J Allan Hobson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Dreaming and the brain: toward a cognitive neuroscience of conscious states
    J A Hobson
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Behav Brain Sci 23:793-842; discussion 904-1121. 2000
  2. doi request reprint REM sleep and dreaming: towards a theory of protoconsciousness
    J Allan Hobson
    Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Neurosci 10:803-13. 2009
  3. ncbi request reprint Sleep and dream suppression following a lateral medullary infarct: a first-person account
    J Allan Hobson
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Conscious Cogn 11:377-90. 2002
  4. ncbi request reprint Wake up or dream on? Six questions for Turnbull and Solms
    J Allan Hobson
    Harvard Medical School, Boston, MA, USA
    Cortex 43:1113-5; discussion 1116-21. 2007
  5. doi request reprint A mind to go out of: reflections on primary and secondary consciousness
    Allan Hobson
    Beth Israel Deaconness Medical Center and Harvard Medical School, Boston, MA, USA
    Conscious Cogn 20:993-7. 2011
  6. ncbi request reprint Sleep is of the brain, by the brain and for the brain
    J Allan Hobson
    Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, 401 Park Drive, 2nd Floor East, Boston, Massachusetts 02115, USA
    Nature 437:1254-6. 2005
  7. ncbi request reprint Cognitive performance by humans during a smoked cocaine binge-abstinence cycle
    Edward F Pace-Schott
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Drug Alcohol Abuse 31:571-91. 2005
  8. ncbi request reprint Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
  9. ncbi request reprint Sleep quality deteriorates over a binge--abstinence cycle in chronic smoked cocaine users
    Edward F Pace-Schott
    Laboratory of Neurophysiology Center for Sleep and Cognition and Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Psychopharmacology (Berl) 179:873-83. 2005
  10. ncbi request reprint Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal
    R Silvestri
    Massachusetts Mental Health Center, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA
    J Clin Psychiatry 62:642-52. 2001

Research Grants

  1. DRUG ABUSE, SLEEP AND COGNITION
    J Hobson; Fiscal Year: 2002
  2. STATE-DEPENDENT ASPECTS OF COGNITION
    J Hobson; Fiscal Year: 1993
  3. STATE DEPENDENT ASPECTS OF COGNITION
    J Hobson; Fiscal Year: 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Dreaming and the brain: toward a cognitive neuroscience of conscious states
    J A Hobson
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Behav Brain Sci 23:793-842; discussion 904-1121. 2000
    ..Both evidence and theory suggest that there are isomorphisms between the phenomenology and the physiology of dreams. We present a three-dimensional model with specific examples from normally and abnormally changing conscious states...
  2. doi request reprint REM sleep and dreaming: towards a theory of protoconsciousness
    J Allan Hobson
    Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Neurosci 10:803-13. 2009
    ....
  3. ncbi request reprint Sleep and dream suppression following a lateral medullary infarct: a first-person account
    J Allan Hobson
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Conscious Cogn 11:377-90. 2002
    ....
  4. ncbi request reprint Wake up or dream on? Six questions for Turnbull and Solms
    J Allan Hobson
    Harvard Medical School, Boston, MA, USA
    Cortex 43:1113-5; discussion 1116-21. 2007
  5. doi request reprint A mind to go out of: reflections on primary and secondary consciousness
    Allan Hobson
    Beth Israel Deaconness Medical Center and Harvard Medical School, Boston, MA, USA
    Conscious Cogn 20:993-7. 2011
    ....
  6. ncbi request reprint Sleep is of the brain, by the brain and for the brain
    J Allan Hobson
    Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, 401 Park Drive, 2nd Floor East, Boston, Massachusetts 02115, USA
    Nature 437:1254-6. 2005
    ..The study of sleep is also shedding light on our understanding of consciousness, which undergoes alteration in parallel with sleep-induced changes in the brain...
  7. ncbi request reprint Cognitive performance by humans during a smoked cocaine binge-abstinence cycle
    Edward F Pace-Schott
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Drug Alcohol Abuse 31:571-91. 2005
    ..Declines were most evident in the afternoon. Data suggest that abstinence can unmask cognitive deficits induced by chronic cocaine use and circadian factors may mediate their severity...
  8. ncbi request reprint Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
    ....
  9. ncbi request reprint Sleep quality deteriorates over a binge--abstinence cycle in chronic smoked cocaine users
    Edward F Pace-Schott
    Laboratory of Neurophysiology Center for Sleep and Cognition and Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Psychopharmacology (Berl) 179:873-83. 2005
    ..Reported here are results of the most extensive study to date on sleep abnormalities during cocaine binge and confirmed abstinence under controlled conditions...
  10. ncbi request reprint Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal
    R Silvestri
    Massachusetts Mental Health Center, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA
    J Clin Psychiatry 62:642-52. 2001
    ....
  11. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
    ..Finally, whereas the majority of sleep-dependent motor-skill learning develops during the first night of sleep following training, additional nights of sleep still offer continued improvements...
