John Hennen

Summary

Affiliation: Harvard Medical School
Country: USA

Publications

  1. ncbi request reprint Statistical methods for longitudinal research on bipolar disorders
    John Hennen
    Consolidated Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 5:156-68. 2003
  2. ncbi request reprint Weight gain during treatment of bipolar I patients with olanzapine
    John Hennen
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 65:1679-87. 2004
  3. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
  4. ncbi request reprint Prediction of the 10-year course of borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:827-32. 2006
  5. ncbi request reprint Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study
    Marc J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:534-9. 2003
  6. ncbi request reprint Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission
    Mary C Zanarini
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 161:2108-14. 2004
  7. ncbi request reprint Suicidal events and accidents in 216 first-episode bipolar I disorder patients: predictive factors
    Hari Mandir Kaur Khalsa
    Department of Psychiatry, Harvard Medical School, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
    J Affect Disord 106:179-84. 2008
  8. doi request reprint Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients
    Christopher Baethge
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 10:738-41. 2008
  9. ncbi request reprint Sexual relationship difficulties among borderline patients and axis II comparison subjects
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Nerv Ment Dis 191:479-82. 2003
  10. ncbi request reprint Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment
    Chris C Streeter
    Division of Psychiatry, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA
    Psychopharmacology (Berl) 182:516-26. 2005

Detail Information

Publications68

  1. ncbi request reprint Statistical methods for longitudinal research on bipolar disorders
    John Hennen
    Consolidated Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 5:156-68. 2003
    ..Longitudinal studies involving relatively large samples, with outcome measures obtained repeatedly over-time, are required. In this report, statistical methods appropriate for such research are reviewed...
  2. ncbi request reprint Weight gain during treatment of bipolar I patients with olanzapine
    John Hennen
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 65:1679-87. 2004
    ..Body weight increase during long-term treatment with olanzapine in schizophrenia patients is well documented, but weight gain and its association with other medical measures are less well evaluated in bipolar disorder patients...
  3. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  4. ncbi request reprint Prediction of the 10-year course of borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:827-32. 2006
    ..The purpose of this study was to determine the most clinically relevant baseline predictors of time to remission for patients with borderline personality disorder...
  5. ncbi request reprint Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study
    Marc J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:534-9. 2003
    ..31, p =.021). Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function...
  6. ncbi request reprint Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission
    Mary C Zanarini
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 161:2108-14. 2004
    ..The purpose of this study was to assess the prevalence of axis I disorders among patients with borderline personality disorder over 6 years of prospective follow-up...
  7. ncbi request reprint Suicidal events and accidents in 216 first-episode bipolar I disorder patients: predictive factors
    Hari Mandir Kaur Khalsa
    Department of Psychiatry, Harvard Medical School, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
    J Affect Disord 106:179-84. 2008
    ..Risks of life-threatening behaviors are high among bipolar disorder (BPD) patients, but early rates and associated risk factors for suicides and accidents remain ill-defined...
  8. doi request reprint Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients
    Christopher Baethge
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 10:738-41. 2008
    ..Since bipolar disorder (BPD) patients have high rates of comorbid substance abuse, and the temporal relationships involved are unclear, we evaluated the sequencing of specific substance use and affective morbidity...
  9. ncbi request reprint Sexual relationship difficulties among borderline patients and axis II comparison subjects
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Nerv Ment Dis 191:479-82. 2003
  10. ncbi request reprint Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment
    Chris C Streeter
    Division of Psychiatry, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA
    Psychopharmacology (Berl) 182:516-26. 2005
    ..There is evidence that prefrontal lobe GABA levels are low in cocaine-dependent (CD) individuals, and treatment with GABA agonists decreases cocaine self-administration...
  11. ncbi request reprint Substance abuse in first-episode bipolar I disorder: indications for early intervention
    Christopher Baethge
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 162:1008-10. 2005
    ..This study clarified the early characteristics of substance use disorders in patients with first-episode bipolar I disorder...
  12. ncbi request reprint Adult experiences of abuse reported by borderline patients and Axis II comparison subjects over six years of prospective follow-up
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Nerv Ment Dis 193:412-6. 2005
    ..They also suggest that adult experiences of abuse are strongly associated with a failure to remit from borderline personality disorder...
