Research Topics
Genomes and Genes
Species | Aditi HazraSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Death receptor 4 and bladder cancer riskAditi Hazra
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:1157-9. 2003....
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancerAditi Hazra
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 21:331-45. 2010..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer...- Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health StudyAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 28:1510-9. 2007..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma... - Uracil misincorporation into DNA and folic acid supplementationAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 91:160-5. 2010..Folate deficiency decreases thymidylate synthesis from deoxyuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil misincorporation (UrMis) into DNA during replication and repair... 
Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up StudyAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:311-9. 2008..00003). The SNP500Cancer database and the Illumina GoldenGate Assay allowed us to test a larger number of SNPs than previously possible. We identified several SNPs worthy of investigation in larger studies...- Association of the TCF7L2 polymorphism with colorectal cancer and adenoma riskAditi Hazra
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 19:975-80. 2008..37-1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation... - Genome-wide significant predictors of metabolites in the one-carbon metabolism pathwayAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Hum Mol Genet 18:4677-87. 2009..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP... - Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumorsYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Mol Cancer 9:125. 2010..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features... - DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancerKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 15:3663-71. 2009..We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer... - Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cellsNatsumi Irahara
Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
J Mol Diagn 12:177-83. 2010..9) in leukocyte DNA. In conclusion, bisulfite conversion and PCR-pyrosequencing assay can measure LINE-1 methylation in macrodissected colon cancer, normal colon, and blood DNA, and may be useful in clinical and research settings... - Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sampleKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
PLoS ONE 3:e3698. 2008..CIMP-high is independently associated with clinical and key molecular features in colorectal cancer. Our data also suggest that KRAS mutation is related with a random CpG island methylation pattern which may lead to CIMP-low tumors... - SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancerKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Mod Pathol 22:922-32. 2009..In conclusion, SIRT1 expression is associated with CIMP-high MSI-high colon cancer, suggesting involvement of SIRT1 in gene silencing in this unique tumor subtype... - MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Carcinogenesis 28:1985-90. 2007..56C>T) of the MGMT promoter and promoter methylation/silencing of MGMT in colorectal cancer. Our data provide compelling evidence for common susceptibility for MGMT promoter CpG island methylation... - Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosisYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 139:1855-64. 2010..IGF2 LOI correlates with hypomethylation at the differentially methylated region (DMR)-0. An assay for methylation of the DMR0 could overcome the limitations of the conventional IGF2 LOI assay... - Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Clin Cancer Res 14:8221-7. 2008..However, previous data on the influence of COX-2 expression on patient outcome have been conflicting... - Common variants of FUT2 are associated with plasma vitamin B12 levelsAditi Hazra
Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
Nat Genet 40:1160-2. 2008..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels... - p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosisShuji Ogino
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 18:2513-21. 2009..Patient BMI also differentially influences prognosis according to p21 CDKN1A status. Our data suggest host-tumor interactions influencing tumor aggressiveness... - Benzo[a]pyrene diol epoxide-induced 9p21 aberrations associated with genetic predisposition to bladder cancerAditi Hazra
Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Genes Chromosomes Cancer 41:330-8. 2004..04, 5.69), 5.14 (1.12, 23.59), and 21.51 (4.75, 97.34), respectively, providing increasing dose-response evidence of the locus-specific alterations. Thus, 9p21 may be a molecular target for BPDE-induced damage in bladder cancer cases... - β-Carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descentSara J Hendrickson
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 96:1379-89. 2012.... - Common variants in ZNF365 are associated with both mammographic density and breast cancer riskSara Lindstrom
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Genet 43:185-7. 2011..6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer... - Traditional breast cancer risk factors in relation to molecular subtypes of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 131:159-67. 2012..Identifying risk factors for less common subtypes such as luminal B, HER2-type and basal-like tumors has important implications for prevention of these more aggressive subtypes... - Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia riskSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Hum Mol Genet 17:2665-72. 2008..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...