Research Topics
Genomes and Genes
| C P HershSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Genetic associations with hypoxemia and pulmonary arterial pressure in COPDPeter J Castaldi
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Chest 135:737-44. 2009..We sought to identify genetic polymorphisms associated with these traits in a population of patients with severe COPD from the National Emphysema Treatment Trial (NETT)...- Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPDCraig P Hersh
Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
Respir Res 14:42. 2013..We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease... - The clinical features of the overlap between COPD and asthmaMegan Hardin
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Respir Res 12:127. 2011..The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma... - Epidemiology, radiology, and genetics of nicotine dependence in COPDDeog Kyeom Kim
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 12:9. 2011..This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers... 
Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
COPD 4:331-7. 2007..Using clinical chest CT scans, we were able to identify an airway-predominant subgroup with asthma-like features among subjects with severe, early-onset COPD...- Comprehensive testing of positionally cloned asthma genes in two populationsCraig P Hersh
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 176:849-57. 2007..Replication of gene-disease associations has become a requirement in complex trait genetics... - Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgeryCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 8:59. 2007..In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability... - Transforming growth factor-beta receptor-3 is associated with pulmonary emphysemaCraig P Hersh
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 41:324-31. 2009.... - Genetic linkage and association analysis of COPD-related traits on chromosome 8pCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
COPD 3:189-94. 2006..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1... - Interobserver variability in the determination of upper lobe-predominant emphysemaCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Chest 131:424-31. 2007..At many centers, radiologists and pulmonary physicians both review the images, but the agreement between readers from these specialties is not known... - Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunitiesCraig P Hersh
Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Pharmacogenomics 11:237-47. 2010..Currently, there are no clinical applications of pharmacogenetics to COPD therapy, but the use of pharmacogenetics to determine initial smoking cessation therapy may be closer to clinical application... - Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility geneCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 182:605-13. 2010..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q... - Genetic determinants of C-reactive protein in COPDC P Hersh
Channing Laboratory, Pulmonary Critical Care Division, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Eur Respir J 28:1156-62. 2006..Preliminary evidence suggests an association of the surfactant protein B gene with systemic inflammation in chronic obstructive pulmonary disease... - Genetic determinants of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Am Thorac Soc 3:476. 2006 - Genetic association analysis of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 173:977-84. 2006..This variation may reflect different COPD subtypes, which may have different genetic predispositions... - Family history is a risk factor for COPDCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Chest 140:343-50. 2011..Therefore, we sought to identify the effects of family history of smoking and family history of COPD on COPD susceptibility... - SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung developmentCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Respir Crit Care Med 183:1482-9. 2011..Chromosome 12p has been linked to chronic obstructive pulmonary disease (COPD) in the Boston Early-Onset COPD Study (BEOCOPD), but a susceptibility gene in that region has not been identified... - National Emphysema Treatment Trial state of the art: genetics of emphysemaCraig P Hersh
Channing Laboratory, Center for Genomic Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Am Thorac Soc 5:486-93. 2008.... - Polymorphic variation in surfactant protein B is associated with COPD exacerbationsM G Foreman
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Eur Respir J 32:938-44. 2008..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency... - Attempted replication of reported chronic obstructive pulmonary disease candidate gene associationsCraig P Hersh
Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 33:71-8. 2005..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs... - Genetic association analysis of COPD candidate genes with bronchodilator responsivenessWoo Jin Kim
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Respir Med 103:552-7. 2009..SNPs in SFTPB, TGFB1, and GSTP1 genes were not associated with BDR. In conclusion, a polymorphism of EPHX1 was associated with bronchodilator responsiveness phenotypes in subjects with severe COPD... - Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPDI C Sørheim
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
COPD 7:262-8. 2010..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies... - Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studiesP J Castaldi
Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
Thorax 66:903-9. 2011.... - MMP12, lung function, and COPD in high-risk populationsGary M Hunninghake
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 361:2599-608. 2009..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups... - Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa RicaCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Thorax 62:224-30. 2007..A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans... - Variants in FAM13A are associated with chronic obstructive pulmonary diseaseMichael H Cho
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 42:200-2. 2010..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)... - The COPD genetic association compendium: a comprehensive online database of COPD genetic associationsPeter J Castaldi
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Hum Mol Genet 19:526-34. 2010..Quantitative meta-analysis identified four variants in GSTM1, TGFB1, TNF and SOD3 that show statistically significant evidence of association with COPD susceptibility... - Clinical determinants of exacerbations in severe, early-onset COPDM G Foreman
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Eur Respir J 30:1124-30. 2007..The familial aggregation of exacerbations suggests a genetic basis for susceptibility to chronic obstructive pulmonary disease exacerbations... - The protease inhibitor PI*S allele and COPD: a meta-analysisM Dahl
Dept of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
Eur Respir J 26:67-76. 2005..In conclusion, the results show that the PI SZ genotype is a significant risk factor for chronic obstructive pulmonary disease. The risk of chronic obstructive pulmonary disease due to the PI MS genotype is not substantially elevated... - Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa RicaJuan C Celedon
Channing Laboratory, Department of Medicine and Respiratory Disorders Program, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Hum Genet 120:691-9. 2007..Our results suggest that chromosome 12q24.31 contains a locus (or loci) that influence a critical intermediate phenotype of asthma (airway responsiveness) in Costa Ricans... - Genetic determinants of emphysema distribution in the national emphysema treatment trialDawn L DeMeo
Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 176:42-8. 2007.... - Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary diseaseMichael H Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 40:751-5. 2009..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD... - A novel instrument for the evaluation of the pleural space: an experience in 34 patientsArmin Ernst
Divisions of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Chest 122:1530-4. 2002..To test a novel semirigid pleuroscope to be used by pulmonologists for the diagnosis and treatment of pleural diseases... - Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD)Emily S Wan
Channing Laboratory, Boston, MA 02115, USA
Respir Med 105:588-94. 2011..We undertook a study to determine the clinical factors associated with "frequent exacerbator" status within a population of subjects with severe COPD... - Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysisC P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harcard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Thorax 59:843-9. 2004..The risk of COPD in PI MZ heterozygous individuals is controversial... - Predictors of survival in severe, early onset COPDCraig P Hersh
Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Chest 126:1443-51. 2004..CONCLUSION: In this cohort, recent smoking status predicted increased mortality independent of the effects of lifetime smoking intensity. Smoking cessation may confer a survival benefit even among patients with very severe COPD...