Research Topics
Genomes and Genes
| Zhigang HeSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Knowing how to navigate: mechanisms of semaphorin signaling in the nervous systemZhigang He
1Division of Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Sci STKE 2002:re1. 2002..Thus, semaphorins may serve as important probes for exploring the mechanisms of intercellular communication during the development and function of the nervous system...- The Nogo signaling pathway for regeneration blockZhigang He
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Neurosci 27:341-68. 2004..These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury... - EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycansVuk Koprivica
Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
Science 310:106-10. 2005..Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury... - A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitorsJong Bae Park
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 45:345-51. 2005..Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system... 
SOCS3 deletion promotes optic nerve regeneration in vivoPatrice D Smith
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Neuron 64:617-23. 2009..Thus, developing strategies to modulate negative signaling regulators may be an efficient strategy of promoting axon regeneration after CNS injury...- PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regenerationYingjie Shen
Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Science 326:592-6. 2009..These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration... - P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgpKevin C Wang
Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 420:74-8. 2002..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin... - PTEN deletion enhances the regenerative ability of adult corticospinal neuronsKai Liu
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
Nat Neurosci 13:1075-81. 2010..Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury... - Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cellsYang Hu
F M Kirby Neurobiology Center, Children s Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Neuron 73:445-52. 2012.... - Sustained axon regeneration induced by co-deletion of PTEN and SOCS3Fang Sun
F M Kirby Neurobiology Center, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 480:372-5. 2011..Our results reveal concurrent activation of mTOR and STAT3 pathways as key for sustaining long-distance axon regeneration in adult CNS, a crucial step towards functional recovery... 
Neuronal intrinsic mechanisms of axon regenerationKai Liu
FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Neurosci 34:131-52. 2011..This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury...- PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regenerationRajeev Sivasankaran
Division of Neuroscience, 320 Longwood Avenue, Children's Hospital, Boston, Massachusetts 02115, USA
Nat Neurosci 7:261-8. 2004..Thus, perturbing PKC activity could represent a therapeutic approach to stimulating axon regeneration after brain and spinal cord injuries... - A local mechanism mediates NAD-dependent protection of axon degenerationJing Wang
Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 170:349-55. 2005..Furthermore, we provide evidence that such Nmnat1/NAD-mediated protection is primarily mediated by their effects on local bioenergetics. Together, our results suggest a novel molecular pathway for axon degeneration... - Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthKevin C Wang
Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 417:941-4. 2002..Thus, OMgp is an important inhibitor of neurite outgrowth that acts through NgR and its associated receptor complex. Interfering with the OMgp/NgR pathway may allow lesioned axons to regenerate after injury in vivo... - Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayKevin Kyungsuk Park
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 322:963-6. 2008..Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury... - Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis modelsShinjiro Kaneko
Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:9794-804. 2006..Finally, we demonstrate that delayed NAm treatment is also beneficial to EAE models, pointing to the therapeutic potential of NAm as a protective agent for EAE and perhaps MS patients... - Neuronal intrinsic barriers for axon regeneration in the adult CNSFang Sun
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Neurobiol 20:510-8. 2010..This review will summarize the molecular mechanisms regulating intrinsic axon growth capacity in the adult CNS and discuss potential implications for therapeutic strategies... - Glial inhibition of CNS axon regenerationGlenn Yiu
Division of Neuroscience, Children's Hospital, Boston, Massachusetts 02115, USA
Nat Rev Neurosci 7:617-27. 2006..Greater insight into glial inhibition is crucial for developing therapies to promote functional recovery after neural injury... - Signaling mechanisms of the myelin inhibitors of axon regenerationGlenn Yiu
Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Curr Opin Neurobiol 13:545-51. 2003.... - PTEN/mTOR and axon regenerationKevin K Park
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Exp Neurol 223:45-50. 2010..In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury... - No simpler than mammals: axon and dendrite regeneration in DrosophilaHomaira Nawabi
F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Genes Dev 26:1509-14. 2012..With forward genetic potential, such invertebrates should be powerful in dissecting the cellular and molecular control of neuronal repair... - Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth stateDietmar Fischer
Department of Neurosurgery, Children's Hospital Boston, Massachusetts 02115, USA
J Neurosci 24:1646-51. 2004..We conclude that gene therapy is an effective approach to enhancing axon regeneration in the CNS and that inactivation of NgR functioning greatly enhances axon regeneration provided the intrinsic growth program of neurons is activated... - Involvement of the ubiquitin-proteasome system in the early stages of wallerian degenerationQiwei Zhai
Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 39:217-25. 2003..Our findings suggest a possibility that inhibiting UPS activity may serve to retard axon degeneration in pathological conditions... - Axon regeneration: electrical silencing is a condition for regrowthAndrea Tedeschi
F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
Curr Biol 20:R713-4. 2010..A recent study in primary sensory neurons shows that electrical activity--mediated through L-type voltage-gated calcium channels--could suppress axon growth after injury... - LINGO-1 negatively regulates myelination by oligodendrocytesSha Mi
Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Neurosci 8:745-51. 2005..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination... - The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitorsOnanong Chivatakarn
Interdepartmental Graduate Program in Neuroscience, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 27:7117-24. 2007..We also conclude that chronic axon growth inhibition by myelin is mediated by NgR1-independent mechanisms... - Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cordMaryline Sicotte
Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4
Mol Cell Neurosci 23:251-63. 2003..This work shows, however, that axon growth inhibitors in myelin can be selectively blocked using this immunization approach to promote long-distance axon regeneration in the spinal cord... - Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowthMarco Domeniconi
The Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
Neuron 35:283-90. 2002..Also, MAG and Nogo66 compete for binding to NgR. These results suggest redundancy in myelin inhibitors and indicate therapies for CNS injuries... - Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibitionXiaolin L He
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Neuron 38:177-85. 2003..These results now provide a detailed framework for focused structure-function studies aimed at assessing the physiological relevance of NgR-mediated protein-protein interactions to axon regeneration inhibition... - A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cordShinjiro Kaneko
Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
Nat Med 12:1380-9. 2006..Thus, Sema3A is essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury (SCI). These results support the possibility of using Sema3A inhibitors in the treatment of human SCI...