Martin Hemberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites
    Martin Hemberg
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02215, USA
    Nucleic Acids Res 40:7858-69. 2012
  2. pmc Quantification of mRNA in single cells and modelling of RT-qPCR induced noise
    Martin Bengtsson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, The Churchill Hospital, Oxford, OX3 7LJ, UK
    BMC Mol Biol 9:63. 2008
  3. pmc Widespread transcription at neuronal activity-regulated enhancers
    Tae Kyung Kim
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 465:182-7. 2010
  4. pmc Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
    Harrison W Gabel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 522:89-93. 2015
  5. pmc Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
    Sonia Cohen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 72:72-85. 2011
  6. pmc MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers
    Milena M Andzelm
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston MA 02115, USA
    Neuron 86:247-63. 2015
  7. pmc Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:292-303. 2012
  8. pmc Conservation of transcription factor binding events predicts gene expression across species
    Martin Hemberg
    Children s Hospital Boston, Program in Biophysics and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nucleic Acids Res 39:7092-102. 2011
  9. pmc Genome-wide identification and characterization of functional neuronal activity-dependent enhancers
    Athar N Malik
    1 Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA 2 MD PhD Program, Harvard Medical School, Boston, Massachusetts, USA 3 Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 17:1330-9. 2014
  10. pmc Quantitative profiling of peptides from RNAs classified as noncoding
    Sudhakaran Prabakaran
    1 Proteomics Center, Boston Children s Hospital, Boston, Massachusetts 02115, USA 2 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Commun 5:5429. 2014

Collaborators

  • Michael E Greenberg
  • Gabriel Kreiman
  • Steven W Flavell
  • Sonia Cohen
  • Elio Raviola
  • Hanno Steen
  • Jeremy Gunawardena
  • Jing Wu
  • Haruhiko Bito
  • Nicole Cloonan
  • David A Harmin
  • Athar N Malik
  • Tae Kyung Kim
  • Harrison W Gabel
  • Milena M Andzelm
  • Hume Stroud
  • Sudhakaran Prabakaran
  • Sarah E Ross
  • Martin Bengtsson
  • Michael A Sandberg
  • Timothy J Cherry
  • Nathaniel R Kastan
  • Benyam Kinde
  • Daniel H Ebert
  • Basil Pawlyk
  • Caitlin S Gilbert
  • Annabel C Boeke
  • Charlotte Lee
  • Cameron H Couch
  • Kyle Kai How Farh
  • Elizabeth Hong
  • Ruchi Chauhan
  • Christian Dittrich
  • Dominic Winter
  • Thomas Vierbuchen
  • Emi Ling
  • Judith A Steen
  • Ivo Spiegel
  • Ry Y Tweedie-Cullen
  • Alex A Rubin
  • Cynthia Jung
  • Roderick R McInnes
  • John Salogiannis
  • Yingxi Lin
  • Linda Hu
  • Dana Harrar
  • Alejandra E McCord
  • Stephanie I Mok
  • Denize Atan
  • Allen M Costa
  • Scott Kuersten
  • Paul F Worley
  • Eirene Markenscoff-Papadimitriou
  • Dietmar Kuhl
  • Jesse M Gray
  • Mike Laptewicz
  • Daniel M Bear
  • Kellie Barbara-Haley
  • Anders StÃ¥hlberg
  • Patrik Rorsman

Detail Information

Publications11

  1. pmc Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites
    Martin Hemberg
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02215, USA
    Nucleic Acids Res 40:7858-69. 2012
    ..Extending these findings across multiple cell types and tissues, we propose that most conserved non-coding genomic DNA in vertebrate genomes corresponds to promoter-distal regulatory elements...
  2. pmc Quantification of mRNA in single cells and modelling of RT-qPCR induced noise
    Martin Bengtsson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, The Churchill Hospital, Oxford, OX3 7LJ, UK
    BMC Mol Biol 9:63. 2008
    ..Quantitative reverse transcription PCR (RT-qPCR) is the most accessible method which provides sufficiently accurate measurements of mRNA in single cells...
  3. pmc Widespread transcription at neuronal activity-regulated enhancers
    Tae Kyung Kim
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 465:182-7. 2010
    ..These findings reveal that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis...
  4. pmc Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
    Harrison W Gabel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 522:89-93. 2015
    ..These findings suggest that mutations in MeCP2 may cause neurological dysfunction by specifically disrupting long gene expression in the brain. ..
  5. pmc Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
    Sonia Cohen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 72:72-85. 2011
    ..We propose that RTT results in part from a loss of this experience-dependent chromatin remodeling...
  6. pmc MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers
    Milena M Andzelm
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston MA 02115, USA
    Neuron 86:247-63. 2015
    ..These findings demonstrate that broadly expressed TFs acquire specific functions through competitive recruitment to enhancers by tissue-specific TFs and through selective activation of these enhancers to regulate tissue-specific genes. ..
  7. pmc Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:292-303. 2012
    ..These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11...
  8. pmc Conservation of transcription factor binding events predicts gene expression across species
    Martin Hemberg
    Children s Hospital Boston, Program in Biophysics and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nucleic Acids Res 39:7092-102. 2011
    ..These results link conservation of structural elements (TFBEs) to conservation of function (gene expression) and suggest a higher degree of functional conservation than implied by previous studies...
  9. pmc Genome-wide identification and characterization of functional neuronal activity-dependent enhancers
    Athar N Malik
    1 Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA 2 MD PhD Program, Harvard Medical School, Boston, Massachusetts, USA 3 Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 17:1330-9. 2014
    ....
  10. pmc Quantitative profiling of peptides from RNAs classified as noncoding
    Sudhakaran Prabakaran
    1 Proteomics Center, Boston Children s Hospital, Boston, Massachusetts 02115, USA 2 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Commun 5:5429. 2014
    ..These observations highlight a potentially large and complex set of biologically regulated translational events from transcripts formerly thought to lack coding potential...
  11. pmc Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    Steven W Flavell
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology and Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 60:1022-38. 2008
    ..Taken together, these analyses suggest that the ubiquitously expressed transcription factor MEF2 regulates an intricate transcriptional program in neurons that controls synapse development...