S Heckers

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    Stephan Heckers
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02429, USA
    Arch Gen Psychiatry 59:521-9. 2002
  2. ncbi Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia
    S Heckers
    Psychotic Disorders Unit, Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Boston, USA
    Arch Gen Psychiatry 56:1117-23. 1999
  3. ncbi Reversed hemispheric asymmetry during simple visual perception in schizophrenia
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital East, Harvard Medical School, Charlestown, MA 02129, USA
    Psychiatry Res 116:25-32. 2002
  4. ncbi How many bipolar mixed states are there?
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    Harv Rev Psychiatry 10:276-9. 2002
  5. ncbi Anterior cingulate cortex activation during cognitive interference in schizophrenia
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02129, USA
    Am J Psychiatry 161:707-15. 2004
  6. ncbi Hippocampal and brain stem activation during word retrieval after repeated and semantic encoding
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
    Cereb Cortex 12:900-7. 2002
  7. ncbi Hippocampal activation during transitive inference in humans
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, East CNY 9112, Bldg 149, Thirteenth Street, Charlestown, MA 02129, USA
    Hippocampus 14:153-62. 2004
  8. ncbi Neuroimaging studies of the hippocampus in schizophrenia
    S Heckers
    Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, USA
    Hippocampus 11:520-8. 2001
  9. ncbi Anatomic and molecular principles of psychopharmacology. A primer for psychiatrists
    S Heckers
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Child Adolesc Psychiatr Clin N Am 9:1-22. 2000
  10. ncbi Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: evidence from PET
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Brain 124:219-31. 2001

Detail Information

Publications50

  1. ncbi Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    Stephan Heckers
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02429, USA
    Arch Gen Psychiatry 59:521-9. 2002
    ..Cellular GAD(67) mRNA expression was normal in both groups. CONCLUSION: We have found a region-specific deficit of GAD(65) and GAD(67) mRNA expression in bipolar disorder...
  2. ncbi Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia
    S Heckers
    Psychotic Disorders Unit, Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Boston, USA
    Arch Gen Psychiatry 56:1117-23. 1999
    ..The deficit and nondeficit forms of schizophrenia were predicted to differ in prefrontal cortical activity, but not in medial temporal lobe activity...
  3. ncbi Reversed hemispheric asymmetry during simple visual perception in schizophrenia
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital East, Harvard Medical School, Charlestown, MA 02129, USA
    Psychiatry Res 116:25-32. 2002
    ..These results are consistent with the notion of reversed hemispheric asymmetry during the processing of sensory information in schizophrenia...
  4. ncbi How many bipolar mixed states are there?
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    Harv Rev Psychiatry 10:276-9. 2002
  5. ncbi Anterior cingulate cortex activation during cognitive interference in schizophrenia
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02129, USA
    Am J Psychiatry 161:707-15. 2004
    ..Previous studies have reported evidence of structural and functional abnormalities in the anterior cingulate cortex of patients with schizophrenia...
  6. ncbi Hippocampal and brain stem activation during word retrieval after repeated and semantic encoding
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
    Cereb Cortex 12:900-7. 2002
    ..These findings confirm the importance of hippocampal recruitment during word retrieval and provide novel evidence for a role of brainstem neurons in word retrieval after semantic encoding...
  7. ncbi Hippocampal activation during transitive inference in humans
    Stephan Heckers
    Department of Psychiatry, Massachusetts General Hospital, East CNY 9112, Bldg 149, Thirteenth Street, Charlestown, MA 02129, USA
    Hippocampus 14:153-62. 2004
    ..We conclude that immediate access to simple stimulus-stimulus relationships is mediated via the parahippocampal gyrus, whereas the flexible representation of memory requires the recruitment of the hippocampus...
  8. ncbi Neuroimaging studies of the hippocampus in schizophrenia
    S Heckers
    Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, USA
    Hippocampus 11:520-8. 2001
    ..These results of neuroimaging studies complement evidence from post-mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia...
  9. ncbi Anatomic and molecular principles of psychopharmacology. A primer for psychiatrists
    S Heckers
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Child Adolesc Psychiatr Clin N Am 9:1-22. 2000
    ..Third, the intracellular integration of receptor-mediated responses leads to immediate or delayed effects on neuronal function...
  10. ncbi Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: evidence from PET
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Brain 124:219-31. 2001
    ..Once initiated, lateral regions of left prefrontal cortex control verbal semantic organization...
  11. ncbi Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
    ..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition...
