MARTIN HEMLER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance
    I Tachibana
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 146:893-904. 1999
  2. ncbi Structural organization and interactions of transmembrane domains in tetraspanin proteins
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Struct Biol 5:11. 2005
  3. ncbi Integrin associated proteins
    M E Hemler
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Cell Biol 10:578-85. 1998
  4. ncbi Tetraspanin functions and associated microdomains
    Martin E Hemler
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 6:801-11. 2005
  5. ncbi Targeting of tetraspanin proteins--potential benefits and strategies
    Martin E Hemler
    Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachussetts 02115, USA
    Nat Rev Drug Discov 7:747-58. 2008
  6. ncbi Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain
    Martin E Hemler
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 19:397-422. 2003
  7. ncbi Beta1 integrins show specific association with CD98 protein in low density membranes
    T V Kolesnikova
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    BMC Biochem 2:10. 2001
  8. ncbi Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts
    C Claas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7974-84. 2001
  9. ncbi Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins
    X A Zhang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:25005-13. 2001
  10. ncbi FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein
    C S Stipp
    Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:4853-62. 2001

Research Grants

  1. Investigation of integrin alpha6beta4 microdomain functions
    MARTIN HEMLER; Fiscal Year: 2007
  2. Characterization of tetraspanin-EWI protein complexes and functions
    Martin E Hemler; Fiscal Year: 2010
  3. TRANSMEMBRANE LINKER FUNCTIONS OF TM4SF PROTEINS
    MARTIN HEMLER; Fiscal Year: 2003
  4. INSIDE/OUT REGULATION OF BETA 1 INTEGRIN FUNCTION
    MARTIN HEMLER; Fiscal Year: 2003
  5. FASEB Summer Conference--Advance in Tetraspanin Research
    MARTIN HEMLER; Fiscal Year: 2002
  6. Alpha6 integrin complexes and tumor progression
    Martin E Hemler; Fiscal Year: 2010
  7. Characterization of tetraspanin-EWI protein complexes and functions
    MARTIN HEMLER; Fiscal Year: 2009
  8. Linker functions for tetraspanins CD9 and CD81
    MARTIN HEMLER; Fiscal Year: 2007
  9. Interactions of CD147 Involved in MMP Induction
    MARTIN HEMLER; Fiscal Year: 2007
  10. INTERACTIONS BETWEEN TM4SF PROTEINS AND INTEGRINS
    MARTIN HEMLER; Fiscal Year: 1999

