Martin Hemberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites
    Martin Hemberg
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02215, USA
    Nucleic Acids Res 40:7858-69. 2012
  2. pmc Quantification of mRNA in single cells and modelling of RT-qPCR induced noise
    Martin Bengtsson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, The Churchill Hospital, Oxford, OX3 7LJ, UK
    BMC Mol Biol 9:63. 2008
  3. pmc Widespread transcription at neuronal activity-regulated enhancers
    Tae Kyung Kim
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 465:182-7. 2010
  4. pmc Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
    Sonia Cohen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 72:72-85. 2011
  5. pmc Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:292-303. 2012
  6. pmc Conservation of transcription factor binding events predicts gene expression across species
    Martin Hemberg
    Children s Hospital Boston, Program in Biophysics and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nucleic Acids Res 39:7092-102. 2011
  7. pmc Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    Steven W Flavell
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology and Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 60:1022-38. 2008

Collaborators

  • Gabriel Kreiman
  • Sonia Cohen
  • Jing Wu
  • Haruhiko Bito
  • Nicole Cloonan
  • Steven W Flavell
  • Tae Kyung Kim
  • Sarah E Ross
  • Michael E Greenberg
  • Martin Bengtsson
  • Alejandra E McCord
  • Dana Harrar
  • Yingxi Lin
  • John Salogiannis
  • Stephanie I Mok
  • Denize Atan
  • Linda Hu
  • Cynthia Jung
  • Roderick R McInnes
  • Mike Laptewicz
  • Eirene Markenscoff-Papadimitriou
  • Dietmar Kuhl
  • Scott Kuersten
  • David A Harmin
  • Paul F Worley
  • Kellie Barbara-Haley
  • Jesse M Gray
  • Allen M Costa
  • Daniel M Bear
  • Patrik Rorsman
  • Anders StÃ¥hlberg

Detail Information

Publications7

  1. pmc Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites
    Martin Hemberg
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02215, USA
    Nucleic Acids Res 40:7858-69. 2012
    ..Extending these findings across multiple cell types and tissues, we propose that most conserved non-coding genomic DNA in vertebrate genomes corresponds to promoter-distal regulatory elements...
  2. pmc Quantification of mRNA in single cells and modelling of RT-qPCR induced noise
    Martin Bengtsson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, The Churchill Hospital, Oxford, OX3 7LJ, UK
    BMC Mol Biol 9:63. 2008
    ..Quantitative reverse transcription PCR (RT-qPCR) is the most accessible method which provides sufficiently accurate measurements of mRNA in single cells...
  3. pmc Widespread transcription at neuronal activity-regulated enhancers
    Tae Kyung Kim
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 465:182-7. 2010
    ..These findings reveal that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis...
  4. pmc Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
    Sonia Cohen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 72:72-85. 2011
    ..We propose that RTT results in part from a loss of this experience-dependent chromatin remodeling...
  5. pmc Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:292-303. 2012
    ..These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11...
  6. pmc Conservation of transcription factor binding events predicts gene expression across species
    Martin Hemberg
    Children s Hospital Boston, Program in Biophysics and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nucleic Acids Res 39:7092-102. 2011
    ..These results link conservation of structural elements (TFBEs) to conservation of function (gene expression) and suggest a higher degree of functional conservation than implied by previous studies...
  7. pmc Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    Steven W Flavell
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology and Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 60:1022-38. 2008
    ..Taken together, these analyses suggest that the ubiquitously expressed transcription factor MEF2 regulates an intricate transcriptional program in neurons that controls synapse development...