Research Topics
Species | J L HechtSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Molecular and pathologic aspects of endometrial carcinogenesisJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
J Clin Oncol 24:4783-91. 2006..This article reviews the genetic aspects of endometrial carcinogenesis and progression. We will define the precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression...- Monoclonal antibody MOC-31 reactivity as a marker for adenocarcinoma in cytologic preparationsJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Cancer 108:56-9. 2006..The current immunohistochemical study confirmed the effectiveness of MOC-31 as a marker for adenocarcinoma from a broad range of primary sites in body fluid cytology prepared as paraffin sections of cell blocks... 
Overexpression of the alphavbeta6 integrin in endometrial cancerJonathan L Hecht
Biogen Idec, Cambridge, MA, USA
Appl Immunohistochem Mol Morphol 16:543-7. 2008..Expression is high in metastatic lesions. The level of expression of the primary tumor was not indicative of the presence of nodal metastasis; however, the number of cases with nodal metastases was limited...- Reference weights for placentas delivered before the 28th week of gestationJ L Hecht
Beth Israel Deaconess Medical Center, Department of Pathology, 330 Brookline Avenue, Boston, MA 02215, USA
Placenta 28:987-90. 2007..Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week... - Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissuesJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Pediatr Dev Pathol 11:15-22. 2008..Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation... 
Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health StudyJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Cancer Epidemiol Biomarkers Prev 17:3043-50. 2008..Tissue microarrays (TMAs) allow high-throughput evaluation of protein expression from archived tissue samples. We identified characteristics specific to ovarian cancer that may influence TMA interpretation...- The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesotheliomaJonathan L Hecht
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer 96:105-9. 2002..In assessment of effusion specimens with metastatic carcinoma, nuclear reactivity for WT1 is highly suggestive of an ovary primary tumor.. - Factors associated with small head circumference at birth among infants born before the 28th weekThomas F McElrath
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 203:138.e1-8. 2010..We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns... - The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung originJ L Hecht
Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
Am J Clin Pathol 116:483-8. 2001..All mesotheliomas were nonreactive. In cytologic preparations, TTF-1 is a highly selective marker for pulmonary adenocarcinoma and also can have a role in the distinction between pulmonary adenocarcinoma and mesothelioma... - Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancerShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cancer 112:1169-77. 2008..Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses... - Congenital cytomegalovirus infection: a cause of renal dysplasia?Maren Chan
Department of Pathology at Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Pediatr Dev Pathol 10:300-4. 2007..Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia... - Colonization of second-trimester placenta parenchymaAndrew B Onderdonk
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 199:52.e1-52.e10. 2008..The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation... - Patterns of misinterpretation of adnexal masses on CT and MR in an academic radiology departmentElizabeth Asch
Harvard Medical School, Boston, MA, USA
Acad Radiol 16:969-80. 2009..The aim of this study was to assess potential quality assurance (QA) issues in the diagnosis and characterization of adnexal masses on pelvic computed tomographic (CT) and magnetic resonance (MR) imaging studies... - Breastfeeding and risk of ovarian cancer in two prospective cohortsKim N Danforth
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
Cancer Causes Control 18:517-23. 2007..To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts... - Assessment of factors that affect the quality of performance and interpretation of sonography of adnexal massesDeborah Levine
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Ultrasound Med 27:721-8. 2008..The purpose of this study was to assess factors that affect the quality of performance and interpretation of sonography of adnexal masses... - Acardiac twin presenting as fetus amorphous with an attenuated umbilical cordL Corey Hanley
Department of Pathology, Beth Israel Deaconess Medical Center, MA 02215, USA
Pediatr Dev Pathol 10:487-90. 2007..We discuss the controversy regarding the requirement of an umbilical cord in the definition of acardiac twin and distinguish this case from placental teratoma... - Do enteric neurons make hypocretin?Christian R Baumann
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, USA
Regul Pept 147:1-3. 2008..These results raise doubts about whether enteric neurons produce hypocretin... - Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA NewbornsJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Pediatr Res 69:68-73. 2011..These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns... - Intake of folate and related nutrients in relation to risk of epithelial ovarian cancerShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 163:1101-11. 2006..There was little evidence that folate, methionine, and vitamin B(6) are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses... - Management of asymptomatic ovarian and other adnexal cysts imaged at US Society of Radiologists in Ultrasound consensus conference statementDeborah Levine
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Ultrasound Q 26:121-31. 2010.... - WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluidsBenjamin H Lee
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Am J Clin Pathol 117:745-50. 2002..Reactivity for ER and PR did not distinguish between breast and ovarian metastases; however; studies for WTI protein and GCDFP may aid in making this distinction... - Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual weekAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
Early Hum Dev 86:515-21. 2010..Little is known about the antecedents of microcephaly in early childhood among children born at extremely low gestational age... - A mesothelial cyst of the round ligament presenting as an inguinal hernia after gonadotropin stimulation for in vitro fertilizationDavid A Ryley