  12. ncbi Neuroimaging of declarative memory in schizophrenia
    A P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Scand J Psychol 42:239-50. 2001
    ..Memory impairment in schizophrenia appears to involve abnormal connectivity between the prefrontal cortex and three regions important in normal learning and memory: the hippocampus, thalamus, and cerebellum...
  13. ncbi Schizophrenia and cognitive function
    G Kuperberg
    Department of Psychiatry, CNY 9, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Curr Opin Neurobiol 10:205-10. 2000
    ..Cognitive skills in schizophrenia predict social functioning and may serve as outcome measures in the development of effective treatment strategies...
  14. ncbi Fronto-hippocampal function during temporal context monitoring in schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
    Biol Psychiatry 60:1268-77. 2006
    ..Given the importance of the hippocampus and prefrontal cortex (PFC) in this type of memory, we hypothesized that this cognitive deficit stemmed from aberrant fronto-hippocampal activation during memory retrieval...
  15. ncbi Impaired hippocampal function during the detection of novel words in schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 55:668-75. 2004
    ..CONCLUSIONS: The impaired ability to classify new items as previously not experienced is associated with decreased recruitment and smaller volume of the hippocampus in schizophrenia...
  16. ncbi Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia...
  17. ncbi Intact associative learning in patients with schizophrenia: evidence from a Go/NoGo paradigm
    Austin A Woolard
    Department of Psychiatry, Vanderbilt University, 1601 23rd Avenue South, Nashville, TN 37212 3133, USA
    Schizophr Res 122:131-5. 2010
    ..In the present study, we investigated the effect of associative learning during a Go/NoGo task in healthy controls subjects and patients with schizophrenia...
  18. ncbi The role of the hippocampus in transitive inference
    Martin Zalesak
    The Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, United States
    Psychiatry Res 172:24-30. 2009
    ..Hippocampal activation thus scales with the degree of relational processing necessary for TI judgments. Both findings confirm a role of the hippocampus in transitive inference in humans...
  19. ncbi Prefrontal cortical thickness in first-episode psychosis: a magnetic resonance imaging study
    Laura C Wiegand
    Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:131-40. 2004
    ....
  20. ncbi Impaired hippocampal recruitment during normal modulation of memory performance in schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Biol Psychiatry 53:48-55. 2003
    ..Impaired hippocampal recruitment, in concert with greater prefrontal activation, may reflect a specific deficit in conscious recollection in schizophrenia...
  21. ncbi Intact suppression of increased false recognition in schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 159:1506-13. 2002
    ..By studying pictures of the target word during encoding, healthy adults can suppress false recognition. This study examined the effect of pictorial encoding on subsequent recognition of repeated foils in patients with schizophrenia...
  22. ncbi Schizophrenia
    D C Goff
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Clin North Am 85:663-89. 2001
    ..Good medical care is as important for the patient with schizophrenia as for any other patient...
  23. ncbi Intact hemispheric specialization for spatial and shape working memory in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Schizophr Res 78:1-12. 2005
    ..We hypothesized that reduced specialization in schizophrenia would reflect a failure to adopt optimal domain-specific strategies and would contribute to WM deficits...
  24. ncbi Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study
    Kang Sim
    Schizophrenia and Bipolar Disorders Program, McLean Hospital Harvard Medical School, Mill Street, Belmont, MA, 02478, USA
    Schizophr Bull 32:332-40. 2006
    ..The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia...
  25. ncbi Inefficient face detection in schizophrenia
    Yue Chen
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Schizophr Bull 34:367-74. 2008
    ..Higher levels of facial processing, such as recognition of the individuality and emotional expression of faces, are abnormal in schizophrenia. It is unknown, however, whether the visual detection of a face as face is impaired as well...
  26. ncbi Visual and cognitive processing of face information in schizophrenia: detection, discrimination and working memory
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, USA
    Schizophr Res 107:92-8. 2009
    ..This pattern of results indicates that greater signal strength is required for visual and cognitive processing of facial information in schizophrenia...
  27. ncbi Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Pharmacol Ther 97:153-79. 2003
    ..Here we discuss how the molecular aspects of glutamate malfunction can explain some of the neuropathology observed in schizophrenia, and how the available treatment intervenes through the glutamate system...
  28. ncbi Hemispheric specialization of the lateral prefrontal cortex for strategic processing during spatial and shape working memory
    Dara S Manoach
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 21:894-903. 2004
    ..We designed spatial and shape WM tasks that are relatively easy to perform and that minimize both task-switching and manipulation demands. The tasks use identical stimuli and require the same motor response...
  29. ncbi Molecular evidence for mitochondrial dysfunction in bipolar disorder
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 61:300-8. 2004
    ..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder...
  30. ncbi Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research
    Nicholas Lange
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Stat Med 23:327-50. 2004
    ....
