Zhigang He

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system
    Zhigang He
    1Division of Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2002:re1. 2002
  2. ncbi request reprint The Nogo signaling pathway for regeneration block
    Zhigang He
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 27:341-68. 2004
  3. ncbi request reprint A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors
    Jong Bae Park
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 45:345-51. 2005
  4. pmc SOCS3 deletion promotes optic nerve regeneration in vivo
    Patrice D Smith
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 64:617-23. 2009
  5. ncbi request reprint EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans
    Vuk Koprivica
    Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    Science 310:106-10. 2005
  6. pmc PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
    Yingjie Shen
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Science 326:592-6. 2009
  7. pmc PTEN deletion enhances the regenerative ability of adult corticospinal neurons
    Kai Liu
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1075-81. 2010
  8. ncbi request reprint P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
  9. pmc Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells
    Yang Hu
    F M Kirby Neurobiology Center, Children s Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:445-52. 2012
  10. pmc Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
    Fang Sun
    F M Kirby Neurobiology Center, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 480:372-5. 2011

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system
    Zhigang He
    1Division of Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2002:re1. 2002
    ..Thus, semaphorins may serve as important probes for exploring the mechanisms of intercellular communication during the development and function of the nervous system...
  2. ncbi request reprint The Nogo signaling pathway for regeneration block
    Zhigang He
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 27:341-68. 2004
    ..These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury...
  3. ncbi request reprint A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors
    Jong Bae Park
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 45:345-51. 2005
    ..Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system...
  4. pmc SOCS3 deletion promotes optic nerve regeneration in vivo
    Patrice D Smith
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 64:617-23. 2009
    ..Thus, developing strategies to modulate negative signaling regulators may be an efficient strategy of promoting axon regeneration after CNS injury...
  5. ncbi request reprint EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans
    Vuk Koprivica
    Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    Science 310:106-10. 2005
    ..Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury...
  6. pmc PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
    Yingjie Shen
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Science 326:592-6. 2009
    ..These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration...
  7. pmc PTEN deletion enhances the regenerative ability of adult corticospinal neurons
    Kai Liu
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1075-81. 2010
    ..Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury...
  8. ncbi request reprint P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
    ..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin...
  9. pmc Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells
    Yang Hu
    F M Kirby Neurobiology Center, Children s Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:445-52. 2012
    ....
  10. pmc Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
    Fang Sun
    F M Kirby Neurobiology Center, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 480:372-5. 2011
    ..Our results reveal concurrent activation of mTOR and STAT3 pathways as key for sustaining long-distance axon regeneration in adult CNS, a crucial step towards functional recovery...
  11. pmc Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
    Katherine Zukor
    F M Kirby Program in Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, and Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    J Neurosci 33:15350-61. 2013
    ..Overall, this study reveals insights into the critical extrinsic and intrinsic regulators of axon regeneration and establishes shRNA as a viable means to manipulate these regulators and translate findings into other mammalian models. ..
  12. doi request reprint Neuronal intrinsic mechanisms of axon regeneration
    Kai Liu
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 34:131-52. 2011
    ..This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury...
  13. ncbi request reprint PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration
    Rajeev Sivasankaran
    Division of Neuroscience, 320 Longwood Avenue, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:261-8. 2004
    ..Thus, perturbing PKC activity could represent a therapeutic approach to stimulating axon regeneration after brain and spinal cord injuries...
  14. pmc Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    Kevin Kyungsuk Park
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 322:963-6. 2008
    ..Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury...
  15. ncbi request reprint Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models
    Shinjiro Kaneko
    Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:9794-804. 2006
    ..Finally, we demonstrate that delayed NAm treatment is also beneficial to EAE models, pointing to the therapeutic potential of NAm as a protective agent for EAE and perhaps MS patients...
  16. pmc A local mechanism mediates NAD-dependent protection of axon degeneration
    Jing Wang
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 170:349-55. 2005
    ..Furthermore, we provide evidence that such Nmnat1/NAD-mediated protection is primarily mediated by their effects on local bioenergetics. Together, our results suggest a novel molecular pathway for axon degeneration...
