J L Hecht

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Molecular and pathologic aspects of endometrial carcinogenesis
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Clin Oncol 24:4783-91. 2006
  2. ncbi request reprint Monoclonal antibody MOC-31 reactivity as a marker for adenocarcinoma in cytologic preparations
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer 108:56-9. 2006
  3. doi request reprint Overexpression of the alphavbeta6 integrin in endometrial cancer
    Jonathan L Hecht
    Biogen Idec, Cambridge, MA, USA
    Appl Immunohistochem Mol Morphol 16:543-7. 2008
  4. ncbi request reprint Reference weights for placentas delivered before the 28th week of gestation
    J L Hecht
    Beth Israel Deaconess Medical Center, Department of Pathology, 330 Brookline Avenue, Boston, MA 02215, USA
    Placenta 28:987-90. 2007
  5. doi request reprint Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 11:15-22. 2008
  6. pmc Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 17:3043-50. 2008
  7. ncbi request reprint The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma
    Jonathan L Hecht
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 96:105-9. 2002
  8. pmc Factors associated with small head circumference at birth among infants born before the 28th week
    Thomas F McElrath
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 203:138.e1-8. 2010
  9. ncbi request reprint The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin
    J L Hecht
    Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 116:483-8. 2001
  10. doi request reprint Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer 112:1169-77. 2008

Detail Information

Publications47

  1. ncbi request reprint Molecular and pathologic aspects of endometrial carcinogenesis
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Clin Oncol 24:4783-91. 2006
    ..This article reviews the genetic aspects of endometrial carcinogenesis and progression. We will define the precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression...
  2. ncbi request reprint Monoclonal antibody MOC-31 reactivity as a marker for adenocarcinoma in cytologic preparations
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer 108:56-9. 2006
    ..The current immunohistochemical study confirmed the effectiveness of MOC-31 as a marker for adenocarcinoma from a broad range of primary sites in body fluid cytology prepared as paraffin sections of cell blocks...
  3. doi request reprint Overexpression of the alphavbeta6 integrin in endometrial cancer
    Jonathan L Hecht
    Biogen Idec, Cambridge, MA, USA
    Appl Immunohistochem Mol Morphol 16:543-7. 2008
    ..Expression is high in metastatic lesions. The level of expression of the primary tumor was not indicative of the presence of nodal metastasis; however, the number of cases with nodal metastases was limited...
  4. ncbi request reprint Reference weights for placentas delivered before the 28th week of gestation
    J L Hecht
    Beth Israel Deaconess Medical Center, Department of Pathology, 330 Brookline Avenue, Boston, MA 02215, USA
    Placenta 28:987-90. 2007
    ..Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week...
  5. doi request reprint Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 11:15-22. 2008
    ..Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation...
  6. pmc Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 17:3043-50. 2008
    ..Tissue microarrays (TMAs) allow high-throughput evaluation of protein expression from archived tissue samples. We identified characteristics specific to ovarian cancer that may influence TMA interpretation...
  7. ncbi request reprint The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma
    Jonathan L Hecht
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 96:105-9. 2002
    ..This immunohistochemical study evaluates the effectiveness of WT1 as a marker for malignant mesothelioma in paraffin sections of cell block preparations derived from effusion specimens...
  8. pmc Factors associated with small head circumference at birth among infants born before the 28th week
    Thomas F McElrath
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 203:138.e1-8. 2010
    ..We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns...
  9. ncbi request reprint The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin
    J L Hecht
    Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 116:483-8. 2001
    ..All mesotheliomas were nonreactive. In cytologic preparations, TTF-1 is a highly selective marker for pulmonary adenocarcinoma and also can have a role in the distinction between pulmonary adenocarcinoma and mesothelioma...
  10. doi request reprint Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer 112:1169-77. 2008
    ..Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses...
  11. ncbi request reprint Congenital cytomegalovirus infection: a cause of renal dysplasia?
    Maren Chan
    Department of Pathology at Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 10:300-4. 2007
    ..Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia...
  12. pmc Colonization of second-trimester placenta parenchyma
    Andrew B Onderdonk
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 199:52.e1-52.e10. 2008
    ..The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation...
