Affiliation: Harvard University
- Hidden Markov models for settings with interval-censored transition times and uncertain time origin: application to HIV genetic analysesBrian Healy
Department of Biostatistics, Harvard University, Boston, MA 02115, USA
Biostatistics 8:438-52. 2007..We found that the estimated rates of acquiring certain classes of mutations depended on the presence of others, and that the precision of these estimates can be considerably improved by inclusion of retrospective data...
- Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responsesLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 182:1541-7. 2009..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS...
- Combining cross-sectional and prospective data methods to improve transition parameter estimation for characterizing the accumulation of HIV-1 drug resistance mutationsBrian Healy
Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, Massachusetts 02115, USA
Biometrics 63:742-50. 2007..Combining the two sources of information allows detection of differences between rates of transition that are not detectable using prospective data alone...