Collaborators

Detail Information

Publications60

  1. ncbi Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance
    I Tachibana
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 146:893-904. 1999
    ..In summary, TM4SF proteins such as CD9 and CD81 appear to promote muscle cell fusion and support myotube maintenance...
  2. ncbi Structural organization and interactions of transmembrane domains in tetraspanin proteins
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Struct Biol 5:11. 2005
    ..While structure and function analysis of the larger extracellular loop has been performed, the organization and role of transmembrane domains have not been systematically assessed...
  3. ncbi Integrin associated proteins
    M E Hemler
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Cell Biol 10:578-85. 1998
    ..New evidence suggests that TM4SF proteins may act as linkers between extracellular integrin alpha chain domains and intracellular signaling molecules, such as phosphatidylinositol 4-kinase and protein kinase C...
  4. ncbi Tetraspanin functions and associated microdomains
    Martin E Hemler
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 6:801-11. 2005
    ..These new findings provide a framework for better understanding of these mysterious molecules in the regulation of cellular processes, from signalling to motility...
  5. ncbi Targeting of tetraspanin proteins--potential benefits and strategies
    Martin E Hemler
    Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachussetts 02115, USA
    Nat Rev Drug Discov 7:747-58. 2008
    ..An abundance of recent evidence suggests that targeting tetraspanins, for example, by monoclonal antibodies, soluble large-loop proteins or RNAi technology, should be therapeutically beneficial...
  6. ncbi Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain
    Martin E Hemler
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 19:397-422. 2003
    ..Finally, the enrichment of tetraspanins within secreted vesicles called exosomes, coupled with hints that tetraspanins may regulate vesicle fusion and/or fission, suggests exciting new directions for future research...
  7. ncbi Beta1 integrins show specific association with CD98 protein in low density membranes
    T V Kolesnikova
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    BMC Biochem 2:10. 2001
    ..Several lines of evidence suggest its functional interaction with integrins but the biochemical basis for this interaction has been unclear...
  8. ncbi Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts
    C Claas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7974-84. 2001
    ....
  9. ncbi Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins
    X A Zhang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:25005-13. 2001
    ....
  10. ncbi FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein
    C S Stipp
    Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:4853-62. 2001
    ..In conclusion, our data affirm the existence of distinct TM4SF complexes with unique compositions and specifically characterize FPRP as the most robust, highly stoichiometric CD81- and/or CD9-associated protein yet described...
  11. ncbi Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner
    J A Eble
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 37:10945-55. 1998
    ..In conclusion, studies of our recombinant alpha 3 beta 1 integrin have provided new insights into alpha 3 beta1 structure, ligand binding function, specificity, and regulation...
  12. ncbi NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins
    I Tachibana
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:29181-9. 1997
    ..Also, two-color immunofluorescence showed that NAG-2 was co-localized with CD81 on the surface of spread HT1080 cells. These results confirm the presence of NAG-2 in specific TM4SF.TM4SF and TM4SF-integrin complexes...
  13. ncbi Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6
    F Berditchevski
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:29174-80. 1997
    ..Importantly, EMMPRIN-alpha3beta1 complexes appear not to contain TM4SF proteins, suggesting that they are distinct from TM4SF protein-alpha3beta1 complexes...
  14. ncbi Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding
    R L Yauch
    Division of Tumor Virology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Exp Med 186:1347-55. 1997
    ....
  15. ncbi A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
    F Berditchevski
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:2595-8. 1997
    ....
  16. ncbi Investigation of the role of beta 1 integrins in cell-cell adhesion
    J B Weitzman
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 108:3635-44. 1995
    ..Furthermore, in some cell combinations, alpha 3 expression may actually cause diminished cell-cell adhesion...
  17. ncbi Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines
    M E Hemler
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 264:6529-35. 1989
    ..The beta 4 subunit may be of major importance because (i) it is highly abundant on the surface of colon carcinoma cell lines, and (ii) it is highly immunogenic relative to other surface proteins...
  18. ncbi Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151
    R L Yauch
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:9230-8. 2000
    ..Finally, we demonstrated that both NH(2)- and COOH-terminal domains of CD151 are located on the inside of the plasma membrane, thus confirming a long suspected model of TM4SF protein topology...
  19. ncbi EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily
    C S Stipp
    Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Mssachusetts 02115, USA
    J Biol Chem 276:40545-54. 2001
    ..Thus, EWI-2 potentially contributes to a variety of CD9 and CD81 functions seen in different cell and tissue types...
  20. ncbi Cloning, primary structure and properties of a novel human integrin beta subunit
    H Ramaswamy
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:1561-8. 1990
    ..By immunoprecipitation, beta 5 was most prevalent on carcinoma cell lines, was also present on hepatoma and fibroblast cell lines, and was absent from lymphoblastoid cells and platelets...
  21. ncbi Retooling of the beta 4 integrin in tumor cells--ligands lost and kinase gained
    M E Hemler
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 1:728-30. 2001
    ....
  22. ncbi A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies
    R Pasqualini
    Division of Tumor Virology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    J Cell Sci 105:101-11. 1993
    ....
  23. ncbi Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY
    B M Chan
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:8366-70. 1992
    ....
  24. ncbi Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
    B A Mannion
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:2039-47. 1996
    ..Thus, CD81 and other transmembrane-4 superfamily members may participate in functionally relevant interactions with alpha 4 beta 1 and other integrins...
  25. ncbi Bcr/Abl expression stimulates integrin function in hematopoietic cell lines
    G Bazzoni
    Division of Tumor Virology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 98:521-8. 1996
    ..Consistent with these results, hematopoietic precursor cells from chronic myelogenous leukemia patients also showed increased adhesion to fibronectin...
  26. ncbi Specific association of CD63 with the VLA-3 and VLA-6 integrins
    F Berditchevski
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 270:17784-90. 1995
    ..Knowledge of these specific CD63-alpha 3 beta 1 and CD63-alpha 6 beta 1 biochemical associations should lead to critical insights into the specialized functions of alpha 3 beta 1, alpha 6 beta 1, and CD63...
  27. ncbi Specific tetraspanin functions
    M E Hemler
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 155:1103-7. 2001
    ..Now, the importance of tetraspanins is strongly supported by emerging genetic evidence, coupled with new insights into the biochemistry and functions of tetraspanin protein complexes...
  28. ncbi Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family
    M E Hemler
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Cell Differ Dev 32:229-38. 1990
    ..In addition, we have expressed functional VLA-2 in RD cells, resulting in both Coll and Lm binding functions in vitro, and increased tumor cell metastasis in vivo in nude mice...