  12. ncbi request reprint Eyelid movements measured by Nightcap predict slow eye movements during quiet wakefulness in humans
    Mercedes Atienza
    Laboratory of Neurophysiology, Department of Psychiatry at the Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    J Sleep Res 13:25-9. 2004
    ..82% accuracy) at a time resolution of 2.5 s. Based on these results, we conclude that ELM density reliably predicts moderate changes in the level of alertness during quiet wakefulness...
  13. ncbi request reprint The cognitive neuroscience of sleep: neuronal systems, consciousness and learning
    J Allan Hobson
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 3:679-93. 2002
    ..Different forms and stages of learning and memory might benefit from different stages of sleep and be subserved by different forebrain regions...
  14. doi request reprint Failure to find executive function deficits following one night's total sleep deprivation in university students under naturalistic conditions
    Edward F Pace-Schott
    Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Behav Sleep Med 7:136-63. 2009
    ..Behavioral and physiological adaptation to chronically sleep-restricting lifestyles may confer resistance to the cognitive effects of sleep deprivation in high-functioning young adults...
  15. ncbi request reprint Cognitive flexibility across the sleep-wake cycle: REM-sleep enhancement of anagram problem solving
    Matthew P Walker
    Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Brain Res Cogn Brain Res 14:317-24. 2002
    ....
  16. ncbi request reprint The rat as an experimental model for sleep neurophysiology
    S Datta
    Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA
    Behav Neurosci 114:1239-44. 2000
    ..The results suggest that for many neurophysiological studies, the rat is a suitable alternative to the cat...
  17. ncbi request reprint State-dependent thinking: a comparison of waking and dreaming thought
    David Kahn
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Conscious Cogn 14:429-38. 2005
    ..We found that cognition within a dream scenario was similar to that of wake-state cognition, but that thinking about the scenario itself was deficient and very different than wake-state thinking...
  18. ncbi request reprint Dreaming and episodic memory: a functional dissociation?
    Magdalena J Fosse
    Laboratory of Neurophysiology, Harvard Medical School, Massachusetts Mental Health Center, Boston 02115, USA
    J Cogn Neurosci 15:1-9. 2003
    ..This finding has implications for understanding the unique memory processing that takes place during the night and is consistent with evidence that sleep has no role in episodic memory consolidation...
  19. ncbi request reprint Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  20. ncbi request reprint To dream or not to dream? Relevant data from new neuroimaging and electrophysiological studies
    J A Hobson
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston 02115, USA
    Curr Opin Neurobiol 8:239-44. 1998
    ..These results are complemented by new brain lesion and electrophysiological recording data to give a detailed picture of the brain dynamics of changes in conscious state...
  21. ncbi request reprint Sleep, learning, and dreams: off-line memory reprocessing
    R Stickgold
    Laboratory of Neurophysiology and Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Science 294:1052-7. 2001
    ....
  22. ncbi request reprint Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep
    S Datta
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 16:8-14. 1993
    ..These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL...
  23. ncbi request reprint Sleep and vestibular adaptation: implications for function in microgravity
    J A Hobson
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, USA
    J Vestib Res 8:81-94. 1998
    ..Using these techniques we will test the hypothesis that vestibular adaptation both provokes and is enhanced by REM sleep under both ground-based and space conditions. In this paper we describe preliminary results of some of our studies...
  24. ncbi request reprint Sleep-induced changes in associative memory
    R Stickgold
    Massachusetts Medical Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    J Cogn Neurosci 11:182-93. 1999
    ..Known changes in brainstem activity that control the transition into and maintenance of REM sleep provide a possible explanation of this shift...
  25. ncbi request reprint Carbachol microinjection into the caudal peribrachial area induces long-term enhancement of PGO wave activity but not REM sleep
    J J Quattrochi
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    J Sleep Res 8:281-90. 1999
    ....
  26. ncbi request reprint Visual discrimination task improvement: A multi-step process occurring during sleep
    R Stickgold
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    J Cogn Neurosci 12:246-54. 2000
    ..These results suggest that, in the case of this visual discrimination task, both SWS and REM are required to consolidate experience-dependent neuronal changes into a form that supports improved task performance...
  27. ncbi request reprint Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals
    J J Quattrochi
    Laboratory of Neurophysiology, Program in Neuroscience, Harvard Medical School, Boston, USA
    J Sleep Res 9:185-91. 2000
    ..Integrating our findings with those described previously in humans, we propose that MAs may serve as a homeostatic mechanism which is designed to restore cardiorespiratory function allowing the continuity of sleep...
  28. ncbi request reprint Dynamic suppression of REM sleep by parenteral administration of the serotonin-1 agonist eltoprazine
    J J Quattrochi
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 15:125-32. 1992
    ..PGO wave frequency and REM% increased significantly during the recovery period. Thus our findings demonstrate REM and PGO suppression by eltoprazine and document dramatic rebound effects following its withdrawal...
  29. ncbi request reprint Brain-mind states: I. Longitudinal field study of sleep/wake factors influencing mentation report length
    R Stickgold
    Department of Psychiatry, Harvard Medical School, USA
    Sleep 24:171-9. 2001
    ..To collect and analyze reports of mental activity across sleep/wake states...
