Elizabeth Hay

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    Kwonseop Kim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Biol Int 26:463-76. 2002
  2. ncbi The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    Elizabeth D Hay
    Harvard Medical School, Department of Cell Biology, Boston, Massachusetts 02115, USA
    Dev Dyn 233:706-20. 2005
  3. ncbi TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
    Ali Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, B 1, Room 342, Boston, MA 02115 6092, USA
    J Cell Biol 163:1291-301. 2003
  4. ncbi Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Cells Tissues Organs 179:11-23. 2005
  5. ncbi Microarray analysis of gene expression during epithelial-mesenchymal transformation
    Damian Lagamba
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Dyn 234:132-42. 2005
  6. ncbi Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition
    Damian Medici
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 17:1871-9. 2006
  7. ncbi TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Cell Sci 120:1646-53. 2007

Research Grants

  1. DEVELOPMENT OF THE PALATE AND CRANIOFACIAL MESENCHYME
    Elizabeth Hay; Fiscal Year: 2002
  2. Internat. Meeting on Epithelial-Mesenchymal Transitions
    Elizabeth Hay; Fiscal Year: 2003

Collaborators

  • Ali Nawshad
  • Damian Medici
  • Damian Lagamba
  • Kwonseop Kim
  • Daniel A Goodenough
  • Zifan Lu

Detail Information

Publications7

  1. ncbi Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    Kwonseop Kim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Biol Int 26:463-76. 2002
    ..Normal adult epithelial cells appear to use APC to keep beta-catenin out of the nucleus, thereby avoiding pathologies such as metastases due to LEF/beta-catenin-induced EMT...
  2. ncbi The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    Elizabeth D Hay
    Harvard Medical School, Department of Cell Biology, Boston, Massachusetts 02115, USA
    Dev Dyn 233:706-20. 2005
    ..In the adult, mesenchymal cells may give rise to metastatic tumor cells and other pathological conditions that we will touch on at the end of the review...
  3. ncbi TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
    Ali Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, B 1, Room 342, Boston, MA 02115 6092, USA
    J Cell Biol 163:1291-301. 2003
    ..When phospho-Smad2 and Smad4 are present in the nucleus, LEF1 is activated without beta-catenin. Our paper is the first to show that the Smad2,4/LEF1 complex replaces beta-catenin/LEF1 during activation of EMT in vivo by TGFbeta3...
  4. ncbi Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Cells Tissues Organs 179:11-23. 2005
    ..Here we assess the biochemical signaling pathways of TGF-beta and their potential cross-interaction with traditional Wnt signaling molecules to bring about EMT during embryogenesis and tumor metastasis...
  5. ncbi Microarray analysis of gene expression during epithelial-mesenchymal transformation
    Damian Lagamba
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Dyn 234:132-42. 2005
    ..This knowledge of the changes in gene expression levels during palatogenesis should lead to a better understanding of the mechanisms of EMT...
  6. ncbi Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition
    Damian Medici
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 17:1871-9. 2006
    ....
  7. ncbi TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Cell Sci 120:1646-53. 2007
    ..We proved that TGFbeta3 signaling induces EMT in MEE cells by forming activated transcription complexes of Smad2-P, Smad4 and LEF1 that directly inhibit E-cadherin gene expression...

Research Grants9

  1. DEVELOPMENT OF THE PALATE AND CRANIOFACIAL MESENCHYME
    Elizabeth Hay; Fiscal Year: 2002
    ..Knowledge of the basic cell biology will lead to more effective treatment of human facial clefting. ..
  2. Internat. Meeting on Epithelial-Mesenchymal Transitions
    Elizabeth Hay; Fiscal Year: 2003
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