Research Topics
| J M HausdorffSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gaitJ M Hausdorff
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, 64239 Tel Aviv, Israel
Exp Brain Res 149:187-94. 2003....- Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosisJ M Hausdorff
Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 88:2045-53. 2000..Moreover, a matrix of markers based on gait dynamics may be useful in characterizing certain pathologies of motor control and, possibly, in quantitatively monitoring disease progression and evaluating therapeutic interventions... - Effects of cognitive challenge on gait variability in patients with Parkinson's diseaseJeffrey M Hausdorff
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv, Israel
J Geriatr Psychiatry Neurol 16:53-8. 2003..These results highlight the profound effects of attention on gait and indicate that walking while cognitively challenged impairs the ability of patients with PD to maintain a stable walk... - Etiology and modification of gait instability in older adults: a randomized controlled trial of exerciseJ M Hausdorff
Gerontology Division, Beth Israel Deaconess Medical Center, and Division on Aging, Harvard Medical School, Boston 02215, Massachusetts, USA
J Appl Physiol 90:2117-29. 2001.... - Gait variability and fall risk in community-living older adults: a 1-year prospective studyJ M Hausdorff
Gerontology Division, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, MA 02215, USA
Arch Phys Med Rehabil 82:1050-6. 2001..To test the hypothesis that increased gait variability predicts falls among community-living older adults attending an outpatient clinic... - Association of muscle power with functional status in community-dwelling elderly womenM Foldvari
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Gerontol A Biol Sci Med Sci 55:M192-9. 2000..We tested the hypothesis that peak muscle power is closely associated with self-reported functional status in sedentary elderly community-dwelling women... - The effects of reducing fear of falling on locomotion in older adults with a higher level gait disorderY Balash
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Neural Transm 114:1309-14. 2007..Thus, it appears that the gait disturbances in these patients are apparently not simply the consequence of FOF... - Clinical characteristics of elderly patients with a cautious gait of unknown originN Giladi
Dept of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Neurol 252:300-6. 2005..To evaluate and systematically characterize a group of older adults with disturbed gait of unknown origin... - Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's diseaseJ D Schaafsma
Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Eur J Neurol 10:391-8. 2003..0001) and the number of episodes with akinesia (P < 0.001). Distinction amongst FOG subtypes enables evaluation of distinctive therapeutic response. Levodopa helps in reducing the frequency and duration of 'off'-related FOG... 
Bilateral coordination of gait and Parkinson's disease: the effects of dual taskingM Plotnik
Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
J Neurol Neurosurg Psychiatry 80:347-50. 2009..The present findings suggest that in patients with PD, cognitive resources are used in order to maintain consistent and accurate alternations in left-right stepping...- The power of ageism on physical function of older persons: reversibility of age-related gait changesJ M Hausdorff
Division on Aging, Harvard Medical School, Boston, Massachusetts, USA
J Am Geriatr Soc 47:1346-9. 1999..To test the hypothesis that age-associated changes in physical function, particularly walking performance, are influenced by ageism and that the activation of positive sterotypes of aging can partially reverse these changes... 
