Claudio A Hetz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Stressing out the ER: a role of the unfolded protein response in prion-related disorders
    Claudio A Hetz
    Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA
    Curr Mol Med 6:37-43. 2006
  2. pmc Measurement of autophagy flux in the nervous system in vivo
    K Castillo
    1 Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile 2 Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Cell Death Dis 4:e917. 2013
  3. pmc Autophagy impairment: a crossroad between neurodegeneration and tauopathies
    Melissa Nassif
    Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile
    BMC Biol 10:78. 2012
  4. doi The unfolded protein response: controlling cell fate decisions under ER stress and beyond
    Claudio Hetz
    Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, P O BOX 70086, Chile
    Nat Rev Mol Cell Biol 13:89-102. 2012
  5. ncbi Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
  6. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
  7. pmc Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
  8. ncbi The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Trends Cell Biol 18:38-44. 2008
  9. ncbi ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage
    Claudio A Hetz
    Department of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile and the FONDAP Center for Molecular Studies of the Cell CEMC, Santiago, Chile
    Antioxid Redox Signal 9:2345-55. 2007
  10. pmc Prion pathogenesis is independent of caspase-12
    Andrew D Steele
    Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, Massachusets Institute of Technology, Cambridge Massachusetts 02142, USA
    Prion 1:243-7. 2007

Collaborators

Detail Information

Publications13

  1. pmc Stressing out the ER: a role of the unfolded protein response in prion-related disorders
    Claudio A Hetz
    Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA
    Curr Mol Med 6:37-43. 2006
    ..These findings have applications for developing novel strategies for treatment and early diagnosis of transmissible spongiform encephalopathies and other neurodegenerative diseases...
  2. pmc Measurement of autophagy flux in the nervous system in vivo
    K Castillo
    1 Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile 2 Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Cell Death Dis 4:e917. 2013
    ..Using this approach we efficiently expressed a monomeric tandem mCherry-GFP-LC3 construct in neurons of the peripheral and central nervous system, allowing the measurement of autophagy activity in pharmacological and disease settings. ..
  3. pmc Autophagy impairment: a crossroad between neurodegeneration and tauopathies
    Melissa Nassif
    Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile
    BMC Biol 10:78. 2012
    ..We discuss the implications of this study for understanding the factors driving neurofibrillary tangle formation in Alzheimer's disease and tauopathies...
  4. doi The unfolded protein response: controlling cell fate decisions under ER stress and beyond
    Claudio Hetz
    Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, P O BOX 70086, Chile
    Nat Rev Mol Cell Biol 13:89-102. 2012
    ..In addition, novel physiological outcomes of the UPR that are not directly related to protein-folding stress, such as innate immunity, metabolism and cell differentiation, have been revealed...
  5. ncbi Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
    ..Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR...
  6. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
    ....
  7. pmc Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
    ....
  8. ncbi The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Trends Cell Biol 18:38-44. 2008
    ..Here, we describe the emerging concept that BCL-2-related proteins have alternative functions beyond apoptosis to control the essential functions of the cell...
  9. ncbi ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage
    Claudio A Hetz
    Department of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile and the FONDAP Center for Molecular Studies of the Cell CEMC, Santiago, Chile
    Antioxid Redox Signal 9:2345-55. 2007
    ..Thus, BCL-2-related proteins are not only the "death gateway" keepers, but they also have alternative functions in essential cellular processes...
  10. pmc Prion pathogenesis is independent of caspase-12
    Andrew D Steele
    Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, Massachusets Institute of Technology, Cambridge Massachusetts 02142, USA
    Prion 1:243-7. 2007
    ....
  11. pmc Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo
    Andrew D Steele
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:13022-7. 2007
    ..These results suggest that Bax and Bcl-2 mediated apoptotic pathways are not the major contributing factor to the clinical or pathological features of infectious prion disease...
  12. ncbi Emerging roles of the unfolded protein response signaling in physiology and disease
    Claudio A Hetz
    Curr Mol Med 6:1. 2006