  13. doi request reprint Patterns of misinterpretation of adnexal masses on CT and MR in an academic radiology department
    Elizabeth Asch
    Harvard Medical School, Boston, MA, USA
    Acad Radiol 16:969-80. 2009
    ..The aim of this study was to assess potential quality assurance (QA) issues in the diagnosis and characterization of adnexal masses on pelvic computed tomographic (CT) and magnetic resonance (MR) imaging studies...
  14. ncbi request reprint Breastfeeding and risk of ovarian cancer in two prospective cohorts
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 18:517-23. 2007
    ..To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts...
  15. ncbi request reprint Assessment of factors that affect the quality of performance and interpretation of sonography of adnexal masses
    Deborah Levine
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Ultrasound Med 27:721-8. 2008
    ..The purpose of this study was to assess factors that affect the quality of performance and interpretation of sonography of adnexal masses...
  16. ncbi request reprint Acardiac twin presenting as fetus amorphous with an attenuated umbilical cord
    L Corey Hanley
    Department of Pathology, Beth Israel Deaconess Medical Center, MA 02215, USA
    Pediatr Dev Pathol 10:487-90. 2007
    ..We discuss the controversy regarding the requirement of an umbilical cord in the definition of acardiac twin and distinguish this case from placental teratoma...
  17. pmc Do enteric neurons make hypocretin?
    Christian R Baumann
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, USA
    Regul Pept 147:1-3. 2008
    ..These results raise doubts about whether enteric neurons produce hypocretin...
  18. pmc Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Pediatr Res 69:68-73. 2011
    ..These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns...
  19. ncbi request reprint Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 163:1101-11. 2006
    ..There was little evidence that folate, methionine, and vitamin B(6) are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses...
  20. doi request reprint Management of asymptomatic ovarian and other adnexal cysts imaged at US Society of Radiologists in Ultrasound consensus conference statement
    Deborah Levine
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Ultrasound Q 26:121-31. 2010
    ....
  21. ncbi request reprint WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids
    Benjamin H Lee
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Pathol 117:745-50. 2002
    ..Reactivity for ER and PR did not distinguish between breast and ovarian metastases; however; studies for WTI protein and GCDFP may aid in making this distinction...
  22. pmc Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual week
    Alan Leviton
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Early Hum Dev 86:515-21. 2010
    ..Little is known about the antecedents of microcephaly in early childhood among children born at extremely low gestational age...
  23. ncbi request reprint A mesothelial cyst of the round ligament presenting as an inguinal hernia after gonadotropin stimulation for in vitro fertilization
    David A Ryley
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Fertil Steril 82:944-6. 2004
    ..To report the case of a round ligament cyst which, as the result of gonadotropin stimulation for IVF, simulated an incarcerated inguinal hernia...
  24. ncbi request reprint Enhanced detection of atypical hyperplasia in endometrial polyps by PTEN expression
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston 02215, Massachusetts, USA
    Appl Immunohistochem Mol Morphol 12:36-9. 2004
    ..Thus, in selected cases, the loss of PTEN expression in an area of glandular crowding can highlight biologically significant lesions and afford a more definitive diagnosis...
  25. doi request reprint Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement
    Deborah Levine
    Depts of Radiology, Obstetrics and Gynecology, and Pathology, Beth Israel Deaconess Medical Ctr and Harvard Medical School, Boston, MA 02215, USA
    Radiology 256:943-54. 2010
    ....
  26. pmc Risk factors for epithelial ovarian cancer by histologic subtype
    Margaret A Gates
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 171:45-53. 2010
    ..03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart...
  27. pmc Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Cancer 126:2191-8. 2010
    ..Our data do not support the hypothesis that the relationship between factors involved in one-carbon metabolism and ovarian cancer risk differs by FRalpha status of the tumor...
  28. ncbi request reprint Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas
    Ronny Drapkin
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 65:2162-9. 2005
    ..Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs...
  29. pmc Histological characteristics of singleton placentas delivered before the 28th week of gestation
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02118, USA
    Pathology 40:372-6. 2008
    ..We describe the histological characteristics of 947 singleton placentas from infants born between 23 and 27 weeks gestation...
  30. pmc Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis
    Jonathan L Hecht
    Department of Pathology, Beth Israel Hospital, Boston, MA 02115, USA
    Mod Pathol 18:324-30. 2005
    ....
  31. doi request reprint Incidence and clinicopathologic correlation of fetal vessel thrombosis in mono- and dichorionic twin placentas
    M P Chan
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Perinatol 30:660-4. 2010
    ....