  17. ncbi request reprint Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 417:941-4. 2002
    ..Thus, OMgp is an important inhibitor of neurite outgrowth that acts through NgR and its associated receptor complex. Interfering with the OMgp/NgR pathway may allow lesioned axons to regenerate after injury in vivo...
  18. pmc Glial inhibition of CNS axon regeneration
    Glenn Yiu
    Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 7:617-27. 2006
    ..Greater insight into glial inhibition is crucial for developing therapies to promote functional recovery after neural injury...
  19. pmc Neuronal intrinsic barriers for axon regeneration in the adult CNS
    Fang Sun
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Neurobiol 20:510-8. 2010
    ..This review will summarize the molecular mechanisms regulating intrinsic axon growth capacity in the adult CNS and discuss potential implications for therapeutic strategies...
  20. ncbi request reprint Characterization of long descending premotor propriospinal neurons in the spinal cord
    Yingchun Ni
    F M Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    J Neurosci 34:9404-17. 2014
    ..Molecularly, these PPNs appear to be distinct from other known premotor interneurons, but some are derived from Chx10+ lineages. This study provides an anatomical basis for further exploring different functions of PPNs. ..
  21. ncbi request reprint Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state
    Dietmar Fischer
    Department of Neurosurgery, Children s Hospital Boston, Massachusetts 02115, USA
    J Neurosci 24:1646-51. 2004
    ..We conclude that gene therapy is an effective approach to enhancing axon regeneration in the CNS and that inactivation of NgR functioning greatly enhances axon regeneration provided the intrinsic growth program of neurons is activated...
  22. ncbi request reprint Signaling mechanisms of the myelin inhibitors of axon regeneration
    Glenn Yiu
    Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Neurobiol 13:545-51. 2003
    ....
  23. doi request reprint PTEN/mTOR and axon regeneration
    Kevin K Park
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 223:45-50. 2010
    ..In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury...
  24. pmc No simpler than mammals: axon and dendrite regeneration in Drosophila
    Homaira Nawabi
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Genes Dev 26:1509-14. 2012
    ..With forward genetic potential, such invertebrates should be powerful in dissecting the cellular and molecular control of neuronal repair...
  25. pmc Independent control of aging and axon regeneration
    St├ęphane Belin
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 19:354-6. 2014
    ..However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled...
  26. ncbi request reprint Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration
    Qiwei Zhai
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 39:217-25. 2003
    ..Our findings suggest a possibility that inhibiting UPS activity may serve to retard axon degeneration in pathological conditions...
  27. doi request reprint Axon regeneration: electrical silencing is a condition for regrowth
    Andrea Tedeschi
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Biol 20:R713-4. 2010
    ..A recent study in primary sensory neurons shows that electrical activity--mediated through L-type voltage-gated calcium channels--could suppress axon growth after injury...
  28. ncbi request reprint Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth
    Marco Domeniconi
    The Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 35:283-90. 2002
    ..Also, MAG and Nogo66 compete for binding to NgR. These results suggest redundancy in myelin inhibitors and indicate therapies for CNS injuries...
  29. ncbi request reprint The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors
    Onanong Chivatakarn
    Interdepartmental Graduate Program in Neuroscience, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 27:7117-24. 2007
    ..We also conclude that chronic axon growth inhibition by myelin is mediated by NgR1-independent mechanisms...
  30. ncbi request reprint LINGO-1 negatively regulates myelination by oligodendrocytes
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 8:745-51. 2005
    ..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination...
  31. ncbi request reprint Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord
    Maryline Sicotte
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4
    Mol Cell Neurosci 23:251-63. 2003
    ..This work shows, however, that axon growth inhibitors in myelin can be selectively blocked using this immunization approach to promote long-distance axon regeneration in the spinal cord...
  32. ncbi request reprint Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition
    Xiaolin L He
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 38:177-85. 2003
    ..These results now provide a detailed framework for focused structure-function studies aimed at assessing the physiological relevance of NgR-mediated protein-protein interactions to axon regeneration inhibition...
  33. ncbi request reprint A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord
    Shinjiro Kaneko
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
    Nat Med 12:1380-9. 2006
    ..Thus, Sema3A is essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury (SCI). These results support the possibility of using Sema3A inhibitors in the treatment of human SCI...