  29. ncbi Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma
    J Teixido
    Department of Tumor Virology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    J Clin Invest 90:358-67. 1992
    ..Together these results suggest that CD34hi stem cells may utilize multiple integrin-mediated adhesion pathways to localize within specialized microenvironmental niches created by marrow stromal cells...
  30. ncbi The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain
    Y Takada
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Cell Biol 109:397-407. 1989
    ..J. L. Strominger, and M. E. Hemler. 1987. Proc. Natl. Acad. Sci. USA. 84:3239-3243). Resolution of this discrepancy suggests that there may be another VLA heterodimer that resembles VLA-2 in size but has a different amino acid sequence...
  31. ncbi Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions
    J Sun
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 61:2276-81. 2001
    ....
  32. ncbi The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function
    Y Takada
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 8:1361-8. 1989
    ....
  33. ncbi Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation
    C Pujades
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Biochem J 313:899-908. 1996
    ..Biol. Chem. 268, 7028-2035] also requires Cys 278 and Cys 717, divalent cations and reduced cysteines. thus alpha 4/180 appears to be more functionally relevant than alpha 4/150...
  34. ncbi The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation
    J B Weitzman
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 268:8651-7. 1993
    ..However, this aggregation did not appear to be directly mediated by VLA-3 since it was not inhibited by EDTA. In addition, no enhancement of heterotypic cell-cell adhesion was observed in alpha 3-transfected cells...
  35. ncbi Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody
    B M Chan
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Cell Biol 120:537-43. 1993
    ....
  36. ncbi Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2
    S Kawaguchi
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 268:16279-85. 1993
    ....
  37. ncbi Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions
    S Kawaguchi
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 5:977-88. 1994
    ..In contrast to FAC localization and collagen adhesion results, VLA-2-dependent binding and infection by echovirus were unaffected by either alpha 2 cytoplasmic domain deletion or exchange with other cytoplasmic domains...
  38. ncbi Dystroglycan versatility
    M E Hemler
    Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 97:543-6. 1999
  39. ncbi The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms
    J M Bergelson
    Laboratory of Infectious Disease, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Clin Invest 92:232-9. 1993
    ..Thus VLA-2-mediated events that occur after receptor occupancy by extracellular matrix proteins also appear to be distinct from those that occur after receptor interaction with virus...
  40. ncbi Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth
    K Seipel
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA harvard edu
    J Cell Sci 112:1825-34. 1999
    ..These findings support a role for Trio as a multifunctional protein that integrates and amplifies signals involved in coordinating actin remodeling, which is necessary for cell migration and growth...
  41. ncbi Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1
    A Masumoto
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 268:228-34. 1993
    ....
  42. ncbi Palmitoylation supports assembly and function of integrin-tetraspanin complexes
    Xiuwei Yang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 167:1231-40. 2004
    ..which provides a novel framework for functional regulation...
  43. ncbi Metabolic activation-related CD147-CD98 complex
    Daosong Xu
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Proteomics 4:1061-71. 2005
    ..This approach should also be applicable to many other types of transmembrane proteins besides those associated with CD98hc and CD147...
  44. ncbi A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Proteomics 6:1855-67. 2007
    ....
  45. ncbi Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization
    Xiuwei H Yang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:12976-85. 2006
    ..Hence, because of its specialized properties, C9BB may be more useful than other anti-CD9 antibodies for monitoring CD9 during tumor progression...
  46. ncbi EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins
    Mónica Sala-Valdés
    Servicio de Inmunologia, Hospital Universitario de la Princesa, UAM, Madrid 28006, Spain
    J Biol Chem 281:19665-75. 2006
    ..Hence, EWI proteins, through their direct interaction with ERM proteins, act as linkers to connect tetraspanin-associated microdomains to actin cytoskeleton regulating cell motility and polarity...
  47. ncbi CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization
    Xiuwei H Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 68:3204-13. 2008
    ....
  48. ncbi EWI-2 modulates lymphocyte integrin alpha4beta1 functions
    Tatiana V Kolesnikova
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Blood 103:3013-9. 2004
    ..We suggest that EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions...
  49. ncbi Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association
    Kevin D Little
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 15:2375-87. 2004
    ..These data reveal a potential role for tetraspanins CD9 and CD81 as GPCR scaffolding proteins...
  50. ncbi EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5
    Christopher S Stipp
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:1167-77. 2003
    ..These results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes...
  51. ncbi Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology
    Xiuwei Yang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 13:767-81. 2002
    ..These results point to novel biochemical and biological functions for tetraspanin palmitoylation...
  52. ncbi Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Biochem J 377:407-17. 2004
    ..In conclusion, our results strongly suggest that tetraspanin homodimers, formed in the Golgi and present at the cell surface, serve as building blocks for the assembly of larger, multicomponent tetraspanin protein complexes...
  53. ncbi Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:7616-21. 2003
    ..Hence, CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1...
  54. ncbi Functional domains in tetraspanin proteins
    Christopher S Stipp
    Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Trends Biochem Sci 28:106-12. 2003
    ....
  55. ncbi An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology
    Alexander R Kazarov
    Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 158:1299-309. 2002
    ....
  56. ncbi Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis
    Xin A Zhang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 13:1-11. 2002
    ..Also, antibodies to alpha6beta1 and CD151 inhibited formation of endothelial cell cord-like networks, thus pointing to possible relevance of CD151-alpha6beta1 complexes during angiogenesis...
  57. ncbi Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro
    Yoshito Takeda
    Dana Farber Cancer Institute, Vascular Biology Program, Children s Hospital, and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 109:1524-32. 2007
    ..Selective effects of CD151 on pathologic angiogenesis make it a potentially useful target for anticancer therapy...
  58. ncbi In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs
    Sabina Wunschmann
    Department of Internal Medicine, Iowa City Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Infect Dis 194:1058-67. 2006
    ....
  59. ncbi Links between CD147 function, glycosylation, and caveolin-1
    Wei Tang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 15:4043-50. 2004
    ..These results help explain the previously established tumor suppressor functions of caveolin-1...
  60. ncbi Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering
    Wei Tang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:11112-8. 2004
    ..In conclusion, caveolin-1 associates with CD147, in a complex distinct from CD147-alpha(3) integrin complexes, thereby diminishing both CD147 clustering and CD147-dependent MMP-1-inducing activity...