  32. pmc A prospective study of postmenopausal hormone use and ovarian cancer risk
    K N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 96:151-6. 2007
    ..53, 95% CI 1.20-1.94). Recency of use was not significantly associated with ovarian cancer risk, but statistical power was limited here...
  33. ncbi request reprint Histologic, surgical, and imaging correlations of adnexal masses
    Elizabeth Asch
    Harvard Medical School, Boston, Massachusetts, USA
    J Ultrasound Med 27:327-42. 2008
    ..The purpose of this study was to quantify, categorize, and illustrate discrepancies between preoperative radiologic, surgical, and pathologic diagnoses and to assess the potential impact of discrepancies on clinical care...
  34. ncbi request reprint Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia
    Ronny Drapkin
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Hum Pathol 35:1014-21. 2004
    ..This immunophenotype is preserved in ovarian carcinomas, suggesting that Müllerian metaplasia signals the acquisition of these markers and that their expression is maintained in ovarian carcinomas that originate from this epithelium...
  35. ncbi request reprint T-bet regulates metastasis rate in a murine model of primary prostate cancer
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 64:452-5. 2004
    ....
  36. pmc Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 18:1624-30. 2009
    ..Reproductive and hormonal risk factors are associated with subgroups of ovarian cancer defined by histologic subtype or ERalpha and PR status. These finding support specific models of hormone mediated triggers of ovarian cancer...
  37. ncbi request reprint Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells
    Agnieszka K Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:154-61. 2005
    ..Using antibodies to basal cell markers, we analyzed biopsies with MGH to profile the distribution and evolution of reserve cells and their relationship to these epithelial components...
  38. doi request reprint Invited commentary: Intrauterine epidemiology
    Thomas F McElrath
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Epidemiol 170:159-61; discussion 162-3. 2009
    ..However, these authors have taken a large step toward introducing an "intrauterine" perspective into perinatal epidemiology and into our understanding of the underlying etiologies of preterm birth...
  39. doi request reprint A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement
    Oluwole Fadare
    Department of Pathology, Wilford Hall Medical Center, Lackland AFB, San Antonio, Texas 78236, USA
    Int J Gynecol Pathol 27:483-90. 2008
    ..We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants...
  40. pmc Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification
    T F McElrath
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Epidemiol 168:980-9. 2008
    ..Disorders leading to preterm delivery may be separated into two groups: those associated with intrauterine inflammation and those associated with aberrations of placentation...
  41. ncbi request reprint Does physiologic breakdown mask significant pathology in endometrial biopsies? A retrospective case-control study
    Mark Galan
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Pathol Lab Med 130:1847-9. 2006
    ..Adequacy criteria for endometrial biopsy samples do not exist...
  42. ncbi request reprint A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Int J Cancer 121:2225-32. 2007
    ..If confirmed, these results would provide an important target for ovarian cancer prevention...
  43. ncbi request reprint Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?
    Alessandra F Nascimento
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:638-43. 2004
    ..The possibility that vulvar acanthosis with altered differentiation is a precursor to, or a risk factor for, vulvar carcinoma, merits further study...
  44. ncbi request reprint Pancreatic fine needle aspiration. A comparison of computed tomographic and endoscopic ultrasonographic guidance
    Xiaohua Qian
    Departments of Pathology, Brigham and Women s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Acta Cytol 47:723-6. 2003
    ..To compare the sensitivity and specificity of pancreatic fine needle aspiration (FNA) with computed tomography (CT) and endoscopic ultrasound (EUS) guidance...
  45. pmc Microbiologic and histologic characteristics of the extremely preterm infant's placenta predict white matter damage and later cerebral palsy. the ELGAN study
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 67:95-101. 2010
    ..Organism recovery does not seem to be needed for placenta inflammation to predict diparetic CP...
  46. ncbi request reprint Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Gastroenterol Hepatol 2:534-41. 2004
    ..The purpose of this study was to evaluate the long-term outcome of our previously defined group of UC patients, all with adenoma-like DALMs, who were treated by polypectomy...
  47. ncbi request reprint Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations
    Jonathan L Hecht
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 96:1-4. 2002
    ..The authors compared outcomes after AGUS interpreted in TP specimens and conventional smear preparations (CPs)...