  30. ncbi request reprint Brain-mind states: reciprocal variation in thoughts and hallucinations
    R Fosse
    Institute of Psychology, University of Oslo, Norway
    Psychol Sci 12:30-6. 2001
    ....
  31. ncbi request reprint SSRI treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects
    E F Pace-Schott
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    J Sleep Res 10:129-42. 2001
    ....
  32. ncbi request reprint Dreaming and waking consciousness: a character recognition study
    D Kahn
    Laboratory of Neurophysiology, Harvard Medical School, Boston, MA 02115, USA
    J Sleep Res 9:317-25. 2000
    ....
  33. ncbi request reprint Thinking and hallucinating: reciprocal changes in sleep
    Roar Fosse
    Department of Psychology, University of Oslo, Oslo, Norway
    Psychophysiology 41:298-305. 2004
    ..Biological evidence supports the hypothesis that these cognitive changes are governed by specific state regulatory and neurocognitive processes at several levels of the brain...
  34. ncbi request reprint Emotional experience during rapid-eye-movement sleep in narcolepsy
    Roar Fosse
    Institute of Psychology, University in Oslo
    Sleep 25:724-32. 2002
    ..To describe emotional experience during sleep-onset rapid-eye-movement [(REM) SOREM] sleep and nighttime REM in narcoleptic patients and to relate any differences in REM emotion to the more general abnormalities of this disorder...
  35. ncbi request reprint The neurobiology of sleep: genetics, cellular physiology and subcortical networks
    Edward F Pace-Schott
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 3:591-605. 2002
  36. pmc From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum
    James J Quattrochi
    Laboratory for Cellular and Molecular Neuroscience and Program in Neuroscience, Harvard Medical School, WAB 425 447B, 200 Longwood, Boston, MA 02115, USA
    Brain Res Mol Brain Res 136:164-76. 2005
    ....
  37. ncbi request reprint Nightcap measurement of sleep quality in self-described good and poor sleepers
    E F Pace-Schott
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 17:688-92. 1994
    ..The demonstrated sensitivity of the Nightcap to good and poor sleep in these normal subjects augurs well for its application in a clinical setting...
  38. ncbi request reprint Nightcap: a reliable system for determining sleep onset latency
    Jose L Cantero
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Sleep 25:238-45. 2002
    ..These results suggest that the Nightcap may be a potential alternative to the PSG technique in the assessment of SOL in normal subjects...
  39. ncbi request reprint Freud returns? Like a bad dream
    J Allan Hobson
    Harvard Medical School, USA
    Sci Am 290:89. 2004
  40. ncbi request reprint Nightcap: a home-based sleep monitoring system
    A Mamelak
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 12:157-66. 1989
    ..6 and 10.8 min of polysomnographic records, respectively. These results are encouraging, and suggest that this system could provide a comfortable, subject operable, and inexpensive method for the evaluation of sleep at home...
  41. ncbi request reprint Emotion and cognition: feeling and character identification in dreaming
    David Kahn
    Laboratory of Neurophysiology, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Conscious Cogn 11:34-50. 2002
    ..The findings are also consistent with the suggestion that these limbic areas have minimal input from the dorsolateral prefrontal cortex in the dreaming brain...
  42. ncbi request reprint Michel Jouvet: a personal tribute
    J A Hobson
    Laboratory of Neurophysiology, Harvard Medical School, Department of Psychiatry, 138 High Street, Brookline, MA 02445, USA
    Arch Ital Biol 142:347-52. 2004
  43. pmc The dream as a model for psychosis: an experimental approach using bizarreness as a cognitive marker
    Silvio Scarone
    Department of Medicine, Surgery and Dentistry, University of Milan Medical School, San Paolo Hospital, Milan, Italy
    Schizophr Bull 34:515-22. 2008
    ..Though very preliminary, these results support the hypothesis that the dreaming brain could be a useful experimental model for psychosis...
  44. ncbi request reprint Neurology, psychiatry, and neuroscience
    J Allan Hobson
    Am J Psychiatry 160:1013-4. 2003
  45. ncbi request reprint Do lonely days invade the nights? Potential social modulation of sleep efficiency
    John T Cacioppo
    Department of Psychology, University of Chicago, IL 60637, USA
    Psychol Sci 13:384-7. 2002
    ..These results also raise the possibility that social factors such as loneliness not only may influence the selection of health behaviors but also may modulate the salubrity of restorative behaviors...

Research Grants14

  1. DRUG ABUSE, SLEEP AND COGNITION
    J Hobson; Fiscal Year: 2002
    ..The proposed research will answer fundamental questions regarding the cognitive benefits of sleep and how these benefits are lost when drugs are abused. ..
  2. STATE-DEPENDENT ASPECTS OF COGNITION
    J Hobson; Fiscal Year: 1993
    ..Because we will be able to collect data in a home setting, we expect to eliminate many of the disadvantages of standard sleep laboratory experimentation, and obtain more reliably naturalistic data...
  3. STATE DEPENDENT ASPECTS OF COGNITION
    J Hobson; Fiscal Year: 2003
    ..Finally, we propose to determine which aspects of the visual discrimination task actually lead to the REM increase. ..