Research Grants59

  1. Investigation of integrin alpha6beta4 microdomain functions
    MARTIN HEMLER; Fiscal Year: 2007
    ..Finally, our uncovering of specific alpha6beta4 domains and associated pathways that are critical during carcinogenesis may suggest novel targets for therapeutic intervention. ..
  2. Characterization of tetraspanin-EWI protein complexes and functions
    Martin E Hemler; Fiscal Year: 2010
    ..Findings will be relevant not only to brain cancer (studied here), but also for other types of cancer, as well as for normal cell functions that involve EWI-2 and EWI-F. ..
  3. TRANSMEMBRANE LINKER FUNCTIONS OF TM4SF PROTEINS
    MARTIN HEMLER; Fiscal Year: 2003
    ..Together these experiments will provide considerable information regarding TM4SF protein complexes, will begin to establish the biochemical basis for some of their many proposed functions. ..
  4. INSIDE/OUT REGULATION OF BETA 1 INTEGRIN FUNCTION
    MARTIN HEMLER; Fiscal Year: 2003
    ....
  5. FASEB Summer Conference--Advance in Tetraspanin Research
    MARTIN HEMLER; Fiscal Year: 2002
    ..With the recent application of newly available genomic, proteomic, and genetic technologies, an abundance of new information should be forthcoming. ..
  6. Alpha6 integrin complexes and tumor progression
    Martin E Hemler; Fiscal Year: 2010
    ..Our proposed studies of this alternative method for modulating LB integrins should lead to novel strategies for therapeutic intervention in breast cancer and other cancers. ..
  7. Characterization of tetraspanin-EWI protein complexes and functions
    MARTIN HEMLER; Fiscal Year: 2009
    ..Findings will be relevant not only to brain cancer (studied here), but also for other types of cancer, as well as for normal cell functions that involve EWI-2 and EWI-F. ..
  8. Linker functions for tetraspanins CD9 and CD81
    MARTIN HEMLER; Fiscal Year: 2007
    ..Finally, the lessons learned here for CD9 and CD81 will be applicable to other tetraspanins, which also contribute to a wide variety of physiological activities. ..
  9. Interactions of CD147 Involved in MMP Induction
    MARTIN HEMLER; Fiscal Year: 2007
    ..abstract_text> ..
  10. INTERACTIONS BETWEEN TM4SF PROTEINS AND INTEGRINS
    MARTIN HEMLER; Fiscal Year: 1999
    ..Results showing that integrin/TM4 associations regulate cell morphology, migration, and proliferation will be highly relevant towards understanding of tumor cell growth and metastasis in vivo. ..
  11. STRUCTURE-FUNCTION ANALYSIS OF INTEGRINS
    MARTIN HEMLER; Fiscal Year: 1993
    ..Any newly discovered integrin ligands will then be characterized with respect to cell distribution and biochemistry...
  12. CELL ADHESION FUNCTIONS & CLONING OF VLA PROTEINS
    MARTIN HEMLER; Fiscal Year: 1991
    ....
  13. NOVEL ADHESION PROTEINS IN THE VLA FAMILY
    MARTIN HEMLER; Fiscal Year: 1993
    ..The detailed knowledge gained from this proposal will greatly aid in the understanding of these processes...