Blanca E Himes

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    J Am Med Inform Assoc 16:371-9. 2009
  2. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
  3. pmc Predicting response to short-acting bronchodilator medication using Bayesian networks
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, MA, USA
    Pharmacogenomics 10:1393-412. 2009
  4. pmc Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 365:1173-83. 2011
  5. pmc Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes
    Michael J McGeachie
    Department of Medicine, Channing Division of Network Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Pharmacogenet Genomics 23:324-8. 2013
  6. pmc Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene
    Blanca E Himes
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002824. 2012
  7. pmc Development of a Pharmacogenetic Predictive Test in asthma: proof of concept
    Ann Chen Wu
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215 5301, USA
    Pharmacogenet Genomics 20:86-93. 2010
  8. pmc A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study
    Mark Granada
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 129:840-845.e21. 2012
  9. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
  10. pmc Association of SERPINE2 with asthma
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 140:667-74. 2011

Detail Information

Publications20

  1. pmc Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    J Am Med Inform Assoc 16:371-9. 2009
    ..Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records...
  2. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  3. pmc Predicting response to short-acting bronchodilator medication using Bayesian networks
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, MA, USA
    Pharmacogenomics 10:1393-412. 2009
    ..We sought to relate candidate gene SNP data with bronchodilator response and measure the predictive accuracy of a model constructed with genetic variants...
  4. pmc Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 365:1173-83. 2011
    ..We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids...
  5. pmc Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes
    Michael J McGeachie
    Department of Medicine, Channing Division of Network Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Pharmacogenet Genomics 23:324-8. 2013
    ..Furthermore, our results indicate that multiple SNP main effects, including SNPs as yet unidentified by genome-wide association study methods, together explain a sizable portion of the heritability of these traits...
  6. pmc Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene
    Blanca E Himes
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002824. 2012
    ....
  7. pmc Development of a Pharmacogenetic Predictive Test in asthma: proof of concept
    Ann Chen Wu
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215 5301, USA
    Pharmacogenet Genomics 20:86-93. 2010
    ..To assess the feasibility of developing a Combined Clinical and Pharmacogenetic Predictive Test, comprised of multiple single nucleotide polymorphisms (SNPs) that is associated with poor bronchodilator response (BDR)...
  8. pmc A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study
    Mark Granada
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 129:840-845.e21. 2012
    ..Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation...
  9. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
    ..We hypothesized that the use of random forests classifiers to select SNPs would result in an improved predictive model of asthma exacerbations. We tested this hypothesis in a population of childhood asthmatics...
  10. pmc Association of SERPINE2 with asthma
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 140:667-74. 2011
    ..We sought to determine whether SERPINE2 is associated with asthma and asthma-related phenotypes...
  11. pmc Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Med Genet 12:26. 2011
    ..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts...
  12. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  13. doi Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics
    Ann Chen Wu
    Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Mass Department of Pediatrics, Children s Hospital, Boston, Mass Harvard Medical School, Boston, Mass Electronic address
    J Allergy Clin Immunol 133:723-8.e3. 2014
    ..We hypothesized that use of inhaled corticosteroids could influence the effect of SNPs associated with a bronchodilator response...
  14. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
    ..We sought to determine whether common genetic variants were associated with AHR severity...
  15. pmc Association of variants in innate immune genes with asthma and eczema
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatr Allergy Immunol 23:315-23. 2012
    ..We investigate the association between polymorphisms of genes in the innate immune pathway with childhood asthma and eczema. In addition, we compare individual associations with those discovered using a multivariate approach...
  16. pmc Regulatory haplotypes in ARG1 are associated with altered bronchodilator response
    Qing Ling Duan
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Crit Care Med 183:449-54. 2011
    ..We previously identified single nucleotide polymorphisms in the arginase 1 (ARG1) gene, which are associated with β₂-agonist bronchodilator response (BDR)...
  17. pmc A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:947-57. 2012
    ..08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior...
  18. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  19. pmc Analyses of shared genetic factors between asthma and obesity in children
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 126:631-7.e1-8. 2010
    ..Epidemiologic studies consistently show associations between asthma and obesity. Shared genetics might account for this association...
  20. pmc Predictive genomics of cardioembolic stroke
    Rachel Badovinac Ramoni
    Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Stroke 40:S67-70. 2009
    ....