Is heart rate variability related to gait impairment in patients with Parkinson's disease? A pilot studyM B Aerts
Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Parkinsonism Relat Disord 15:712-5. 2009..The present study was performed to further examine this putative relationship using quantitative measures of autonomic function and gait in order to shed light on the underlying pathophysiology of these symptoms...- Treadmill training for the treatment of gait disturbances in people with Parkinson's disease: a mini-reviewT Herman
Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel
J Neural Transm 116:307-18. 2009..Additional high quality randomized controlled studies are needed before TT can be recommended with evidence-based support... - Disparate effects of socioeconomic status on physical function and emotional well-being in older adultsD A Rios
Division on Aging, Harvard Medical School, Boston, Massachusetts, USA
Aging (Milano) 13:30-7. 2001..SES may have disparate effects on physical function and mental health, perhaps due to different compensatory mechanisms... - Falls in outpatients with Parkinson's disease: frequency, impact and identifying factorsY Balash
Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
J Neurol 252:1310-5. 2005..These findings confirm that falls are a common problem among patients with advanced PD and suggest easily measurable features that may be used to prospectively identify those PD patients with the greatest risk of falls... - Fractal dynamics of human gait: stability of long-range correlations in stride interval fluctuationsJ M Hausdorff
Charles A Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215, USA
J Appl Physiol 80:1448-57. 1996..Furthermore, this fractal property of neural output may be related to the higher nervous centers responsible for the control of walking rhythm... - Progressive nature of a higher level gait disorder: a 3-year prospective studyV Huber-Mahlin
Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Neurol 257:1279-86. 2010.... - Gait instability and fractal dynamics of older adults with a "cautious" gait: why do certain older adults walk fearfully?T Herman
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
Gait Posture 21:178-85. 2005.... - Freezing of gait in older adults with high level gait disorders: association with impaired executive functionN Giladi
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Neural Transm 114:1349-53. 2007..These results indicate that FOG is common in HLGD, and that it is associated with significant functional disability and a specific frontal cognitive disturbance of initiation... - An instrumented timed up and go: the added value of an accelerometer for identifying fall risk in idiopathic fallersA Weiss
Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Physiol Meas 32:2003-18. 2011..Without compromising simplicity of testing, an accelerometer can apparently be combined with TUG duration to provide complementary, objective measures that allow for a more complete, sensitive TUG-based fall risk assessment... - Maturation of gait dynamics: stride-to-stride variability and its temporal organization in childrenJ M Hausdorff
Margret H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Boston 02215, Massachusetts, USA
J Appl Physiol 86:1040-7. 1999..These findings indicate that mature stride dynamics may not be completely developed even in healthy 7-yr-old children and that different aspects of stride dynamics mature at different ages... - PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signalsA L Goldberger
Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
Circulation 101:E215-20. 2000..physionet. org), PhysioNet offers services and training via on-line tutorials to assist users with varying levels of expertise... - When human walking becomes random walking: fractal analysis and modeling of gait rhythm fluctuationsJ M Hausdorff
Beth Israel Deaconness Medical Center, Harvard Medical School, Boston, MA 02215, USA
Physica A 302:138-47. 2001..By tuning one model parameter, the hopping (transition) range, the model can describe alterations in gait dynamics from childhood to adulthood including a decrease in the correlation and volatility exponents with maturation... - R-R interval variation in Parkinson's disease and multiple system atrophyT Yu Gurevich
Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Acta Neurol Scand 109:276-9. 2004..2%) and MSA (6/20, 30%) were higher than among controls (P < 0.004). CONCLUSIONS: RRIV, either at rest or after deep breathing, may be abnormal both in PD and MSA, but does not distinguish between these disorders... - Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failureC T Pu
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Appl Physiol 90:2341-50. 2001..These gains are largely explained by skeletal muscle and not resting cardiac adaptations... - A new measure for quantifying the bilateral coordination of human gait: effects of aging and Parkinson's diseaseMeir Plotnik
Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
Exp Brain Res 181:561-70. 2007..This study demonstrates that bilateral coordination of gait deteriorates with aging, further deteriorates in PD, and is not strongly associated with other spatio-temporal features of gait... - Effects of pharmacological therapy on gait and cognitive function in depressed patientsDiana Paleacu
Neurology Service and Memory Clinic, Abarbanel Mental Health Center, Bat Yam, Israel
Clin Neuropharmacol 30:63-71. 2007..To investigate the relationship among affective status, cognitive function, and gait in depressed patients and to evaluate the effects of treatment of depression on gait and cognitive function... - Gait in attention deficit hyperactivity disorder : effects of methylphenidate and dual taskingYael Leitner
