JONATHAN HIGGINS

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
    Fangwei Wang
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 199:251-68. 2012
  2. ncbi request reprint Chromosome segregation: learning to let go
    Jonathan M G Higgins
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building Room 538A, 1 Jimmy Fund Way, Boston, MA 02115, USA Electronic address
    Curr Biol 23:R883-5. 2013
  3. ncbi request reprint The role of alpha and beta chains in ligand recognition by beta 7 integrins
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25652-64. 2000
  4. ncbi request reprint The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells
    J M Higgins
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 538D, One Jimmy Fund Way, Boston, MA 02115, USA
    Gene 267:55-69. 2001
  5. pmc Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Protein Sci 10:1677-84. 2001
  6. ncbi request reprint Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases
    J M G Higgins
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 538D, One Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 60:446-62. 2003
  7. pmc Haspin: a newly discovered regulator of mitotic chromosome behavior
    Jonathan M G Higgins
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Chromosoma 119:137-47. 2010

Detail Information

Publications8

  1. pmc Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
    Fangwei Wang
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 199:251-68. 2012
    ..Thus, Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling...
  2. ncbi request reprint Chromosome segregation: learning to let go
    Jonathan M G Higgins
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building Room 538A, 1 Jimmy Fund Way, Boston, MA 02115, USA Electronic address
    Curr Biol 23:R883-5. 2013
    ..A new study reveals how distinct centromere populations of the cohesin protector Sgo1 are regulated by microtubule attachments, cyclin-dependent kinases, and the kinetochore kinase Bub1. ..
  3. ncbi request reprint The role of alpha and beta chains in ligand recognition by beta 7 integrins
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25652-64. 2000
    ..Thus, although specificity can be determined by the integrin alpha or beta chain, common structural features of both subunits are required for recognition of dissimilar ligands...
  4. ncbi request reprint The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells
    J M Higgins
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 538D, One Jimmy Fund Way, Boston, MA 02115, USA
    Gene 267:55-69. 2001
    ..Thus haspin is likely to be important in regulation of diploid as well as haploid cell differentiation in a variety of tissues...
  5. pmc Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Protein Sci 10:1677-84. 2001
    ....
  6. ncbi request reprint Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases
    J M G Higgins
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 538D, One Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 60:446-62. 2003
    ..Therefore, the haspins are an intriguing group of kinases likely to have important roles during or following both meiosis and mitosis...
  7. pmc Haspin: a newly discovered regulator of mitotic chromosome behavior
    Jonathan M G Higgins
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Chromosoma 119:137-47. 2010
    ....

Research Grants11

  1. Development of a haspin kinase assay for high throughput drug screening
    JONATHAN HIGGINS; Fiscal Year: 2007
    ..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. ..
  2. Protein Interactions of the Germ Cell Kinase Haspin
    JONATHAN HIGGINS; Fiscal Year: 2004
    ..abstract_text> ..
  3. Function of the chromosomal kinase haspin in mitosis
    JONATHAN M HIGGINS; Fiscal Year: 2010
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  4. Function of the chromosomal kinase haspin in mitosis
    JONATHAN HIGGINS; Fiscal Year: 2009
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  5. Function of the chromosomal kinase haspin in mitosis
    JONATHAN HIGGINS; Fiscal Year: 2007
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  6. Motif-based elucidation of protein modification codes
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..The development of methodology to determine the functional impact of these marks is therefore a critical requirement for future work in all areas of biomedicine. ..
  7. Development of a haspin kinase assay for high throughput drug screening
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. ..
  8. Function of the chromosomal kinase haspin in mitosis
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  9. Function of the chromosomal kinase haspin in mitosis
    JONATHAN M HIGGINS; Fiscal Year: 2010
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..