  31. ncbi Neuroimaging of hallucinations: a review of the literature
    A P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Psychiatry Res 92:61-74. 1999
    ..Furthermore, neural activation may be specifically related to distinct phenomenological features of the hallucinatory experience. Further work is needed to better understand the neural basis of hallucinations...
  32. ncbi Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia
    C Konradi
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Biol Psychiatry 50:729-42. 2001
    ..The concept of schizophrenia as a disorder of synaptic organization will benefit from a better understanding of the synaptic changes induced by antipsychotic drugs...
  33. ncbi Hippocampal neurons in schizophrenia
    S Heckers
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neural Transm 109:891-905. 2002
    ..Taken together, recent studies of hippocampal cell number, protein expression, and gene regulation point towards an abnormality of hippocampal architecture in schizophrenia...
  34. ncbi Anterior and posterior hippocampal volumes in schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Schizophr Res 73:103-12. 2005
    ..Here we present volume estimates of anterior and posterior hippocampal volumes using a novel morphometric protocol...
  35. ncbi Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
    Jonathan J Wisco
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
    Schizophr Res 94:317-27. 2007
    ..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...
  36. ncbi Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats
    Dost Ongur
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:505-12. 2007
    ..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation...
  37. ncbi A role for glia in the action of electroconvulsive therapy
    Dost Ongur
    Schizophrenia and Bipolar Disorder Unit, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Harv Rev Psychiatry 12:253-62. 2004
    ..We suggest that the effectiveness of ECT is, in part, related to its effect on glial cells. This testable hypothesis may advance our understanding and treatment of psychiatric disorders...
  38. ncbi Hippocampus, IV: relational memory
    Stephan Heckers
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5.914, Dallas, TX 75390-9070, USA
    Am J Psychiatry 162:663. 2005
  39. ncbi Hippocampal activation during processing of previously seen visual stimulus pairs
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, AB 347, Belmont, MA, USA
    Psychiatry Res 139:191-8. 2005
    ..Right hippocampal activation during discrimination of previously seen pairs of objects was correlated with activity in the anteromedial thalamus, cingulate cortex, and contralateral hippocampus...
  40. ncbi An in vivo MRI study of prefrontal cortical complexity in first-episode psychosis
    Laura C Wiegand
    Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System-Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 162:65-70. 2005
    ..CONCLUSIONS: An abnormal pattern of asymmetry in the prefrontal cortex of first-episode patients with schizophrenia provides evidence for a neurodevelopmental mechanism in the etiology of schizophrenia...
  41. ncbi Who is at risk for a psychotic disorder?
    Stephan Heckers
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Schizophr Bull 35:847-50. 2009
    ..The assessment of risk carries its own risks, including stigmatization and inappropriate treatment, potentially leading to adverse outcomes...
  42. ncbi Hippocampal function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Hippocampus 14:292-300. 2004
    ....
  43. ncbi Making progress in schizophrenia research
    Stephan Heckers
    Schizophr Bull 34:591-4. 2008
  44. ncbi Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
  45. ncbi Abnormal reward system activation in mania
    Birgit Abler
    Department of Psychiatry, University of Ulm, Germany
    Neuropsychopharmacology 33:2217-27. 2008
    ..These deficits in prediction error processing in acute mania may help to explain symptoms of disinhibition and abnormal goal pursuit regulation...
  46. ncbi The hippocampus in schizophrenia
    Stephan Heckers
    Am J Psychiatry 161:2138-9. 2004
  47. ncbi The neural basis of relational memory deficits in schizophrenia
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Brain Imaging Center, Belmont, MA 02478, USA
    Arch Gen Psychiatry 63:356-65. 2006
    ..Memory deficits are common in schizophrenia. Recent studies have demonstrated that relational memory is particularly impaired...
  48. ncbi Subjective quality of life in first episode schizophrenia spectrum disorders with comorbid depression
    Kang Sim
    Department of Early Psychosis Intervention, Woodbridge Hospital Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore
    Psychiatry Res 129:141-7. 2004
    ..Alternative explanations are also possible, providing possible foci for psychological support and intervention...
  49. ncbi Antipsychotic polypharmacy in patients with schizophrenia: a multicentre comparative study in East Asia
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 58:178-83. 2004
    ..This study seeks to examine the prevalence of antipsychotic polypharmacy in patients with schizophrenia and compare the differences between patients receiving one vs. those receiving more than one antipsychotic...
  50. ncbi Hippocampus, III: GABA-containing cell bodies and GAD mRNA
    Stephan Heckers
    Am J Psychiatry 162:450. 2005