Trey Hedden

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Meta-analysis of amyloid-cognition relations in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, CA, USA
    Neurology 80:1341-8. 2013
  2. pmc Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 32:16233-42. 2012
  3. pmc Failure to modulate attentional control in advanced aging linked to white matter pathology
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cereb Cortex 22:1038-51. 2012
  4. pmc Shared and selective neural correlates of inhibition, facilitation, and shifting processes during executive control
    Trey Hedden
    Psychology Department, Stanford University, USA
    Neuroimage 51:421-31. 2010
  5. pmc Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neurosci 29:12686-94. 2009
  6. pmc The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 23:1317-28. 2013
  7. pmc Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 34:1568-78. 2013
  8. doi request reprint Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults
    Willem Huijbers
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Aging Brain Study, Department of Neurology, and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Neurosci 34:5200-10. 2014
  9. pmc Age and amyloid-related alterations in default network habituation to stimulus repetition
    Patrizia Vannini
    Athinoula A Martinos Center for Biomedical Imaging, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neurobiol Aging 33:1237-52. 2012
  10. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011

Detail Information

Publications21

  1. pmc Meta-analysis of amyloid-cognition relations in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, CA, USA
    Neurology 80:1341-8. 2013
    ..We conducted a meta-analysis of relationships between amyloid burden and cognition in cognitively normal, older adult humans...
  2. pmc Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 32:16233-42. 2012
    ..These findings suggest that even before clinical impairment, amyloid burden and WMH likely represent neuropathological cascades with distinct etiologies and dissociable influences on cognition...
  3. pmc Failure to modulate attentional control in advanced aging linked to white matter pathology
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cereb Cortex 22:1038-51. 2012
    ..These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes...
  4. pmc Shared and selective neural correlates of inhibition, facilitation, and shifting processes during executive control
    Trey Hedden
    Psychology Department, Stanford University, USA
    Neuroimage 51:421-31. 2010
    ..Several of these common regions were also involved during facilitation, suggesting that they are responsive to the number of task-salient channels of information, rather than purely to demands on control processes...
  5. pmc Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neurosci 29:12686-94. 2009
    ....
  6. pmc The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 23:1317-28. 2013
    ..These findings support a specific link between amyloid pathology and neural dysfunction in PMC and elucidate the underpinnings of age-related memory dysfunction...
  7. pmc Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 34:1568-78. 2013
    ....
  8. doi request reprint Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults
    Willem Huijbers
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Aging Brain Study, Department of Neurology, and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Neurosci 34:5200-10. 2014
    ..Together these findings link neocortical amyloid-β deposition to neuronal dysfunction specifically in entorhinal cortex, while aging is associated with more widespread functional changes across the MTL. ..
  9. pmc Age and amyloid-related alterations in default network habituation to stimulus repetition
    Patrizia Vannini
    Athinoula A Martinos Center for Biomedical Imaging, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neurobiol Aging 33:1237-52. 2012
    ....
  10. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
    ....
  11. doi request reprint The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system
    Andrew M Ward
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
    Hum Brain Mapp 35:1061-73. 2014
    ..Our findings support the hypothesis that the MTL memory system represents a functional subnetwork that relates to the cortical nodes of the DMN through parahippocampal functional connections...
  12. ncbi request reprint Insights into the ageing mind: a view from cognitive neuroscience
    Trey Hedden
    Stanford University, Psychology Department, 434 Jordan Hall, Building 420, Stanford, California 94305 2130, USA
    Nat Rev Neurosci 5:87-96. 2004
  13. ncbi request reprint Healthy and pathological processes in adult development: new evidence from neuroimaging of the aging brain
    Trey Hedden
    Stanford University, Stanford, California, Cambridge, Massachusetts, USA
    Curr Opin Neurol 18:740-7. 2005
    ..These variations in cognitive aging can be related to their neural bases via structural and functional neuroimaging methods...
  14. ncbi request reprint Categorical organization in free recall across culture and age
    Angela H Gutchess
    Department of Psychology, University of Michigan, Ann Arbor, Mich, USA
    Gerontology 52:314-23. 2006
    ..Cross-cultural differences in cognition suggest that Westerners use categories more than Easterners, but these differences have only been investigated in young adults...
  15. pmc Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease
    Randy L Buckner
    Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 29:1860-73. 2009
    ....
  16. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  17. pmc Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  18. ncbi request reprint Individual differences in executive processing predict susceptibility to interference in verbal working memory
    Trey Hedden
    Psychology Department, Stanford University, Stanford, CA, USA
    Neuropsychology 20:511-28. 2006
    ....
  19. ncbi request reprint Contributions of processing ability and knowledge to verbal memory tasks across the adult life-span
    Trey Hedden
    Department of Psychology, 434 Jordan Hall, Building 420, Stanford University, Stanford, CA 94305 2130, USA
    Q J Exp Psychol A 58:169-90. 2005
    ....
  20. pmc Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors
    Hesheng Liu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:20499-503. 2009
    ..These findings show the feasibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multiple genetic or environmental mechanisms control cerebral lateralization...
  21. pmc Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects
    Andrew M Ward
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA Department of Neurology, Brigham and Women s Hospital, Boston, MA Departments of Neurology, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA
    Sleep 36:1609-15. 2013
    ..We examine the relationship between chronic daytime somnolence and connectivity in six brain networks in both young and elderly subjects using stimulus-free resting-state functional magnetic resonance imaging...