C P Hersh

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genetic associations with hypoxemia and pulmonary arterial pressure in COPD
    Peter J Castaldi
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 135:737-44. 2009
  2. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
  3. pmc The clinical features of the overlap between COPD and asthma
    Megan Hardin
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Res 12:127. 2011
  4. pmc Epidemiology, radiology, and genetics of nicotine dependence in COPD
    Deog Kyeom Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 12:9. 2011
  5. ncbi Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    COPD 4:331-7. 2007
  6. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
  7. pmc Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 8:59. 2007
  8. pmc Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 41:324-31. 2009
  9. ncbi Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
  10. ncbi Interobserver variability in the determination of upper lobe-predominant emphysema
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 131:424-31. 2007

Detail Information

Publications36

  1. pmc Genetic associations with hypoxemia and pulmonary arterial pressure in COPD
    Peter J Castaldi
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 135:737-44. 2009
    ..We sought to identify genetic polymorphisms associated with these traits in a population of patients with severe COPD from the National Emphysema Treatment Trial (NETT)...
  2. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
    ..We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease...
  3. pmc The clinical features of the overlap between COPD and asthma
    Megan Hardin
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Res 12:127. 2011
    ..The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma...
  4. pmc Epidemiology, radiology, and genetics of nicotine dependence in COPD
    Deog Kyeom Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 12:9. 2011
    ..This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers...
  5. ncbi Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    COPD 4:331-7. 2007
    ..Using clinical chest CT scans, we were able to identify an airway-predominant subgroup with asthma-like features among subjects with severe, early-onset COPD...
  6. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
    ..Replication of gene-disease associations has become a requirement in complex trait genetics...
  7. pmc Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 8:59. 2007
    ..In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability...
  8. pmc Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 41:324-31. 2009
    ....
  9. ncbi Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
    ..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1...
  10. ncbi Interobserver variability in the determination of upper lobe-predominant emphysema
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 131:424-31. 2007
    ..At many centers, radiologists and pulmonary physicians both review the images, but the agreement between readers from these specialties is not known...
  11. pmc Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities
    Craig P Hersh
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Pharmacogenomics 11:237-47. 2010
    ..Currently, there are no clinical applications of pharmacogenetics to COPD therapy, but the use of pharmacogenetics to determine initial smoking cessation therapy may be closer to clinical application...
  12. pmc Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 182:605-13. 2010
    ..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q...
  13. ncbi Genetic determinants of C-reactive protein in COPD
    C P Hersh
    Channing Laboratory, Pulmonary Critical Care Division, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 28:1156-62. 2006
    ..Preliminary evidence suggests an association of the surfactant protein B gene with systemic inflammation in chronic obstructive pulmonary disease...
  14. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  15. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  16. pmc Family history is a risk factor for COPD
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 140:343-50. 2011
    ..Therefore, we sought to identify the effects of family history of smoking and family history of COPD on COPD susceptibility...
  17. pmc SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 183:1482-9. 2011
    ..Chromosome 12p has been linked to chronic obstructive pulmonary disease (COPD) in the Boston Early-Onset COPD Study (BEOCOPD), but a susceptibility gene in that region has not been identified...
  18. pmc National Emphysema Treatment Trial state of the art: genetics of emphysema
    Craig P Hersh
    Channing Laboratory, Center for Genomic Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:486-93. 2008
    ....
  19. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
    ..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency...
  20. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs...
  21. pmc Genetic association analysis of COPD candidate genes with bronchodilator responsiveness
    Woo Jin Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Med 103:552-7. 2009
    ..SNPs in SFTPB, TGFB1, and GSTP1 genes were not associated with BDR. In conclusion, a polymorphism of EPHX1 was associated with bronchodilator responsiveness phenotypes in subjects with severe COPD...
  22. pmc Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD
    I C Sørheim
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    COPD 7:262-8. 2010
    ..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies...
  23. pmc Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies
    P J Castaldi
    Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Thorax 66:903-9. 2011
    ....
  24. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  25. pmc Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Thorax 62:224-30. 2007
    ..A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans...
  26. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  27. pmc The COPD genetic association compendium: a comprehensive online database of COPD genetic associations
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Hum Mol Genet 19:526-34. 2010
    ..Quantitative meta-analysis identified four variants in GSTM1, TGFB1, TNF and SOD3 that show statistically significant evidence of association with COPD susceptibility...
  28. ncbi Clinical determinants of exacerbations in severe, early-onset COPD
    M G Foreman
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 30:1124-30. 2007
    ..The familial aggregation of exacerbations suggests a genetic basis for susceptibility to chronic obstructive pulmonary disease exacerbations...
  29. ncbi The protease inhibitor PI*S allele and COPD: a meta-analysis
    M Dahl
    Dept of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Eur Respir J 26:67-76. 2005
    ..In conclusion, the results show that the PI SZ genotype is a significant risk factor for chronic obstructive pulmonary disease. The risk of chronic obstructive pulmonary disease due to the PI MS genotype is not substantially elevated...
  30. ncbi Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica
    Juan C Celedon
    Channing Laboratory, Department of Medicine and Respiratory Disorders Program, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 120:691-9. 2007
    ..Our results suggest that chromosome 12q24.31 contains a locus (or loci) that influence a critical intermediate phenotype of asthma (airway responsiveness) in Costa Ricans...
  31. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  32. pmc Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 40:751-5. 2009
    ..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD...
  33. ncbi A novel instrument for the evaluation of the pleural space: an experience in 34 patients
    Armin Ernst
    Divisions of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Chest 122:1530-4. 2002
    ..To test a novel semirigid pleuroscope to be used by pulmonologists for the diagnosis and treatment of pleural diseases...
  34. pmc Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD)
    Emily S Wan
    Channing Laboratory, Boston, MA 02115, USA
    Respir Med 105:588-94. 2011
    ..We undertook a study to determine the clinical factors associated with "frequent exacerbator" status within a population of subjects with severe COPD...
  35. pmc Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis
    C P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harcard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Thorax 59:843-9. 2004
    ..The risk of COPD in PI MZ heterozygous individuals is controversial...
  36. ncbi Predictors of survival in severe, early onset COPD
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 126:1443-51. 2004
    ..The purpose of this study was to determine the mortality rate and predictors of survival in subjects with severe, early onset COPD...