Matthias Hediger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Iron transport and hemochromatosis
    Matthias A Hediger
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    J Investig Med 50:239S-246S. 2002
  2. pmc Metal ion transporters in mammals: structure, function and pathological implications
    A Rolfs
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Physiol 518:1-12. 1999
  3. ncbi The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
    Yoshikatsu Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, 181 8611, Tokyo, Japan
    Pflugers Arch 447:469-79. 2004
  4. ncbi The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
    Matthias A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:465-8. 2004
  5. ncbi [Physiology and biochemistry of uric acid]
    M A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ther Umsch 61:541-5. 2004
  6. ncbi Molecular physiology of urate transport
    Matthias A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiology (Bethesda) 20:125-33. 2005
  7. ncbi Glutamate transporters in kidney and brain
    M A Hediger
    Membrane and Biology Program, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:F487-92. 1999
  8. ncbi Introduction: glutamate transport, metabolism, and physiological responses
    M A Hediger
    Membrane Biology Program, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:F477-80. 1999
  9. ncbi A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling
    Ji Bin Peng
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 11:555-61. 2002
  10. ncbi SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:571-9. 2004

Research Grants

  1. Calcium Channel CaT 1 in Prostate Cancer Prevention
    Matthias Hediger; Fiscal Year: 2005
  2. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004

