Hanno Hock

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 431:1002-7. 2004
  2. pmc Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
    Adlen Foudi
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Biotechnol 27:84-90. 2009
  3. pmc A complex Polycomb issue: the two faces of EZH2 in cancer
    Hanno Hock
    Cancer Center, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Genes Dev 26:751-5. 2012
  4. pmc Some hematopoietic stem cells are more equal than others
    Hanno Hock
    The Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1127-30. 2010
  5. ncbi request reprint Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Curr Opin Hematol 13:1-6. 2006
  6. pmc The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development
    Jinzhong Qin
    Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 11:319-32. 2012
  7. ncbi request reprint Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation
    Adlen Foudi
    Cancer Center, 2 Center for Regenerative Medicine, and 3 Department of Pathology, Massachusetts General Hospital, 4 Harvard Medical School, Boston, MA 02114
    J Exp Med 211:909-27. 2014
  8. ncbi request reprint TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia
    Jeffrey W Schindler
    Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 5:43-53. 2009
  9. ncbi request reprint Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    Hanna K A Mikkola
    Department of Pediatric Oncology, Children s Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 421:547-51. 2003
  10. ncbi request reprint Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells
    Sarah Eminli
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts, USA
    Nat Genet 41:968-76. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 431:1002-7. 2004
    ..Thus, Gfi-1 is essential to restrict HSC proliferation and to preserve HSC functional integrity...
  2. pmc Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
    Adlen Foudi
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Biotechnol 27:84-90. 2009
    ..8-1.8% per day)...
  3. pmc A complex Polycomb issue: the two faces of EZH2 in cancer
    Hanno Hock
    Cancer Center, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Genes Dev 26:751-5. 2012
    ..Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer...
  4. pmc Some hematopoietic stem cells are more equal than others
    Hanno Hock
    The Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1127-30. 2010
    ..Several recent studies substantially refine our understanding of the cells at the very top of the hematopoietic hierarchy, and suggest that we may need to revise the criteria we typically use to identify and define HSCs...
  5. ncbi request reprint Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Curr Opin Hematol 13:1-6. 2006
    ..Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoietic development...
  6. pmc The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development
    Jinzhong Qin
    Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 11:319-32. 2012
    ..However, some developmental regulators are repressed by the combined activity of all three complexes. Together, we have uncovered a highly selective, essential role for an atypical PRC1-family complex in ES cells and early development...
  7. ncbi request reprint Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation
    Adlen Foudi
    Cancer Center, 2 Center for Regenerative Medicine, and 3 Department of Pathology, Massachusetts General Hospital, 4 Harvard Medical School, Boston, MA 02114
    J Exp Med 211:909-27. 2014
    ..Together our study establishes Gfi-1b as a master transcriptional repressor of adult erythropoiesis and thrombopoiesis. ..
  8. ncbi request reprint TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia
    Jeffrey W Schindler
    Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 5:43-53. 2009
    ..Our work shows that stem cells are susceptible to subversion by weak oncogenes that can subtly alter their molecular program to provide a latent reservoir for the accumulation of further mutations...
  9. ncbi request reprint Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    Hanna K A Mikkola
    Department of Pediatric Oncology, Children s Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 421:547-51. 2003
    ..These findings contrast with lineage choice mechanisms, in which the identity of haematopoietic lineages requires continuous transcription factor expression...
  10. ncbi request reprint Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells
    Sarah Eminli
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts, USA
    Nat Genet 41:968-76. 2009
    ..Moreover, we identify hematopoietic progenitors as an attractive cell type for applications of iPS cell technology in research and therapy...
  11. ncbi request reprint Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 18:109-20. 2003
    ..Thus, Gfi-1 not only promotes differentiation of neutrophils but also antagonizes traits of the alternate monocyte/macrophage program...
  12. pmc Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival
    Hanno Hock
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:2336-41. 2004
    ..Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs...
  13. pmc Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice
    Jinzhong Qin
    Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 285:27767-75. 2010
    ..In cohorts of mice followed for more than 2 years, lack of L3MBTL1 did not alter normal lifespan or survival with or without sublethal irradiation...
  14. pmc ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex
    Zhe Li
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    Cancer Cell 12:542-58. 2007
    ..Given the increasing relevance of chromosomal translocations in epithelial cancers, such mice serve as a paradigm for the study of their genetic pathogenesis and cellular origins, and generation of preclinical models...
  15. pmc Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1
    Paul A Monach
    Joslin Diabetes Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 62:753-64. 2010
    ..In this study, we developed a system with which to test the importance of the production of specific factors by neutrophils in a mouse model of arthritis...
  16. pmc The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
    Fan Mou
    Department of Molecular Biology, Massachusetts GeneralHospital, Boston, MA 02114, USA
    J Exp Med 209:741-59. 2012
    ..Thus, the Mst1 and Mst2 kinases control Rho GTPase activation and the migratory responses of SP thymocytes...
  17. ncbi request reprint Stem cells: the road not taken
    Hanno Hock
    Nature 435:573-5. 2005