Paediatric Neurology Unit and Child Development Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Neurol 254:1330-8. 2007..Cognitive function and the loading of attention presumably play an important role in gait as well as in fall risk, but previous work has not demonstrated this in any cause-and-effect way... - Gait dynamics, fractals and falls: finding meaning in the stride-to-stride fluctuations of human walkingJeffrey M Hausdorff
Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
Hum Mov Sci 26:555-89. 2007.... - Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's diseaseRossitza Baltadjieva
Laboratory for Gait and Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
Eur J Neurosci 24:1815-20. 2006..PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment... - The role of higher-level cognitive function in gait: executive dysfunction contributes to fall risk in Alzheimer's diseasePamela L Sheridan
Behavioral Neurology Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Dement Geriatr Cogn Disord 24:125-37. 2007..We also briefly examine the current treatment of gait instability in AD, mainly exercise, and propose a new approach targeting cognition... - Six weeks of intensive treadmill training improves gait and quality of life in patients with Parkinson's disease: a pilot studyTalia Herman
Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Department of Physical Therapy, Sackler School of Medicine, Tel Aviv University, Israel
Arch Phys Med Rehabil 88:1154-8. 2007..To evaluate the effects of 6 weeks of intensive treadmill training on gait rhythmicity, functional mobility, and quality of life (QOL) in patients with Parkinson's disease (PD)... - Rhythmic auditory stimulation modulates gait variability in Parkinson's diseaseJeffrey M Hausdorff
Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
Eur J Neurosci 26:2369-75. 2007.... - The role of executive function and attention in gaitGalit Yogev-Seligmann
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Mov Disord 23:329-42; quiz 472. 2008..Lastly, we suggest how assessments of executive function and attention could be applied in the clinical setting as part of the process of identifying and understanding gait disorders and fall risk... - Effects of a new radio frequency-controlled neuroprosthesis on gait symmetry and rhythmicity in patients with chronic hemiparesisJeffrey M Hausdorff
Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Am J Phys Med Rehabil 87:4-13. 2008..To assess the effects of a new neuroprosthesis (NESS L300) designed to ameliorate foot drop on gait symmetry and rhythmicity during walking... - Can methylphenidate reduce fall risk in community-living older adults? A double-blind, single-dose cross-over studyRon Ben-Itzhak
Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Am Geriatr Soc 56:695-700. 2008..To test the hypothesis that methylphenidate modifies markers of fall risk in older adults... - Bilateral coordination of walking and freezing of gait in Parkinson's diseaseMeir Plotnik
Movement Disorders Unit, Laboratory for Gait and Neurodynamics, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
Eur J Neurosci 27:1999-2006. 2008..Poor bilateral coordination of walking may predispose to FOG, especially during challenging tasks that demand a high degree of left-right coordination... - A novel multidomain computerized cognitive assessment for attention-deficit hyperactivity disorder: evidence for widespread and circumscribed cognitive deficitsYael Leitner
Paediatric Neurology Unit and Child Development Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
J Child Neurol 22:264-76. 2007..Hence, on the limited basis of this pilot study, the set of computerized tests studied appears to be useful for measuring cognitive function in ADHD; however, additional studies are needed to confirm this... - Assessing fear of falling: Can a short version of the Activities-specific Balance Confidence scale be useful?Chava Peretz
Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Mov Disord 21:2101-5. 2006..ICCs between the short and the long versions was 0.88 (HLGDs), 0.83 (PDs), and 0.78 (Controls). To conclude, the short version of the ABC has properties analogous to the parent questionnaire and is apparently useful in assessing FOF... - A common cognitive profile in elderly fallers and in patients with Parkinson's disease: the prominence of impaired executive function and attentionJeffrey M Hausdorff
Movement Disorders Unit, Tel Aviv Sourasky Medical Center
Exp Aging Res 32:411-29. 2006..e., variability of response timing) and underscore the importance of executive function and attention as potential targets for fall risk screening and interventions... - Quantifying fractal dynamics of human respiration: age and gender effectsC K Peng
Margret and H. A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Ann Biomed Eng 30:683-92. 2002.... - The power of cueing to circumvent dopamine deficits: a review of physical therapy treatment of gait disturbances in Parkinson's diseaseTamar C Rubinstein
Movement Disorders Unit, Neurology Department, Tel-Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Mov Disord 17:1148-60. 2002.... - Balance and gait in older adults with systemic hypertensionJeffrey M Hausdorff
Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Am J Cardiol 91:643-5. 2003 - Gait dynamics in Parkinson's disease: relationship to Parkinsonian features, falls and response to levodopaJoanna D Schaafsma