Collaborators

Detail Information

Publications38

  1. ncbi Iron transport and hemochromatosis
    Matthias A Hediger
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    J Investig Med 50:239S-246S. 2002
  2. pmc Metal ion transporters in mammals: structure, function and pathological implications
    A Rolfs
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Physiol 518:1-12. 1999
    ..The purpose of this review is to summarize these advances and to give an overview on the growing number of mammalian metal ion transporters...
  3. ncbi The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
    Yoshikatsu Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, 181 8611, Tokyo, Japan
    Pflugers Arch 447:469-79. 2004
    ....
  4. ncbi The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
    Matthias A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:465-8. 2004
    ..A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction...
  5. ncbi [Physiology and biochemistry of uric acid]
    M A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ther Umsch 61:541-5. 2004
    ..In the kidney, uric acid is reabsorbed via the uric acid transporter URAT1. This transporter is the major mechanism for regulating blood uric acid levels and therefore may prove an interesting target for future drug development...
  6. ncbi Molecular physiology of urate transport
    Matthias A Hediger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiology (Bethesda) 20:125-33. 2005
    ..The recently identified human urate transporters URAT1, MRP4, OAT1, and OAT3 are thought to play central roles in homeostasis and may prove interesting targets for future drug development...
  7. ncbi Glutamate transporters in kidney and brain
    M A Hediger
    Membrane and Biology Program, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:F487-92. 1999
    ..In the kidney, glutamate transporters are involved in reabsorption of filtered acidic amino acids, regulation of ammonia and bicarbonate production, and protection of cells against osmotic stress...
  8. ncbi Introduction: glutamate transport, metabolism, and physiological responses
    M A Hediger
    Membrane Biology Program, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:F477-80. 1999
    ..Finally, T. C. Welbourne and J. C. Matthews introduce the "functional unit" concept of glutamate transport and how this relates to both glutamine metabolism and paracellular permeability...
  9. ncbi A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling
    Ji Bin Peng
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 11:555-61. 2002
    ..In this review, we present new developments in the area of calcium transport at the apical membrane, the first step in transepithelial calcium transport...
  10. ncbi SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:571-9. 2004
    ..DMT1 is up-regulated dramatically in the intestine by dietary iron restriction and, despite high serum iron levels, is not appropriately down-regulated in hereditary hemochromatosis...
  11. ncbi Intestinal expression of genes involved in iron absorption in humans
    Andreas Rolfs
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 282:G598-607. 2002
    ..The lack of appropriate downregulation of apical and basolateral iron transporters in duodenum likely leads to excessive iron absorption in persons with HHC...
  12. ncbi The glutamate and neutral amino acid transporter family: physiological and pharmacological implications
    Yoshikatsu Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Eur J Pharmacol 479:237-47. 2003
    ....
  13. ncbi Iron transport: emerging roles in health and disease
    Tapasree Goswami
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Biochem Cell Biol 80:679-89. 2002
    ..Investigation of the transport proteins and their functions is beginning to unravel the detailed mechanisms underlying the diseases associated with iron deficiency, iron overload, and other dysfunctions of iron metabolism...
  14. ncbi Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs
    Urs V Berger
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anat Embryol (Berl) 211:595-606. 2006
    ....
  15. ncbi Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, 02115, USA
    Pflugers Arch 451:544-58. 2006
    ....
  16. ncbi Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies
    Liyan Zhuang
    The Urologic Laboratory, Department of Urology, Children s Hospital Boston, Massachusetts 02115, USA
    Lab Invest 82:1755-64. 2002
    ..Our findings indicate that CaT1 is likely to serve as a component of transcellular calcium transport mechanisms in many tissues and epithelial cancers...
  17. ncbi Apical entry channels in calcium-transporting epithelia
    Ji Bin Peng
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    News Physiol Sci 18:158-63. 2003
    ..These channels are regulated directly or indirectly by vitamin D and dietary calcium and undergo feedback control by intracellular calcium, suggesting their rate-limiting roles in transcellular calcium transport...
  18. pmc Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond
    Ji Bin Peng
    Membrane Biology Program and Renal and Endocrine Hypertension Divisions, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Physiol 551:729-40. 2003
    ..Finally, CaT1 expression is upregulated in prostate cancer and other cancers of epithelial origin, highlighting its potential as a target for cancer therapy...
  19. pmc The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
    Claudine H Kos
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 111:1021-8. 2003
    ..Thus, CaR is necessary for the fine regulation of serum calcium levels and renal calcium excretion independent of its effect on PTH secretion...
  20. ncbi Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene
    Suzy D C Bianco
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 22:274-85. 2007
    ..Trpv6 encodes a Ca(2+)-permeable cation channel responsible for vitamin D-dependent intestinal Ca(2+) absorption. Trpv6 is expressed in the intestine and also in the skin, placenta, kidney, and exocrine organs...
  21. ncbi Sodium-dependent ascorbic acid transporter family SLC23
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:677-82. 2004
    ..An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear...
  22. ncbi Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:23720-30. 2003
    ....
  23. pmc Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Biochem J 403:59-69. 2007
    ..We therefore propose that these variations serve as tissue-specific signals or cues to direct DMT1 to the appropriate subcellular compartments (e.g. in erythroid cells) or the plasma membrane (e.g. in intestine)...
  24. ncbi Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT1 expression topography
    Ali Tavakkolizadeh
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 75:181-5. 2003
    ..We hypothesized that anastomosis of this neointestine to the native bowel would result in regeneration of mucosal morphology and enterocyte dynamics...
  25. ncbi Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:8974-84. 2005
    ..The human slc6a20 gene coding SIT1 is an appropriate target for investigation of hereditary forms of iminoaciduria in man...
  26. ncbi Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice
    Yurong Song
    Interdepartmental Nutrition Program, Purdue University, West Lafayette, Indiana 47907, USA
    Endocrinology 144:3885-94. 2003
    ..The rapid induction of intestinal CaT1 mRNA expression by 1,25(OH)(2)D(3), and the marked induction at weaning, suggest that CaT1 is critical for 1,25(OH)(2)D(3)-mediated intestinal Ca absorption...
  27. ncbi The SLC14 gene family of urea transporters
    Chairat Shayakul
    Renal Unit, Department of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand
    Pflugers Arch 447:603-9. 2004
    ....
  28. pmc Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport
    Yoshiro Suzuki
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    J Bone Miner Res 23:1249-56. 2008
    ..These results provide the first in vivo evidence that TRPV6 is involved in maternal-fetal Ca(2+) transport. We propose that TRPV6 functions as a Ca(2+) entry pathway, which is critical for fetal Ca(2+) homeostasis...
  29. doi Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation
    Yoshiro Suzuki
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Hum Mol Genet 17:1613-8. 2008
    ..01 pmol/min/oocyte for ancestral versus derived haplotype, P < 0.01). These results suggest that the ancestral gain-of-function haplotype in TRPV6 plays a role in calcium stone formation in certain forms of absorptive hypercalciuria...
  30. ncbi Kidney function: gateway to a long life?
    Matthias A Hediger
    Nature 417:393, 395. 2002
  31. ncbi Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1
    Bryan Mackenzie
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, PO Box 670576, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 294:C451-9. 2008
    ....
  32. doi The role of TRPV6 in breast carcinogenesis
    Katrin A Bolanz
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Mol Cancer Ther 7:271-9. 2008
    ..TRPV6 may be a novel target for the development of calcium channel inhibitors to treat breast adenocarcinoma expressing TRPV6...
  33. ncbi Mechanisms and regulation of epithelial Ca2+ absorption in health and disease
    Yoshiro Suzuki
    Institute of Biochemistry and Molecular Medicine, University of Bern, CH 3012 Berne, Switzerland
    Annu Rev Physiol 70:257-71. 2008
    ..These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets...
  34. pmc Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement
    Martin Konrad
    University Children s Hospital, Inselspital, Bern, Switzerland
    Am J Hum Genet 79:949-57. 2006
    ....
  35. ncbi New view at C
    Matthias A Hediger
    Nat Med 8:445-6. 2002
  36. pmc CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells
    Heike Kahr
    Institute for Biophysics, University of Linz, A 4040 Linz, Austria
    J Physiol 557:121-32. 2004
    ..The data further demonstrate a novel strategy for CRAC current inhibition by an N-terminal structure of CaT1...
  37. ncbi K+ amino acid transporter KAAT1 mutant Y147F has increased transport activity and altered substrate selectivity
    Zhilin Liu
    The Whitney Laboratory, University of Florida, St Augustine, FL 32080, USA
    J Exp Biol 206:245-54. 2003
    ....
  38. doi Characterization of a stem cell population in lung cancer A549 cells
    Ji Min Sung
    Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Hwayang Dong 1, Kwangjin gu, Seoul 143 701, Republic of Korea
    Biochem Biophys Res Commun 371:163-7. 2008
    ..Therefore, we suggest that the expression of the ABCG2 transporter plays an important role in the multidrug resistance phenotype of A549 SP cells...

Research Grants8

  1. Calcium Channel CaT 1 in Prostate Cancer Prevention
    Matthias Hediger; Fiscal Year: 2005
    ..abstract_text> ..
  2. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004
    ....