Richard A Hawkins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Structure of the blood-brain barrier and its role in the transport of amino acids
    Richard A Hawkins
    Department of Biochemistry and Molecular Biology, Facultad de Medicina y Farmacia, Universidad de Valencia, Valencia, Spain
    J Nutr 136:218S-26S. 2006
  2. pmc Glutamate permeability at the blood-brain barrier in insulinopenic and insulin-resistant rats
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Metabolism 59:258-66. 2010
  3. pmc The blood-brain barrier and glutamate
    Richard A Hawkins
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Am J Clin Nutr 90:867S-874S. 2009
  4. ncbi request reprint Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    FEBS Lett 580:4382-6. 2006
  5. ncbi request reprint An active transport system in the blood-brain barrier may reduce levodopa availability
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 195:267-71. 2005
  6. ncbi request reprint Na+ -dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removal
    Robyn L O'Kane
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, IL 60064 3095, USA
    Am J Physiol Endocrinol Metab 287:E622-9. 2004
  7. doi request reprint Na(+)-dependent transport of taurine is found only on the abluminal membrane of the blood-brain barrier
    Hector Rasgado-Flores
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095 USA
    Exp Neurol 233:457-62. 2012
  8. ncbi request reprint Transport studies using membrane vesicles
    Darryl R Peterson
    Department of Physiology and Biophysics, Finch University of Health Sciences, Chicago Medical School, North Chicago, IL, USA
    Methods Mol Med 89:233-47. 2003
  9. ncbi request reprint Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier
    Robyn L O'Kane
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Rd, North Chicago, Illinois 60064 3095, USA
    Am J Physiol Endocrinol Metab 285:E1167-73. 2003
  10. ncbi request reprint The complementary membranes forming the blood-brain barrier
    Richard A Hawkins
    Department of Physiology and Biophysics, Finch University of Health Science The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    IUBMB Life 54:101-7. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Structure of the blood-brain barrier and its role in the transport of amino acids
    Richard A Hawkins
    Department of Biochemistry and Molecular Biology, Facultad de Medicina y Farmacia, Universidad de Valencia, Valencia, Spain
    J Nutr 136:218S-26S. 2006
    ..Pyroglutamate stimulates secondary active AA transporters at the abluminal membrane, thereby reducing the net influx of AAs to the brain. It is now clear that BBB participates in the active regulation of the AA content of the brain...
  2. pmc Glutamate permeability at the blood-brain barrier in insulinopenic and insulin-resistant rats
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Metabolism 59:258-66. 2010
    ..Brain GLU uptake also did not differ among the diet groups. Together, the results indicate that the blood-brain barrier remains intact to the penetration of GLU in 2 models of diabetes under the conditions examined...
  3. pmc The blood-brain barrier and glutamate
    Richard A Hawkins
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Am J Clin Nutr 90:867S-874S. 2009
    ..This issue was tested in rats with diet-induced obesity and insulin resistance or with streptozotocin-induced diabetes. Neither condition produced any detectable effect on BBB glutamate transport...
  4. ncbi request reprint Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    FEBS Lett 580:4382-6. 2006
    ..This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain...
  5. ncbi request reprint An active transport system in the blood-brain barrier may reduce levodopa availability
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 195:267-71. 2005
    ..The activity of this system reduces the net availability of levodopa...
  6. ncbi request reprint Na+ -dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removal
    Robyn L O'Kane
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, IL 60064 3095, USA
    Am J Physiol Endocrinol Metab 287:E622-9. 2004
    ..The presence of Na+ -dependent carriers on the abluminal membrane provides a mechanism by which NAA concentrations in the ECF of brain are maintained at approximately 10% of those of the plasma...
  7. doi request reprint Na(+)-dependent transport of taurine is found only on the abluminal membrane of the blood-brain barrier
    Hector Rasgado-Flores
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095 USA
    Exp Neurol 233:457-62. 2012
    ..The Na(+)-dependent transport system was sensitive to osmolality with the greatest rate observed at 229 mOsm/kg H(2)O...
  8. ncbi request reprint Transport studies using membrane vesicles
    Darryl R Peterson
    Department of Physiology and Biophysics, Finch University of Health Sciences, Chicago Medical School, North Chicago, IL, USA
    Methods Mol Med 89:233-47. 2003
  9. ncbi request reprint Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier
    Robyn L O'Kane
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Rd, North Chicago, Illinois 60064 3095, USA
    Am J Physiol Endocrinol Metab 285:E1167-73. 2003
    ....
  10. ncbi request reprint The complementary membranes forming the blood-brain barrier
    Richard A Hawkins
    Department of Physiology and Biophysics, Finch University of Health Science The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    IUBMB Life 54:101-7. 2002
    ..In conclusion, it is now clear that the blood-brain barrier participates in the active regulation of brain extracellular fluid, and that the diverse functions of each plasma membrane domain contributes to these regulatory functions...
  11. ncbi request reprint Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+
    Robyn L O'Kane
    Natural and Applied Science Department, LaGuardia Community College City University of New York, New York, USA
    Am J Physiol Endocrinol Metab 291:E412-9. 2006
    ..These results confirm that system y+ is the only CAA transporter in the BBB and suggest that NO can be produced in brain endothelial cells...