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Fertil Steril 82:944-6. 2004..To report the case of a round ligament cyst which, as the result of gonadotropin stimulation for IVF, simulated an incarcerated inguinal hernia... - Enhanced detection of atypical hyperplasia in endometrial polyps by PTEN expressionJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston 02215, Massachusetts, USA
Appl Immunohistochem Mol Morphol 12:36-9. 2004..Thus, in selected cases, the loss of PTEN expression in an area of glandular crowding can highlight biologically significant lesions and afford a more definitive diagnosis... - Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound Consensus Conference StatementDeborah Levine
Depts of Radiology, Obstetrics and Gynecology, and Pathology, Beth Israel Deaconess Medical Ctr and Harvard Medical School, Boston, MA 02215, USA
Radiology 256:943-54. 2010.... - Risk factors for epithelial ovarian cancer by histologic subtypeMargaret A Gates
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Epidemiol 171:45-53. 2010..03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart... - Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumorsJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Cancer 126:2191-8. 2010..Our data do not support the hypothesis that the relationship between factors involved in one-carbon metabolism and ovarian cancer risk differs by FRalpha status of the tumor... - Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomasRonny Drapkin
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Res 65:2162-9. 2005..Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs... - Histological characteristics of singleton placentas delivered before the 28th week of gestationJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02118, USA
Pathology 40:372-6. 2008..We describe the histological characteristics of 947 singleton placentas from infants born between 23 and 27 weeks gestation... - Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosisJonathan L Hecht
Department of Pathology, Beth Israel Hospital, Boston, MA 02115, USA
Mod Pathol 18:324-30. 2005.... - Incidence and clinicopathologic correlation of fetal vessel thrombosis in mono- and dichorionic twin placentasM P Chan
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Perinatol 30:660-4. 2010.... - A prospective study of postmenopausal hormone use and ovarian cancer riskK N Danforth
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Br J Cancer 96:151-6. 2007..53, 95% CI 1.20-1.94). Recency of use was not significantly associated with ovarian cancer risk, but statistical power was limited here... - Histologic, surgical, and imaging correlations of adnexal massesElizabeth Asch
Harvard Medical School, Boston, Massachusetts, USA
J Ultrasound Med 27:327-42. 2008..The purpose of this study was to quantify, categorize, and illustrate discrepancies between preoperative radiologic, surgical, and pathologic diagnoses and to assess the potential impact of discrepancies on clinical care... - Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasiaRonny Drapkin
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
Hum Pathol 35:1014-21. 2004..This immunophenotype is preserved in ovarian carcinomas, suggesting that Müllerian metaplasia signals the acquisition of these markers and that their expression is maintained in ovarian carcinomas that originate from this epithelium... - T-bet regulates metastasis rate in a murine model of primary prostate cancerStanford L Peng
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Res 64:452-5. 2004.... - Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health StudyJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 18:1624-30. 2009..Reproductive and hormonal risk factors are associated with subgroups of ovarian cancer defined by histologic subtype or ERalpha and PR status. These finding support specific models of hormone mediated triggers of ovarian cancer... - Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cellsAgnieszka K Witkiewicz
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 36:154-61. 2005..Similar patterns are seen in cervical neoplasia, suggesting a link between benign and neoplastic cervical epithelial differentiation... - Invited commentary: Intrauterine epidemiologyThomas F McElrath
Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 170:159-61; discussion 162-3. 2009..However, these authors have taken a large step toward introducing an "intrauterine" perspective into perinatal epidemiology and into our understanding of the underlying etiologies of preterm birth... - A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvementOluwole Fadare
Department of Pathology, Wilford Hall Medical Center, Lackland AFB, San Antonio, Texas 78236, USA
Int J Gynecol Pathol 27:483-90. 2008..We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants... - Does physiologic breakdown mask significant pathology in endometrial biopsies? A retrospective case-control studyMark Galan
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Arch Pathol Lab Med 130:1847-9. 2006..Adequacy criteria for endometrial biopsy samples do not exist... - A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancerMargaret A Gates
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
Int J Cancer 121:2225-32. 2007..If confirmed, these results would provide an important target for ovarian cancer prevention... - Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?Alessandra F Nascimento
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 28:638-43. 2004..The possibility that vulvar acanthosis with altered differentiation is a precursor to, or a risk factor for, vulvar carcinoma, merits further study... - Pancreatic fine needle aspiration. A comparison of computed tomographic and endoscopic ultrasonographic guidanceXiaohua Qian
Departments of Pathology, Brigham and Women's Hospital and Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Acta Cytol 47:723-6. 2003..The specificity and negative predictive value of EUS and CT are similar... - Microbiologic and histologic characteristics of the extremely preterm infant's placenta predict white matter damage and later cerebral palsy. the ELGAN studyAlan Leviton
Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 67:95-101. 2010..Organism recovery does not seem to be needed for placenta inflammation to predict diparetic CP... - Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitisRobert D Odze
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Clin Gastroenterol Hepatol 2:534-41. 2004..The purpose of this study was to evaluate the long-term outcome of our previously defined group of UC patients, all with adenoma-like DALMs, who were treated by polypectomy... - Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparationsJonathan L Hecht
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer 96:1-4. 2002..027% of all cases using TPs and in 0.025% of all cases using CPs. CONCLUSIONS: The use of TPs may increase the diagnostic specificity of AGUS for a high-grade precursor lesion or carcinoma...