  13. ncbi request reprint The McLean Study of Adult Development (MSAD): overview and implications of the first six years of prospective follow-up
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, USA
    J Pers Disord 19:505-23. 2005
    ..Taken together, these results suggest that the prognosis for BPD is better than previously recognized...
  14. ncbi request reprint Assessing the utility of atypical antipsychotic medication in adults with mild mental retardation and comorbid psychiatric disorders
    Karen J Shedlack
    Developmental Disabilities Program, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 66:52-62. 2005
    ....
  15. ncbi request reprint Double-blind, placebo-controlled, multicenter trial of selegiline augmentation of antipsychotic medication to treat negative symptoms in outpatients with schizophrenia
    J Alexander Bodkin
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Am J Psychiatry 162:388-90. 2005
    ..The authors' goal was to test the efficacy of selegiline augmentation of antipsychotic medication in outpatients with schizophrenia who had negative symptoms of moderate or greater severity...
  16. ncbi request reprint Olanzapine versus placebo in acute mania: treatment responses in subgroups
    Ross J Baldessarini
    International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 23:370-6. 2003
    ..5-1.7, all P < 0.01). These well-powered comparisons of subgroups of interest indicate broad efficacy of olanzapine in the treatment of acute mania...
  17. ncbi request reprint Psychosocial functioning of borderline patients and axis II comparison subjects followed prospectively for six years
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 19:19-29. 2005
    ..27% at 6 year follow-up). Taken together, the results of this study suggest that psychosocial improvement is both common among borderline patients and strongly related to their symptomatic status...
  18. ncbi request reprint Use of combinations of antipsychotics: McLean Hospital inpatients, 2002
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA 02478 9106, USA
    Hum Psychopharmacol 20:485-92. 2005
    ..Such treatment was evaluated in hospitalized psychiatric patients...
  19. ncbi request reprint Reported childhood onset of self-mutilation among borderline patients
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 20:9-15. 2006
    ..The results of this study suggest that a sizable minority of borderline patients first engage in self-harm as children and that the course of their self-mutilation may be particularly malignant...
  20. ncbi request reprint Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatr Serv 58:85-91. 2007
    ..A growing number of psychotropic drugs are used to treat bipolar disorder, often off-label and in untested, complex combinations...
  21. ncbi request reprint Long-term combination therapy versus monotherapy with lithium and carbamazepine in 46 bipolar I patients
    Christopher Baethge
    Department of Psychiatry, Harvard Medical School, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 66:174-82. 2005
    ..These trials suggest added benefit of combination treatment over use of either agent alone but also indicate the need for further studies...
  22. ncbi request reprint The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology of borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, MA, USA
    Am J Psychiatry 160:274-83. 2003
    ..The syndromal and subsyndromal phenomenology of borderline personality disorder was tracked over 6 years of prospective follow-up...
  23. ncbi request reprint A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women
    D Bradford Reich
    Trauma and Dissociative Disorders Program, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 65:1601-6. 2004
    ..This study evaluated the effectiveness of risperidone in women for the treatment of posttraumatic stress disorder (PTSD) related to childhood physical, sexual, verbal, and emotional abuse...
  24. ncbi request reprint A screening measure for BPD: the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD)
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 17:568-73. 2003
    ..93 at a cutoff of 7 for the 63 subjects who were 25 years old or younger. The results of this study suggest that the MSI-BPD may be a useful screening instrument for the presence of DSM-IV borderline personality disorder...
  25. ncbi request reprint A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study
    Michael E Henry
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1576-83. 2005
    ....
  26. ncbi request reprint A comparison of the Aberrant Behavior Checklist and the GAF among adults with mental retardation and mental illness
    Karen J Shedlack
    McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Psychiatr Serv 56:484-6. 2005
    ..The ABC provided a more useful measure of treatment response than the GAF in this patient population...
  27. ncbi request reprint Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 123:87-100. 2003
    ....
  28. ncbi request reprint Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review
    Ross J Baldessarini
    International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:625-39. 2006
    ..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment...