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
J Neurol Sci 212:47-53. 2003..Stride-to-stride variability is especially impaired among PD subjects with a history of falls, suggesting, for the first time, the possibility of exaggerated impairment of internal clock function in PD fallers... - Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer's diseasePamela L Sheridan
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Am Geriatr Soc 51:1633-7. 2003..To evaluate how cognitive function and divided attention affect gait in Alzheimer's disease (AD)... - Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomenaBastiaan R Bloem
Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
Mov Disord 19:871-84. 2004.... - Gait unsteadiness and fall risk in two affective disorders: a preliminary studyJeffrey M Hausdorff
Division on Aging, Harvard Medical School, Boston, MA, USA
BMC Psychiatry 4:39. 2004.... - Is freezing of gait in Parkinson's disease related to asymmetric motor function?Meir Plotnik
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Ann Neurol 57:656-63. 2005..Taken together, the results of this study suggest that bilateral uncoordinated gait and marked gait asymmetry, but not asymmetry in motor performance in general, are associated with FOG... - Walking is more like catching than tapping: gait in the elderly as a complex cognitive taskJeffrey M Hausdorff
Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Exp Brain Res 164:541-8. 2005.... - Fractal dynamics in physiology: alterations with disease and agingAry L Goldberger
Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 99:2466-72. 2002..Elucidating the fractal and nonlinear mechanisms involved in physiologic control and complex signaling networks is emerging as a major challenge in the postgenomic era... - Gait asymmetry in patients with Parkinson's disease and elderly fallers: when does the bilateral coordination of gait require attention?Galit Yogev
Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
Exp Brain Res 177:336-46. 2007..In contrast, however, when gait becomes impaired and less automatic, GA apparently relies on cognitive input and attention... - The role of mental function in the pathogenesis of freezing of gait in Parkinson's diseaseNir Giladi
Movement Disorders Unit, NPF Center for Parkinson s Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Neurol Sci 248:173-6. 2006..A conceptual model that explains how mental conditions may modulate FOG is developed... - Cognitive function may be important for fall injury prevention trialsJeffrey M Hausdorff
J Am Geriatr Soc 54:865; author reply 865-6. 2006 - Dual-tasking effects on gait variability: the role of aging, falls, and executive functionShmuel Springer
Movement Disorders Unit, Neurology Department, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Mov Disord 21:950-7. 2006..In contrast, dual tasking destabilizes the gait of idiopathic elderly fallers, an effect that appears to be mediated in part by a decline in EF... - Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot studyEitan Auriel
Movement Disorders Unit, NPF Center of Excellence, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Clin Neuropharmacol 29:15-7. 2006..These findings suggest a new potential pharmacologic means of enhancing mobility and decreasing fall risk in Parkinson's disease... - Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding?Galit Yogev
Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
Eur J Neurosci 22:1248-56. 2005..Moreover, the associations between executive function and gait variability suggest that a decline in executive function in PD may exacerbate the effects of dual tasking on gait, potentially increasing fall risk... - Treadmill walking as an external pacemaker to improve gait rhythm and stability in Parkinson's diseaseSilvi Frenkel-Toledo
Department of Physical Therapy, Sackler School of Medicine, Tel-Aviv, Israel
Mov Disord 20:1109-14. 2005.... - Heart rate dynamics during three forms of meditationC K Peng
Margret and H A Rey Institute for Nonlinear Dynamics in Physiology and Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Int J Cardiol 95:19-27. 2004..This study was designed to quantify and compare the instantaneous heart rate dynamics and cardiopulmonary interactions during sequential performance of three meditation protocols with different breathing patterns... - "Brain Screen": A self-referral, screening program for strokes, falls and dementia risk factorsNir Giladi
Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
J Neurol 253:307-15. 2006..Falls, strokes and dementia can be predicted and their occurrence can be delayed or even prevented by treatment of risk factors. The value of screening self-referred adults is unknown... - Detecting scaling in the period dynamics of multimodal signals: application to Parkinsonian tremorNir Sapir
Department of Physics and Gonda-Goldschmied Medical Diagnostic Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel
Phys Rev E Stat Nonlin Soft Matter Phys 67:031903. 2003.... - Influence of African American elders' age stereotypes on their cardiovascular response to stressBecca R Levy
Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520 8034, USA
Anxiety Stress Coping 21:85-93. 2008..These results suggest that negative age stereotypes generate a susceptibility to stress among African American elders, whereas positive age may provide them with a defense against this stress... - The sensory feedback mechanisms enabling couples to walk synchronously: an initial investigationAri Z Zivotofsky
Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel
J Neuroeng Rehabil 4:28. 2007....