Falet
    Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
    Blood 100:2113-22. 2002
    ..Taken together, our findings show that platelets activate Arp2/3 complex, assemble actin, and change shape in the absence of WASp, indicating a more specialized role for WASp in these cells...
  10. ncbi request reprint Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets
    Wolfgang Bergmeier
    The CBR Institute for Biomedical Research, Inc, 800 Huntington Ave, Boston, MA 02115, USA
    Blood 102:4229-35. 2003
    ..Surface expression of GPIbalpha might be a powerful marker to determine the quality of platelet concentrates, because it reflects metalloproteinase activity in vitro...
  11. ncbi request reprint The clearance mechanism of chilled blood platelets
    Karin M Hoffmeister
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 112:87-97. 2003
    ..Chilled platelets bind vWf and function normally in vitro and ex vivo after transfusion into CR3-deficient mice. Therefore, GPIb modification might permit cold platelet storage...
  12. pmc Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts
    Hervé Falet
    Division of Hematology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16782-7. 2002
    ..We conclude that Arp23 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping...
  13. ncbi request reprint Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment
    Nisreen El-Hashemite
    Brigham and Women s Hospital, Hematology Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 64:3436-43. 2004
    ..Rapamycin-IFN-gamma has unique potential therapeutic benefit for management of TSC tumors...

Research Grants5

  1. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2010
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  2. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2007
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  3. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  4. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..