S Hernandez-Diaz

..To assess the safety of the newer antiepileptic drugs (AEDs) during pregnancy...

..However, the potential dose effect of insulin overall, and insulin glargine in particular, on colon and breast cancer deserves further attention...

..Underappreciated sources of exposure include phthalates in the polymers coating some oral medications...

..Taken together, these two approaches can facilitate discussion of underlying biological mechanisms...

..Later analyses have also included the effect of patterns of NSAID use, risk factors for UGIB, and modifiers of NSAID effect...

..34) for aspirin. In conclusion, prescription of non-aspirin NSAIDs for at least 1 year might be associated with a slightly reduced risk of lung cancer. Aspirin was not associated with a risk reduction, perhaps due to residual confounding...

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..An appropriate justification for conditioning on birth weight requires specifying 1) the causal question motivating this analytical approach and 2) the assumptions regarding the proposed underlying biologic mechanisms...

..There was a suggestion of a small increased risk with ibuprofen. Also, data suggest a small reduced risk for naproxen present only in non-users of aspirin, mainly people free of clinically apparent vascular disease...

..0) and 12.7 (95% CI: 6.2, 26.1), compared with users of none. Whenever possible, antiinflammatory drugs should be given in monotherapy and at the lowest effective dose in order to reduce the risk of upper gastrointestinal complications...

..Few studies have examined the incidence of uncomplicated peptic ulcer or the trends in factors affecting its incidence...

..It is also unknown whether the fetal genotype is relevant, or whether folic acid supplementation modifies this association...

..Because folate intake can reduce homocysteine levels, we investigated the association between dietary folate intake and nonfatal myocardial infarction...

..The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial...

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..Asthma is among the most common serious medical problems in pregnancy, and its prevalence may be increasing. Management is problematic because asthma may harm the fetus, yet little is known about fetal risks of asthma medications...

..64; 95% CI = 1.24 to 2.18). The methods described here are also applicable to observational studies with time-varying treatments...

..We furthermore show these tests for mechanistic interaction can be extended to scenarios in which the genetic and environmental factors are negatively associated in the population rather than independent...

..The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes...

..We assessed the PPV of diagnosis codes in THIN, a primary-care medical-record database, to ascertain individuals with uncomplicated PU, and to identify UGIC and Helicobacter pylori infection status (HPIS) among these patients...

..65 (95% confidence interval: 0.46, 0.94) should be used because the adjusted odds ratio is invalid. Causal diagrams are used to encode qualitative a priori subject matter knowledge...

..The purpose of this study was to assess the effects of treatment with selective serotonin reuptake inhibitors (SSRIs) on the risks of gestational hypertension and preeclampsia...

..Current evidence is insufficient to support or refute a carcinogenic effect of antibiotics...

..To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS)...

..However, the sensitivity of this algorithm is lower for preterm deliveries, suggesting limited validity to assess drug safety for pregnancy outcomes associated with prematurity...

..To evaluate the effect of antidepressant use on lung cancer risk...

..This classification also leads to a unified approach to adjust for selection bias...

..To summarize current evidence on statin use and fracture risk and to explore potential sources of heterogeneity among study results...

..We used case-crossover, case-time-control, and bidirectional case-crossover designs to supplement findings from a case-control study of maternal smoking and oral clefts among offspring in a large birth registry...

..The purpose of this study was to describe recent trends in folic acid awareness and use in the periconceptional period among pregnant women in relation to maternal sociodemographic and other relevant factors...

..To investigate the association between infertility treatments and gestational hypertension and preeclampsia...

..Together with selected demographic characteristics that differentiate early- vs. late-onset NVP, these findings warrant further investigation...

..9 (95% CI: 1.2, 7.2), but it requires controls. In the presence of gestational time trends of exposure, the new designs do not offer clear advantages over the case-control design...

..To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies...

..We performed a case-control study to determine possible antenatal and perinatal predictors of persistent pulmonary hypertension of the newborn...

..We describe the patterns of over-the-counter medication use among pregnant women...

..TA extracellular BPI, LBP, and sCD14 were positively correlated. TAs from intubated neonates demonstrate endotoxin accumulation and mobilization of endotoxin-directed innate immunity, potentially contributing to pulmonary inflammation...

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..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..

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