Robin L Haynes

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
    Robin L Haynes
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:441-50. 2003
  2. ncbi request reprint Lipid peroxidation during human cerebral myelination
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 65:894-904. 2006
  3. pmc Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia
    Rebecca D Folkerth
    Department of Pathology, Children s Hospital, Boston, MA, USA
    J Neuropathol Exp Neurol 67:677-86. 2008
  4. pmc Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity
    Poonam Ligam
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:524-9. 2009
  5. pmc The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons
    Sarah E Andiman
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
    Brain Pathol 20:803-14. 2010
  6. pmc Late development of the GABAergic system in the human cerebral cortex and white matter
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 70:841-58. 2011
  7. ncbi request reprint Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter
    Rebecca D Folkerth
    From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
    J Neuropathol Exp Neurol 63:990-9. 2004
  8. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
  9. pmc Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
    Acta Neuropathol 118:391-9. 2009
  10. pmc Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin
    Robin L Haynes
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 63:656-61. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
    Robin L Haynes
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:441-50. 2003
    ..Agents that prevent nitrosative and oxidative stress may play a key role in ameliorating PVL in premature infants in the intensive care nursery...
  2. ncbi request reprint Lipid peroxidation during human cerebral myelination
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 65:894-904. 2006
    ....
  3. pmc Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia
    Rebecca D Folkerth
    Department of Pathology, Children s Hospital, Boston, MA, USA
    J Neuropathol Exp Neurol 67:677-86. 2008
    ..Thus, oxidative/nitrative damage to cortical and "pioneer" neurons, although mild overall, may contribute to cortical volume loss and cognitive/behavioral impairment in survivors of prematurity...
  4. pmc Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity
    Poonam Ligam
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:524-9. 2009
    ..01), with substantial involvement of the mediodorsal, and reticular nuclei in PVL. The prevention of thalamic damage may be required for the eradication of defects in survivors with PVL...
  5. pmc The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons
    Sarah E Andiman
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
    Brain Pathol 20:803-14. 2010
    ..This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity...
  6. pmc Late development of the GABAergic system in the human cerebral cortex and white matter
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 70:841-58. 2011
    ..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant...
  7. ncbi request reprint Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter
    Rebecca D Folkerth
    From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
    J Neuropathol Exp Neurol 63:990-9. 2004
    ..The previously unrecognized dissociation between the expression of the SODs and that of catalase and GPx in the fetal period has potential implications for future antioxidant therapy in PVL...
  8. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
    ..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL...
  9. pmc Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
    Acta Neuropathol 118:391-9. 2009
    ..This study supports an important role for iNOS-induced nitrosative stress in the reactive/inflammatory component of PVL...
  10. pmc Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin
    Robin L Haynes
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 63:656-61. 2008
    ..We conclude that diffuse axonal injury, as determined by apoptotic marker fractin, occurs in PVL and that its cause likely includes primary ischemia and trophic degeneration secondary to corticothalamic neuronal damage...
  11. pmc Neuron deficit in the white matter and subplate in periventricular leukomalacia
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:397-406. 2012
    ..We tested the hypothesis that the overall density of neurons in the white matter and subplate region is significantly lower in PVL cases compared to non-PVL controls...
  12. ncbi request reprint Axonal development in the cerebral white matter of the human fetus and infant
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 484:156-67. 2005
    ..These data suggest that immature axons are susceptible to damage in PVL and that the timing of axonal maturation must be considered toward establishing its pathology relative to the oligodendrocyte/myelin/axonal unit...
  13. pmc Potential neuronal repair in cerebral white matter injury in the human neonate
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 69:62-7. 2011
    ..e. 35-42 postconceptional weeks. These data provide the first evidence suggestive of an attempt at neuronal repair or regeneration in human neonatal white matter injury...
  14. ncbi request reprint Interferon-gamma expression in periventricular leukomalacia in the human brain
    Rebecca D Folkerth
    Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Brain Pathol 14:265-74. 2004
    ..In PVL, IFN-gamma produced by macrophages and reactive astrocytes may play a role in cytokine-induced toxicity to premyelinating oligodendrocytes as part of a cytokine response stimulated by ischemia and/or infection...
  15. pmc Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 24:579-92. 2014
    ..This study provides baseline information for interpreting radial coherence in tractography studies of the preterm brain in the assessment of the encephalopathy of prematurity. ..
  16. pmc Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice
    Caitlin A Massey
    Department of Anesthesiology, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurochem 126:749-57. 2013
    ..Thus, brainstem 5-HT(1A)-heteroreceptor-binding sites do not appear developmentally sensitive to reduced brain 5-HT levels...
  17. ncbi request reprint Development of microglia in the cerebral white matter of the human fetus and infant
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
    J Comp Neurol 497:199-208. 2006
    ..j...
  18. pmc Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome
    Ingvar Jon Rognum
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 118:519-30. 2009
    ..Aberrant interactions between IL-6 and the arcuate nucleus may contribute to impaired responses to hypercapnia generated by infection (hyper-metabolism) combined with rebreathing...
  19. ncbi request reprint TLR8: an innate immune receptor in brain, neurons and axons
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cell Cycle 6:2859-68. 2007
    ....
  20. ncbi request reprint Is the late preterm infant more vulnerable to gray matter injury than the term infant?
    Saraid S Billiards
    Department of Pathology, Enders Building, Room 1109, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Perinatol 33:915-33; abstract x-xi. 2006
    ..Future research involving closer examination of the late preterm period is essential to provide a greater understanding of the neuronal vulnerability in the face of hypoxic-ischemic injury...
  21. pmc 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia
    Robin L Haynes
    Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Neurosci 35:140-54. 2013
    ..Our data support a role for 12/15-LOX activation as an inflammatory mediator of injury in PVL, with a contribution of 12/15-LOX to PVL-induced damage to or cell death of OLs, including those at the O1 and O4 stages. ..
  22. pmc Disconnection of the ascending arousal system in traumatic coma
    Brian L Edlow
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    J Neuropathol Exp Neurol 72:505-23. 2013
    ..We propose that traumatic coma may be a subcortical disconnection syndrome related to the disconnection of specific brainstem arousal nuclei from the thalamus and basal forebrain...
  23. pmc Novel neuropathologic findings in the Haddad syndrome
    Nestor D Tomycz
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 119:261-9. 2010
    ..This study implicates novel brain findings in Haddad syndrome mimicking those in murine Phox2b null mutants. This case suggests that abnormalities occur in CCHS in a network of sites critical to chemoreception...