  29. ncbi request reprint Clinical outcome in patients with bipolar I disorder, obsessive compulsive disorder or both
    Franca Centorrino
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont 02478, and Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    Hum Psychopharmacol 21:189-93. 2006
    ..Bipolar disorder (BPD) is often comorbid with obsessive-compulsive (OCD) and other anxiety disorders, but the impact of such comorbidity on long-term outcome has not been evaluated systematically...
  30. ncbi request reprint Mental health service utilization by borderline personality disorder patients and Axis II comparison subjects followed prospectively for 6 years
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 65:28-36. 2004
    ..The purpose of this study was to describe the psychiatric treatment received by a well-defined sample of patients with borderline personality disorder and Axis II comparison subjects over 6 years of prospective follow-up...
  31. ncbi request reprint Lithium treatment and suicide risk in major affective disorders: update and new findings
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 64:44-52. 2003
    ..An exception is growing evidence for such suicidal risk reduction with long-term lithium maintenance. This report updates and extends analyses of lithium treatment and suicides and attempts...
  32. ncbi request reprint Manual assisted cognitive treatment for deliberate self-harm in borderline personality disorder patients
    Igor Weinberg
    McLean Hospital, Harvard Medical School, Boston, USA
    J Pers Disord 20:482-92. 2006
    ..In contrast, MACT did not affect the level of suicide ideation and time-to-repeat of DSH. In conclusion, MACT seems to be a promising intervention for DSH in patients with BPD. More definitive studies are needed...
  33. ncbi request reprint Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 17:233-42. 2003
    ..Taken together, the results of this study suggest that the ZAN-BPD is a promising clinician-administered scale for the assessment of change in borderline psychopathology over time...
  34. ncbi request reprint Low-field magnetic stimulation in bipolar depression using an MRI-based stimulator
    Michael Rohan
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 161:93-8. 2004
    ..This study evaluated possible mood improvement associated with this procedure...
  35. ncbi request reprint Borderline psychopathology in the first-degree relatives of borderline and axis II comparison probands
    Mary C Zanarini
    The Laboratory for the Study for Adult Development, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    J Pers Disord 18:439-47. 2004
    ..Taken together, the results of this study suggest that the subsyndromal phenomenology of BPD may be more common than the borderline diagnosis itself...
  36. ncbi request reprint Greater depression severity in elderly patients with memory complaints is associated with decreased left temporal-parietal dominance indicated by dynamic susceptibility contrast magnetic resonance imaging cerebral blood volume measures
    Helen H Kyomen
    Division on Aging, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Geriatr Psychiatry 15:604-10. 2007
    ..To assess the relationships among depressive signs and symptoms and left versus right temporal-parietal cerebral blood volumes (CBVs) in elderly patients with a primary complaint of memory loss...
  37. ncbi request reprint Birth outcomes following prenatal exposure to antidepressants
    Kimberly H Pearson
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 68:1284-9. 2007
    ..Antidepressant use during pregnancy and the peripartum period is common despite the absence of clear evidence-based guidelines to direct clinical use of these compounds...
  38. ncbi request reprint Adherence to pharmacotherapy in bipolar disorder patients with and without co-occurring substance use disorders
    Sumita G Manwani
    Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA, USA
    J Clin Psychiatry 68:1172-6. 2007
    ..To examine patterns of adherence to mood stabilizers and reasons for nonadherence in patients with bipolar disorder, with and without substance use disorder (SUD)...
  39. ncbi request reprint Hypersexual desire in males: are males with paraphilias different from males with paraphilia-related disorders?
    Martin P Kafka
    McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Sex Abuse 15:307-21. 2003
    ....
  40. ncbi request reprint A DSM-IV Axis I comorbidity study of males (n = 120) with paraphilias and paraphilia-related disorders
    Martin P Kafka
    Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Sex Abuse 14:349-66. 2002
    ..The prevalence of any ADHD in the sex offender paraphiliacs was 43.3%, and nearly 25% of offenders were diagnosed with ADHD-combined subtype...
  41. ncbi request reprint Suicidal risk during treatment with clozapine: a meta-analysis
    John Hennen
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Schizophr Res 73:139-45. 2005
    ..Evidence of reduced suicidal risk with available psychiatric treatments is limited, but emerging data suggest such an effect of clozapine in chronically psychotic patients, leading us to compile the reported evidence...
  42. ncbi request reprint Treatment-latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disorders
    Ross J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Bipolar Disord 5:169-79. 2003
    ..To clarify relationships of treatment delay and pretreatment episode count with pretreatment morbidity and responses to maintenance treatments in bipolar disorders...
  43. ncbi request reprint Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine
    Donald C Goff
    Schizophrenia Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 51:493-7. 2002
    ..Recent evidence suggests that effects upon glutamatergic transmission may contribute to the therapeutic action of certain atypical antipsychotic agents...
  44. ncbi request reprint Multiple versus single antipsychotic agents for hospitalized psychiatric patients: case-control study of risks versus benefits
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and Bipolar and Psychotic Disorders Clinic, McLean Hospital, Boston, MA USA
    Am J Psychiatry 161:700-6. 2004
    ....
  45. ncbi request reprint Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
    Gail Musen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes 55:326-33. 2006
    ..Our study represents the first comprehensive study of gray matter density changes in type 1 diabetes and suggests that persistent hyperglycemia and acute severe hypoglycemia have an impact on brain structure...
  46. ncbi request reprint Cerebral blood volume and clinical changes on the third day of placebo substitution for SSRI treatment
    Michael E Henry
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 53:100-5. 2003
    ..We hypothesized that brain regions implicated in depression, with extensive serotonergic innervation, would exhibit changes in activity associated with emergence of symptoms following drug discontinuation...
  47. ncbi request reprint Is lithium still worth using? An update of selected recent research
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Harv Rev Psychiatry 10:59-75. 2002
    ....
  48. ncbi request reprint Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study
    Yong Ke
    Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychiatry Res 130:283-93. 2004
    ..However, cocaine-dependent subjects without an alcohol disorder (N=12) also had lower GABA levels (1.04 mM/kg) than the comparison subjects (t [d.f.=30]=2.09, P=0.045), suggesting that cocaine dependence alone can decrease GABA levels...
  49. ncbi request reprint Smaller frontal lobe white matter volumes in depressed adolescents
    Ronald J Steingard
    Department of Psychiatry, University of Massachusetts Medical School RJS, ML, DFC, THA, Worcester, Massachusetts, USA
    Biol Psychiatry 52:413-7. 2002
    ..Prior studies have demonstrated reduced frontal lobe volumes in depressed adolescents. In this study, frontal lobe gray and white matter volumes in adolescents with major depressive disorder were evaluated...
  50. ncbi request reprint Genetics of suicide: an overview
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    Harv Rev Psychiatry 12:1-13. 2004
    ....
  51. ncbi request reprint Evaluation of the adequacy of outpatient antidepressant treatment
    Jeffrey B Weilburg
    Department of Psychiatry, Massachusetts General Hospital, Wang Ambulatory Care Center, Room 815, 55 Fruit Street, Boston, MA 02144, USA
    Psychiatr Serv 54:1233-9. 2003
    ..This study assessed the rates and determinants of the adequacy of antidepressant treatment among all outpatients who receive antidepressants...
  52. ncbi request reprint EEG abnormalities during treatment with typical and atypical antipsychotics
    Franca Centorrino
    Bipolar and Psychotic Disorder Program, McLean Hospital, MA 02478, USA
    Am J Psychiatry 159:109-15. 2002
    ..Much less is known about EEG effects of newer antipsychotics. The present study therefore examined the risk of EEG abnormalities associated with various antipsychotic drugs...
  53. ncbi request reprint Severity of reported childhood sexual abuse and its relationship to severity of borderline psychopathology and psychosocial impairment among borderline inpatients
    Mary C Zanarini
    The Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Nerv Ment Dis 190:381-7. 2002
    ....
  54. ncbi request reprint Estrogen therapy and noncognitive psychiatric signs and symptoms in elderly patients with dementia
    Helen H Kyomen
    McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Am J Psychiatry 159:1225-7. 2002
    ..This study investigated the efficacy and safety of short-term estrogen therapy in decreasing noncognitive signs and symptoms of dementia in demented elderly patients...
  55. ncbi request reprint Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care
    Hadine Joffe
    Perinatal and Reproductive Psychiatry Program, Reproductive Endocrine Unit, and Medical Service, Massachusetts General Hospital, Boston, MA, USA
    Menopause 9:392-8. 2002
    ..To compare the relationship between vasomotor symptoms (hot flushes and night sweats) and depression in perimenopausal women with that in postmenopausal and older premenopausal women...
  56. ncbi request reprint An ongoing study of group treatment for men involved in problematic Internet-enabled sexual behavior
    Maressa Hecht Orzack
    Computer Addiction Study Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Cyberpsychol Behav 9:348-60. 2006
    ..It is clear from this report that more attention must be focused on the treatment of problematic IESB, as opposed to exploratory studies...
  57. pmc Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder
    Melissa Frumin
    Consolidated Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System Brockton Division, 02301, USA
    Am J Psychiatry 159:866-8. 2002
    ..Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality...
  58. pmc Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3)
    John J Mooney
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 42:605-11. 2008
    ..Inhibition of the extraneuronal monoamine transporter may be an important component in the clinical pharmacology of the norepinephrine reuptake inhibitor antidepressant drugs, such as desipramine...
  59. ncbi request reprint Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline
    Blaise deB Frederick
    MacLean Hospital Brain Imaging Center, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 10:81-8. 2002
    ..Specifically, increased levels of cytosolic choline, a precursor pool for acetylcholine synthesis, were associated with greater progression in memory impairment during treatment...
  60. ncbi request reprint Recovery and functional outcomes following olanzapine treatment for bipolar I mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Bipolar Disord 7:68-76. 2005
    ..Typical experimental categorizations of treatment responses in bipolar disorder (BPD) patients may have limited relationship to clinical recovery or functional status, and there is inadequate research on such clinically important outcomes...
  61. ncbi request reprint The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence
    Mauricio Tohen
    Lilly Research Laboratories, Brougher Building, 525 South Meridian, Indianapolis, IN 46225, USA
    Am J Psychiatry 160:2099-107. 2003
    ..Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new illness onset following first hospitalization for mania...
  62. ncbi request reprint Factors associated with parent-reported suicide threats by children and adolescents with community-diagnosed bipolar disorder
    Demitri Papolos
    The Juvenile Bipolar Research Foundation, 550 Ridgewood Road, Maplewood, NJ 07040, USA
    J Affect Disord 86:267-75. 2005
    ..Aggression, impulsivity and risk-taking behaviors may be strong indicators of suicidality in children and adolescents with symptoms of bipolar disorder...
  63. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data
    Eduard Vieta
    Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 65:1420-8. 2004
    ..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine...
  64. ncbi request reprint The child bipolar questionnaire: a dimensional approach to screening for pediatric bipolar disorder
    Demitri Papolos
    The Juvenile Bipolar Research Foundation, USA
    J Affect Disord 95:149-58. 2006
    ..This report provides preliminary data on the reliability and validity of the CBQ...
  65. ncbi request reprint Obsessive fears about harm to self or others and overt aggressive behaviors in youth diagnosed with juvenile-onset bipolar disorder
    Demitri Papolos
    Juvenile Bipolar Research Foundation, 550 Ridgewood Rd, Maplewood, NJ 07040, United States
    J Affect Disord 89:99-105. 2005
    ..Obsessive fear-of-harm, either fear of doing harm or fear of harm coming to self, may be closely associated with aggressive behaviors in juvenile-onset bipolar disorder...
  66. ncbi request reprint Mild traumatic brain injury in psychiatric inpatients
    Magdalena A Mateo
    School of Nursing at Northeastern University, USA
    J Neurosci Nurs 37:28-33. 2005
    ..Data from this study suggest that psychiatric inpatients with a history of MTBI may differ in frequency and length of hospitalization from otherwise similar inpatients without MTBI history...
  67. ncbi request reprint Risk of mania with antidepressants
    Ross J Baldessarini
    Arch Pediatr Adolesc Med 159:298; author reply 298-9. 2005
  68. ncbi request reprint A strategy for identifying phenotypic subtypes: concordance of symptom dimensions between sibling pairs who met screening criteria for a genetic linkage study of childhood-onset bipolar disorder using the Child Bipolar Questionnaire
    Demitri Papolos
    The Juvenile Bipolar Research Foundation, Research Department, 550 Ridgewood Road, Maplewood, NJ 07040, USA
    J Affect Disord 99:27-36. 2007
    ..This report presents data on the potential usefulness of these dimensions in genotyping...